CDH1 (cadherin 1) - Rat Genome Database

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Gene: CDH1 (cadherin 1) Sus scrofa
Analyze
Symbol: CDH1
Name: cadherin 1
RGD ID: 14081125
Description: ENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); bicellular tight junction assembly (ortholog); calcium-dependent cell-cell adhesion (ortholog); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); axon terminus (ortholog); INTERACTS WITH Monobutylphthalate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin 1, type 1, E-cadherin (epithelial); cadherin-1; E-cadherin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,075,487 - 18,155,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
bipolar disorder  (ISO)
blepharocheilodontic syndrome 1  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast lobular carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
depressive disorder  (ISO)
developmental and epileptic encephalopathy 16  (ISO)
diabetes mellitus  (ISO)
diffuse midline glioma, H3 K27-altered  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
DOORS syndrome  (ISO)
Ductal Carcinoma  (ISO)
early myoclonic encephalopathy  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Failure to Thrive  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
gingivitis  (ISO)
GM1 gangliosidosis type 1  (ISO)
goiter  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hyperopia  (ISO)
hyperthyroidism  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
kidney disease  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (ISO)
mucoepidermoid carcinoma  (ISO)
Mycoplasma Infections  (ISO)
Myoclonic Epilepsy, Familial Infantile  (ISO)
myopia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Seeding  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
oral squamous cell carcinoma  (ISO)
orofacial cleft  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Salivary Gland Neoplasms  (ISO)
spinocerebellar ataxia 45  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus endometrial carcinoma  (ISO)
Vertigo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adherens junction organization  (IEA)
bicellular tight junction assembly  (ISO)
calcium-dependent cell-cell adhesion  (ISO)
cell adhesion  (IEA)
cell-cell adhesion  (IEA,ISO)
cell-cell adhesion mediated by cadherin  (IEA,ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to indole-3-methanol  (IEA)
cellular response to lithium ion  (IEA)
cochlea development  (ISO)
decidualization  (ISO)
desmosome assembly  (IEA)
embryo implantation  (ISO)
epithelial cell morphogenesis  (ISO)
establishment of skin barrier  (ISO)
homophilic cell-cell adhesion  (IEA)
in utero embryonic development  (ISO)
intestinal epithelial cell development  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of protein processing  (ISO)
neuron projection development  (ISO)
pituitary gland development  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein localization  (IEA)
protein localization to plasma membrane  (IEA)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of gene expression  (IEA)
regulation of neuron migration  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to cell surface  (ISO)
response to Gram-positive bacterium  (ISO)
response to heparin  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
salivary gland cavitation  (ISO)
sensory perception of sound  (ISO)
synapse assembly  (ISO)
trophectodermal cell differentiation  (ISO)
uterine epithelium development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:20865782   PMID:21089074   PMID:22301074   PMID:23820247   PMID:25976454   PMID:28912304   PMID:30032202  


Genomics

Comparative Map Data
CDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,075,487 - 18,155,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,737,292 - 68,835,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,737,242 - 68,835,543 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371668,771,195 - 68,869,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,328,696 - 67,426,945 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341667,328,695 - 67,426,945NCBI
Celera1653,280,506 - 53,378,750 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1654,643,861 - 54,742,830 (+)NCBIHuRef
CHM1_11670,179,154 - 70,277,601 (+)NCBICHM1_1
T2T-CHM13v2.01674,533,467 - 74,631,804 (+)NCBIT2T-CHM13v2.0
Cdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,329,982 - 107,396,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,329,941 - 107,396,880 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388106,603,350 - 106,670,247 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,603,351 - 106,670,246 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv378109,127,268 - 109,194,146 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368109,492,497 - 109,559,375 (+)NCBIMGSCv36mm8
Celera8110,827,793 - 110,895,640 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.18NCBI
Cdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,402,178 - 51,471,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1951,402,034 - 51,471,565 (+)EnsemblGRCr8
mRatBN7.21934,492,371 - 34,561,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,492,371 - 34,561,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1941,307,916 - 41,377,323 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,961,239 - 42,030,653 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,260,374 - 44,329,781 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1945,189,436 - 45,258,858 (+)NCBI
Lyon_Normotensive1943,314,318 - 43,383,735 (+)NCBI
Lyon_Hypertensive1945,187,673 - 45,257,095 (+)NCBI
F344_StmMcwi1942,944,913 - 43,013,856 (+)NCBI
Rnor_6.01938,768,467 - 38,838,395 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01949,635,965 - 49,705,893 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41936,442,693 - 36,512,091 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,919,043 - 33,988,306 (+)NCBICelera
RGSC_v3.11936,447,573 - 36,516,972 (+)NCBI
Cytogenetic Map19q12NCBI
Cdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,782,772 - 7,860,967 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554847,782,409 - 7,861,082 (-)NCBIChiLan1.0ChiLan1.0
CDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,278,865 - 78,376,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,190,211 - 84,288,055 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,108,745 - 49,206,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,502,399 - 68,597,748 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,502,584 - 68,596,488 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,757,508 - 80,834,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,757,508 - 80,834,878 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha580,748,132 - 80,825,726 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0581,192,046 - 81,269,949 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,190,208 - 81,269,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,019,133 - 81,096,989 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,702,291 - 80,780,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,341,865 - 81,420,857 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11545,278,085 - 45,353,286 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440934940,523,052 - 40,598,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,990,474 - 19,067,203 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,990,529 - 19,065,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1565,685,841 - 65,787,008 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604721,315,122 - 21,416,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1558,578,244 - 58,679,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,578,146 - 58,679,541 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Cdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474617,480,472 - 17,557,722 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462474617,483,469 - 17,557,581 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl755,087,607 - 55,163,251 (+)Ensembl
Cdh1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11726,323,024 - 26,391,331 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in CDH1
2935 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 3 23 3 2 5 13 11 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000029834   ⟹   ENSSSCP00000019442
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,075,480 - 18,155,126 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000041655   ⟹   ENSSSCP00000058117
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000058692   ⟹   ENSSSCP00000059570
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000107929   ⟹   ENSSSCP00000082302
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,075,481 - 18,155,986 (-)Ensembl
RefSeq Acc Id: NM_001163060   ⟹   NP_001156532
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1618,075,487 - 18,155,986 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001156532 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB87474 (Get FASTA)   NCBI Sequence Viewer  
  ABP88101 (Get FASTA)   NCBI Sequence Viewer  
  ACI94878 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000058117
  ENSSSCP00000058117.2
  ENSSSCP00000059570.3
  ENSSSCP00000082302.1
RefSeq Acc Id: NP_001156532   ⟸   NM_001163060
- Peptide Label: precursor
- UniProtKB: C6EVT4 (UniProtKB/TrEMBL),   A0A287BPL8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000019442   ⟸   ENSSSCT00000029834
Ensembl Acc Id: ENSSSCP00000059570   ⟸   ENSSSCT00000058692
Ensembl Acc Id: ENSSSCP00000058117   ⟸   ENSSSCT00000041655
Ensembl Acc Id: ENSSSCP00000082302   ⟸   ENSSSCT00000107929
Protein Domains
Cadherin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041655 ENTREZGENE
  ENSSSCT00000041655.4 UniProtKB/TrEMBL
  ENSSSCT00000058692.4 UniProtKB/TrEMBL
  ENSSSCT00000107929.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Cadherin_pro_dom UniProtKB/TrEMBL
  Catenin_binding_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100048953 UniProtKB/TrEMBL
NCBI Gene CDH1 ENTREZGENE
PANTHER CADHERIN-1 UniProtKB/TrEMBL
  PTHR24027 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
SMART Cadherin_pro UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
UniProt A0A287BPL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BSR8_PIG UniProtKB/TrEMBL
  A0ABB5UQ11_PIG UniProtKB/TrEMBL
  C6EVT4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86473 ENTREZGENE