Adrb1 (adrenergic receptor, beta 1) - Rat Genome Database

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Gene: Adrb1 (adrenergic receptor, beta 1) Mus musculus
Analyze
Symbol: Adrb1
Name: adrenergic receptor, beta 1
RGD ID: 10106
MGI Page MGI
Description: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in positive regulation of cold-induced thermogenesis and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Located in Schaffer collateral - CA1 synapse and membrane. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adrb; Adrb-1; beta 1-AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; beta-AR; cardiac beta adrenergic receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)Ensembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBImm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (ISO)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,2-dichloroethane  (EXP)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17beta-estradiol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
acebutolol  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
albuterol  (ISO)
alprenolol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arbutamine  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP)
asbestos  (ISO)
atenolol  (ISO)
befunolol  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
betaxolol  (ISO)
bevantolol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bupranolol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carteolol  (ISO)
carvedilol  (ISO)
CGP 12177  (ISO)
chlorpyrifos  (ISO)
cicloprolol  (ISO)
clofibrate  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloromethane  (ISO)
dieldrin  (ISO)
diltiazem  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
fenoterol  (ISO)
fipronil  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
genistein  (EXP)
hexane  (ISO)
icariin  (EXP)
ICI 118551  (ISO)
idazoxan  (ISO)
imipramine  (ISO)
iodocyanopindolol  (ISO)
isoprenaline  (EXP,ISO)
labetalol  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
metoprolol  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
nadolol  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
octopamine  (ISO)
paracetamol  (EXP)
Phenoxybenzamine  (ISO)
phenylmercury acetate  (ISO)
pindolol  (ISO)
potassium atom  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
putrescine  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
sotalol  (ISO)
spermidine  (ISO)
spermine  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
trandolapril  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vincristine  (ISO)
vortioxetine  (ISO)
Xamoterol  (ISO)
yohimbine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
adrenergic receptor signaling pathway  (IBA)
aging  (ISO)
apoptotic process  (ISO)
brown fat cell differentiation  (IGI)
diet induced thermogenesis  (IGI)
fear response  (IMP)
G protein-coupled receptor signaling pathway  (ISO)
glycogen catabolic process  (ISO)
heat generation  (IGI)
inhibitory postsynaptic potential  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
negative regulation of multicellular organism growth  (IGI)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,IGI,IMP)
positive regulation of adenylate cyclase activity  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cold-induced thermogenesis  (IGI,IMP)
positive regulation of GTPase activity  (ISO)
positive regulation of heart contraction  (IEA)
positive regulation of heart rate  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (IBA,IMP)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of renin secretion into blood stream  (ISO)
positive regulation of saliva secretion  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (IDA,IMP)
positive regulation of the force of heart contraction by norepinephrine  (ISO)
protein localization to organelle  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of circadian sleep/wake cycle, sleep  (IMP,ISO)
response to cold  (IGI)
Rho protein signal transduction  (ISO)
sensory perception of pain  (ISO)
signal transduction  (IEA)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endocytosis pathway  (IEA)
epinephrine signaling pathway via adrenergic receptor beta  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphas family  (ISS)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
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2. Ahmet I, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):178-85. Epub 2009 Jul 8.
3. Arnold AS, etal., J Hypertens. 2007 Jan;25(1):197-205.
4. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
5. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Bengtsson Bostrom K, etal., Int J Hypertens. 2010 Mar 30;2010. pii: 458410.
7. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
8. Busch L, etal., Arch Oral Biol. 2008 Jun;53(6):509-16. Epub 2008 Feb 13.
9. Communal C, etal., Circulation. 1999 Nov 30;100(22):2210-2.
10. Dorow P, etal., J Cardiovasc Pharmacol. 1990;16 Suppl 5:S36-44.
11. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
12. Frishman WH Am J Ther. 2008 Nov-Dec;15(6):565-76.
13. Fung MM, etal., Nephrol Dial Transplant. 2009 Dec;24(12):3677-86. doi: 10.1093/ndt/gfp471. Epub 2009 Sep 10.
14. Galinier M, etal., Fundam Clin Pharmacol. 1994;8(1):90-9.
15. Goyagi T, etal., Brain Res. 2010 Jul 9;1343:213-7. Epub 2010 May 6.
16. Inagaki Y, etal., Mol Vis. 2006 Jun 12;12:673-80.
17. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
18. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
19. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
20. Liang Y, etal., J Biomed Sci. 2007 Jan;14(1):155-64. Epub 2007 Feb 3.
21. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
22. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
23. MGD and Homologene mouse data transfer
24. MGD data from the GO Consortium
25. MGD IEA
26. Mialet Perez J, etal., Nat Med 2003 Oct;9(10):1300-5. Epub 2003 Sep 14.
27. Nabika T, etal., Mamm Genome 1997 Mar;8(3):215-7.
28. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. Oliver E, etal., J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. Epub 2008 Dec 5.
30. OMIM Disease Annotation Pipeline
31. Peschke E, etal., Diabetologia. 2011 Jul;54(7):1831-40. Epub 2011 Apr 15.
32. Pipeline to import KEGG annotations from KEGG into RGD
33. Pipeline to import SMPDB annotations from SMPDB into RGD
34. RGD automated import pipeline
35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. Rohrer DK, etal., J Biol Chem. 1999 Jun 11;274(24):16701-8.
38. Sakanashi M, etal., Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):55-60.
39. Segovia M, etal., J Oral Pathol Med. 2012 Mar;41(3):242-8. doi: 10.1111/j.1600-0714.2011.01090.x. Epub 2011 Sep 30.
40. Shibata O, etal., J Anesth. 2008;22(1):21-6. Epub 2008 Feb 27.
41. Steinfath M, etal., Naunyn Schmiedebergs Arch Pharmacol. 1991 Feb;343(2):217-20.
42. Thackeray JT, etal., Nucl Med Biol. 2011 Oct;38(7):1059-66. Epub 2011 Aug 9.
43. Zhang W, etal., Eur J Pharmacol. 2011 Jan 10;650(1):303-8. Epub 2010 Oct 17.
44. Zhao LS, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Feb;38(2):139-42.
45. Zhi JM, etal., Acta Biochim Biophys Sin (Shanghai). 2004 Dec;36(12):793-7.
Additional References at PubMed
PMID:1358795   PMID:1460423   PMID:1676978   PMID:1868874   PMID:2154750   PMID:7558020   PMID:7738011   PMID:7761854   PMID:7835879   PMID:8043950   PMID:8392347   PMID:8395893  
PMID:8499657   PMID:8693001   PMID:8812459   PMID:8917529   PMID:9139936   PMID:9305915   PMID:9575921   PMID:9826121   PMID:10338466   PMID:10349636   PMID:10359838   PMID:10487769  
PMID:10578521   PMID:10595521   PMID:11042159   PMID:11076861   PMID:11448841   PMID:11502890   PMID:11641423   PMID:11737201   PMID:11748583   PMID:12006674   PMID:12054854   PMID:12097326  
PMID:12387862   PMID:12477932   PMID:12618516   PMID:12676574   PMID:12730078   PMID:12925702   PMID:14966518   PMID:15016730   PMID:15066288   PMID:15474034   PMID:15598970   PMID:15791602  
PMID:15939797   PMID:16002745   PMID:16040722   PMID:16113068   PMID:16141072   PMID:16141073   PMID:16458323   PMID:16537791   PMID:16554742   PMID:16602821   PMID:16631628   PMID:16767221  
PMID:16876797   PMID:16978452   PMID:17404268   PMID:17417650   PMID:17425584   PMID:17446185   PMID:17515456   PMID:17885689   PMID:18006587   PMID:18056263   PMID:18079196   PMID:18084319  
PMID:18188154   PMID:18193078   PMID:18245567   PMID:18305025   PMID:18483557   PMID:18579737   PMID:18635825   PMID:18694395   PMID:18801900   PMID:18851973   PMID:18930063   PMID:19103994  
PMID:19213958   PMID:19276108   PMID:19333138   PMID:19420258   PMID:19633206   PMID:19855129   PMID:19945464   PMID:20185685   PMID:20395378   PMID:20406048   PMID:20413718   PMID:20443853  
PMID:20495143   PMID:21130738   PMID:21138422   PMID:21139071   PMID:21148315   PMID:21209093   PMID:21267068   PMID:21366703   PMID:21377513   PMID:21389089   PMID:21505145   PMID:21614075  
PMID:21680711   PMID:21705675   PMID:21850156   PMID:21873635   PMID:21954455   PMID:21976502   PMID:22028912   PMID:22323706   PMID:22326222   PMID:22398028   PMID:22407956   PMID:22457517  
PMID:22593095   PMID:22728333   PMID:23093370   PMID:23133676   PMID:23363625   PMID:23473322   PMID:23486971   PMID:23579242   PMID:23595884   PMID:23750586   PMID:23780416   PMID:23785004  
PMID:23894672   PMID:23965992   PMID:23969695   PMID:24011077   PMID:24041537   PMID:24121510   PMID:24170934   PMID:24215978   PMID:24334028   PMID:24622771   PMID:24677713   PMID:24828496  
PMID:24947582   PMID:24952961   PMID:24966659   PMID:25000590   PMID:25008179   PMID:25083013   PMID:25348166   PMID:25378171   PMID:25392270   PMID:25401477   PMID:25503457   PMID:25677623  
PMID:25828762   PMID:25852085   PMID:25944088   PMID:26132918   PMID:26193120   PMID:26203906   PMID:26391182   PMID:26410627   PMID:26464333   PMID:26566631   PMID:26727203   PMID:26777404  
PMID:26796036   PMID:26936457   PMID:27342779   PMID:27548523   PMID:27577254   PMID:27978539   PMID:28219977   PMID:28283550   PMID:28394333   PMID:28416795   PMID:28487987   PMID:28724789  
PMID:28752049   PMID:28778765   PMID:28877454   PMID:28918935   PMID:29123236   PMID:29167435   PMID:29249692   PMID:29514069   PMID:29627294   PMID:29688375   PMID:29715048   PMID:29914852  
PMID:30093491   PMID:30483153   PMID:30538132   PMID:30747396   PMID:30758330   PMID:31107911   PMID:31230416   PMID:31242414   PMID:31473062   PMID:31759979   PMID:32426489   PMID:32610084  
PMID:33183171   PMID:33397973  


Genomics

Comparative Map Data
Adrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)Ensembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBImm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
ADRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
Adrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21255,772,217 - 255,773,617 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)Ensembl
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Celera1251,470,349 - 251,471,554 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543119,025,663 - 19,027,026 (+)NCBIChiLan1.0ChiLan1.0
ADRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110114,075,628 - 114,076,596 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0panPan3
ADRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12824,908,224 - 24,909,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,908,224 - 24,909,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2825,059,492 - 25,060,922 (+)NCBI
ROS_Cfam_1.02825,441,579 - 25,443,005 (+)NCBI
UMICH_Zoey_3.12824,997,230 - 24,998,684 (+)NCBI
UNSW_CanFamBas_1.02825,011,917 - 25,013,353 (+)NCBI
UU_Cfam_GSD_1.02825,206,065 - 25,207,486 (+)NCBI
Adrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,159,710 - 21,160,831 (-)NCBI
SpeTri2.0NW_0049364864,400,467 - 4,401,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,400,189 - 124,401,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,400,330 - 124,401,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,520,692 - 135,522,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,920,520 - 106,923,424 (+)NCBI
ChlSab1.1 Ensembl9106,920,610 - 106,922,058 (+)Ensembl
Vero_WHO_p1.0NW_02366604868,152,893 - 68,156,014 (+)NCBI
Adrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473732,536,096 - 32,563,721 (-)NCBI

Position Markers
Adrb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381956,723,611 - 56,723,783UniSTSGRCm38
MGSCv371956,798,101 - 56,798,273UniSTSGRCm37
Celera1958,912,150 - 58,912,322UniSTS
Cytogenetic Map19D2UniSTS
cM Map1951.0UniSTS
cM Map1951.0UniSTS
Adrb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381956,723,623 - 56,723,722UniSTSGRCm38
MGSCv371956,798,113 - 56,798,212UniSTSGRCm37
Celera1958,912,162 - 58,912,261UniSTS
Cytogenetic Map19D2UniSTS
cM Map1951.0UniSTS
Adrb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381956,722,645 - 56,723,166UniSTSGRCm38
MGSCv371956,797,135 - 56,797,656UniSTSGRCm37
Celera1958,911,184 - 58,911,705UniSTS
Cytogenetic Map19D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse
4141562Pas3b_mpulmonary adenoma susceptibility 3b (mouse)Not determined2977296261431566Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193015278561431566Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193015279261431566Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193015279261431566Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193090944161431566Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193300371961431566Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193396351461431566Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3460834861431566Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193676416661431566Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193789455061431566Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193838761861431566Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193919563261431566Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193960763461431566Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194259842761431566Mouse
11667075Led3_mlate embryonic death 3 (mouse)195109994059135440Mouse
11528548Sluc35_msusceptibility to lung cancer 35 (mouse)195538761859135440Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:282
Interacting mature miRNAs:334
Transcripts:ENSMUST00000038949
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038949   ⟹   ENSMUSP00000040847
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1956,710,631 - 56,713,582 (+)Ensembl
GRCm38.p6 Ensembl1956,722,199 - 56,725,150 (+)Ensembl
RefSeq Acc Id: ENSMUST00000236875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1956,712,295 - 56,721,545 (+)Ensembl
GRCm38.p6 Ensembl1956,723,863 - 56,733,113 (+)Ensembl
RefSeq Acc Id: NM_007419   ⟹   NP_031445
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391956,710,549 - 56,713,582 (+)NCBI
GRCm381956,722,117 - 56,725,150 (+)NCBI
MGSCv371956,796,862 - 56,799,352 (+)RGD
Celera1958,910,911 - 58,913,400 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031445   ⟸   NM_007419
- UniProtKB: P34971 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040847   ⟸   ENSMUST00000038949
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:13679838
Promoter ID:EPDNEW_M24068
Type:single initiation site
Name:Adrb1_1
Description:Mus musculus adrenergic receptor, beta 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381956,722,331 - 56,722,391EPDNEW
RGD ID:6829776
Promoter ID:MM_KWN:27400
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_007419
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361956,796,091 - 56,797,607 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87937 AgrOrtholog
Ensembl Genes ENSMUSG00000035283 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040847 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038949 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11554 UniProtKB/Swiss-Prot
MGD MGI:87937 ENTREZGENE
NCBI Gene 11554 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADRB1 RGD
PhenoGen Adrb1 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADRB1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CRR2_MOUSE UniProtKB/TrEMBL
UniProt Secondary B2RVY4 UniProtKB/Swiss-Prot