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Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.

Authors: Jimenez, Maria  Léger, Bertrand  Canola, Kriss  Lehr, Lorenz  Arboit, Patrizia  Seydoux, Josiane  Russell, Aaron P  Giacobino, Jean Paul  Muzzin, Patrick  Preitner, Frédéric 
Citation: Jimenez M, etal., FEBS Lett. 2002 Oct 23;530(1-3):37-40.
Pubmed: (View Article at PubMed) PMID:12387862

Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). To test this hypothesis, we generated beta(1)/beta(2)/beta(3)-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.


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RGD Object Information
RGD ID: 13673775
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.