Snx20 (sorting nexin 20) - Rat Genome Database

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Gene: Snx20 (sorting nexin 20) Rattus norvegicus
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Symbol: Snx20
Name: sorting nexin 20
RGD ID: 1307787
Description: Predicted to enable phosphatidylinositol-3-phosphate binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in protein transport. Predicted to be located in nucleoplasm. Predicted to be active in early endosome membrane. Orthologous to human SNX20 (sorting nexin 20); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307742; MGC108869; RGD1307787; selectin ligand interactor cytoplasmic-1; similar to RIKEN cDNA 9130017C17 gene; Slic1; sorting nexin-20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81934,609,397 - 34,618,569 (+)NCBIGRCr8
mRatBN7.21918,435,935 - 18,445,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,435,935 - 18,445,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,115,486 - 20,124,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,310,096 - 25,319,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,267,854 - 28,277,004 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,395,655 - 19,404,846 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,395,655 - 19,404,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,428,393 - 30,436,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,715,997 - 19,726,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,720,822 - 19,730,970 (+)NCBI
Celera1918,322,643 - 18,331,589 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
early endosome membrane  (IBA,ISO,ISS)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:25882846  


Genomics

Comparative Map Data
Snx20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81934,609,397 - 34,618,569 (+)NCBIGRCr8
mRatBN7.21918,435,935 - 18,445,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,435,935 - 18,445,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,115,486 - 20,124,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,310,096 - 25,319,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,267,854 - 28,277,004 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,395,655 - 19,404,846 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,395,655 - 19,404,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,428,393 - 30,436,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,715,997 - 19,726,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,720,822 - 19,730,970 (+)NCBI
Celera1918,322,643 - 18,331,589 (+)NCBICelera
Cytogenetic Map19p11NCBI
SNX20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,666,300 - 50,681,312 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,666,300 - 50,681,353 (-)EnsemblGRCh38hg38GRCh38
GRCh371650,700,211 - 50,715,223 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,264,387 - 49,272,667 (-)NCBINCBI36Build 36hg18NCBI36
Celera1635,215,527 - 35,230,577 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,588,004 - 36,603,054 (-)NCBIHuRef
CHM1_11652,107,729 - 52,122,779 (-)NCBICHM1_1
T2T-CHM13v2.01656,463,916 - 56,478,923 (-)NCBIT2T-CHM13v2.0
Snx20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,353,189 - 89,362,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,353,191 - 89,362,756 (-)EnsemblGRCm39 Ensembl
GRCm38888,626,561 - 88,636,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,626,563 - 88,636,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv37891,150,727 - 91,160,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,516,933 - 91,526,233 (-)NCBIMGSCv36mm8
Celera892,907,268 - 92,916,455 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.51NCBI
Snx20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,727,493 - 8,731,398 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,725,950 - 8,734,699 (-)NCBIChiLan1.0ChiLan1.0
SNX20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21860,124,381 - 60,138,701 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11666,030,121 - 66,044,337 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,928,545 - 30,944,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,814,315 - 49,822,209 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,809,077 - 49,818,459 (-)Ensemblpanpan1.1panPan2
SNX20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,681,329 - 64,689,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,681,303 - 64,692,486 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,254,013 - 61,262,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,226,579 - 65,235,362 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,226,554 - 65,237,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,050,248 - 62,059,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,070,208 - 63,078,984 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,957,752 - 63,966,522 (+)NCBIUU_Cfam_GSD_1.0
SNX20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,176,748 - 34,191,570 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,176,753 - 34,188,233 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SNX20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,467,839 - 36,481,083 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,469,366 - 36,480,514 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604740,021,561 - 40,031,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snx20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247576,014,238 - 6,019,378 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247576,011,750 - 6,019,378 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Snx20
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000019130
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019130   ⟹   ENSRNOP00000019130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,435,935 - 18,445,107 (+)Ensembl
Rnor_6.0 Ensembl1919,395,655 - 19,404,835 (+)Ensembl
RefSeq Acc Id: NM_001024999   ⟹   NP_001020170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81934,609,397 - 34,618,569 (+)NCBI
mRatBN7.21918,435,935 - 18,445,108 (+)NCBI
Rnor_6.01919,395,655 - 19,404,836 (+)NCBI
Rnor_5.01930,428,393 - 30,436,777 (+)NCBI
RGSC_v3.41919,715,997 - 19,726,145 (+)RGD
Celera1918,322,643 - 18,331,589 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91194 (Get FASTA)   NCBI Sequence Viewer  
  EDL87528 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019130.4
  ENSRNOP00055027021
  ENSRNOP00060021622
GenBank Protein Q5BK61 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020170   ⟸   NM_001024999
- UniProtKB: Q5BK61 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019130   ⟸   ENSRNOT00000019130
Protein Domains
PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK61-F1-model_v2 AlphaFold Q5BK61 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700975
Promoter ID:EPDNEW_R11499
Type:multiple initiation site
Name:Snx20_1
Description:sorting nexin 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01919,395,643 - 19,395,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307787 AgrOrtholog
BioCyc Gene G2FUF-6279 BioCyc
Ensembl Genes ENSRNOG00000014202 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055019519 UniProtKB/Swiss-Prot
  ENSRNOG00060015755 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019130.6 UniProtKB/Swiss-Prot
  ENSRNOT00055033310 UniProtKB/Swiss-Prot
  ENSRNOT00060026965 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1520.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7373920 IMAGE-MGC_LOAD
InterPro Phox UniProtKB/Swiss-Prot
  PX_dom_sf UniProtKB/Swiss-Prot
  SNX20/SNX21 UniProtKB/Swiss-Prot
KEGG Report rno:307742 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108869 IMAGE-MGC_LOAD
NCBI Gene 307742 ENTREZGENE
PANTHER PTHR20939 UniProtKB/Swiss-Prot
  SORTING NEXIN-20 UniProtKB/Swiss-Prot
Pfam PF00787 UniProtKB/Swiss-Prot
PhenoGen Snx20 PhenoGen
PROSITE PS50195 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014202 RatGTEx
  ENSRNOG00055019519 RatGTEx
  ENSRNOG00060015755 RatGTEx
SMART SM00312 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF64268 UniProtKB/Swiss-Prot
UniProt Q5BK61 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-24 Snx20  sorting nexin 20  Slic1  selectin ligand interactor cytoplasmic-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Slic1  selectin ligand interactor cytoplasmic-1  RGD1307787  similar to RIKEN cDNA 9130017C17 gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307787  similar to RIKEN cDNA 9130017C17 gene  RGD1307787_predicted  similar to RIKEN cDNA 9130017C17 gene (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307787_predicted  similar to RIKEN cDNA 9130017C17 gene (predicted)  LOC307742_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307742_predicted  similar to RIKEN cDNA 9130017C17 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL