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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:6343
Term: labetalol
Definition: A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure.
Chemical ID: MESH:D007741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDLabetalol binds to ADRB1 protein

PMID:11483288, PMID:2462161
multiple interactionsEXP 6480464CTDLabetalol binds to and results in decreased activity of ADRB1 protein

Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]

Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]

PMID:11425575, PMID:2462161
decreases activityISORGD:7312896480464CTDLabetalol results in decreased activity of ADRB1 protein

PMID:2567112
increases activityISORGD:7312896480464CTDLabetalol results in increased activity of ADRB1 protein

PMID:12761341
multiple interactionsISORGD:7312896480464CTD[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP

CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]

PMID:12761341
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.