Rps12l1 (ribosomal protein S12 like 1) - Rat Genome Database

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Gene: Rps12l1 (ribosomal protein S12 like 1) Rattus norvegicus
No known orthologs.
Symbol: Rps12l1 (Ensembl: LOC100360573)
Name: ribosomal protein S12 like 1 (Ensembl:ribosomal protein S12-like)
RGD ID: 2321884
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in maintenance of translational fidelity and ribosomal small subunit biogenesis. Predicted to be located in nucleolus. Predicted to be part of cytosolic small ribosomal subunit and small-subunit processome. Orthologous to human RPS12 (ribosomal protein S12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 40S ribosomal protein S12; 40S ribosomal protein S12-like; LOC100360573; ribosomal protein S12-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81951,253,770 - 51,254,409 (+)NCBIGRCr8
mRatBN7.21934,343,930 - 34,344,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,343,929 - 34,344,569 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01938,619,672 - 38,620,321 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,619,764 - 38,620,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,487,604 - 49,488,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,293,808 - 36,294,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1933,770,614 - 33,771,263 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed



Variants in Rps12l1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:43
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 2 16 16 3 16 13 2 15 2
Low 1 41 41 25 16 25 8 11 61 33 26 9 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000027225   ⟹   ENSRNOP00000027226
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,343,929 - 34,344,569 (+)Ensembl
Rnor_6.0 Ensembl1938,619,764 - 38,620,298 (+)Ensembl
RefSeq Acc Id: NM_001408967   ⟹   NP_001395896
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81951,253,770 - 51,254,409 (+)NCBI
mRatBN7.21934,343,930 - 34,344,569 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395896 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027226
RefSeq Acc Id: ENSRNOP00000027226   ⟸   ENSRNOT00000027225
RefSeq Acc Id: NP_001395896   ⟸   NM_001408967
- UniProtKB: P63324 (UniProtKB/Swiss-Prot),   D3ZHB3 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHB3-F1-model_v2 AlphaFold D3ZHB3 1-132 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701118
Promoter ID:EPDNEW_R11635
Type:multiple initiation site
Description:ribosomal protein S12-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,619,680 - 38,619,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321884 AgrOrtholog
BioCyc Gene G2FUF-5780 BioCyc
Ensembl Genes ENSRNOG00000020093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027225 ENTREZGENE
  ENSRNOT00000027225.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L30e-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Ribosomal_eL8/eL30/eS12/Gad45 UniProtKB/Swiss-Prot
  Ribosomal_eS12 UniProtKB/Swiss-Prot
  Ribosomal_eS12_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_S12e UniProtKB/TrEMBL
KEGG Report rno:100360573 UniProtKB/TrEMBL
NCBI Gene 100360573 ENTREZGENE
  40S RIBOSOMAL PROTEIN S12 UniProtKB/Swiss-Prot
  Ribosomal_S12e UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rps12l1 PhenoGen
RatGTEx ENSRNOG00000020093 RatGTEx
Superfamily-SCOP L30e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P63324 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P09388 UniProtKB/Swiss-Prot
  P12728 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Rps12l1  ribosomal protein S12 like 1  LOC100360573  ribosomal protein S12-like  Symbol and Name Changed 1299863 APPROVED
2010-05-06 LOC100360573  ribosomal protein S12-like      Symbol and Name status set to provisional 70820 PROVISIONAL