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Gene: Adrb3 (adrenoceptor beta 3) Rattus norvegicus
Symbol: Adrb3
Name: adrenoceptor beta 3
RGD ID: 2061
Description: Exhibits epinephrine binding activity and norepinephrine binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; eating behavior; and response to cold. Localizes to nucleus. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; non-alcoholic fatty liver disease; and obesity. Orthologous to human ADRB3 (adrenoceptor beta 3); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (R)-octopamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ADRB; adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor
Homo sapiens (human) : ADRB3 (adrenoceptor beta 3)  HGNC  Alliance
Mus musculus (house mouse) : Adrb3 (adrenergic receptor, beta 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb3 (adrenoceptor beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB3 (adrenoceptor beta 3)
Canis lupus familiaris (dog) : ADRB3 (adrenoceptor beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb3 (adrenoceptor beta 3)
Sus scrofa (pig) : ADRB3 (adrenoceptor beta 3)
Chlorocebus sabaeus (African green monkey) : ADRB3 (adrenoceptor beta 3)
Heterocephalus glaber (naked mole-rat) : Adrb3 (adrenoceptor beta 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
RH 3.4 Map16573.12RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adrb3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2061
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.