Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cyld (CYLD lysine 63 deubiquitinase) Rattus norvegicus
Symbol: Cyld
Name: CYLD lysine 63 deubiquitinase
RGD ID: 1308346
Description: Predicted to have several functions, including proline-rich region binding activity; ubiquitinyl hydrolase activity; and zinc ion binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of lymphocyte differentiation; and regulation of signal transduction. Predicted to colocalize with cytoplasmic microtubule and midbody. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
Also known as: cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; LOC100362727; LOC312937; LRRGT00003; probable ubiquitin carboxyl-terminal hydrolase CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD-like; retinitis pigmentosa 1 (autosomal dominant); retinitis pigmentosa 1 homolog; retinitis pigmentosa 1 homolog (human); Rp1; Rp1h; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD
Homo sapiens (human) : CYLD (CYLD lysine 63 deubiquitinase)  HGNC  Alliance
Mus musculus (house mouse) : Cyld (CYLD lysine 63 deubiquitinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cyld (CYLD lysine 63 deubiquitinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYLD (CYLD lysine 63 deubiquitinase)
Canis lupus familiaris (dog) : CYLD (CYLD lysine 63 deubiquitinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyld (CYLD lysine 63 deubiquitinase)
Sus scrofa (pig) : CYLD (CYLD lysine 63 deubiquitinase)
Chlorocebus sabaeus (African green monkey) : CYLD (CYLD lysine 63 deubiquitinase)
Heterocephalus glaber (naked mole-rat) : Cyld (CYLD lysine 63 deubiquitinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01919,264,984 - 19,323,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,265,164 - 19,315,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,298,220 - 30,357,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,616,209 - 19,619,221 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1918,203,184 - 18,261,162 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Cyld
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308346
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.