Rln3 (relaxin 3) - Rat Genome Database

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Gene: Rln3 (relaxin 3) Rattus norvegicus
Analyze
Symbol: Rln3
Name: relaxin 3
RGD ID: 628745
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Orthologous to human RLN3 (relaxin 3); INTERACTS WITH ammonium chloride; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Insl7; insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; prorelaxin R3; relaxin-3
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,107,401 - 24,109,432 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,107,401 - 24,109,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,928,656 - 30,930,687 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,583,062 - 31,585,093 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,805,790 - 33,807,821 (+)NCBIRnor_WKY
Rnor_6.01925,164,497 - 25,166,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,164,497 - 25,166,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,141,375 - 36,143,406 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,792,783 - 25,794,814 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,797,608 - 25,800,095 (+)NCBI
Celera1923,655,324 - 23,657,355 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. Burazin TC, etal., J Neurochem 2002 Sep;82(6):1553-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Production of recombinant human relaxin 3 in AtT20 cells. Kizawa H, etal., Regul Pept 2003 May 15;113(1-3):79-84.
4. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. Liu C, etal., J Biol Chem 2003 Dec 12;278(50):50754-64. Epub 2003 Sep 30.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Samuel CS, etal., Endocrinology 2004 Sep;145(9):4125-33. Epub 2004 May 20.
Additional References at PubMed
PMID:15845093   PMID:16112403   PMID:16764952   PMID:17071007   PMID:17870193   PMID:18492777   PMID:19373968   PMID:21410550   PMID:22134882   PMID:23135160   PMID:23425370   PMID:23697547  
PMID:24297931   PMID:24345292   PMID:24629399   PMID:25406021   PMID:27791297   PMID:28726252   PMID:28776188   PMID:30006349   PMID:30125684   PMID:30412752   PMID:31897576   PMID:32532885  
PMID:34214757  


Genomics

Comparative Map Data
Rln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,107,401 - 24,109,432 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,107,401 - 24,109,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,928,656 - 30,930,687 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,583,062 - 31,585,093 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,805,790 - 33,807,821 (+)NCBIRnor_WKY
Rnor_6.01925,164,497 - 25,166,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,164,497 - 25,166,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,141,375 - 36,143,406 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,792,783 - 25,794,814 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,797,608 - 25,800,095 (+)NCBI
Celera1923,655,324 - 23,657,355 (+)NCBICelera
Cytogenetic Map19q11NCBI
RLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,028,148 - 14,031,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1914,028,148 - 14,031,551 (+)EnsemblGRCh38hg38GRCh38
GRCh371914,138,960 - 14,142,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,000,017 - 14,002,783 (+)NCBINCBI36Build 36hg18NCBI36
Build 341914,000,016 - 14,002,783NCBI
Celera1914,032,810 - 14,035,579 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,711,000 - 13,713,769 (+)NCBIHuRef
CHM1_11914,139,564 - 14,142,327 (+)NCBICHM1_1
T2T-CHM13v2.01914,154,437 - 14,157,840 (+)NCBIT2T-CHM13v2.0
Rln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,769,696 - 84,771,608 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,769,558 - 84,771,629 (-)EnsemblGRCm39 Ensembl
GRCm38884,043,067 - 84,044,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,042,929 - 84,045,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,566,966 - 86,568,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,933,172 - 86,935,084 (-)NCBIMGSCv36mm8
Celera888,337,588 - 88,339,500 (-)NCBICelera
Cytogenetic Map8C2NCBI
Rln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,747,362 - 32,749,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,747,362 - 32,749,338 (+)NCBIChiLan1.0ChiLan1.0
RLN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2048,346,966 - 48,363,409 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,990,479 - 49,007,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,990,461 - 48,993,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,201,525 - 48,217,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,628,214 - 48,644,650 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,871,026 - 48,887,717 (-)NCBIUU_Cfam_GSD_1.0
Rln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,649,485 - 207,651,697 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,703,024 - 2,704,664 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366592,703,024 - 2,704,664 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,149,896 - 65,162,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,149,883 - 65,173,306 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,424,035 - 65,447,470 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RLN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,645,677 - 12,679,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl612,675,383 - 12,678,601 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,971,269 - 7,012,214 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rln3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,272,425 - 1,274,669 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,272,414 - 1,274,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rln3
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:117
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000007775
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 7 7 15 20 15 5
Below cutoff 21 15 12 4 12 1 36 11 16 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007775   ⟹   ENSRNOP00000007775
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,107,401 - 24,109,886 (+)Ensembl
Rnor_6.0 Ensembl1925,164,497 - 25,166,528 (-)Ensembl
RefSeq Acc Id: NM_170667   ⟹   NP_733767
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,107,401 - 24,109,432 (+)NCBI
Rnor_6.01925,164,497 - 25,166,528 (-)NCBI
Rnor_5.01936,141,375 - 36,143,406 (-)NCBI
RGSC_v3.41925,792,783 - 25,794,814 (+)RGD
Celera1923,655,324 - 23,657,355 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_733767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM56033 (Get FASTA)   NCBI Sequence Viewer  
  BAC53759 (Get FASTA)   NCBI Sequence Viewer  
  EDL92241 (Get FASTA)   NCBI Sequence Viewer  
  Q8BFS3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_733767   ⟸   NM_170667
- Peptide Label: precursor
- UniProtKB: Q8BFS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007775   ⟸   ENSRNOT00000007775

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BFS3-F1-model_v2 AlphaFold Q8BFS3 1-140 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628745 AgrOrtholog
BioCyc Gene G2FUF-6051 BioCyc
Ensembl Genes ENSRNOG00000005911 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007775 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007775 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:266997 UniProtKB/Swiss-Prot
NCBI Gene 266997 ENTREZGENE
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Rln3 PhenoGen
PRINTS INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt Q8BFS3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rln3  relaxin 3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Rln3  relaxin 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons of the ventromedial dorsal tegmental nucleus (vmDTg) in the pons 633790
gene_function ligand for GPCR135 receptor 1304438
gene_process modulates cardiac fibroblast proliferation, differentiation, and collagen production 1304329