RGD Reference Report - Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats. - Rat Genome Database

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Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats.

Authors: Lahaye Sle, D  Gratas-Delamarche, A  Malarde, L  Vincent, S  Zguira, MS  Morel, SL  Delamarche, P  Zouhal, H  Carre, F  Bekono, FR 
Citation: Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
RGD ID: 5129115
Pubmed: PMID:21054861   (View Abstract at PubMed)
PMCID: PMC2992048   (View Article at PubMed Central)
DOI: DOI:10.1186/1475-2840-9-72   (Journal Full-text)

BACKGROUND: Informations about the effects of intense exercise training on diabetes-induced myocardial dysfunctions are lacking. We have examined the effects of intense exercise training on the cardiac function of diabetic rats, especially focusing on the Langendorff beta-adrenergic responsiveness and on the beta-adrenoceptors protein expression. METHODS: Control or Streptozotocin induced-diabetic male Wistar rats were randomly assigned to sedentary or trained groups. The training program consisted of 8 weeks running on a treadmill (10 degrees incline, up to 25 m/min, 60 min/day) and was considered to be intense for diabetic rats. RESULTS: This intense exercise training amplified the in vivo diabetes-induced bradycardia. It had no effect on Langendorff basal cardiac contraction and relaxation performances in control and diabetic rats. In diabetic rats, it accentuated the Langendorff reduced responsiveness to beta-adrenergic stimulation. It did not blunt the diabetes-induced decrease of beta1-adrenoceptors protein expression, displayed a significant decrease in the beta2-adrenoceptors protein expression and normalized the beta3-adrenoceptors protein expression. CONCLUSIONS: Intense exercise training accentuated the decrease in the myocardial responsiveness to beta-adrenergic stimulation induced by diabetes. This defect stems principally from the beta2-adrenoceptors protein expression reduction. Thus, these results demonstrate that intense exercise training induces specific effects on the beta-adrenergic system in diabetes.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
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Original Reference(s)
ADRB1HumanExperimental Diabetes Mellitus  ISOAdrb1 (Rattus norvegicus)protein:decreased expression:left ventricle muscular partRGD 
ADRB3HumanExperimental Diabetes Mellitus  ISOAdrb3 (Rattus norvegicus)protein:increased expression:left ventricle muscular partRGD 
Adrb1RatExperimental Diabetes Mellitus  IEP protein:decreased expression:left ventricle muscular partRGD 
Adrb1MouseExperimental Diabetes Mellitus  ISOAdrb1 (Rattus norvegicus)protein:decreased expression:left ventricle muscular partRGD 
Adrb3RatExperimental Diabetes Mellitus  IEP protein:increased expression:left ventricle muscular partRGD 
Adrb3MouseExperimental Diabetes Mellitus  ISOAdrb3 (Rattus norvegicus)protein:increased expression:left ventricle muscular partRGD 


Genes (Rattus norvegicus)
Adrb1  (adrenoceptor beta 1) Adrb3  (adrenoceptor beta 3)

Genes (Mus musculus)
Adrb1  (adrenergic receptor, beta 1) Adrb3  (adrenergic receptor, beta 3)

Genes (Homo sapiens)
ADRB1  (adrenoceptor beta 1) ADRB3  (adrenoceptor beta 3)