Prmt9 (protein arginine methyltransferase 9) - Rat Genome Database

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Gene: Prmt9 (protein arginine methyltransferase 9) Rattus norvegicus
Analyze
Symbol: Prmt9
Name: protein arginine methyltransferase 9
RGD ID: 1306157
Description: Predicted to enable protein-arginine omega-N monomethyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mRNA processing. Predicted to be located in cytoplasm. Orthologous to human PRMT9 (protein arginine methyltransferase 9); INTERACTS WITH bisphenol A; 2-hydroxypropanoic acid (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC291947; Prmt10; protein arginine methyltransferase 10 (putative); putative protein arginine N-methyltransferase 10; putative protein arginine N-methyltransferase 9; RGD1306157; similar to CG9882-PA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,376,342 - 30,414,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,380,124 - 30,414,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,213,106 - 37,247,448 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01937,866,979 - 37,901,319 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01940,116,065 - 40,150,409 (-)NCBIRnor_WKY
Rnor_6.01934,067,008 - 34,105,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,070,632 - 34,105,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,948,450 - 44,987,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,192,864 - 32,227,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,197,748 - 32,266,698 (-)NCBI
Celera1929,861,593 - 29,895,884 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25737013   PMID:25979344  


Genomics

Comparative Map Data
Prmt9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,376,342 - 30,414,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,380,124 - 30,414,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,213,106 - 37,247,448 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01937,866,979 - 37,901,319 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01940,116,065 - 40,150,409 (-)NCBIRnor_WKY
Rnor_6.01934,067,008 - 34,105,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,070,632 - 34,105,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,948,450 - 44,987,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,192,864 - 32,227,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,197,748 - 32,266,698 (-)NCBI
Celera1929,861,593 - 29,895,884 (-)NCBICelera
Cytogenetic Map19q11NCBI
PRMT9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,637,785 - 147,684,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4147,637,785 - 147,684,163 (-)EnsemblGRCh38hg38GRCh38
GRCh374148,558,936 - 148,605,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,778,983 - 148,824,730 (-)NCBINCBI36Build 36hg18NCBI36
Celera4145,880,642 - 145,926,389 (-)NCBICelera
Cytogenetic Map4q31.23NCBI
HuRef4144,286,651 - 144,332,385 (-)NCBIHuRef
CHM1_14148,537,945 - 148,583,674 (-)NCBICHM1_1
T2T-CHM13v2.04150,961,873 - 151,008,254 (-)NCBIT2T-CHM13v2.0
Prmt9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,276,015 - 78,307,967 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,276,026 - 78,307,967 (+)EnsemblGRCm39 Ensembl
GRCm38877,549,388 - 77,581,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,549,397 - 77,581,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv37880,073,296 - 80,105,237 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,445,469 - 80,480,387 (+)NCBIMGSCv36mm8
Celera881,840,756 - 81,872,252 (+)NCBICelera
Cytogenetic Map8C1NCBI
Prmt9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,215,335 - 3,243,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,215,335 - 3,243,569 (-)NCBIChiLan1.0ChiLan1.0
PRMT9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,631,498 - 151,677,866 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,631,498 - 151,677,866 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,976,090 - 140,022,757 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRMT9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,981,568 - 46,023,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,955,356 - 46,022,854 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,375,218 - 46,416,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01546,655,810 - 46,697,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,655,001 - 46,697,194 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,924,097 - 45,965,491 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01546,020,836 - 46,062,599 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,330,525 - 46,371,891 (-)NCBIUU_Cfam_GSD_1.0
Prmt9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,374,041 - 44,420,874 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,811,360 - 1,859,288 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365351,811,376 - 1,855,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRMT9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,072,709 - 81,114,579 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,076,709 - 81,113,545 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,168,459 - 86,191,871 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRMT9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1794,136,300 - 94,181,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl794,137,041 - 94,181,627 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603773,837,443 - 73,887,254 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prmt9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004625006193,577 - 232,292 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004625006193,626 - 229,414 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prmt9
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000017347
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
BE120629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,380,170 - 30,380,325 (+)MAPPERmRatBN7.2
Rnor_6.01934,070,675 - 34,070,829NCBIRnor6.0
Rnor_5.01944,952,117 - 44,952,271UniSTSRnor5.0
RGSC_v3.41932,192,911 - 32,193,065UniSTSRGSC3.4
Celera1929,861,640 - 29,861,794UniSTS
RH 3.4 Map19227.5UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 44 28 19 28 1 1 74 28 37 11 1
Low 1 17 13 13 13 7 10 7 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017347   ⟹   ENSRNOP00000017347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,380,124 - 30,414,458 (-)Ensembl
Rnor_6.0 Ensembl1934,070,632 - 34,105,610 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101255   ⟹   ENSRNOP00000094756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,380,124 - 30,409,237 (-)Ensembl
RefSeq Acc Id: NM_001191599   ⟹   NP_001178528
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,380,124 - 30,414,458 (-)NCBI
Rnor_6.01934,070,628 - 34,105,586 (-)NCBI
Rnor_5.01944,948,450 - 44,987,030 (-)NCBI
Celera1929,861,593 - 29,895,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255424   ⟹   XP_006255486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,376,342 - 30,414,491 (-)NCBI
Rnor_6.01934,067,008 - 34,105,626 (-)NCBI
Rnor_5.01944,948,450 - 44,987,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097591   ⟹   XP_038953519
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,380,124 - 30,406,840 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178528 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255486 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953519 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178528   ⟸   NM_001191599
- UniProtKB: D3ZDR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255486   ⟸   XM_006255424
- Peptide Label: isoform X1
- UniProtKB: D3ZDR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017347   ⟸   ENSRNOT00000017347
RefSeq Acc Id: XP_038953519   ⟸   XM_039097591
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000094756   ⟸   ENSRNOT00000101255

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDR5-F1-model_v2 AlphaFold D3ZDR5 1-841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701058
Promoter ID:EPDNEW_R11581
Type:initiation region
Name:Prmt9_1
Description:protein arginine methyltransferase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01934,105,557 - 34,105,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306157 AgrOrtholog
BioCyc Gene G2FUF-5903 BioCyc
Ensembl Genes ENSRNOG00000012928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017347 ENTREZGENE
  ENSRNOP00000017347.6 UniProtKB/TrEMBL
  ENSRNOP00000094756.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017347 ENTREZGENE
  ENSRNOT00000017347.8 UniProtKB/TrEMBL
  ENSRNOT00000101255.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
InterPro Arg_MeTrfase UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report rno:291947 UniProtKB/TrEMBL
NCBI Gene 291947 ENTREZGENE
PANTHER PTHR11006 UniProtKB/TrEMBL
PhenoGen Prmt9 PhenoGen
PROSITE SAM_MT_PRMT UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
UniProt A0A8I6AMT6_RAT UniProtKB/TrEMBL
  D3ZDR5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Prmt9  protein arginine methyltransferase 9  Prmt10  protein arginine methyltransferase 10 (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Prmt10  protein arginine methyltransferase 10 (putative)  RGD1306157  similar to CG9882-PA   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306157  similar to CG9882-PA   RGD1306157_predicted  similar to CG9882-PA (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306157_predicted  similar to CG9882-PA (predicted)  LOC291947_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291947_predicted  similar to CG9882-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL