GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDIsoproterenol results in decreased expression of ADRB1 mRNA

PMID:1312942, PMID:16731636
increases uptakeEXP 6480464CTDIsoproterenol results in increased uptake of ADRB1 protein

PMID:18194989
multiple interactionsEXP 6480464CTDADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]

ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]

AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]

Isoproterenol binds to and results in increased activity of ADRB1 protein

Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]

PMID:1312942, PMID:16731636, PMID:18378355, PMID:8096834, PMID:8723169
affects response to substanceISORGD:7312896480464CTDADRB1 protein polymorphism affects the susceptibility to Isoproterenol

PMID:14502278
decreases expressionISORGD:101066480464CTDIsoproterenol results in decreased expression of ADRB1

Isoproterenol results in decreased expression of ADRB1 mRNA

PMID:12963636, PMID:17350036, PMID:20003209
increases activityISORGD:7312896480464CTDIsoproterenol results in increased activity of ADRB1 protein

PMID:12761341
increases phosphorylationISORGD:7312896480464CTDIsoproterenol results in increased phosphorylation of ADRB1 protein

PMID:18787115
multiple interactionsISORGD:101066480464CTD[ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol

PMID:11159692
multiple interactionsISORGD:7312896480464CTD[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP

Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

Isoproterenol binds to and results in increased activity of ADRB1 protein

Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]

Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]

Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]

Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]

Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]

Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]

PMID:12761341, PMID:14730417, PMID:15627480, PMID:17200720, PMID:18787115, PMID:8096834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.