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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3094
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c2affects expressionEXP 6480464CTDbisphenol A affects the expression of NR3C2 mRNAPMID:24857958 PMID:25181051
Nr3c2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NR3C2 mRNAPMID:30816183
Nr3c2increases expressionEXP 6480464CTDbisphenol A results in increased expression of NR3C2 mRNAPMID:26060449 PMID:36136478
Nr3c2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of NR3C2 genePMID:28505145
Nr3c2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNAPMID:25607892
Nr3c2multiple interactionsISONr3c2 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NR3C2 mRNAPMID:32518293
Nr3c2multiple interactionsISONR3C2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of NR3C2 gene; bisphenol A inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]PMID:30951782 PMID:31601247
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