Adrb3 (adrenoceptor beta 3) - Rat Genome Database
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Gene: Adrb3 (adrenoceptor beta 3) Rattus norvegicus
Analyze
Symbol: Adrb3
Name: adrenoceptor beta 3
RGD ID: 2061
Description: Exhibits epinephrine binding activity and norepinephrine binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; eating behavior; and response to cold. Localizes to nucleus. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; obesity; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (R)-octopamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ADRB; adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21664,839,820 - 64,844,552 (+)NCBI
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (EXP,ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
alprenolol  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atenolol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clenbuterol  (EXP)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dobutamine  (EXP)
ethanol  (ISO)
fenoterol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formoterol fumarate  (ISO)
furan  (ISO)
glucose  (ISO)
griseofulvin  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ICI 118551  (EXP,ISO)
isoprenaline  (EXP,ISO)
kojic acid  (ISO)
L-methionine  (ISO)
Licarin A  (ISO)
mangiferin  (ISO)
metoprolol  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
octopamine  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (EXP)
pindolol  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propranolol  (ISO)
pyruvic acid  (ISO)
rac-lactic acid  (ISO)
Salmeterol xinafoate  (ISO)
solabegron  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
terbutaline  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Babol K, etal., J Exp Clin Cancer Res. 2004 Dec;23(4):669-74.
2. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
3. Barbero R, etal., J Vet Pharmacol Ther. 2006 Aug;29(4):289-97.
4. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Bensaid M, etal., FEBS Lett 1993 Mar 8;318(3):223-6.
6. Boivin B, etal., Cardiovasc Res. 2006 Jul 1;71(1):69-78. Epub 2006 Mar 24.
7. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
8. Bracale R, etal., Eur J Clin Nutr. 2007 Oct;61(10):1213-9. Epub 2007 Feb 14.
9. Clement K, etal., N Engl J Med 1995 Aug 10;333(6):352-4.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Granneman JG, etal., Mol Pharmacol 1991 Dec;40(6):895-9.
13. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
14. Higashi K, etal., Biochem Biophys Res Commun. 1997 Mar 27;232(3):728-30.
15. Hoffstedt J, etal., Diabetes. 1999 Jan;48(1):203-5.
16. Jimenez M, etal., FEBS Lett. 2002 Oct 23;530(1-3):37-40.
17. Kawamura T, etal., Metabolism. 1999 Nov;48(11):1367-70.
18. Khan I, etal., Pharmacology. 2002 Feb;64(2):98-105.
19. Kumar MV, etal., Pflugers Arch. 1999 Oct;438(5):681-8.
20. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
22. Lehman DM, etal., Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):331-6.
23. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
24. Llado I, etal., Obes Res 2002 Apr;10(4):296-305.
25. Mahmoudian M J Mol Graph. 1994 Mar;12(1):22-8, 34.
26. Manneras L, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1124-31. Epub 2009 Jan 21.
27. MGD data from the GO Consortium
28. Moniotte S, etal., Circulation. 2001 Mar 27;103(12):1649-55.
29. Moniotte S, etal., Eur J Heart Fail. 2007 Dec;9(12):1163-71. Epub 2007 Nov 19.
30. Morcillo S, etal., Clin Endocrinol (Oxf). 2008 Jan;68(1):102-7. Epub 2007 Aug 28.
31. Munoz-Valle JF, etal., Rheumatol Int. 2003 May;23(3):99-103. Epub 2003 Mar 12.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Nozaki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):106S-110S.
34. OMIM Disease Annotation Pipeline
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Pulkkinen A, etal., Metabolism. 1999 Jul;48(7):853-6.
37. RGD automated data pipeline
38. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. RGD automated import pipeline for gene-chemical interactions
40. RGD comprehensive gene curation
41. Ringel J, etal., Am J Hypertens. 2000 Sep;13(9):1027-31.
42. Ristori C, etal., Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):155-70. Print 2011 Jan.
43. Sakane N, etal., Diabetes. 1997 Oct;46(10):1633-6.
44. Sakane N, etal., Diabetologia. 1998 Dec;41(12):1533-4.
45. Santos JL, etal., Nutrition. 2002 Mar;18(3):255-8.
46. Scarpace PJ, etal., Pflugers Arch. 1999 Feb;437(3):479-83.
47. Shi H, etal., Obesity (Silver Spring). 2009 Sep;17(9):1702-9. Epub 2009 Apr 16.
48. Stangl K, etal., Metabolism. 2001 Feb;50(2):184-8.
49. Sun J, etal., Gen Comp Endocrinol. 2011 Jul 1;172(3):518-25. Epub 2011 Apr 28.
50. Surwit RS, etal., Endocrinology. 2000 Oct;141(10):3630-7.
51. Susulic VS, etal., J Biol Chem. 1995 Dec 8;270(49):29483-92.
52. Vasina V, etal., Neurogastroenterol Motil. 2008 Sep;20(9):1030-41. Epub 2008 May 15.
53. Vonkeman HE, etal., AIDS. 2000 Jul 7;14(10):1463-4.
54. Wang B, etal., J Rheumatol. 2011 Apr;38(4):738-40. Epub 2011 Feb 1.
55. Wang L, etal., J Card Fail. 2010 Jan;16(1):36-44. Epub 2009 Sep 25.
56. Wang Y, etal., Diabet Med. 2010 Apr;27(4):376-83.
57. Wankhade UD, etal., PLoS One. 2010 Aug 23;5(8):e12324.
58. Yang M, etal., Br J Clin Pharmacol. 2009 Jul;68(1):14-22.
Additional References at PubMed
PMID:1721063   PMID:7738011   PMID:8889548   PMID:9305915   PMID:10358009   PMID:15123695   PMID:15750837   PMID:17092981   PMID:17131040   PMID:17440824   PMID:17600560   PMID:17631141  
PMID:18031735   PMID:18154937   PMID:18583384   PMID:18703049   PMID:18799656   PMID:19120133   PMID:19577538   PMID:19726315   PMID:20097768   PMID:20432431   PMID:20443655   PMID:20654104  
PMID:20661603   PMID:21046653   PMID:21661032   PMID:21901314   PMID:22248722   PMID:23008154   PMID:23373597   PMID:24055266   PMID:24161401   PMID:24220331   PMID:24378642   PMID:24727346  
PMID:25139049   PMID:25144690   PMID:25322941   PMID:25804391   PMID:25920933   PMID:28276515   PMID:28446460   PMID:29208473   PMID:29363058   PMID:29566368   PMID:29859189   PMID:30613975  
PMID:31295748  


Genomics

Candidate Gene Status
Adrb3 is a candidate Gene for QTL Arunc1
Comparative Map Data
Adrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21664,839,820 - 64,844,552 (+)NCBI
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
ADRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl837,962,990 - 37,966,599 (-)EnsemblGRCh38hg38GRCh38
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37837,820,508 - 37,824,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
Adrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,715,804 - 27,720,833 (-)NCBIGRCm39mm39
GRCm39 Ensembl827,715,804 - 27,740,644 (-)Ensembl
GRCm38827,225,776 - 27,230,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,225,776 - 27,250,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37828,336,248 - 28,340,060 (-)NCBIGRCm37mm9NCBIm37
MGSCv36828,691,712 - 28,695,524 (-)NCBImm8
Celera828,716,093 - 28,719,905 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.94NCBI
Adrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546313,663,064 - 13,665,553 (-)NCBIChiLan1.0ChiLan1.0
ADRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1834,440,099 - 34,444,043 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0837,263,730 - 37,267,475 (-)NCBIMhudiblu_PPA_v0panPan3
ADRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1627,445,601 - 27,447,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11627,445,601 - 27,446,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367101,410,589 - 1,413,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11548,468,803 - 48,478,370 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,481,787 - 55,489,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1835,993,553 - 35,998,200 (-)NCBI
Adrb3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,653,499 - 5,656,138 (+)NCBI

Position Markers
RH94766  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01669,006,016 - 69,006,264NCBIRnor6.0
Rnor_5.01668,676,131 - 68,676,379UniSTSRnor5.0
RGSC_v3.41669,165,768 - 69,166,016UniSTSRGSC3.4
Celera1662,765,427 - 62,765,675UniSTS
RH 3.4 Map16573.12UniSTS
Cytogenetic Map16q12.3UniSTS
PMC164531P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01669,004,234 - 69,004,311NCBIRnor6.0
Rnor_5.01668,674,349 - 68,674,426UniSTSRnor5.0
RGSC_v3.41669,163,986 - 69,164,063UniSTSRGSC3.4
Celera1662,763,645 - 62,763,722UniSTS
Cytogenetic Map16q12.3UniSTS
UniSTS:471071  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01669,005,148 - 69,005,659NCBIRnor6.0
Rnor_5.01668,675,263 - 68,675,774UniSTSRnor5.0
RGSC_v3.41669,164,900 - 69,165,411UniSTSRGSC3.4
Celera1662,764,559 - 62,765,070UniSTS
Cytogenetic Map16q12.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162484654169846541Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162751998072519980Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162834031573340315Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:171
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000016907
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 2 1
Low 3 1 12 6 4 9 10 8
Below cutoff 19 2 2 4 2 6 6 37 11 19 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016907   ⟹   ENSRNOP00000016907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)Ensembl
RefSeq Acc Id: NM_013108   ⟹   NP_037240
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21664,841,788 - 64,844,552 (+)NCBI
Rnor_6.01669,003,868 - 69,006,632 (+)NCBI
Rnor_5.01668,673,983 - 68,676,747 (+)NCBI
RGSC_v3.41669,163,620 - 69,166,384 (+)RGD
Celera1662,763,279 - 62,766,043 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771315   ⟹   XP_008769537
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21664,839,820 - 64,844,552 (+)NCBI
Rnor_6.01669,003,541 - 69,006,632 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037240   ⟸   NM_013108
- UniProtKB: P26255 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769537   ⟸   XM_008771315
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016907   ⟸   ENSRNOT00000016907

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2061 AgrOrtholog
Ensembl Genes ENSRNOG00000012674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016907 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016907 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRB3_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25645 UniProtKB/Swiss-Prot
NCBI Gene 25645 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Adrb3 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCB3AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt ADRB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adrb3  adrenoceptor beta 3  Adrb3  adrenergic, beta-3-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Adrb3  adrenergic, beta-3-, receptor  Adrb3  adrenergic receptor, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adrb3  adrenergic receptor, beta 3    Adrenergic receptor, beta 3  Name updated 625702 APPROVED
2002-06-10 Adrb3  Adrenergic receptor, beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in colon 632161
gene_expression expressed in adipose tissue 632162
gene_function binds to BRL 37344 with high affinity and to norepinephrine with lower affinity 632162
gene_process may be involved in an adrenergic signaling pathway 632162