NCOA2 (nuclear receptor coactivator 2) - Rat Genome Database
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Gene: NCOA2 (nuclear receptor coactivator 2) Homo sapiens
Analyze
Symbol: NCOA2
Name: nuclear receptor coactivator 2
RGD ID: 732737
HGNC Page HGNC
Description: Exhibits RNA polymerase II-specific DNA-binding transcription factor binding activity; nuclear receptor transcription coactivator activity; and protein domain specific binding activity. Predicted to be involved in cellular response to hormone stimulus and regulation of gene expression. Localizes to nuclear body and protein-containing complex. Implicated in acute myeloid leukemia. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1; GRIP1; hTIF2; KAT13C; MGC138808; NCoA-2; p160 steroid receptor coactivator 2; SRC2; TIF2; transcriptional intermediary factor 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl870,109,782 - 70,403,808 (-)EnsemblGRCh38hg38GRCh38
GRCh38870,109,770 - 70,405,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37871,022,017 - 71,316,452 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37871,021,997 - 71,316,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,186,821 - 71,478,574 (-)NCBINCBI36hg18NCBI36
Build 34871,186,820 - 71,478,574NCBI
Celera867,021,935 - 67,313,703 (-)NCBI
Cytogenetic Map8q13.3NCBI
HuRef866,517,566 - 66,809,329 (-)NCBIHuRef
CHM1_1871,077,538 - 71,372,108 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-linalyl acetate  (EXP)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (EXP)
2,3,4,5-Tetrachloro-4'-biphenylol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (ISO)
2-hydroxypropanoic acid  (EXP)
22,23-dihydroavermectin B1a  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3beta-hydroxycholest-5-en-26-oic acid  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-terpineol  (EXP)
4-tert-Octylphenol  (EXP)
9,9-bis(4-hydroxyphenyl)fluorene  (EXP)
[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID  (EXP)
acetamide  (ISO)
acrolein  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-acitretin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
alpha-terpineol  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
androst-4-ene-3,17-dione  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
benidipine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzyl parahydroxybenzoate  (EXP)
bezafibrate  (EXP)
bicalutamide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butamben  (EXP)
butanal  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
chenodeoxycholic acid  (EXP)
cholesterol  (ISO)
cilnidipine  (EXP)
clevidipine  (EXP)
cobalt dichloride  (EXP)
coenzyme Q10  (EXP)
coumestrol  (EXP)
cyproterone acetate  (EXP)
daidzein  (EXP)
daunorubicin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
Doramectin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
emamectin  (EXP)
emodin  (ISO)
entinostat  (EXP)
eprinomectin  (EXP)
ethanol  (ISO)
Ethyl salicylate  (EXP)
ethylparaben  (EXP)
Falecalcitriol  (EXP)
felodipine  (EXP)
flavonol  (EXP)
fulvestrant  (EXP)
furan  (ISO)
galangin  (EXP)
geldanamycin  (EXP)
genistein  (EXP,ISO)
guggulsterone  (EXP)
GW 1929  (EXP)
hexadecanoic acid  (EXP)
Isradipine  (EXP)
ivermectin  (EXP)
lacidipine  (EXP)
lead diacetate  (EXP,ISO)
linalyl acetate  (EXP)
linoleic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
methotrexate  (ISO)
methyl salicylate  (EXP)
methylparaben  (EXP)
methylseleninic acid  (EXP)
mifepristone  (EXP)
milbemycin  (EXP)
N-benzoyl-L-alanine  (EXP)
Nicardipine  (EXP)
nimodipine  (EXP)
oxybenzone  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
pentanal  (EXP)
pirinixic acid  (EXP)
potassium chromate  (EXP)
progesterone  (ISO)
propylparaben  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rifampicin  (EXP)
selenium atom  (EXP)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
toxaphene  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
vorinostat  (EXP)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:8670870   PMID:9111344   PMID:9192892   PMID:9430642   PMID:9558366   PMID:9590696   PMID:9717843   PMID:9751728   PMID:9774463   PMID:9812974   PMID:9920895   PMID:10381882  
PMID:10454563   PMID:10478845   PMID:10490106   PMID:10594042   PMID:10598588   PMID:10617585   PMID:10652338   PMID:10692587   PMID:10706629   PMID:10748178   PMID:11014206   PMID:11050077  
PMID:11085509   PMID:11117530   PMID:11265755   PMID:11266503   PMID:11376110   PMID:11435616   PMID:11477071   PMID:11500849   PMID:11514567   PMID:11518802   PMID:11583620   PMID:11675124  
PMID:11704662   PMID:11818499   PMID:11851396   PMID:11877444   PMID:11931740   PMID:11937504   PMID:11964378   PMID:11971985   PMID:11981034   PMID:11986669   PMID:12024042   PMID:12050280  
PMID:12060666   PMID:12082103   PMID:12089346   PMID:12114525   PMID:12130539   PMID:12145209   PMID:12151000   PMID:12208521   PMID:12403846   PMID:12477932   PMID:12481024   PMID:12482968  
PMID:12503607   PMID:12554772   PMID:12588987   PMID:12612084   PMID:12630920   PMID:12682292   PMID:12714702   PMID:12756300   PMID:12796488   PMID:12810069   PMID:12893883   PMID:12970370  
PMID:14500758   PMID:14578343   PMID:14593076   PMID:14662770   PMID:14747462   PMID:14757047   PMID:14766010   PMID:14966121   PMID:14966289   PMID:15026545   PMID:15072553   PMID:15146197  
PMID:15184363   PMID:15207724   PMID:15231721   PMID:15557560   PMID:15563469   PMID:15572661   PMID:15641800   PMID:15657427   PMID:15684378   PMID:15698540   PMID:15731352   PMID:15766871  
PMID:15769988   PMID:15888456   PMID:15919723   PMID:15987788   PMID:15988012   PMID:16051665   PMID:16344550   PMID:16344560   PMID:16362036   PMID:16410316   PMID:16613851   PMID:16645043  
PMID:16649994   PMID:16728408   PMID:16860316   PMID:16923966   PMID:16930961   PMID:16957778   PMID:17081983   PMID:17363140   PMID:17476305   PMID:17513608   PMID:17635946   PMID:17697320  
PMID:17704997   PMID:17932106   PMID:17947383   PMID:18174919   PMID:18267973   PMID:18281529   PMID:18499756   PMID:18511550   PMID:18656523   PMID:18660489   PMID:18798693   PMID:18845648  
PMID:19052561   PMID:19074285   PMID:19095746   PMID:19183483   PMID:19240160   PMID:19255064   PMID:19264843   PMID:19277704   PMID:19453261   PMID:19460354   PMID:19596656   PMID:19641626  
PMID:19805480   PMID:19828458   PMID:19913121   PMID:20047289   PMID:20195357   PMID:20348541   PMID:20374707   PMID:20379614   PMID:20448036   PMID:20628086   PMID:21049972   PMID:21059860  
PMID:21195347   PMID:21220509   PMID:21370964   PMID:21478865   PMID:21492233   PMID:21735116   PMID:21873635   PMID:22034177   PMID:22337624   PMID:22379092   PMID:22504882   PMID:22581837  
PMID:23132854   PMID:23144319   PMID:23160820   PMID:23178929   PMID:23247143   PMID:23252872   PMID:23319000   PMID:23462962   PMID:23463663   PMID:23542129   PMID:23707616   PMID:23936147  
PMID:24124145   PMID:24187139   PMID:24204309   PMID:24213582   PMID:24258712   PMID:24529706   PMID:24561505   PMID:24571987   PMID:24586072   PMID:24811170   PMID:24839999   PMID:24856853  
PMID:24888778   PMID:24905738   PMID:24952745   PMID:25281560   PMID:25295534   PMID:25544563   PMID:25609649   PMID:25664849   PMID:25823027   PMID:25986860   PMID:26040939   PMID:26066330  
PMID:26098207   PMID:26098214   PMID:26149616   PMID:26186194   PMID:26261634   PMID:26267537   PMID:26350169   PMID:26438513   PMID:26487511   PMID:26496610   PMID:26553876   PMID:26638075  
PMID:26799514   PMID:26869487   PMID:26898479   PMID:26970301   PMID:26972000   PMID:26983699   PMID:27432908   PMID:27544802   PMID:27609421   PMID:27633981   PMID:28273073   PMID:28390937  
PMID:28514442   PMID:28611094   PMID:28611215   PMID:28794006   PMID:28890360   PMID:29117863   PMID:29202468   PMID:29395067   PMID:29507755   PMID:29596896   PMID:29877893   PMID:30048685  
PMID:30177747   PMID:30179902   PMID:30273195   PMID:30325183   PMID:31751430   PMID:32489143  


Genomics

Comparative Map Data
NCOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl870,109,782 - 70,403,808 (-)EnsemblGRCh38hg38GRCh38
GRCh38870,109,770 - 70,405,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37871,022,017 - 71,316,452 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37871,021,997 - 71,316,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,186,821 - 71,478,574 (-)NCBINCBI36hg18NCBI36
Build 34871,186,820 - 71,478,574NCBI
Celera867,021,935 - 67,313,703 (-)NCBI
Cytogenetic Map8q13.3NCBI
HuRef866,517,566 - 66,809,329 (-)NCBIHuRef
CHM1_1871,077,538 - 71,372,108 (-)NCBICHM1_1
Ncoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,209,329 - 13,444,451 (-)NCBIGRCm39mm39
GRCm38113,139,105 - 13,374,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,139,105 - 13,374,083 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,129,240 - 13,364,164 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,127,689 - 13,359,278 (-)NCBImm8
Celera113,103,226 - 13,334,430 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.12NCBI
Ncoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.055,466,544 - 5,696,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0510,306,581 - 10,538,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,197,891 - 5,275,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.155,197,890 - 5,273,000 (+)NCBI
Celera55,570,901 - 5,648,759 (+)NCBICelera
Cytogenetic Map5q11NCBI
Ncoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,313,447 - 9,584,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,313,748 - 9,587,109 (+)NCBIChiLan1.0ChiLan1.0
NCOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1868,293,012 - 68,480,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,293,018 - 68,400,479 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0866,632,139 - 66,929,526 (-)NCBIMhudiblu_PPA_v0panPan3
NCOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2919,222,842 - 19,545,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12919,253,849 - 19,471,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ncoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649614,844,923 - 15,102,922 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,954,120 - 65,246,572 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1464,888,029 - 65,245,757 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,584,741 - 70,791,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1865,855,232 - 66,151,733 (-)NCBI
ChlSab1.1 Ensembl865,855,235 - 66,040,947 (-)Ensembl
Ncoa2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474420,795,385 - 21,078,706 (+)NCBI

Position Markers
RH91396  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,024,906 - 71,025,032UniSTSGRCh37
Build 36871,187,460 - 71,187,586RGDNCBI36
Celera867,022,574 - 67,022,700RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,518,205 - 66,518,331UniSTS
GeneMap99-GB4 RH Map8382.62UniSTS
RH123810  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,062,519 - 71,062,792UniSTSGRCh37
Build 36871,225,073 - 71,225,346RGDNCBI36
Celera867,060,200 - 67,060,473RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,555,832 - 66,556,105UniSTS
TNG Radiation Hybrid Map835824.0UniSTS
SHGC-142567  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,106,781 - 71,107,129UniSTSGRCh37
Build 36871,269,335 - 71,269,683RGDNCBI36
Celera867,104,476 - 67,104,823RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,600,193 - 66,600,541UniSTS
TNG Radiation Hybrid Map835841.0UniSTS
D8S2130  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,024,906 - 71,025,046UniSTSGRCh37
Build 36871,187,460 - 71,187,600RGDNCBI36
Celera867,022,574 - 67,022,714RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,518,205 - 66,518,345UniSTS
PMC170950P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,040,680 - 71,041,148UniSTSGRCh37
Build 36871,203,234 - 71,203,702RGDNCBI36
Celera867,038,349 - 67,038,817RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,533,978 - 66,534,446UniSTS
STS-X97674  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,025,627 - 71,025,874UniSTSGRCh37
Build 36871,188,181 - 71,188,428RGDNCBI36
Celera867,023,295 - 67,023,542RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,518,926 - 66,519,173UniSTS
GeneMap99-GB4 RH Map8374.18UniSTS
NCBI RH Map8852.9UniSTS
STS-H93122  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,101,441 - 71,101,652UniSTSGRCh37
Build 36871,263,995 - 71,264,206RGDNCBI36
Celera867,099,136 - 67,099,347RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,594,853 - 66,595,064UniSTS
GeneMap99-GB4 RH Map8371.67UniSTS
NCBI RH Map8833.0UniSTS
SHGC-58132  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,285,920 - 71,286,075UniSTSGRCh37
Build 36871,448,474 - 71,448,629RGDNCBI36
Celera867,283,600 - 67,283,755RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,779,225 - 66,779,380UniSTS
TNG Radiation Hybrid Map835886.0UniSTS
A006O24  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,079,214 - 71,079,354UniSTSGRCh37
Build 36871,241,768 - 71,241,908RGDNCBI36
Celera867,076,903 - 67,077,043RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,572,572 - 66,572,712UniSTS
GeneMap99-GB4 RH Map8374.87UniSTS
RH12853  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,079,294 - 71,079,435UniSTSGRCh37
Build 36871,241,848 - 71,241,989RGDNCBI36
Celera867,076,983 - 67,077,124RGD
Cytogenetic Map8q13.3UniSTS
HuRef866,572,652 - 66,572,793UniSTS
GeneMap99-GB4 RH Map8383.25UniSTS
NCOA2_3768  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37871,024,714 - 71,025,564UniSTSGRCh37
Build 36871,187,268 - 71,188,118RGDNCBI36
Celera867,022,382 - 67,023,232RGD
HuRef866,518,013 - 66,518,863UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3849
Count of miRNA genes:1146
Interacting mature miRNAs:1430
Transcripts:ENST00000267974, ENST00000452400, ENST00000518287, ENST00000518363, ENST00000519724, ENST00000520416, ENST00000521239, ENST00000522054, ENST00000524223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1389 1451 1244 373 1219 253 3208 707 1541 249 1309 1427 133 835 1856 4
Low 1044 1528 480 249 727 211 1147 1483 2170 168 139 181 38 369 932
Below cutoff 2 6 1 3 1 1 3 16 1 4 3 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001321703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC021558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC084251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI652063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL712418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW504723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB270668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK002637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK141607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK903771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN291204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ834204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA691975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF374064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN607830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000452400   ⟹   ENSP00000399968
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,109,782 - 70,403,808 (-)Ensembl
RefSeq Acc Id: ENST00000518287   ⟹   ENSP00000430148
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,112,070 - 70,402,079 (-)Ensembl
RefSeq Acc Id: ENST00000518363   ⟹   ENSP00000429132
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,113,569 - 70,148,460 (-)Ensembl
RefSeq Acc Id: ENST00000519724   ⟹   ENSP00000430348
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,216,696 - 70,245,375 (-)Ensembl
RefSeq Acc Id: ENST00000520416   ⟹   ENSP00000430850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,216,721 - 70,402,587 (-)Ensembl
RefSeq Acc Id: ENST00000521239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,126,609 - 70,128,747 (-)Ensembl
RefSeq Acc Id: ENST00000522054
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,137,973 - 70,141,242 (-)Ensembl
RefSeq Acc Id: ENST00000524223
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl870,155,971 - 70,157,146 (-)Ensembl
RefSeq Acc Id: NM_001321703   ⟹   NP_001308632
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,404,217 (-)NCBI
CHM1_1871,077,538 - 71,372,108 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321707   ⟹   NP_001308636
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,403,390 (-)NCBI
CHM1_1871,077,538 - 71,371,262 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321711   ⟹   NP_001308640
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,403,808 (-)NCBI
CHM1_1871,077,538 - 71,371,710 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321712   ⟹   NP_001308641
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,403,390 (-)NCBI
CHM1_1871,077,538 - 71,371,125 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321713   ⟹   NP_001308642
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,403,390 (-)NCBI
CHM1_1871,077,538 - 71,371,125 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006540   ⟹   NP_006531
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,782 - 70,403,808 (-)NCBI
GRCh37871,021,997 - 71,316,062 (-)NCBI
Build 36871,186,821 - 71,478,574 (-)NCBI Archive
HuRef866,517,566 - 66,809,329 (-)ENTREZGENE
CHM1_1871,077,538 - 71,371,710 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012961   ⟹   XP_016868450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,770 - 70,403,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012962   ⟹   XP_016868451
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,403,349 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012963   ⟹   XP_016868452
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,405,390 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012964   ⟹   XP_016868453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,402,582 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012966   ⟹   XP_016868455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,403,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012967   ⟹   XP_016868456
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,256,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012968   ⟹   XP_016868457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,403,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012969   ⟹   XP_016868458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,217,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012970   ⟹   XP_016868459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,224,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012971   ⟹   XP_016868460
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,245,375 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012972   ⟹   XP_016868461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,109,812 - 70,213,984 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012973   ⟹   XP_016868462
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,141,309 - 70,403,828 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006531   ⟸   NM_006540
- Peptide Label: isoform a
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308632   ⟸   NM_001321703
- Peptide Label: isoform a
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308640   ⟸   NM_001321711
- Peptide Label: isoform b
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot),   B4DPW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308636   ⟸   NM_001321707
- Peptide Label: isoform a
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308642   ⟸   NM_001321713
- Peptide Label: isoform c
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308641   ⟸   NM_001321712
- Peptide Label: isoform b
- UniProtKB: Q15596 (UniProtKB/Swiss-Prot),   B4DPW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016868452   ⟸   XM_017012963
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868455   ⟸   XM_017012966
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868450   ⟸   XM_017012961
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868457   ⟸   XM_017012968
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868451   ⟸   XM_017012962
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868453   ⟸   XM_017012964
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868456   ⟸   XM_017012967
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868460   ⟸   XM_017012971
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868459   ⟸   XM_017012970
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868458   ⟸   XM_017012969
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868461   ⟸   XM_017012972
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016868462   ⟸   XM_017012973
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000429132   ⟸   ENST00000518363
RefSeq Acc Id: ENSP00000430148   ⟸   ENST00000518287
RefSeq Acc Id: ENSP00000430348   ⟸   ENST00000519724
RefSeq Acc Id: ENSP00000399968   ⟸   ENST00000452400
RefSeq Acc Id: ENSP00000430850   ⟸   ENST00000520416
Protein Domains
bHLH   DUF1518   DUF4927   PAS

Promoters
RGD ID:7213487
Promoter ID:EPDNEW_H12489
Type:initiation region
Name:NCOA2_1
Description:nuclear receptor coactivator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12490  EPDNEW_H12491  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,403,808 - 70,403,868EPDNEW
RGD ID:7213489
Promoter ID:EPDNEW_H12490
Type:initiation region
Name:NCOA2_2
Description:nuclear receptor coactivator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12489  EPDNEW_H12491  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38870,404,217 - 70,404,277EPDNEW
RGD ID:6814805
Promoter ID:HG_XEF:7991
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001087670,   NM_001142159,   NM_001161395,   NM_031822
Position:
Human AssemblyChrPosition (strand)Source
Build 36871,291,766 - 71,292,266 (-)MPROMDB
RGD ID:6806891
Promoter ID:HG_KWN:61483
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000267974,   NM_006540
Position:
Human AssemblyChrPosition (strand)Source
Build 36871,478,091 - 71,479,092 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q13.2-13.3(chr8:68488015-71476177)x1 copy number loss See cases [RCV000050801] Chr8:68488015..71476177 [GRCh38]
Chr8:69400250..72388412 [GRCh37]
Chr8:69562804..72550966 [NCBI36]
Chr8:8q13.2-13.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.1-21.13(chr8:57361243-79170078)x3 copy number gain See cases [RCV000053653] Chr8:57361243..79170078 [GRCh38]
Chr8:58273802..80082313 [GRCh37]
Chr8:58436356..80244868 [NCBI36]
Chr8:8q12.1-21.13
pathogenic
GRCh38/hg38 8q12.3-21.13(chr8:61691800-82537696)x3 copy number gain See cases [RCV000053654] Chr8:61691800..82537696 [GRCh38]
Chr8:62604359..83449931 [GRCh37]
Chr8:62766913..83612486 [NCBI36]
Chr8:8q12.3-21.13
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q12.3-21.11(chr8:62230636-73227786)x1 copy number loss See cases [RCV000054242] Chr8:62230636..73227786 [GRCh38]
Chr8:63143195..74140021 [GRCh37]
Chr8:63305749..74302575 [NCBI36]
Chr8:8q12.3-21.11
pathogenic
NM_006540.2(NCOA2):c.817C>T (p.Arg273Cys) single nucleotide variant Malignant melanoma [RCV000068382] Chr8:70163480 [GRCh38]
Chr8:71075715 [GRCh37]
Chr8:71238269 [NCBI36]
Chr8:8q13.3
not provided
NM_006540.2(NCOA2):c.-20+16306G>C single nucleotide variant Lung cancer [RCV000107645] Chr8:70280438 [GRCh38]
Chr8:71192673 [GRCh37]
Chr8:8q13.3
uncertain significance
NM_006540.2(NCOA2):c.-76-6429A>G single nucleotide variant Lung cancer [RCV000107646] Chr8:70303229 [GRCh38]
Chr8:71215464 [GRCh37]
Chr8:8q13.3
uncertain significance
GRCh38/hg38 8q13.2-13.3(chr8:68987881-71640028)x1 copy number loss See cases [RCV000134801] Chr8:68987881..71640028 [GRCh38]
Chr8:69900116..72552263 [GRCh37]
Chr8:70062670..72714817 [NCBI36]
Chr8:8q13.2-13.3
pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1
pathogenic
GRCh38/hg38 8q13.1-21.13(chr8:66633845-80100089)x3 copy number gain See cases [RCV000138027] Chr8:66633845..80100089 [GRCh38]
Chr8:67546080..81012324 [GRCh37]
Chr8:67708634..81174879 [NCBI36]
Chr8:8q13.1-21.13
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q13.2-13.3(chr8:68987835-71663466)x1 copy number loss See cases [RCV000138251] Chr8:68987835..71663466 [GRCh38]
Chr8:69900070..72575701 [GRCh37]
Chr8:70062624..72738255 [NCBI36]
Chr8:8q13.2-13.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69955127-72552241)x1 copy number loss See cases [RCV000240421] Chr8:69955127..72552241 [GRCh37]
Chr8:8q13.2-13.3
pathogenic
GRCh37/hg19 8q13.3-21.13(chr8:70971013-82019151)x3 copy number gain See cases [RCV000240367] Chr8:70971013..82019151 [GRCh37]
Chr8:8q13.3-21.13
likely pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69899336-72597645)x1 copy number loss See cases [RCV000446721] Chr8:69899336..72597645 [GRCh37]
Chr8:8q13.2-13.3
pathogenic
GRCh37/hg19 8q13.3(chr8:71077789-72943097)x3 copy number gain See cases [RCV000446539] Chr8:71077789..72943097 [GRCh37]
Chr8:8q13.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q13.2-13.3(chr8:69899336-72597645)x1 copy number loss See cases [RCV000510185] Chr8:69899336..72597645 [GRCh37]
Chr8:8q13.2-13.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q13.3(chr8:71198990-71920676)x1 copy number loss See cases [RCV000512294] Chr8:71198990..71920676 [GRCh37]
Chr8:8q13.3
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_006540.4(NCOA2):c.846T>G (p.Ser282=) single nucleotide variant not provided [RCV000897792] Chr8:70162841 [GRCh38]
Chr8:71075076 [GRCh37]
Chr8:8q13.3
likely benign
NM_006540.4(NCOA2):c.4086C>T (p.Gly1362=) single nucleotide variant not provided [RCV000938992] Chr8:70124696 [GRCh38]
Chr8:71036931 [GRCh37]
Chr8:8q13.3
likely benign
NM_006540.4(NCOA2):c.3394G>A (p.Val1132Ile) single nucleotide variant not provided [RCV000893421] Chr8:70128911 [GRCh38]
Chr8:71041146 [GRCh37]
Chr8:8q13.3
likely benign
NM_006540.4(NCOA2):c.1653G>A (p.Ser551=) single nucleotide variant not provided [RCV000962921] Chr8:70156712 [GRCh38]
Chr8:71068947 [GRCh37]
Chr8:8q13.3
benign
NM_006540.4(NCOA2):c.3666T>C (p.Pro1222=) single nucleotide variant not provided [RCV000965080] Chr8:70128448 [GRCh38]
Chr8:71040683 [GRCh37]
Chr8:8q13.3
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q13.3(chr8:70848713-71632067)x3 copy number gain not provided [RCV001006112] Chr8:70848713..71632067 [GRCh37]
Chr8:8q13.3
uncertain significance
NM_006540.4(NCOA2):c.18A>G (p.Glu6=) single nucleotide variant not provided [RCV000956642] Chr8:70216728 [GRCh38]
Chr8:71128963 [GRCh37]
Chr8:8q13.3
benign
GRCh37/hg19 8q13.3(chr8:71244655-71685822)x3 copy number gain not provided [RCV001258414] Chr8:71244655..71685822 [GRCh37]
Chr8:8q13.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7669 AgrOrtholog
COSMIC NCOA2 COSMIC
Ensembl Genes ENSG00000140396 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000399968 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429132 UniProtKB/TrEMBL
  ENSP00000430148 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000430348 UniProtKB/TrEMBL
  ENSP00000430850 UniProtKB/TrEMBL
Ensembl Transcript ENST00000452400 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518287 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000518363 UniProtKB/TrEMBL
  ENST00000519724 UniProtKB/TrEMBL
  ENST00000520416 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000140396 GTEx
HGNC ID HGNC:7669 ENTREZGENE
Human Proteome Map NCOA2 Human Proteome Map
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa_int_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_rcpt_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC/p160_LXXLL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10499 UniProtKB/Swiss-Prot
NCBI Gene 10499 ENTREZGENE
OMIM 601993 OMIM
PANTHER PTHR10684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10684:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rec_co-act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31471 PharmGKB
PIRSF Nuclear_receptor_coactivator UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B6XJZ8_HUMAN UniProtKB/TrEMBL
  A0A1D5RMT0_HUMAN UniProtKB/TrEMBL
  B4DPW8 ENTREZGENE, UniProtKB/TrEMBL
  E5RFN9_HUMAN UniProtKB/TrEMBL
  E7EWM1_HUMAN UniProtKB/TrEMBL
  H0YBB6_HUMAN UniProtKB/TrEMBL
  NCOA2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q569J4_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q14CD2 UniProtKB/Swiss-Prot