RGD Reference Report - Changes in autoantibodies against beta1-adrenoceptor and M2-muscarinic receptor during development of renovascular hypertension in rats. - Rat Genome Database

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Changes in autoantibodies against beta1-adrenoceptor and M2-muscarinic receptor during development of renovascular hypertension in rats.

Authors: Zhi, JM  Chen, RF  Wu, H  Liu, HR  Zhao, RR 
Citation: Zhi JM, etal., Acta Biochim Biophys Sin (Shanghai). 2004 Dec;36(12):793-7.
RGD ID: 7241580
Pubmed: PMID:15592645   (View Abstract at PubMed)

In an experimental rat's renovascular hypertension model, we studied the genesis of anti-cardiac beta1-adrenoceptor and M2-muscarinic receptor autoantibodies in relation to the changes in immunological function during the development of renal hypertension. The biological activities of these autoantibodies were also examined. It was shown that after two weeks of operation both the frequency of occurrence and the titre of autoantibodies to cardiac beta1-adrenoceptor and M2-muscarinic receptor were significantly increased as compared with the control of pre-treatment. The increased autoantibodies lasted for several weeks and then automatically decreased gradually to the pre-clipping level at 10 weeks. Meanwhile the ratio of CD4+/CD8+ was also undergone an initial increase followed by gradual recovery and correlated well with the changes in antibody titre. The biological effects of these autoantibodies displayed an "gonistic-like" activities on the beating frequency of cultured neonatal cardiomyocyte. It is suggested that autoimmune mechanisms are involved in the pathogenesis of renal hypertension and the cardiac receptor autoantibodies might be one of the mechanisms leading to cardiac dysfunction.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renovascular hypertension  ISOAdrb1 (Rattus norvegicus)7241580; 7241580 RGD 
renovascular hypertension  IDA 7241580 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb1  (adrenoceptor beta 1)

Genes (Mus musculus)
Adrb1  (adrenergic receptor, beta 1)

Genes (Homo sapiens)
ADRB1  (adrenoceptor beta 1)


Additional Information