Akap5 (A-kinase anchoring protein 5) - Rat Genome Database

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Gene: Akap5 (A-kinase anchoring protein 5) Rattus norvegicus
Analyze
Symbol: Akap5
Name: A-kinase anchoring protein 5
RGD ID: 620829
Description: Enables several functions, including SH3 domain binding activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including central nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and regulation of metal ion transport. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and dendritic shaft. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human AKAP5 (A-kinase anchoring protein 5); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 150 kDa; A-kinase anchor protein 5; AKAP 150; AKAP-5; AKAP150; Akap79; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; P150; RII-B-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,787,169 - 100,796,712 (+)NCBIGRCr8
mRatBN7.2695,051,527 - 95,061,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,051,537 - 95,061,578 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,444,564 - 95,449,969 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,743,071 - 95,748,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,171,884 - 95,177,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,356,509 - 99,361,909 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,356,509 - 99,361,909 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,768,060 - 108,773,460 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,923,105 - 98,928,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,926,570 - 98,931,955 (+)NCBI
Celera693,476,351 - 93,481,725 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
endosulfan  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
ozone  (EXP)
paracetamol  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP)
poly(I:C)  (EXP)
progesterone  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
amylase secretion  (ISO)
calcineurin-NFAT signaling cascade  (ISO)
cellular response to calcium ion  (ISO)
cellular response to organonitrogen compound  (IEP)
cellular response to xenobiotic stimulus  (ISO)
clustering of voltage-gated calcium channels  (ISO)
clustering of voltage-gated potassium channels  (ISO)
establishment of localization in cell  (ISO)
gene expression  (ISO)
hippocampus development  (IEP)
maternal process involved in female pregnancy  (IEP)
negative regulation of adenylate cyclase activity  (IDA)
negative regulation of monoatomic ion transport  (IMP)
negative regulation of potassium ion transport  (IMP)
positive regulation of adenylate cyclase activity  (IDA)
positive regulation of calcineurin-NFAT signaling cascade  (IMP)
positive regulation of calcium ion transport into cytosol  (IDA)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of endosome to plasma membrane protein transport  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (IMP)
postsynaptic neurotransmitter receptor cycle  (ISO)
protein-containing complex disassembly  (IDA)
receptor clustering  (ISO)
regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (IDA,IMP)
regulation of protein kinase A signaling  (ISO)
response to electrical stimulus  (IEP)
response to muscle activity  (IEP)
spinal cord development  (IEP)
synapse assembly  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors. Bhattacharyya S, etal., Nat Neurosci. 2009 Feb;12(2):172-81. Epub 2009 Jan 25.
2. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Brandon NJ, etal., Mol Cell Neurosci 2003 Jan;22(1):87-97.
3. High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B. Cloning, characterization, and expression of cDNAs for rat brain P150. Bregman DB, etal., J Biol Chem 1989 Mar 15;264(8):4648-56.
4. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
5. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Colledge M, etal., Neuron. 2000 Jul;27(1):107-19.
6. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. De Windt LJ, etal., Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3322-7.
7. A role for AKAP (A kinase anchoring protein) scaffolding in the loss of a cyclic adenosine 3',5'-monophosphate inhibitory response in late pregnant rat myometrium. Dodge KL, etal., Mol Endocrinol. 1999 Dec;13(12):1977-87.
8. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. Gardner LA, etal., J Biol Chem. 2006 Nov 3;281(44):33537-53. Epub 2006 Aug 28.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. LTP but not seizure is associated with up-regulation of AKAP-150. Genin A, etal., Eur J Neurosci. 2003 Jan;17(2):331-40.
11. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. Gomez LL, etal., J Neurosci. 2002 Aug 15;22(16):7027-44.
12. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Gorski JA, etal., Mol Biol Cell. 2005 Aug;16(8):3574-90. Epub 2005 Jun 1.
13. Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression. Horne EA and Dell'Acqua ML, J Neurosci. 2007 Mar 28;27(13):3523-34.
14. Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes. Hoshi N and Scott JD, Eur J Cell Biol. 2006 Jul;85(7):621-2. Epub 2006 Feb 7.
15. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Hoshi N, etal., Nat Neurosci 2003 Jun;6(6):564-71.
16. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Jeske NA, etal., Pain. 2008 Sep 15;138(3):604-16. Epub 2008 Apr 1.
17. cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. Jicha GA, etal., J Neurosci. 1999 Sep 1;19(17):7486-94.
18. Progesterone prevents the pregnancy-related decline in protein kinase A association with rat myometrial plasma membrane and A-kinase anchoring protein. Ku CY and Sanborn BM, Biol Reprod. 2002 Aug;67(2):605-9.
19. Regulation of Na,K-ATPase by cAMP-dependent protein kinase anchored on membrane via A-kinase anchoring protein subtype, AKAP-150, in rat parotid gland. Kurihara K and Nakanishi N, Ann N Y Acad Sci 2003 Apr;986:636-8.
20. Specific expression of an A-kinase anchoring protein subtype, AKAP-150, and specific regulatory mechanism for Na(+),K(+)-ATPase via protein kinase A in the parotid gland among the three major salivary glands of the rat. Kurihara K, etal., Biochem Pharmacol. 2003 Jul 15;66(2):239-50.
21. Repeated electroconvulsive shock treatment increases the expression of A kinase anchoring proteins in the rat hippocampus. Lee YI, etal., Neurosci Lett 2004 Jan 30;355(3):213-6.
22. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Li H, etal., Nat Struct Mol Biol. 2012 Feb 19;19(3):337-45. doi: 10.1038/nsmb.2238.
23. Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers. Lilly SM, etal., Neuroscience. 2005;134(1):155-63.
24. Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. Liu G, etal., EMBO J. 2004 Jun 2;23(11):2196-205. Epub 2004 May 13.
25. Identification of an IQGAP1/AKAP79 complex in beta-cells. Nauert JB, etal., J Cell Biochem 2003 Sep 1;90(1):97-108.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Possible mechanisms by which adipocyte lipolysis is enhanced in exercise-trained rats. Nomura S, etal., Biochem Biophys Res Commun. 2002 Jul 12;295(2):236-42.
28. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Oliveria SF, etal., Neuron. 2007 Jul 19;55(2):261-75.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. Robertson HR, etal., J Neurosci. 2009 Jun 17;29(24):7929-43.
33. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. Smith KE, etal., J Neurosci. 2006 Mar 1;26(9):2391-402.
34. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
35. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. Wang D, etal., FASEB J. 2010 Sep;24(9):3511-21. doi: 10.1096/fj.10-156661. Epub 2010 Apr 15.
36. AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. Willoughby D, etal., J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.
37. A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex. Willoughby D, etal., J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12.
38. Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Zhang X, etal., Neuron. 2008 Aug 14;59(3):450-61.
Additional References at PubMed
PMID:10753752   PMID:15458848   PMID:17081159   PMID:17279627   PMID:17548344   PMID:17911601   PMID:19292454   PMID:19767149   PMID:19858198   PMID:20164376   PMID:20694001   PMID:21273417  
PMID:21502359   PMID:21569553   PMID:21674494   PMID:21771783   PMID:22623657   PMID:22789851   PMID:23392692   PMID:24121510   PMID:24501172   PMID:25005497   PMID:25451194   PMID:25451626  
PMID:25589740   PMID:26199377   PMID:27693258   PMID:28331977   PMID:29800717   PMID:30053369   PMID:30102916   PMID:33716104   PMID:36115111   PMID:36565899  


Genomics

Comparative Map Data
Akap5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,787,169 - 100,796,712 (+)NCBIGRCr8
mRatBN7.2695,051,527 - 95,061,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,051,537 - 95,061,578 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,444,564 - 95,449,969 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,743,071 - 95,748,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,171,884 - 95,177,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,356,509 - 99,361,909 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,356,509 - 99,361,909 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,768,060 - 108,773,460 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,923,105 - 98,928,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,926,570 - 98,931,955 (+)NCBI
Celera693,476,351 - 93,481,725 (+)NCBICelera
Cytogenetic Map6q24NCBI
AKAP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,465,499 - 64,474,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,465,499 - 64,474,503 (+)EnsemblGRCh38hg38GRCh38
GRCh371464,932,217 - 64,941,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,001,970 - 64,010,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 341464,003,577 - 64,006,172NCBI
Celera1444,989,946 - 44,998,950 (+)NCBICelera
Cytogenetic Map14q23.3ENTREZGENE
HuRef1445,104,846 - 45,113,850 (+)NCBIHuRef
CHM1_11464,871,930 - 64,880,934 (+)NCBICHM1_1
T2T-CHM13v2.01458,673,265 - 58,682,271 (+)NCBIT2T-CHM13v2.0
Akap5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,371,652 - 76,380,925 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,371,665 - 76,380,927 (+)EnsemblGRCm39 Ensembl
GRCm381276,324,617 - 76,334,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,324,891 - 76,334,153 (+)EnsemblGRCm38mm10GRCm38
MGSCv371277,425,878 - 77,435,138 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,246,657 - 77,249,859 (+)NCBIMGSCv36mm8
Celera1277,415,834 - 77,425,026 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Akap5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,411,650 - 5,412,960 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,411,190 - 5,422,043 (-)NCBIChiLan1.0ChiLan1.0
AKAP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,575,340 - 65,586,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,793,349 - 64,802,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,045,476 - 45,050,946 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,299,369 - 63,303,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,302,200 - 63,303,483 (+)Ensemblpanpan1.1panPan2
AKAP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,891,637 - 38,902,390 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,896,840 - 38,898,126 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,581,009 - 38,593,805 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,110,721 - 39,123,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,115,361 - 39,120,432 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,732,786 - 38,745,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,804,178 - 38,816,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,164,258 - 39,177,033 (+)NCBIUU_Cfam_GSD_1.0
Akap5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,010,194 - 66,018,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,176,249 - 8,177,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,173,521 - 8,179,249 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,538,984 - 88,547,392 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,538,938 - 88,544,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,900,300 - 94,905,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,669,206 - 41,678,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,672,098 - 41,673,381 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,846,241 - 29,855,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,550,447 - 36,551,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,550,020 - 36,555,142 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap5
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000008416
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 37 3 11
Low 3 30 45 29 19 29 7 7 37 27 35 7
Below cutoff 9 12 12 12 1 3 8 3 1

Sequence


Ensembl Acc Id: ENSRNOT00000008416   ⟹   ENSRNOP00000008416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,051,560 - 95,057,025 (+)Ensembl
Rnor_6.0 Ensembl699,356,509 - 99,361,909 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119804   ⟹   ENSRNOP00000094047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,051,537 - 95,061,578 (+)Ensembl
RefSeq Acc Id: NM_133515   ⟹   NP_598199
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,787,169 - 100,792,569 (+)NCBI
mRatBN7.2695,051,527 - 95,056,929 (+)NCBI
Rnor_6.0699,356,509 - 99,361,909 (+)NCBI
Rnor_5.06108,768,060 - 108,773,460 (+)NCBI
RGSC_v3.4698,923,105 - 98,928,505 (+)RGD
Celera693,476,351 - 93,481,725 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111734   ⟹   XP_038967662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,787,599 - 100,796,712 (+)NCBI
mRatBN7.2695,051,953 - 95,061,075 (+)NCBI
Protein Sequences
Protein RefSeqs NP_598199 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967662 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA50420 (Get FASTA)   NCBI Sequence Viewer  
  AAB07887 (Get FASTA)   NCBI Sequence Viewer  
  EDM03657 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008416.4
  ENSRNOP00000094047.1
GenBank Protein P24587 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598199   ⟸   NM_133515
- UniProtKB: P70593 (UniProtKB/Swiss-Prot),   P24587 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008416   ⟸   ENSRNOT00000008416
RefSeq Acc Id: XP_038967662   ⟸   XM_039111734
- Peptide Label: isoform X1
- UniProtKB: P70593 (UniProtKB/Swiss-Prot),   P24587 (UniProtKB/Swiss-Prot),   A0A8I6AK18 (UniProtKB/TrEMBL),   A6HCA2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094047   ⟸   ENSRNOT00000119804
Protein Domains
A kinase-anchoring proteins AKAP-5 and AKAP-12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24587-F1-model_v2 AlphaFold P24587 1-714 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694674
Promoter ID:EPDNEW_R5198
Type:multiple initiation site
Name:Akap5_1
Description:A-kinase anchoring protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0699,356,549 - 99,356,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620829 AgrOrtholog
BioCyc Gene G2FUF-37065 BioCyc
Ensembl Genes ENSRNOG00000006410 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008416.6 UniProtKB/TrEMBL
  ENSRNOT00000119804.1 UniProtKB/TrEMBL
InterPro AKAP5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase-A_anch_WSK-motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171026 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap5 PhenoGen
PROSITE AKAP_CAM_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006410 RatGTEx
Superfamily-SCOP Phage fibre proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AK18 ENTREZGENE, UniProtKB/TrEMBL
  A6HCA2 ENTREZGENE, UniProtKB/TrEMBL
  AKAP5_RAT UniProtKB/Swiss-Prot
  F1LPP6_RAT UniProtKB/TrEMBL
  P24587 ENTREZGENE
  P70593 ENTREZGENE
UniProt Secondary P70593 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap5  A-kinase anchoring protein 5  Akap5  A kinase (PRKA) anchor protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Akap5  A kinase (PRKA) anchor protein 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Akap5  A kinase (PRKA) anchor protein 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 631906
gene_physical_interaction binds scaffold protein IQGAP1; may form a complex with PKA 1304429