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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7312896480464CTD[Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

Formoterol Fumarate binds to and results in increased activity of ADRB1 protein

Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB1 protein]

PMID:14730417
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.