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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:135123
Term: bupranolol
Definition: null
Chemical ID: MESH:D002046
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7312896480464CTDBupranolol results in decreased activity of ADRB1 protein

PMID:2565296
multiple interactionsISORGD:7312896480464CTD[Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP

Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

PMID:12761341, PMID:15060759
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.