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Gene: Ces4a (carboxylesterase 4A) Rattus norvegicus

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Symbol:

Ces4a

Name:

carboxylesterase 4A

RGD ID:

1307418

Description:

Predicted to enable carboxylic ester hydrolase activity. Orthologous to human CES4A (carboxylesterase 4A); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

carboxylesterase 8; carboxylesterase 8 (putative); Ces8; LOC291955; RGD1307418; similar to cDNA sequence BC026374

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CES4A (carboxylesterase 4A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ces4a (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ces4a (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CES4A (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ces4a (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CES4A (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ces4a (carboxylesterase 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ces4a (carboxylesterase 4A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CES4A (carboxylesterase 4A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ces3 (carboxylesterase 3)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	B0238.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Caenorhabditis elegans (roundworm):	C52A10.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-P	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Jhe	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6414	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4382	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4757	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	XB5902317 [provisional:ces1c]	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	49,921,643 - 49,942,838 (+)	NCBI		GRCr8
mRatBN7.2	19	33,011,731 - 33,030,119 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,011,731 - 33,029,545 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	39,826,676 - 39,844,484 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	40,480,577 - 40,498,389 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	42,770,004 - 42,787,802 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,090,018 - 37,111,448 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,090,056 - 37,107,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	47,955,432 - 47,976,806 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	34,948,427 - 34,966,243 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	34,934,136 - 34,970,531 (+)	NCBI
Celera	19	32,440,941 - 32,458,727 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ces4a	Rat	autosomal dominant dyskeratosis congenita 6		ISO	RGD:1602823	8554872	ClinVar Annotator: match by term: Dyskeratosis congenita, autosomal dominant 6	ClinVar	PMID:28492532
Ces4a	Rat	cataract 5 multiple types		ISO	RGD:1602823	8554872	ClinVar Annotator: match by term: Cataract 5 multiple types	ClinVar	PMID:15959809\|PMID:20421844\|PMID:23329665\|PMID:28492532
Ces4a	Rat	Chromosome 16q12 Duplication Syndrome		ISO	RGD:1602823	8554872	ClinVar Annotator: match by term: Chromosome 16q12 duplication syndrome	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ces4a	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CES4A mRNA]	CTD	PMID:31150632
Ces4a	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1316604	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CES4A mRNA	CTD	PMID:36331819
Ces4a	Rat	17beta-estradiol	increases expression	ISO	RGD:1316604	6480464	Estradiol results in increased expression of CES4A mRNA	CTD	PMID:39298647
Ces4a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1602823	6480464	Tetrachlorodibenzodioxin affects the expression of CES4A mRNA	CTD	PMID:22574217
Ces4a	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CES4A mRNA	CTD	PMID:33387578
Ces4a	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1316604	6480464	Tetrachlorodibenzodioxin results in decreased expression of CES4A mRNA	CTD	PMID:25975270\|PMID:28238261
Ces4a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1316604	6480464	Tetrachlorodibenzodioxin affects the expression of CES4A mRNA	CTD	PMID:25703434
Ces4a	Rat	2-hydroxypropanoic acid	decreases expression	ISO	RGD:1602823	6480464	Lactic Acid results in decreased expression of CES4A mRNA	CTD	PMID:30851411
Ces4a	Rat	3,7-dihydropurine-6-thione	increases expression	EXP		6480464	Mercaptopurine results in increased expression of CES4A mRNA	CTD	PMID:23358152
Ces4a	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1316604	6480464	bisphenol S results in increased expression of CES4A mRNA	CTD	PMID:39298647
Ces4a	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	RGD:1316604	6480464	bisphenol S affects the methylation of CES4A gene	CTD	PMID:31683443
Ces4a	Rat	4,4'-sulfonyldiphenol	increases methylation	ISO	RGD:1316604	6480464	bisphenol S results in increased methylation of CES4A exon	CTD	PMID:33297965
Ces4a	Rat	4-hydroxyphenyl retinamide	decreases expression	ISO	RGD:1316604	6480464	Fenretinide results in decreased expression of CES4A mRNA	CTD	PMID:28973697
Ces4a	Rat	acrylamide	decreases expression	ISO	RGD:1602823	6480464	Acrylamide results in decreased expression of CES4A mRNA	CTD	PMID:32763439
Ces4a	Rat	alpha-Zearalanol	multiple interactions	EXP		6480464	[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of CES4A mRNA	CTD	PMID:35163327
Ces4a	Rat	antirheumatic drug	decreases expression	ISO	RGD:1602823	6480464	Antirheumatic Agents results in decreased expression of CES4A mRNA	CTD	PMID:24449571
Ces4a	Rat	arsane	multiple interactions	ISO	RGD:1602823	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CES4A more ...	CTD	PMID:32525701
Ces4a	Rat	arsane	affects methylation	ISO	RGD:1602823	6480464	Arsenic affects the methylation of CES4A gene	CTD	PMID:25304211
Ces4a	Rat	arsenic atom	multiple interactions	ISO	RGD:1602823	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CES4A more ...	CTD	PMID:32525701
Ces4a	Rat	arsenic atom	affects methylation	ISO	RGD:1602823	6480464	Arsenic affects the methylation of CES4A gene	CTD	PMID:25304211
Ces4a	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1316604	6480464	Benzo(a)pyrene results in decreased expression of CES4A mRNA	CTD	PMID:25908611\|PMID:32417428
Ces4a	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1602823	6480464	Benzo(a)pyrene results in decreased expression of CES4A mRNA	CTD	PMID:32234424
Ces4a	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1316604	6480464	[Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of CES4A more ...	CTD	PMID:33484791
Ces4a	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1316604	6480464	Diethylhexyl Phthalate results in decreased expression of CES4A mRNA	CTD	PMID:34319233
Ces4a	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1602823	6480464	Diethylhexyl Phthalate results in decreased expression of CES4A mRNA	CTD	PMID:31163220
Ces4a	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CES4A mRNA	CTD	PMID:25181051
Ces4a	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of CES4A mRNA	CTD	PMID:32145629
Ces4a	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with Genistein] results in increased methylation of CES4A gene	CTD	PMID:28505145
Ces4a	Rat	DDE	decreases expression	ISO	RGD:1602823	6480464	Dichlorodiphenyl Dichloroethylene results in decreased expression of CES4A mRNA	CTD	PMID:38568856
Ces4a	Rat	dibenzo[a,l]pyrene	decreases expression	ISO	RGD:1316604	6480464	dibenzo(a,l)pyrene results in decreased expression of CES4A mRNA	CTD	PMID:25908611
Ces4a	Rat	dichloroacetic acid	decreases expression	ISO	RGD:1316604	6480464	Dichloroacetic Acid results in decreased expression of CES4A mRNA	CTD	PMID:28962523
Ces4a	Rat	doxorubicin	decreases expression	ISO	RGD:1602823	6480464	Doxorubicin results in decreased expression of CES4A mRNA	CTD	PMID:29803840
Ces4a	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of CES4A mRNA	CTD	PMID:29391264
Ces4a	Rat	epoxiconazole	decreases expression	ISO	RGD:1316604	6480464	epoxiconazole results in decreased expression of CES4A mRNA	CTD	PMID:35436446
Ces4a	Rat	ethanol	decreases expression	ISO	RGD:1316604	6480464	Ethanol results in decreased expression of CES4A mRNA	CTD	PMID:19167417
Ces4a	Rat	genistein	multiple interactions	EXP		6480464	[bisphenol A co-treated with Genistein] results in increased methylation of CES4A gene	CTD	PMID:28505145
Ces4a	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of CES4A mRNA	CTD	PMID:33387578
Ces4a	Rat	GSK-J4	decreases expression	ISO	RGD:1602823	6480464	GSK-J4 results in decreased expression of CES4A mRNA	CTD	PMID:29301935
Ces4a	Rat	lead diacetate	decreases expression	ISO	RGD:1602823	6480464	lead acetate results in decreased expression of CES4A mRNA	CTD	PMID:38568856
Ces4a	Rat	mercaptopurine	increases expression	EXP		6480464	Mercaptopurine results in increased expression of CES4A mRNA	CTD	PMID:23358152
Ces4a	Rat	nickel atom	decreases expression	ISO	RGD:1602823	6480464	Nickel results in decreased expression of CES4A mRNA	CTD	PMID:24768652
Ces4a	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of CES4A mRNA	CTD	PMID:33387578
Ces4a	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1316604	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CES4A mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
Ces4a	Rat	perfluorooctanoic acid	multiple interactions	EXP		6480464	[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of CES4A mRNA	CTD	PMID:35163327
Ces4a	Rat	phenformin	decreases expression	EXP		6480464	Phenformin results in decreased expression of CES4A mRNA	CTD	PMID:31324951
Ces4a	Rat	phenobarbital	decreases expression	ISO	RGD:1316604	6480464	Phenobarbital results in decreased expression of CES4A mRNA	CTD	PMID:23091169
Ces4a	Rat	progesterone	decreases expression	ISO	RGD:1602823	6480464	Progesterone results in decreased expression of CES4A mRNA	CTD	PMID:21540246
Ces4a	Rat	purine-6-thiol	increases expression	EXP		6480464	Mercaptopurine results in increased expression of CES4A mRNA	CTD	PMID:23358152
Ces4a	Rat	rac-lactic acid	decreases expression	ISO	RGD:1602823	6480464	Lactic Acid results in decreased expression of CES4A mRNA	CTD	PMID:30851411
Ces4a	Rat	rotenone	decreases expression	EXP		6480464	Rotenone results in decreased expression of CES4A mRNA	CTD	PMID:28374803
Ces4a	Rat	sodium arsenate	multiple interactions	ISO	RGD:1602823	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of CES4A more ...	CTD	PMID:32525701
Ces4a	Rat	streptozocin	multiple interactions	ISO	RGD:1316604	6480464	[Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of CES4A more ...	CTD	PMID:33484791
Ces4a	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CES4A mRNA]	CTD	PMID:31150632
Ces4a	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of CES4A mRNA	CTD	PMID:31150632
Ces4a	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of CES4A mRNA	CTD	PMID:34492290
Ces4a	Rat	trichloroethene	decreases expression	ISO	RGD:1316604	6480464	Trichloroethylene results in decreased expression of CES4A mRNA	CTD	PMID:25549359
Ces4a	Rat	Triptolide	decreases expression	ISO	RGD:1316604	6480464	triptolide results in decreased expression of CES4A mRNA	CTD	PMID:32835833
Ces4a	Rat	triptonide	increases expression	ISO	RGD:1316604	6480464	triptonide results in increased expression of CES4A mRNA	CTD	PMID:33045310

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ces4a	Rat	carboxylic ester hydrolase activity	enables	IEA	ARBA:ARBA00028109	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Ces4a	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

BioCyc Pathways

retinol biosynthesis

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Ces4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	49,921,643 - 49,942,838 (+)	NCBI		GRCr8
mRatBN7.2	19	33,011,731 - 33,030,119 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,011,731 - 33,029,545 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	39,826,676 - 39,844,484 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	40,480,577 - 40,498,389 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	42,770,004 - 42,787,802 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,090,018 - 37,111,448 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,090,056 - 37,107,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	47,955,432 - 47,976,806 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	34,948,427 - 34,966,243 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	34,934,136 - 34,970,531 (+)	NCBI
Celera	19	32,440,941 - 32,458,727 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

CES4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	66,988,589 - 67,010,417 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	66,988,589 - 67,010,417 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,022,492 - 67,044,320 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	65,580,134 - 65,601,162 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	51,530,751 - 51,551,914 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	52,896,600 - 52,917,778 (+)	NCBI		HuRef
CHM1_1	16	68,429,500 - 68,450,660 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	72,782,888 - 72,804,710 (+)	NCBI		T2T-CHM13v2.0

Ces4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	105,858,432 - 105,876,741 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	105,858,432 - 105,876,741 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,131,800 - 105,150,109 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,131,800 - 105,150,109 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	107,655,700 - 107,674,009 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,020,929 - 108,039,238 (+)	NCBI		MGSCv36	mm8
Celera	8	109,354,206 - 109,372,500 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

Ces4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	9,583,684 - 9,601,287 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	9,583,684 - 9,601,285 (-)	NCBI	ChiLan1.0	ChiLan1.0

CES4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	76,528,674 - 76,539,615 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	82,441,847 - 82,452,200 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	47,344,584 - 47,354,287 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Ces4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	42,067,757 - 42,082,614 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	17,504,820 - 17,521,201 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	17,506,499 - 17,521,225 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CES4A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	60,468,003 - 60,483,557 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666047	23,210,588 - 23,231,587 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ces4a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	19,281,382 - 19,301,884 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Ces4a
52 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	63
Count of miRNA genes:	60
Interacting mature miRNAs:	61
Transcripts:	ENSRNOT00000019169
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61328	Eae8	Experimental allergic encephalomyelitis QTL 8	4		nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	19	24816041	33061905	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	15114598	34521833	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	27530207	37947399	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	27530207	37947399	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	27530207	37947399	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	5	10	66	75	70	45	15	45	6	146	43	48	45	58	25


RefSeq Transcripts	NM_001106176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019169 ⟹ ENSRNOP00000019169

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	33,011,731 - 33,029,545 (+)	Ensembl
Rnor_6.0 Ensembl	19	37,090,056 - 37,107,872 (+)	Ensembl

RefSeq Acc Id:

NM_001106176 ⟹ NP_001099646

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,921,644 - 49,939,460 (+)	NCBI
mRatBN7.2	19	33,011,731 - 33,029,545 (+)	NCBI
Rnor_6.0	19	37,090,056 - 37,107,872 (+)	NCBI
Rnor_5.0	19	47,955,432 - 47,976,806 (+)	NCBI
RGSC_v3.4	19	34,948,427 - 34,966,243 (+)	RGD
Celera	19	32,440,941 - 32,458,727 (+)	RGD

Sequence:

show sequence

AGGCTCCACAGCTGGGGAGAAGCTGGTCATAACTCCTCCAGCCCCAGCTGGGAATGATGGGAATCGAGAAGATAAAGGCAGAACTTTCTGGTGCTTGCACACGTACTCAGAGCTCCCTTCTGACCCCA
GAAGCGTAGGCATCACCGCAGCCCATGGCAGAAGCTGGCTGGAGCATGAAGTGGACTCTGGACTTGAGCCTCACCCTGTGGCTGGTAGTCCAGACAGCCTTAGGTGCTTTGCACACCAAGGAACCTCT
CCTGATCACCAAACACGGGATCCTACAAGGAAAGCAAGTGCATGTGGGAGACACACCCATCCGAGTCTTCCTGGGAGTCCCCTTCTCTCAACCTCCTGTGGGCACACGCAGGTTTGCTCCTCCAGAGC
CCCCGCTACCCTGGAACGGAATCAGAGACGCCACCACCTACCCACCTTCGTGCCTTCAGGAATCCTGGGGGCAGATAACATCCATGTACTTAAACACGCGGAAACAGTACGAGTGGCTGCATTTCAGC
GAGGACTGCCTTTACCTGAATGTATATGCCCCAGTACTCGCACCTGGGGACCCTCTGCTGCCGGTGATGGTTTGGTTCCCTGGAGGTGCCTTCCTCGTCGGTTCGGCTTCCACCTATGAAGGCTCAGA
GTTGGCGGCCCGTGGGAAAGTGGTGCTGGTGTTTCTTCAGTATAGGCTGGGCATCCTGGGCTTCTTCAGCACGGGCAACAGCCATGCCCGCGGGAACTGGGGGCTACTGGATCAGATAGCTGCTCTGC
GGTGGGTGCAGGAGAACATCGAAGCTTTTGGTGGAGACCCGGACAGTGTAACACTATTTGGCCAGTCGGCAGGAGCTATGAGCGTCTCAGGACTGCTGATGTCACCTCTAGCCCAGGGCTTATTCCAT
CAAGCCATTTCCCAGAGTGGTACTGCGGTACTGAAAACCTTCATCACTCACGATCCACTGAAGTCAGCCAAGAAAATTGCTCACCTGGCTGGCTGTGACCACAACAGTACGAAGATTATGGTAAAATG
CCTGAAGGCTCTACCGGCAGAGAAGGTGATGCTTGTTTCCAAGAAGATGACATTCTTCCGTGCTAACTCCCATAAAGATCCAAAAGACATCGTGTGGTTCCTGAGCCCAGTGGTGGATGGTTTGGTGT
TCCCAGAAGACCCTGTGGTGCTCCTGACCCGTGGGCAGGTTAAACCTGTACCCTACCTTCTAGGTGTCAACAGCGCGGAGTTCGAGTGGTCCTTGCCTTTTCTCATGAAGCTCCAGCTAAATCAGCGC
ATAATGAACAAAAACTACATCACCAAACTACTCTGGAGTTGCAGCATTTTGCTGAATATCACTGAGGAGCAAATCCCACTGGTGGCAAGAGAGTACTTGAGTGATGCTATCAGTCACCACGACTGGAA
GATGTTCCGAAACCACCTGATAGACCTAGTCGGAGATGCCACCTTTGTCTATGCCACACTCCAAGCTGCGCGATATCACCGAGATGCTGGCTCGCCTGTCTATCTGTATGAATTCAAGCACCATGCTC
CAGGCATCATTGTCAAACCTCGAAGTGATGGAGCAGACCACGGAGACGAGCTTTCCTATCTCTTCGGGAGCCCTTTCTCCAAAGGCTCATCCAGAGGTGAGGAAAAGGAATTCAGCCTCCAGATGATG
AAATACTGGGCCAACTTTGCTCACACTGGGGACCCCAATGACAGAGAGCTGCCCTACTGGCCTCGCTTTGACAAGGAAGAAAAGTACCTGCAGTTGGACTTCGATACAAGAGTGGGTGTGAAGCTCAG
GGAGAAACAAATGACTTTCTGGAGACGGCTGCGCCAGCCTCAAAAACCTTAGAAGCACCGGCCATACTGAGAGTGACCAAGCAAGTGGAAGCTATTCTGCCTCAAGGAGACTGGCCCTAGATACATCT
GAGGACAAGAGTCCTCCCCACTCAATCTAGGACCGGTAGGTGCTCCTGACTGCCTTCAGGCCATAGCTGGAGCCCTTGTCCATCTTTGGGGCTTAGCACCACCAGTCTAGCCTGATGTCCCATGACAC
TTTATATCTCACTGTTTAAACCAGGTCAGGCAGGGCCTTTCATCGCACTGTGCTCTACCTGCTCCCTCCTTAGCCCCACCCCCATCTCAAGGCAATCTCTTTTTTCTGTTTTATAAGACCTCTTATCC
TTCATGATGTATCTGCAGCCCTCTCTTGTGGAATGTTCTCACGGGTGCCACTTCCTGTCATTGTACCCTGCAGTCATTGATCATCTGCTCTGTTCAACCTGCTTGCTTACACTGGCCTTGAGGCCCCA
GACAATCCATTTATGATAAGGAGAAAAGCTTCGATGGCTCAGAATCTGTATTCCCTTCTCACACTCATCTCCCCCTTGGTGCTCCCAAAGCCTGTTCCTAGGGATTGTGCTCAATAAAACAATGTGTT
GATTT

hide sequence

RefSeq Acc Id:

XM_039097592 ⟹ XP_038953520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,891 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,975 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097593 ⟹ XP_038953521

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,528 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,615 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097594 ⟹ XP_038953522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,599 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,690 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097595 ⟹ XP_038953523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,712 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,797 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097596 ⟹ XP_038953524

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,511 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,598 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097597 ⟹ XP_038953525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,616 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,701 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097598 ⟹ XP_038953526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,594 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,689 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_039097599 ⟹ XP_038953527

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,503 - 49,939,462 (+)	NCBI
mRatBN7.2	19	33,014,585 - 33,030,119 (+)	NCBI

RefSeq Acc Id:

XM_063277901 ⟹ XP_063133971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,921,643 - 49,942,838 (+)	NCBI

RefSeq Acc Id:

XM_063277902 ⟹ XP_063133972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	49,924,520 - 49,942,838 (+)	NCBI


Protein RefSeqs	NP_001099646	(Get FASTA)	NCBI Sequence Viewer
	XP_038953520	(Get FASTA)	NCBI Sequence Viewer
	XP_038953521	(Get FASTA)	NCBI Sequence Viewer
	XP_038953522	(Get FASTA)	NCBI Sequence Viewer
	XP_038953523	(Get FASTA)	NCBI Sequence Viewer
	XP_038953524	(Get FASTA)	NCBI Sequence Viewer
	XP_038953525	(Get FASTA)	NCBI Sequence Viewer
	XP_038953526	(Get FASTA)	NCBI Sequence Viewer
	XP_038953527	(Get FASTA)	NCBI Sequence Viewer
	XP_063133971	(Get FASTA)	NCBI Sequence Viewer
	XP_063133972	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL92347	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019169
	ENSRNOP00000019169.2

RefSeq Acc Id:	NP_001099646 ⟸ NM_001106176
- Peptide Label:	precursor
- UniProtKB:	D4AE76 (UniProtKB/TrEMBL), A6IYL9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEAGWSMKWTLDLSLTLWLVVQTALGALHTKEPLLITKHGILQGKQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNV YAPVLAPGDPLLPVMVWFPGGAFLVGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGT AVLKTFITHDPLKSAKKIAHLAGCDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLSPVVDGLVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYIT KLLWSCSILLNITEEQIPLVAREYLSDAISHHDWKMFRNHLIDLVGDATFVYATLQAARYHRDAGSPVYLYEFKHHAPGIIVKPRSDGADHGDELSYLFGSPFSKGSSRGEEKEFSLQMMKYWANFAH TGDPNDRELPYWPRFDKEEKYLQLDFDTRVGVKLREKQMTFWRRLRQPQKP hide sequence

Ensembl Acc Id:

ENSRNOP00000019169 ⟸ ENSRNOT00000019169

RefSeq Acc Id:	XP_038953527 ⟸ XM_039097599
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038953524 ⟸ XM_039097596
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038953521 ⟸ XM_039097593
- Peptide Label:	isoform X4

Protein Domains

Carboxylesterase type B

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AE76-F1-model_v2	AlphaFold	D4AE76	1-563	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13701063

Promoter ID:

EPDNEW_R11587

Type:

single initiation site

Name:

Ces4a_1

Description:

carboxylesterase 4A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	37,090,049 - 37,090,109	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-5859	BioCyc
BioCyc Pathway	PWY-6857 [retinol biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6857	BioCyc
Ensembl Genes	ENSRNOG00000014257	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019169	ENTREZGENE
	ENSRNOT00000019169.4	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	CarbesteraseB	UniProtKB/TrEMBL
	Carboxylesterase_B_AS	UniProtKB/TrEMBL
	Carboxylesterase_B_CS	UniProtKB/TrEMBL
	Type-B_Carboxylest/Lipase	UniProtKB/TrEMBL
KEGG Report	rno:291955	UniProtKB/TrEMBL
NCBI Gene	291955	ENTREZGENE
PANTHER	CARBOXYLESTERASE	UniProtKB/TrEMBL
Pfam	COesterase	UniProtKB/TrEMBL
PhenoGen	Ces4a	PhenoGen
PROSITE	CARBOXYLESTERASE_B_1	UniProtKB/TrEMBL
	CARBOXYLESTERASE_B_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014257	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A6IYL9	ENTREZGENE, UniProtKB/TrEMBL
	D4AE76	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-11-18	Ces4a	carboxylesterase 4A	Ces8	carboxylesterase 8 (putative)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-12	Ces8	carboxylesterase 8 (putative)	RGD1307418	similar to cDNA sequence BC026374	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1307418	similar to cDNA sequence BC026374	RGD1307418_predicted	similar to cDNA sequence BC026374 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1307418_predicted	similar to cDNA sequence BC026374 (predicted)	LOC291955_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291955_predicted	similar to cDNA sequence BC026374 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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