ADRB1 (adrenoceptor beta 1) - Rat Genome Database

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Gene: ADRB1 (adrenoceptor beta 1) Homo sapiens
Analyze
Symbol: ADRB1
Name: adrenoceptor beta 1
RGD ID: 731289
HGNC Page HGNC
Description: Enables several functions, including PDZ domain binding activity; alpha-2A adrenergic receptor binding activity; and guanyl-nucleotide exchange factor activity. Involved in adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of GTPase activity; and regulation of circadian sleep/wake cycle, sleep. Located in early endosome and plasma membrane. Implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Biomarker of aortic valve stenosis and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRB1R; adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; B1AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; BETA1AR; FNSS2; RHR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (EXP)
(S)-nicotine  (EXP)
(S)-timolol (anhydrous)  (EXP)
1,2-dichloroethane  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (EXP)
17beta-estradiol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
acebutolol  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
albuterol  (EXP,ISO)
alprenolol  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
arbutamine  (ISO)
aristolochic acid  (EXP)
arsenite(3-)  (ISO)
asbestos  (EXP)
atenolol  (EXP,ISO)
befunolol  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
betaxolol  (EXP,ISO)
bevantolol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP,ISO)
bisphenol A  (ISO)
bupranolol  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carteolol  (EXP)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chlorpyrifos  (ISO)
cicloprolol  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (EXP)
dieldrin  (ISO)
diltiazem  (EXP)
dioxygen  (ISO)
dobutamine  (EXP,ISO)
dorsomorphin  (EXP)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
fenoterol  (EXP)
fipronil  (EXP)
formaldehyde  (EXP)
formoterol fumarate  (EXP)
genistein  (ISO)
hexane  (EXP)
icariin  (ISO)
ICI 118551  (EXP,ISO)
idazoxan  (ISO)
imipramine  (ISO)
iodocyanopindolol  (EXP,ISO)
isoprenaline  (EXP,ISO)
labetalol  (EXP,ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
metoprolol  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
nadolol  (EXP)
nebivolol  (EXP,ISO)
nickel atom  (EXP)
nicotine  (EXP)
octopamine  (EXP)
paracetamol  (ISO)
Phenoxybenzamine  (ISO)
phenylmercury acetate  (EXP)
pindolol  (EXP,ISO)
potassium atom  (EXP)
propafenone  (EXP)
propanal  (EXP)
propranolol  (EXP,ISO)
putrescine  (EXP)
reserpine  (ISO)
resveratrol  (ISO)
Salmeterol xinafoate  (EXP)
SB 431542  (EXP)
simvastatin  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sotalol  (EXP)
spermidine  (EXP)
spermine  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
terbutaline  (EXP,ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trandolapril  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vincristine  (EXP)
vortioxetine  (EXP)
Xamoterol  (EXP,ISO)
yohimbine  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (TAS)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,IDA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
aging  (ISO)
apoptotic process  (ISO)
brown fat cell differentiation  (IEA,ISO)
diet induced thermogenesis  (IEA,ISO)
fear response  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glycogen catabolic process  (ISO)
heat generation  (IEA,ISO)
inhibitory postsynaptic potential  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
negative regulation of multicellular organism growth  (IEA,ISO)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,IEA,ISO)
positive regulation of adenylate cyclase activity  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of GTPase activity  (IDA)
positive regulation of heart contraction  (IEA)
positive regulation of heart rate  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (IBA,IEA,ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of renin secretion into blood stream  (ISO)
positive regulation of saliva secretion  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (IEA,ISO)
positive regulation of the force of heart contraction by norepinephrine  (ISO)
protein localization to organelle  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of circadian sleep/wake cycle, sleep  (IEA,IMP)
regulation of postsynaptic membrane potential  (IEA)
response to cold  (IEA,ISO)
Rho protein signal transduction  (ISO)
sensory perception of pain  (ISO)
signal transduction  (IEA)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (EXP)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (EXP,TAS)
amiodarone pharmacodynamics pathway  (EXP)
amlodipine pharmacodynamics pathway  (EXP)
atenolol pharmacodynamics pathway  (EXP)
betaxolol pharmacodynamics pathway  (EXP)
bisoprolol pharmacodynamics pathway  (EXP)
bupranolol drug pathway  (EXP)
bupranolol pharmacodynamics pathway  (EXP)
carvedilol pharmacodynamics pathway  (EXP)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (EXP)
disopyramide pharmacodynamics pathway  (EXP)
dobutamine pharmacodynamics pathway  (EXP)
endocytosis pathway  (IEA)
epinephrine signaling pathway via adrenergic receptor beta  (TAS)
esmolol pharmacodynamics pathway  (EXP)
flecainde pharmacodynamics pathway  (EXP)
fosphenytoin pharmacodynamics pathway  (EXP)
G protein mediated signaling pathway via Galphas family  (ISS)
ibutilide pharmacodynamics pathway  (EXP)
isoprenaline pharmacodynamics pathway  (EXP)
isradipine pharmacodynamics pathway  (EXP)
levobunolol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
metoprolol pharmacodynamics pathway  (EXP)
mexiletine pharmacodynamics pathway  (EXP)
nadolol pharmacodynamics pathway  (EXP)
nebivolol pharmacodynamics pathway  (EXP)
nifedipine pharmacodynamics pathway  (EXP)
nimodipine pharmacodynamics pathway  (EXP)
nisoldipine pharmacodynamics pathway  (EXP)
nitrendipine pharmacodynamics pathway  (EXP)
penbutolol pharmacodynamics pathway  (EXP)
phenytoin pharmacodynamics pathway  (EXP)
pindolol pharmacodynamics pathway  (EXP)
procainamide pharmacodynamics pathway  (EXP)
propranolol pharmacodynamics pathway  (EXP)
quinidine pharmacodynamics pathway  (EXP)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
sotalol pharmacodynamics pathway  (EXP)
timolol pharmacodynamics pathway  (EXP)
verapamil pharmacodynamics pathway  (EXP)

References

References - curated
1. Ahmet I, etal., J Pharmacol Exp Ther. 2008 May;325(2):491-9. Epub 2008 Feb 20.
2. Ahmet I, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):178-85. Epub 2009 Jul 8.
3. Arnold AS, etal., J Hypertens. 2007 Jan;25(1):197-205.
4. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
5. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Bengtsson Bostrom K, etal., Int J Hypertens. 2010 Mar 30;2010. pii: 458410.
7. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
8. Busch L, etal., Arch Oral Biol. 2008 Jun;53(6):509-16. Epub 2008 Feb 13.
9. Communal C, etal., Circulation. 1999 Nov 30;100(22):2210-2.
10. Dorow P, etal., J Cardiovasc Pharmacol. 1990;16 Suppl 5:S36-44.
11. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
12. Frishman WH Am J Ther. 2008 Nov-Dec;15(6):565-76.
13. Fung MM, etal., Nephrol Dial Transplant. 2009 Dec;24(12):3677-86. doi: 10.1093/ndt/gfp471. Epub 2009 Sep 10.
14. Galinier M, etal., Fundam Clin Pharmacol. 1994;8(1):90-9.
15. GOA_HUMAN data from the GO Consortium
16. Goyagi T, etal., Brain Res. 2010 Jul 9;1343:213-7. Epub 2010 May 6.
17. Inagaki Y, etal., Mol Vis. 2006 Jun 12;12:673-80.
18. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
19. Liang Y, etal., J Biomed Sci. 2007 Jan;14(1):155-64. Epub 2007 Feb 3.
20. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
21. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
22. Mialet Perez J, etal., Nat Med 2003 Oct;9(10):1300-5. Epub 2003 Sep 14.
23. Oliver E, etal., J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. Epub 2008 Dec 5.
24. OMIM Disease Annotation Pipeline
25. Peschke E, etal., Diabetologia. 2011 Jul;54(7):1831-40. Epub 2011 Apr 15.
26. Pipeline to import KEGG annotations from KEGG into RGD
27. Pipeline to import SMPDB annotations from SMPDB into RGD
28. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. RGD automated import pipeline for gene-chemical interactions
30. Sakanashi M, etal., Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):55-60.
31. Segovia M, etal., J Oral Pathol Med. 2012 Mar;41(3):242-8. doi: 10.1111/j.1600-0714.2011.01090.x. Epub 2011 Sep 30.
32. Shibata O, etal., J Anesth. 2008;22(1):21-6. Epub 2008 Feb 27.
33. Steinfath M, etal., Naunyn Schmiedebergs Arch Pharmacol. 1991 Feb;343(2):217-20.
34. Thackeray JT, etal., Nucl Med Biol. 2011 Oct;38(7):1059-66. Epub 2011 Aug 9.
35. Zhang W, etal., Eur J Pharmacol. 2011 Jan 10;650(1):303-8. Epub 2010 Oct 17.
36. Zhao LS, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Feb;38(2):139-42.
37. Zhi JM, etal., Acta Biochim Biophys Sin (Shanghai). 2004 Dec;36(12):793-7.
Additional References at PubMed
PMID:2154750   PMID:2465637   PMID:2536864   PMID:2825170   PMID:6305985   PMID:7583452   PMID:8892658   PMID:9843378   PMID:10212248   PMID:10477438   PMID:10535961   PMID:10794544  
PMID:10862778   PMID:10995758   PMID:11052857   PMID:11140838   PMID:11337934   PMID:11447084   PMID:11526121   PMID:11700307   PMID:11753577   PMID:11854867   PMID:11942593   PMID:12023679  
PMID:12029453   PMID:12032746   PMID:12036966   PMID:12069593   PMID:12090746   PMID:12106601   PMID:12140284   PMID:12184796   PMID:12197595   PMID:12244098   PMID:12270132   PMID:12374873  
PMID:12387862   PMID:12391161   PMID:12422153   PMID:12455717   PMID:12519093   PMID:12529373   PMID:12544508   PMID:12643891   PMID:12709726   PMID:12724327   PMID:12815745   PMID:12844134  
PMID:12847069   PMID:12851615   PMID:12921807   PMID:14534524   PMID:14553962   PMID:14734649   PMID:14990580   PMID:15055253   PMID:15079793   PMID:15086532   PMID:15123239   PMID:15212591  
PMID:15212839   PMID:15237695   PMID:15312808   PMID:15331590   PMID:15342173   PMID:15358775   PMID:15388645   PMID:15452121   PMID:15464701   PMID:15479221   PMID:15542284   PMID:15564877  
PMID:15685248   PMID:15719258   PMID:15735607   PMID:15824464   PMID:15833937   PMID:15861037   PMID:15864115   PMID:15917856   PMID:15932670   PMID:16122377   PMID:16153393   PMID:16187973  
PMID:16189366   PMID:16210433   PMID:16227135   PMID:16287427   PMID:16315032   PMID:16316992   PMID:16325708   PMID:16402084   PMID:16421173   PMID:16485781   PMID:16487965   PMID:16500896  
PMID:16533813   PMID:16534528   PMID:16648137   PMID:16728691   PMID:16760361   PMID:16765375   PMID:16815314   PMID:16844790   PMID:16907703   PMID:16914520   PMID:16940053   PMID:16946993  
PMID:16997396   PMID:17023080   PMID:17118120   PMID:17217681   PMID:17223428   PMID:17270896   PMID:17329986   PMID:17334644   PMID:17335470   PMID:17339538   PMID:17345787   PMID:17383306  
PMID:17463065   PMID:17496726   PMID:17512307   PMID:17541557   PMID:17585213   PMID:17591269   PMID:17635183   PMID:17644825   PMID:17667029   PMID:17680533   PMID:17845930   PMID:17893006  
PMID:17919552   PMID:17998459   PMID:18059082   PMID:18075464   PMID:18155231   PMID:18158268   PMID:18193079   PMID:18209576   PMID:18219297   PMID:18239290   PMID:18240029   PMID:18253135  
PMID:18298953   PMID:18308161   PMID:18311486   PMID:18323523   PMID:18331634   PMID:18346809   PMID:18403719   PMID:18413308   PMID:18413560   PMID:18429752   PMID:18452871   PMID:18479335  
PMID:18534365   PMID:18540901   PMID:18596718   PMID:18615004   PMID:18622236   PMID:18625943   PMID:18679149   PMID:18702937   PMID:18702968   PMID:18754404   PMID:18772317   PMID:18773997  
PMID:18776959   PMID:18787115   PMID:18794726   PMID:18797399   PMID:18936436   PMID:18937294   PMID:18947427   PMID:18996102   PMID:19010176   PMID:19033826   PMID:19036891   PMID:19037712  
PMID:19056576   PMID:19073901   PMID:19086053   PMID:19094446   PMID:19167638   PMID:19301767   PMID:19378229   PMID:19477404   PMID:19509284   PMID:19515093   PMID:19538012   PMID:19542315  
PMID:19553224   PMID:19576569   PMID:19578796   PMID:19621046   PMID:19623647   PMID:19628119   PMID:19673943   PMID:19743955   PMID:19779464   PMID:19842931   PMID:19845516   PMID:19883298  
PMID:19913121   PMID:19956635   PMID:20023040   PMID:20044737   PMID:20079238   PMID:20116105   PMID:20123316   PMID:20129829   PMID:20144152   PMID:20185488   PMID:20235788   PMID:20300048  
PMID:20352314   PMID:20374546   PMID:20384459   PMID:20414837   PMID:20426789   PMID:20443839   PMID:20459474   PMID:20468064   PMID:20470286   PMID:20537417   PMID:20538960   PMID:20581797  
PMID:20587416   PMID:20602615   PMID:20625396   PMID:20628086   PMID:20643254   PMID:20693591   PMID:20705341   PMID:20726983   PMID:20731869   PMID:20803192   PMID:20821015   PMID:20831043  
PMID:20952631   PMID:21034538   PMID:21044781   PMID:21059181   PMID:21238583   PMID:21305273   PMID:21311897   PMID:21375401   PMID:21422729   PMID:21464135   PMID:21516734   PMID:21527343  
PMID:21540189   PMID:21553224   PMID:21573230   PMID:21599570   PMID:21614075   PMID:21626217   PMID:21807569   PMID:21847570   PMID:21873635   PMID:21878665   PMID:21909110   PMID:22192668  
PMID:22253823   PMID:22299391   PMID:22306453   PMID:22340652   PMID:22378779   PMID:22388998   PMID:22447021   PMID:22495925   PMID:22617224   PMID:22703382   PMID:22723743   PMID:22728333  
PMID:22742717   PMID:22811559   PMID:22815685   PMID:22994654   PMID:23060133   PMID:23065660   PMID:23114278   PMID:23115322   PMID:23202124   PMID:23223178   PMID:23257656   PMID:23261005  
PMID:23266473   PMID:23271137   PMID:23275278   PMID:23291003   PMID:23318885   PMID:23351074   PMID:23370410   PMID:23381222   PMID:23533220   PMID:23588958   PMID:23729404   PMID:24121510  
PMID:24151242   PMID:24159564   PMID:24324269   PMID:24332148   PMID:24334028   PMID:24342311   PMID:24371822   PMID:24437165   PMID:24466231   PMID:24552127   PMID:24713698   PMID:24749907  
PMID:24885710   PMID:24972470   PMID:24982877   PMID:25083013   PMID:25091480   PMID:25172623   PMID:25351416   PMID:25406899   PMID:25451930   PMID:25510377   PMID:25558679   PMID:25614626  
PMID:25638254   PMID:25673629   PMID:25815601   PMID:25823457   PMID:25837585   PMID:26058836   PMID:26125791   PMID:26248277   PMID:26313487   PMID:26602751   PMID:26879662   PMID:27016578  
PMID:27027728   PMID:27108086   PMID:27665326   PMID:27816670   PMID:27993566   PMID:28165045   PMID:28167537   PMID:28177749   PMID:28351962   PMID:28456594   PMID:28472170   PMID:28522796  
PMID:28746336   PMID:28756611   PMID:28801655   PMID:29197114   PMID:29514624   PMID:29549925   PMID:29587766   PMID:30538132   PMID:30591463   PMID:30668166   PMID:30747396   PMID:30753253  
PMID:30756358   PMID:31425733   PMID:31473062   PMID:31620969   PMID:31812970   PMID:31884750   PMID:32371991   PMID:32491001   PMID:32555462   PMID:32586526   PMID:33238186   PMID:33451866  
PMID:33593484   PMID:34088840   PMID:34270905  


Genomics

Comparative Map Data
ADRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
Adrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)Ensembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBImm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
Adrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21255,772,217 - 255,773,617 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)Ensembl
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Celera1251,470,349 - 251,471,554 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543119,025,663 - 19,027,026 (+)NCBIChiLan1.0ChiLan1.0
ADRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110114,075,628 - 114,076,596 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0panPan3
ADRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12824,908,224 - 24,909,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,908,224 - 24,909,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2825,059,492 - 25,060,922 (+)NCBI
ROS_Cfam_1.02825,441,579 - 25,443,005 (+)NCBI
ROS_Cfam_1.0 Ensembl2825,441,579 - 25,443,005 (+)Ensembl
UMICH_Zoey_3.12824,997,230 - 24,998,684 (+)NCBI
UNSW_CanFamBas_1.02825,011,917 - 25,013,353 (+)NCBI
UU_Cfam_GSD_1.02825,206,065 - 25,207,486 (+)NCBI
Adrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,159,710 - 21,160,831 (-)NCBI
SpeTri2.0NW_0049364864,400,467 - 4,401,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,400,189 - 124,401,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,400,330 - 124,401,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,520,692 - 135,522,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,920,520 - 106,923,424 (+)NCBIChlSab1.1chlSab2
ChlSab1.19106,920,520 - 106,923,424 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl9106,920,610 - 106,922,058 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604868,152,893 - 68,156,014 (+)NCBIVero_WHO_p1.0
Adrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473732,536,096 - 32,563,721 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
GDB:193846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,805,385 - 115,805,487UniSTSGRCh37
Build 3610115,795,375 - 115,795,477RGDNCBI36
Celera10109,532,757 - 109,532,859RGD
Cytogenetic Map10q25.3UniSTS
HuRef10109,431,056 - 109,431,158UniSTS
RH68963  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,805,401 - 115,805,525UniSTSGRCh37
Build 3610115,795,391 - 115,795,515RGDNCBI36
Celera10109,532,773 - 109,532,897RGD
Cytogenetic Map10q25.3UniSTS
HuRef10109,431,072 - 109,431,196UniSTS
GeneMap99-GB4 RH Map10519.76UniSTS
STS-U29690  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,805,954 - 115,806,215UniSTSGRCh37
Build 3610115,795,944 - 115,796,205RGDNCBI36
Celera10109,533,326 - 109,533,587RGD
Cytogenetic Map10q25.3UniSTS
HuRef10109,431,620 - 109,431,881UniSTS
GeneMap99-GB4 RH Map10519.76UniSTS
NCBI RH Map101250.0UniSTS
UniSTS:256461  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,804,165 - 115,804,686UniSTSGRCh37
Build 3610115,794,155 - 115,794,676RGDNCBI36
Celera10109,531,536 - 109,532,057RGD
HuRef10109,429,836 - 109,430,357UniSTS
ADRB1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,806,617 - 115,806,807UniSTSGRCh37
Build 3610115,796,607 - 115,796,797RGDNCBI36
Celera10109,533,989 - 109,534,179RGD
HuRef10109,432,283 - 109,432,473UniSTS
UniSTS:489671  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710115,803,820 - 115,805,432UniSTSGRCh37
Celera10109,531,191 - 109,532,804UniSTS
HuRef10109,429,491 - 109,431,103UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:604
Count of miRNA genes:432
Interacting mature miRNAs:491
Transcripts:ENST00000369295
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 92 563 28 4 15 4 33 327 533 16 86 545 131 3
Low 2182 676 792 184 882 135 1472 1072 2317 200 751 804 56 1 1005 498 1 2
Below cutoff 144 1580 835 388 825 277 2677 755 826 150 562 232 114 68 2178 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000369295   ⟹   ENSP00000358301
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)Ensembl
RefSeq Acc Id: NM_000684   ⟹   NP_000675
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810114,043,866 - 114,046,904 (+)NCBI
GRCh3710115,803,806 - 115,806,667 (+)ENTREZGENE
Build 3610115,793,796 - 115,796,657 (+)NCBI Archive
HuRef10109,429,477 - 109,432,333 (+)ENTREZGENE
CHM1_110116,087,711 - 116,090,573 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000675   ⟸   NM_000684
- UniProtKB: P08588 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000358301   ⟸   ENST00000369295


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000684.3(ADRB1):c.1165G>C (p.Gly389Arg) single nucleotide variant Congestive heart failure and beta-blocker response, modifier of [RCV000019322] Chr10:114045297 [GRCh38]
Chr10:115805056 [GRCh37]
Chr10:10q25.3
drug response
NM_000684.3(ADRB1):c.145A>G (p.Ser49Gly) single nucleotide variant Resting heart rate [RCV000019323]|not specified [RCV000600843] Chr10:114044277 [GRCh38]
Chr10:115804036 [GRCh37]
Chr10:10q25.3
pathogenic|association|likely benign
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3
pathogenic
GRCh38/hg38 10q25.1-26.11(chr10:107191100-118761489)x1 copy number loss See cases [RCV000052570] Chr10:107191100..118761489 [GRCh38]
Chr10:108950858..120521001 [GRCh37]
Chr10:108940848..120510991 [NCBI36]
Chr10:10q25.1-26.11
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
GRCh37/hg19 10q25.2-26.3(chr10:114544537-135427143)x3 copy number gain not provided [RCV000847820] Chr10:114544537..135427143 [GRCh37]
Chr10:10q25.2-26.3
pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:112074094-115537174)x1 copy number loss See cases [RCV000135960] Chr10:112074094..115537174 [GRCh38]
Chr10:113833852..117032437 [GRCh37]
Chr10:113823842..117286674 [NCBI36]
Chr10:10q25.2-25.3
pathogenic
GRCh38/hg38 10q25.2-26.12(chr10:112701186-120970617)x3 copy number gain See cases [RCV000137511] Chr10:112701186..120970617 [GRCh38]
Chr10:114460945..122730130 [GRCh37]
Chr10:114450935..122720120 [NCBI36]
Chr10:10q25.2-26.12
likely pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:110804735-114884010)x1 copy number loss See cases [RCV000139783] Chr10:110804735..114884010 [GRCh38]
Chr10:112564493..116643769 [GRCh37]
Chr10:112554483..116633759 [NCBI36]
Chr10:10q25.2-25.3
likely pathogenic
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3
pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_000684.3(ADRB1):c.1317G>A (p.Thr439=) single nucleotide variant not provided [RCV000959707] Chr10:114045449 [GRCh38]
Chr10:115805208 [GRCh37]
Chr10:10q25.3
likely benign
NM_000684.3(ADRB1):c.1065C>A (p.Pro355=) single nucleotide variant not provided [RCV000972598] Chr10:114045197 [GRCh38]
Chr10:115804956 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.1145A>G (p.Asp382Gly) single nucleotide variant not provided [RCV000937956] Chr10:114045277 [GRCh38]
Chr10:115805036 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.207G>A (p.Val69=) single nucleotide variant not provided [RCV000965818] Chr10:114044339 [GRCh38]
Chr10:115804098 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.540C>T (p.Cys180=) single nucleotide variant not provided [RCV000963467] Chr10:114044672 [GRCh38]
Chr10:115804431 [GRCh37]
Chr10:10q25.3
benign
GRCh37/hg19 10q25.1-26.3(chr10:110022170-135439095) copy number gain not provided [RCV000767665] Chr10:110022170..135439095 [GRCh37]
Chr10:10q25.1-26.3
pathogenic
NM_000684.3(ADRB1):c.808G>A (p.Ala270Thr) single nucleotide variant not provided [RCV000959889] Chr10:114044940 [GRCh38]
Chr10:115804699 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.228T>C (p.Asn76=) single nucleotide variant not provided [RCV000962072] Chr10:114044360 [GRCh38]
Chr10:115804119 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.560C>T (p.Ala187Val) single nucleotide variant SHORT SLEEP, FAMILIAL NATURAL, 2 [RCV000851538] Chr10:114044692 [GRCh38]
Chr10:115804451 [GRCh37]
Chr10:10q25.3
affects
NM_000684.3(ADRB1):c.1166G>T (p.Gly389Val) single nucleotide variant not provided [RCV000910669] Chr10:114045298 [GRCh38]
Chr10:115805057 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.315G>T (p.Leu105=) single nucleotide variant not provided [RCV000956868] Chr10:114044447 [GRCh38]
Chr10:115804206 [GRCh37]
Chr10:10q25.3
benign
NM_000684.3(ADRB1):c.14T>C (p.Val5Ala) single nucleotide variant not provided [RCV000889915] Chr10:114044146 [GRCh38]
Chr10:115803905 [GRCh37]
Chr10:10q25.3
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:285 AgrOrtholog
COSMIC ADRB1 COSMIC
Ensembl Genes ENSG00000043591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000358301 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000369295 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000043591 GTEx
HGNC ID HGNC:285 ENTREZGENE
Human Proteome Map ADRB1 Human Proteome Map
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRB1_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:153 UniProtKB/Swiss-Prot
NCBI Gene 153 ENTREZGENE
OMIM 109630 OMIM
  607276 OMIM
  618591 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRB1 RGD, PharmGKB
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCB1AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt ADRB1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0LPE2 UniProtKB/Swiss-Prot
  Q5T5Y4 UniProtKB/Swiss-Prot
  Q9UKG7 UniProtKB/Swiss-Prot
  Q9UKG8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 ADRB1  adrenoceptor beta 1  ADRB1  adrenergic, beta-1-, receptor  Symbol and/or name change 5135510 APPROVED
2011-08-16 ADRB1  adrenergic, beta-1-, receptor  ADRB1  adrenergic, beta-1-, receptor  Symbol and/or name change 5135510 APPROVED