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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3094
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c2affects bindingEXP 6480464CTDDexamethasone binds to NR3C2 proteinPMID:21281618
Nr3c2increases expressionEXP 6480464CTDDexamethasone results in increased expression of NR3C2 mRNAPMID:36790081
Nr3c2multiple interactionsEXP 6480464CTDDexamethasone promotes the reaction [NR3C2 protein binds to TBX2 promoter]; Dexamethasone promotes the reaction [NR3C2 protein promotes the reaction [EP300 protein binds to TBX2 promoter]]; Dexamethasone results in increased expression of and affects the localization of NR3C2 protein; Fluoxetine affects the reaction [Dexamethasone binds to NR3C2 protein]PMID:21281618 PMID:36790081
Nr3c2increases activityISONR3C2 (Homo sapiens)6480464CTDDexamethasone results in increased activity of NR3C2 proteinPMID:15362971
Nr3c2increases expressionISONR3C2 (Homo sapiens)6480464CTDDexamethasone results in increased expression of NR3C2 mRNAPMID:19022236
Nr3c2multiple interactionsISONR3C2 (Homo sapiens)6480464CTD[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of NR3C2 mRNAPMID:23275455
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