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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:73370
Term: iodocyanopindolol
Definition: An indole that is 1H-indole substituted at positions 2, 3 and 7 by cyano, iodo and 3-(tert-butylamino)-2-hydroxypropoxy groups respectively.
Chemical ID: MESH:D020120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDIodocyanopindolol binds to ADRB1 protein

PMID:8096834, PMID:9260993
multiple interactionsEXP 6480464CTDAlbuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834, PMID:9260993
affects bindingISORGD:7312896480464CTDIodocyanopindolol binds to ADRB1 protein

PMID:10344530, PMID:8096834
multiple interactionsISORGD:7312896480464CTDAlbuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

CGP 20712A inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

ICI 89406 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

soterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:10344530, PMID:8096834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.