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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:2379
Term: acebutolol
Definition: An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.
Chemical ID: MESH:D000070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:7312896480464CTDAcebutolol results in increased activity of ADRB1 protein

PMID:12761341
multiple interactionsISORGD:7312896480464CTD[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]

CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein]

PMID:12761341
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.