Adrb1 (adrenoceptor beta 1) - Rat Genome Database
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Gene: Adrb1 (adrenoceptor beta 1) Rattus norvegicus
Analyze
Symbol: Adrb1
Name: adrenoceptor beta 1
RGD ID: 2059
Description: Exhibits beta1-adrenergic receptor activity. Involved in several processes, including positive regulation of transport; regulation of heart contraction; and regulation of muscle system process. Localizes to cytoplasm; nucleus; and plasma membrane. Used to study congestive heart failure; dilated cardiomyopathy; myocardial infarction; periodontitis; and renovascular hypertension. Biomarker of hyperglycemia; hypertension; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Adrenergic receptor beta 1; adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; B1AR; beta 1-adrenergic receptor beta 1-AR; beta 1-adrenergic receptor, beta 1-AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; RATB1AR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21255,772,217 - 255,773,617 (+)NCBI
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Celera1251,470,349 - 251,471,554 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (ISO)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,2-dichloroethane  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17beta-estradiol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
acebutolol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (EXP,ISO)
alprenolol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arbutamine  (EXP)
asbestos  (ISO)
atenolol  (EXP,ISO)
befunolol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
betaxolol  (EXP,ISO)
bevantolol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP,ISO)
bisphenol A  (EXP,ISO)
bupranolol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chlorpyrifos  (EXP)
cicloprolol  (EXP)
clofibrate  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (ISO)
dieldrin  (EXP)
diltiazem  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (EXP,ISO)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
fenoterol  (ISO)
fipronil  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
genistein  (ISO)
hexane  (ISO)
icariin  (ISO)
ICI 118551  (EXP,ISO)
idazoxan  (EXP)
imipramine  (EXP)
iodocyanopindolol  (EXP,ISO)
isoprenaline  (EXP,ISO)
labetalol  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
metoprolol  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
nadolol  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nicotine  (ISO)
octopamine  (ISO)
paracetamol  (ISO)
Phenoxybenzamine  (EXP)
phenylmercury acetate  (ISO)
pindolol  (EXP,ISO)
potassium atom  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (EXP,ISO)
putrescine  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotalol  (ISO)
spermidine  (ISO)
spermine  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
terbutaline  (EXP,ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trandolapril  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincristine  (ISO)
vortioxetine  (ISO)
Xamoterol  (EXP,ISO)
yohimbine  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,IEA,ISO,ISS)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
aging  (IEP)
apoptotic process  (IDA)
brown fat cell differentiation  (IEA,ISO)
diet induced thermogenesis  (IEA,ISO)
fear response  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IDA)
glycogen catabolic process  (IDA)
heat generation  (IEA,ISO)
inhibitory postsynaptic potential  (IMP)
lipid homeostasis  (IMP)
memory  (IMP)
negative regulation of multicellular organism growth  (IEA,ISO)
negative regulation of smooth muscle contraction  (IMP)
negative regulation of urine volume  (IDA)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,IEA,ISO)
positive regulation of adenylate cyclase activity  (IMP)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of calcium ion import across plasma membrane  (IDA)
positive regulation of cation channel activity  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of GTPase activity  (IEA,ISO,ISS)
positive regulation of heart rate  (IMP)
positive regulation of heart rate by epinephrine-norepinephrine  (IBA,IEA,ISO)
positive regulation of long-term synaptic potentiation  (IDA)
positive regulation of renin secretion into blood stream  (IMP)
positive regulation of saliva secretion  (IMP)
positive regulation of systemic arterial blood pressure  (IMP)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (IEA,ISO)
positive regulation of the force of heart contraction by norepinephrine  (IDA)
protein localization to organelle  (IDA)
regulation of calcium ion transport  (IDA)
regulation of cardiac muscle cell contraction  (IDA,IMP)
regulation of circadian sleep/wake cycle, sleep  (IEA,ISO,ISS)
regulation of postsynaptic membrane potential  (IEA)
response to cold  (IEA,ISO)
Rho protein signal transduction  (IMP)
sensory perception of pain  (IMP)
wound healing  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endocytosis pathway  (IEA)
epinephrine signaling pathway via adrenergic receptor beta  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphas family  (TAS)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
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28. GOA data from the GO Consortium
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Additional References at PubMed
PMID:1695899   PMID:7738011   PMID:7761854   PMID:8693001   PMID:9305915   PMID:10358009   PMID:10595521   PMID:11526121   PMID:11641423   PMID:12529373   PMID:12742828   PMID:12832552  
PMID:15066288   PMID:15375008   PMID:15381255   PMID:15539636   PMID:15840637   PMID:16005083   PMID:17053072   PMID:17158652   PMID:17671986   PMID:17869266   PMID:18006556   PMID:18154937  
PMID:18202120   PMID:18296565   PMID:18396264   PMID:18423428   PMID:18469068   PMID:18487315   PMID:18583384   PMID:18596687   PMID:18680159   PMID:19003918   PMID:19111114   PMID:19120131  
PMID:19120133   PMID:19283875   PMID:19336623   PMID:19442879   PMID:19900965   PMID:19932173   PMID:20096470   PMID:20417717   PMID:20547682   PMID:20667477   PMID:21170495   PMID:21540189  
PMID:21777029   PMID:21787468   PMID:21901315   PMID:22099178   PMID:22165287   PMID:22248722   PMID:22253850   PMID:22270541   PMID:22425752   PMID:22506532   PMID:22609523   PMID:22715380  
PMID:23373597   PMID:23488860   PMID:23533220   PMID:23696820   PMID:23916734   PMID:23969695   PMID:24037783   PMID:24121510   PMID:24161401   PMID:24412308   PMID:24744110   PMID:24836853  
PMID:25083013   PMID:25096537   PMID:25211027   PMID:25634756   PMID:25881071   PMID:25966954   PMID:26248277   PMID:26462734   PMID:27035432   PMID:27577254   PMID:28060734   PMID:28160015  
PMID:28167537   PMID:28339772   PMID:28343149   PMID:29212811   PMID:29709009   PMID:30355197   PMID:30591463   PMID:30836825   PMID:31433293   PMID:31553425   PMID:32471715  


Genomics

Candidate Gene Status
Adrb1 is a candidate Gene for QTL Lnnr2
Comparative Map Data
Adrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21255,772,217 - 255,773,617 (+)NCBI
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Celera1251,470,349 - 251,471,554 (+)NCBICelera
Cytogenetic Map1q55NCBI
ADRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
Adrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)Ensembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBImm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
Adrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543119,025,663 - 19,027,026 (+)NCBIChiLan1.0ChiLan1.0
ADRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110114,075,628 - 114,076,596 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0panPan3
ADRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2824,908,224 - 24,909,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12824,908,224 - 24,909,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364864,400,467 - 4,401,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,400,189 - 124,401,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,400,330 - 124,401,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,520,692 - 135,522,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,920,520 - 106,923,424 (+)NCBI
ChlSab1.1 Ensembl9106,920,610 - 106,922,058 (+)Ensembl
Adrb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473732,536,096 - 32,563,721 (-)NCBI

Position Markers
D1Arb28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q55UniSTS
D1Smu1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01277,550,706 - 277,550,874NCBIRnor6.0
Rnor_5.01284,930,993 - 284,931,161UniSTSRnor5.0
RGSC_v3.41263,038,775 - 263,038,943UniSTSRGSC3.4
Celera1251,483,273 - 251,483,441UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:141043  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01277,538,836 - 277,538,935NCBIRnor6.0
Rnor_5.01284,919,123 - 284,919,222UniSTSRnor5.0
RGSC_v3.41263,026,906 - 263,027,005UniSTSRGSC3.4
Celera1251,471,405 - 251,471,504UniSTS
Cytogenetic Map1q55UniSTS
Adrb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01277,537,858 - 277,538,379NCBIRnor6.0
Rnor_5.01284,918,145 - 284,918,666UniSTSRnor5.0
RGSC_v3.41263,025,928 - 263,026,449UniSTSRGSC3.4
Celera1251,470,427 - 251,470,948UniSTS
Cytogenetic Map1q55UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1252955158280632620Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1252948438281795785Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1266793821279986079Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1258709726281795785Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:73
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000022813
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 2 5
Low 2 39 15 6 14 6 58 23 14 6
Below cutoff 1 40 33 5 33 7 10 14 8 25 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022813   ⟹   ENSRNOP00000022813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)Ensembl
RefSeq Acc Id: NM_012701   ⟹   NP_036833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21255,772,217 - 255,773,617 (+)NCBI
Rnor_6.01277,537,585 - 277,538,985 (+)NCBI
Rnor_5.01284,917,872 - 284,919,272 (+)NCBI
RGSC_v3.41263,025,655 - 263,027,055 (+)RGD
Celera1251,470,349 - 251,471,554 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40792 (Get FASTA)   NCBI Sequence Viewer  
  ALD83745 (Get FASTA)   NCBI Sequence Viewer  
  BAA00527 (Get FASTA)   NCBI Sequence Viewer  
  EDL94502 (Get FASTA)   NCBI Sequence Viewer  
  P18090 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036833   ⟸   NM_012701
- UniProtKB: P18090 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022813   ⟸   ENSRNOT00000022813
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2059 AgrOrtholog
Ensembl Genes ENSRNOG00000017002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022813 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022813 ENTREZGENE, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24925 UniProtKB/Swiss-Prot
NCBI Gene 24925 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADRB1 RGD
PhenoGen Adrb1 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235823
UniProt A0A0G2JSP7_RAT UniProtKB/TrEMBL
  A0A0M4LAM5_RAT UniProtKB/TrEMBL
  ADRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adrb1  adrenoceptor beta 1  Adrb1  adrenergic, beta-1-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Adrb1  adrenergic, beta-1-, receptor  Adrb1  adrenergic receptor, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adrb1  adrenergic receptor, beta 1    Adrenergic receptor beta 1  Name updated 625702 APPROVED
2002-06-10 Adrb1  Adrenergic receptor beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a putative N-linked glycosylation site at Asn-15 632157
gene_domains contains three putative sites for cAMP-dependent protein kinase phosphorylation at Ser-296, Ser-301, and Ser-401 632157
gene_expression mRNA detected in many tissues including pineal gland and other regions of the brain, and heart 632157
gene_function binds beta-adrenergic receptor agonists isoproterenol, norepinephrine, and epinephrine 632157
gene_process mediates induction of adenylylcyclase 632157
gene_process mediates regulation of calcium current 632158
gene_product member of the G-protein coupled receptor family 632157
gene_protein protein sequence contains 466 amino acids 632157