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Gene: NCOA2 (nuclear receptor coactivator 2) Homo sapiens
Symbol: NCOA2
Name: nuclear receptor coactivator 2
Description: Exhibits RNA polymerase II-specific DNA-binding transcription factor binding activity; nuclear receptor transcription coactivator activity; and protein domain specific binding activity. Predicted to be involved in cellular response to hormone stimulus; circadian regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Localizes to the nuclear body and protein-containing complex. Implicated in acute myeloid leukemia. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1; GRIP1; hTIF2; KAT13C; MGC138808; NCoA-2; p160 steroid receptor coactivator 2; SRC2; TIF2; transcriptional intermediary factor 2
Mus musculus (house mouse) : Ncoa2 (nuclear receptor coactivator 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ncoa2 (nuclear receptor coactivator 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncoa2 (nuclear receptor coactivator 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NCOA2 (nuclear receptor coactivator 2)
Canis lupus familiaris (dog) : NCOA2 (nuclear receptor coactivator 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncoa2 (nuclear receptor coactivator 2)
Sus scrofa (pig) : NCOA2 (nuclear receptor coactivator 2)
Chlorocebus sabaeus (African green monkey) : NCOA2 (nuclear receptor coactivator 2)
Heterocephalus glaber (naked mole-rat) : Ncoa2 (nuclear receptor coactivator 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl870,109,782 - 70,403,808 (-)Ensembl
GRCh38870,109,770 - 70,405,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37871,021,997 - 71,316,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,186,821 - 71,478,574 (-)NCBINCBI36hg18NCBI36
Build 34871,186,820 - 71,478,574NCBI
Celera867,021,935 - 67,313,703 (-)NCBI
Cytogenetic Map8q13.3NCBI
HuRef866,517,566 - 66,809,329 (-)NCBIHuRef
CHM1_1871,077,538 - 71,372,108 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCOA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732737
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.