Adcy7 (adenylate cyclase 7) - Rat Genome Database

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Gene: Adcy7 (adenylate cyclase 7) Rattus norvegicus
Analyze
Symbol: Adcy7
Name: adenylate cyclase 7
RGD ID: 619966
Description: Enables adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and maternal process involved in female pregnancy. Located in membrane. Orthologous to human ADCY7 (adenylate cyclase 7); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate cyclase type 7; adenylyl cyclase 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,740,875 - 18,798,924 (-)NCBI
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01919,702,307 - 19,762,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01930,730,189 - 30,752,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,051,639 - 20,073,861 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1918,626,035 - 18,648,205 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fucoxanthin  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:11113152   PMID:12454008   PMID:17760784   PMID:18205980   PMID:18541530   PMID:20505140   PMID:22871113   PMID:23178822   PMID:23229509   PMID:23842570  


Genomics

Comparative Map Data
Adcy7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,740,875 - 18,798,924 (-)NCBI
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01919,702,307 - 19,762,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01930,730,189 - 30,752,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,051,639 - 20,073,861 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1918,626,035 - 18,648,205 (-)NCBICelera
Cytogenetic Map19p11NCBI
ADCY7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,246,137 - 50,318,135 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,246,138 - 50,318,135 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,300,462 - 50,352,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,879,324 - 48,909,544 (+)NCBINCBI36hg18NCBI36
Build 341648,879,322 - 48,909,544NCBI
Celera1634,836,237 - 34,866,457 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,209,729 - 36,239,954 (+)NCBIHuRef
CHM1_11651,728,925 - 51,759,142 (+)NCBICHM1_1
Adcy7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,998,818 - 89,056,593 (+)NCBIGRCm39mm39
GRCm39 Ensembl888,999,031 - 89,056,590 (+)Ensembl
GRCm38888,272,190 - 88,329,965 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,272,403 - 88,329,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,796,302 - 90,853,861 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,162,508 - 91,220,066 (+)NCBImm8
Celera892,546,581 - 92,603,919 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.06NCBI
Adcy7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,362,756 - 8,426,997 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,362,957 - 8,428,773 (+)NCBIChiLan1.0ChiLan1.0
ADCY7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,410,136 - 49,462,178 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,410,143 - 49,462,278 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,507,836 - 30,581,068 (+)NCBIMhudiblu_PPA_v0panPan3
ADCY7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,003,891 - 65,034,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,006,038 - 65,034,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,576,124 - 61,613,996 (-)NCBI
ROS_Cfam_1.0265,548,675 - 65,586,554 (-)NCBI
UMICH_Zoey_3.1262,372,148 - 62,410,016 (-)NCBI
UNSW_CanFamBas_1.0263,391,818 - 63,429,762 (-)NCBI
UU_Cfam_GSD_1.0264,280,085 - 64,318,009 (-)NCBI
Adcy7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934956,195,769 - 56,248,303 (-)NCBI
SpeTri2.0NW_0049364753,368,069 - 3,393,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,519,180 - 34,585,779 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,521,503 - 34,586,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADCY7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,086,680 - 36,122,021 (+)NCBI
ChlSab1.1 Ensembl536,065,319 - 36,113,921 (+)Ensembl
Vero_WHO_p1.0NW_02366604740,386,043 - 40,459,914 (-)NCBI
Adcy7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247576,336,395 - 6,391,149 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124933090Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127635288Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19129558305Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19129558305Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19132379055Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19138221845Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19138221845Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19138221845Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19138221845Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19500757143907843Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191073992926201726Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191529452433991703Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191593952838798459Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:297
Interacting mature miRNAs:367
Transcripts:ENSRNOT00000020700
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 10 25 11
Low 1 43 49 41 41 8 11 64 35 14 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF184150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF542508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020700   ⟹   ENSRNOP00000020700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)Ensembl
RefSeq Acc Id: NM_053396   ⟹   NP_445848
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,763,102 (-)NCBI
Rnor_6.01919,704,859 - 19,727,081 (-)NCBI
Rnor_5.01930,730,189 - 30,752,411 (-)NCBI
RGSC_v3.41920,051,639 - 20,073,861 (-)RGD
Celera1918,626,035 - 18,648,205 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601381   ⟹   XP_017456870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,782,584 (-)NCBI
Rnor_6.01919,702,307 - 19,746,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601382   ⟹   XP_017456871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,898 (-)NCBI
Rnor_6.01919,702,307 - 19,740,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601383   ⟹   XP_017456872
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,706 (-)NCBI
Rnor_6.01919,702,307 - 19,739,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601384   ⟹   XP_017456873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,706 (-)NCBI
Rnor_6.01919,702,307 - 19,739,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601386   ⟹   XP_017456875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,765,784 (-)NCBI
Rnor_6.01919,702,307 - 19,729,709 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601388   ⟹   XP_017456877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,805 (-)NCBI
Rnor_6.01919,702,307 - 19,762,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601390   ⟹   XP_017456879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,772,472 (-)NCBI
Rnor_6.01919,702,307 - 19,736,027 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601391   ⟹   XP_017456880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,732 (-)NCBI
Rnor_6.01919,702,307 - 19,762,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601392   ⟹   XP_017456881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,766,435 (-)NCBI
Rnor_6.01919,702,307 - 19,730,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601393   ⟹   XP_017456882
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,924 (-)NCBI
Rnor_6.01919,703,670 - 19,762,973 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445848   ⟸   NM_053396
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456877   ⟸   XM_017601388
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456880   ⟸   XM_017601391
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456870   ⟸   XM_017601381
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456871   ⟸   XM_017601382
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456873   ⟸   XM_017601384
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456872   ⟸   XM_017601383
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456879   ⟸   XM_017601390
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456881   ⟸   XM_017601392
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456875   ⟸   XM_017601386
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456882   ⟸   XM_017601393
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020700   ⟸   ENSRNOT00000020700
Protein Domains
Guanylate cyclase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619966 AgrOrtholog
Ensembl Genes ENSRNOG00000014776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020700 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020700 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adenylate_cyclase-like UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
KEGG Report rno:84420 UniProtKB/TrEMBL
NCBI Gene 84420 ENTREZGENE
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PhenoGen Adcy7 PhenoGen
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP A/G_cyclase UniProtKB/TrEMBL
UniProt F1LQT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Adcy7  adenylate cyclase 7    adenylyl cyclase 7  Name updated 1299863 APPROVED
2002-08-07 Adcy7  adenylyl cyclase 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in Scarpa's ganglion, vestibular end organs and cerebellum 632012