Adcy7 (adenylate cyclase 7) - Rat Genome Database

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Gene: Adcy7 (adenylate cyclase 7) Rattus norvegicus
Analyze
Symbol: Adcy7
Name: adenylate cyclase 7
RGD ID: 619966
Description: Enables adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and maternal process involved in female pregnancy. Located in membrane. Orthologous to human ADCY7 (adenylate cyclase 7); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase type 7; adenylyl cyclase 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,740,875 - 18,798,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,740,875 - 18,776,311 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,420,432 - 20,442,652 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01925,615,052 - 25,637,279 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01928,572,695 - 28,594,923 (-)NCBIRnor_WKY
Rnor_6.01919,702,307 - 19,762,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,730,189 - 30,752,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,051,639 - 20,073,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1918,626,035 - 18,648,205 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fucoxanthin  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IDA,ISO)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. Fan P, etal., Mol Pharmacol. 2009 Sep;76(3):526-33. Epub 2009 Jun 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
13. Changes in the expression of adenylyl cyclases in the rat uterus during the course of pregnancy. Suzuki Y, etal., Biol Reprod. 1997 Oct;57(4):778-82.
14. Adenylyl cyclase isoforms in the vestibular periphery of the rat. Wackym PA, etal., Brain Res 2000 Mar 24;859(2):378-80.
Additional References at PubMed
PMID:11113152   PMID:12454008   PMID:17760784   PMID:18205980   PMID:18541530   PMID:20505140   PMID:22871113   PMID:23178822   PMID:23229509   PMID:23842570   PMID:34177802  


Genomics

Comparative Map Data
Adcy7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,740,875 - 18,798,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,740,875 - 18,776,311 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,420,432 - 20,442,652 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01925,615,052 - 25,637,279 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01928,572,695 - 28,594,923 (-)NCBIRnor_WKY
Rnor_6.01919,702,307 - 19,762,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,730,189 - 30,752,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,051,639 - 20,073,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1918,626,035 - 18,648,205 (-)NCBICelera
Cytogenetic Map19p11NCBI
ADCY7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,244,699 - 50,318,135 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1650,246,137 - 50,318,135 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,300,462 - 50,352,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,879,324 - 48,909,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 341648,879,322 - 48,909,544NCBI
Celera1634,836,237 - 34,866,457 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,209,729 - 36,239,954 (+)NCBIHuRef
CHM1_11651,728,925 - 51,759,142 (+)NCBICHM1_1
T2T-CHM13v2.01656,064,385 - 56,115,969 (+)NCBIT2T-CHM13v2.0
Adcy7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,998,818 - 89,056,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl888,999,031 - 89,056,590 (+)EnsemblGRCm39 Ensembl
GRCm38888,272,190 - 88,329,965 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,272,403 - 88,329,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,796,302 - 90,853,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,162,508 - 91,220,066 (+)NCBIMGSCv36mm8
Celera892,546,581 - 92,603,919 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.06NCBI
Adcy7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,362,756 - 8,426,997 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,362,957 - 8,428,773 (+)NCBIChiLan1.0ChiLan1.0
ADCY7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,410,136 - 49,462,178 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,410,143 - 49,462,278 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,507,836 - 30,581,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADCY7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,003,891 - 65,034,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,006,038 - 65,034,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,576,124 - 61,613,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,548,675 - 65,586,554 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,548,666 - 65,581,747 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,372,148 - 62,410,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,391,818 - 63,429,762 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0264,280,085 - 64,318,009 (-)NCBIUU_Cfam_GSD_1.0
Adcy7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934956,195,769 - 56,248,303 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364753,368,069 - 3,393,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,519,180 - 34,585,779 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,521,503 - 34,586,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADCY7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,086,680 - 36,122,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,065,319 - 36,113,921 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604740,386,043 - 40,459,914 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247576,338,006 - 6,389,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247576,336,395 - 6,391,149 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:669
Count of miRNA genes:297
Interacting mature miRNAs:367
Transcripts:ENSRNOT00000020700
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 10 25 11
Low 1 43 49 41 41 8 11 64 35 14 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF184150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF542508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020700   ⟹   ENSRNOP00000020700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,740,875 - 18,776,311 (-)Ensembl
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)Ensembl
RefSeq Acc Id: NM_053396   ⟹   NP_445848
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,763,102 (-)NCBI
Rnor_6.01919,704,859 - 19,727,081 (-)NCBI
Rnor_5.01930,730,189 - 30,752,411 (-)NCBI
RGSC_v3.41920,051,639 - 20,073,861 (-)RGD
Celera1918,626,035 - 18,648,205 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601381   ⟹   XP_017456870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,782,584 (-)NCBI
Rnor_6.01919,702,307 - 19,746,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601382   ⟹   XP_017456871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,898 (-)NCBI
Rnor_6.01919,702,307 - 19,740,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601383   ⟹   XP_017456872
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,706 (-)NCBI
Rnor_6.01919,702,307 - 19,739,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601384   ⟹   XP_017456873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,775,706 (-)NCBI
Rnor_6.01919,702,307 - 19,739,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601386   ⟹   XP_017456875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,765,784 (-)NCBI
Rnor_6.01919,702,307 - 19,729,709 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601388   ⟹   XP_017456877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,805 (-)NCBI
Rnor_6.01919,702,307 - 19,762,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601390   ⟹   XP_017456879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,772,472 (-)NCBI
Rnor_6.01919,702,307 - 19,736,027 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601391   ⟹   XP_017456880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,732 (-)NCBI
Rnor_6.01919,702,307 - 19,762,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601392   ⟹   XP_017456881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,766,435 (-)NCBI
Rnor_6.01919,702,307 - 19,730,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601393   ⟹   XP_017456882
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21918,740,875 - 18,798,924 (-)NCBI
Rnor_6.01919,703,670 - 19,762,973 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445848   ⟸   NM_053396
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456877   ⟸   XM_017601388
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456880   ⟸   XM_017601391
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456870   ⟸   XM_017601381
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456871   ⟸   XM_017601382
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456873   ⟸   XM_017601384
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456872   ⟸   XM_017601383
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456879   ⟸   XM_017601390
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456881   ⟸   XM_017601392
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456875   ⟸   XM_017601386
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456882   ⟸   XM_017601393
- Peptide Label: isoform X1
- UniProtKB: F1LQT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020700   ⟸   ENSRNOT00000020700
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQT1-F1-model_v2 AlphaFold F1LQT1 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619966 AgrOrtholog
BioCyc Gene G2FUF-6274 BioCyc
Ensembl Genes ENSRNOG00000014776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020700 ENTREZGENE
  ENSRNOP00000020700.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020700 ENTREZGENE
  ENSRNOT00000020700.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adenylate_cyclase-like UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
KEGG Report rno:84420 UniProtKB/TrEMBL
NCBI Gene 84420 ENTREZGENE
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PhenoGen Adcy7 PhenoGen
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP A/G_cyclase UniProtKB/TrEMBL
UniProt F1LQT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Adcy7  adenylate cyclase 7    adenylyl cyclase 7  Name updated 1299863 APPROVED
2002-08-07 Adcy7  adenylyl cyclase 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in Scarpa's ganglion, vestibular end organs and cerebellum 632012