Cdh1 (cadherin 1) - Rat Genome Database

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Gene: Cdh1 (cadherin 1) Rattus norvegicus
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Symbol: Cdh1
Name: cadherin 1
RGD ID: 69279
Description: Predicted to have several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to drug. Localizes to several cellular components, including glutamatergic synapse; plasma membrane; and postsynapse. Predicted to colocalize with cortical actin cytoskeleton. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; endometrial cancer pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cadherin-1; E-cadherin; epithelial cadherin; uvomorulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21934,492,371 - 34,561,775 (+)NCBI
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01938,768,467 - 38,838,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01949,635,965 - 49,705,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,442,693 - 36,512,091 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11936,447,573 - 36,516,972 (+)NCBI
Celera1933,919,043 - 33,988,306 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
blepharocheilodontic syndrome 1  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast lobular carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IDA,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (IDA)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mesothelioma  (ISO)
mucoepidermoid carcinoma  (ISO)
Mycoplasma Infections  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Seeding  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
oral squamous cell carcinoma  (ISO)
orofacial cleft  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,ISO)
renal cell carcinoma  (ISO)
Salivary Gland Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
syndromic microphthalmia 5  (ISO)
thyroid gland papillary carcinoma  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (IEP,ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-Ethylhexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aldrin  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ametryn  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antroquinonol  (ISO)
arecoline  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
beta-carotene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
blebbistatin  (ISO)
bleomycin A2  (ISO)
bosutinib  (ISO)
bromodichloromethane  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
captopril  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
DAPT  (ISO)
DDT  (ISO)
Deguelin  (ISO)
delphinidin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
erlotinib hydrochloride  (EXP,ISO)
ethanol  (ISO)
everolimus  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flubendazole  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP)
Ginkgoic acid  (ISO)
glucose  (ISO)
glycidol  (EXP)
hemin  (EXP)
heptachlor  (ISO)
hexachlorobenzene  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isobutanol  (ISO)
isoprene  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
latrunculin A  (ISO)
leupeptin  (EXP)
limonin  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lithocholic acid  (ISO)
losartan  (ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
melittin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (ISO)
morusin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oridonin  (ISO)
Osajin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pelargonidin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
plerixafor  (ISO)
poly(guanylic acid)  (EXP)
Pomiferin  (ISO)
potassium iodide  (EXP)
procyanidin B2  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-allylcysteine  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
sorbinil  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulindac sulfide  (ISO)
Swertiamarin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylenepentamine  (ISO)
tetraphene  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
wortmannin  (ISO)
XAV939  (ISO)
Y-27632  (EXP,ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
adherens junction organization  (ISO)
bicellular tight junction assembly  (ISO)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (ISO)
cell-cell adhesion  (ISO,TAS)
cell-cell adhesion mediated by cadherin  (ISO)
cell-cell adhesion via plasma-membrane adhesion molecules  (IBA)
cellular response to amino acid stimulus  (ISO)
cellular response to indole-3-methanol  (ISO)
cellular response to lithium ion  (ISO)
cochlea development  (ISO)
decidualization  (ISO)
embryo implantation  (ISO)
epithelial cell morphogenesis  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
in utero embryonic development  (ISO)
intestinal epithelial cell development  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of protein processing  (ISO)
neuron projection development  (IEP)
pituitary gland development  (IEP)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein localization to plasma membrane  (ISO)
protein metabolic process  (ISO)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
regulation of gene expression  (ISO,ISS)
regulation of neuron migration  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (IDA,IMP)
regulation of protein localization  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of water loss via skin  (ISO)
response to drug  (IEP)
response to organic substance  (IEP)
response to toxic substance  (IEP)
salivary gland cavitation  (ISO)
sensory perception of sound  (ISO)
synapse assembly  (IBA,IMP)
trophectodermal cell differentiation  (ISO)
uterine epithelium development  (ISO)

References

References - curated