Akap5 (A-kinase anchoring protein 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Akap5 (A-kinase anchoring protein 5) Chinchilla lanigera
Analyze
Symbol: Akap5
Name: A-kinase anchoring protein 5
RGD ID: 9005946
Description: ENCODES a protein that exhibits actin binding (ortholog); adenylate cyclase binding (ortholog); beta-2 adrenergic receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amylase secretion (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Cardiomegaly (ortholog); COVID-19 (ortholog); FOUND IN asymmetric synapse (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,411,650 - 5,412,960 (-)Ensembl
ChiLan1.0NW_0049554665,411,190 - 5,422,043 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
amylase secretion  (ISO)
calcineurin-NFAT signaling cascade  (ISO)
cellular response to calcium ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
clustering of voltage-gated calcium channels  (ISO)
clustering of voltage-gated potassium channels  (ISO)
establishment of localization in cell  (ISO)
gene expression  (ISO)
hippocampus development  (ISO)
maternal process involved in female pregnancy  (ISO)
negative regulation of adenylate cyclase activity  (ISO)
negative regulation of monoatomic ion transport  (ISO)
negative regulation of potassium ion transport  (ISO)
positive regulation of adenylate cyclase activity  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of endosome to plasma membrane protein transport  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
postsynaptic neurotransmitter receptor cycle  (ISO)
protein-containing complex disassembly  (ISO)
receptor clustering  (ISO)
regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein kinase A signaling  (ISO)
response to electrical stimulus  (ISO)
response to muscle activity  (ISO)
spinal cord development  (ISO)
synapse assembly  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Akap5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,411,650 - 5,412,960 (-)Ensembl
ChiLan1.0NW_0049554665,411,190 - 5,422,043 (-)NCBIChiLan1.0ChiLan1.0
AKAP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,465,499 - 64,474,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,465,499 - 64,474,503 (+)Ensemblhg38GRCh38
GRCh371464,932,217 - 64,941,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,001,970 - 64,010,974 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341464,003,577 - 64,006,172NCBI
Celera1444,989,946 - 44,998,950 (+)NCBICelera
Cytogenetic Map14q23.3ENTREZGENE
HuRef1445,104,846 - 45,113,850 (+)NCBIHuRef
CHM1_11464,871,930 - 64,880,934 (+)NCBICHM1_1
T2T-CHM13v2.01458,673,265 - 58,682,271 (+)NCBIT2T-CHM13v2.0
Akap5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,371,652 - 76,380,925 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,371,665 - 76,380,927 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381276,324,617 - 76,334,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,324,891 - 76,334,153 (+)Ensemblmm10GRCm38
MGSCv371277,425,878 - 77,435,138 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361277,246,657 - 77,249,859 (+)NCBIMGSCv36mm8
Celera1277,415,834 - 77,425,026 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Akap5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,787,169 - 100,796,712 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6100,790,148 - 100,796,620 (+)EnsemblGRCr8
mRatBN7.2695,051,527 - 95,061,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,051,537 - 95,061,578 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx695,444,564 - 95,449,969 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,743,071 - 95,748,478 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,171,884 - 95,177,291 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,356,509 - 99,361,909 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,356,509 - 99,361,909 (+)Ensemblrn6Rnor6.0
Rnor_5.06108,768,060 - 108,773,460 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4698,923,105 - 98,928,505 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,476,351 - 93,481,725 (+)NCBICelera
RGSC_v3.1698,926,570 - 98,931,955 (+)NCBI
Cytogenetic Map6q24NCBI
AKAP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,575,340 - 65,586,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,793,349 - 64,802,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,045,476 - 45,050,946 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,299,369 - 63,303,516 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,302,200 - 63,303,483 (+)EnsemblpanPan2panpan1.1
AKAP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,891,637 - 38,902,390 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,896,840 - 38,898,126 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha838,581,009 - 38,593,805 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0839,110,721 - 39,123,499 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,115,361 - 39,120,432 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,732,786 - 38,745,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,804,178 - 38,816,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,164,258 - 39,177,033 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akap5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,010,194 - 66,018,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,176,249 - 8,177,556 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,173,521 - 8,179,249 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,538,984 - 88,547,392 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1788,538,938 - 88,544,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,900,300 - 94,905,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,669,206 - 41,678,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,672,098 - 41,673,381 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605329,846,241 - 29,855,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,550,447 - 36,551,742 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473436,550,020 - 36,555,142 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025768   ⟹   ENSCLAP00000025507
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554665,411,650 - 5,412,960 (-)Ensembl
RefSeq Acc Id: XM_005399128   ⟹   XP_005399185
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554665,411,190 - 5,422,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005399129   ⟹   XP_005399186
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554665,411,190 - 5,416,584 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005399185 (Get FASTA)   NCBI Sequence Viewer  
  XP_005399186 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000025507
  ENSCLAP00000025507.1
RefSeq Acc Id: XP_005399185   ⟸   XM_005399128
- UniProtKB: A0A8C2YV39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399186   ⟸   XM_005399129
- UniProtKB: A0A8C2YV39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000025507   ⟸   ENSCLAT00000025768
Protein Domains
A kinase-anchoring proteins AKAP-5 and AKAP-12


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017594 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025768 ENTREZGENE
  ENSCLAT00000025768.1 UniProtKB/TrEMBL
InterPro AKAP5 UniProtKB/TrEMBL
  AKAP_WSK UniProtKB/TrEMBL
NCBI Gene Akap5 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 5 UniProtKB/TrEMBL
  PTHR15182 UniProtKB/TrEMBL
Pfam WSK UniProtKB/TrEMBL
PROSITE AKAP_CAM_BD UniProtKB/TrEMBL
UniProt A0A8C2YV39 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Akap5  A-kinase anchoring protein 5    A kinase (PRKA) anchor protein 5  Symbol and/or name change 5135510 APPROVED