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Gene: ADRB3 (adrenoceptor beta 3) Homo sapiens
Symbol: ADRB3
Name: adrenoceptor beta 3
Description: Exhibits beta3-adrenergic receptor activity and protein homodimerization activity. Contributes to norepinephrine binding activity. Involved in activation of adenylate cyclase activity and positive regulation of MAPK cascade. Localizes to the receptor complex. Implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; non-alcoholic fatty liver disease; and obesity. Biomarker of congestive heart failure and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor; BETA3AR; FLJ99960
Mus musculus (house mouse) : Adrb3 (adrenergic receptor, beta 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adrb3 (adrenoceptor beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb3 (adrenoceptor beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB3 (adrenoceptor beta 3)
Canis lupus familiaris (dog) : ADRB3 (adrenoceptor beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb3 (adrenoceptor beta 3)
Sus scrofa (pig) : ADRB3 (adrenoceptor beta 3)
Chlorocebus sabaeus (African green monkey) : ADRB3 (adrenoceptor beta 3)
Heterocephalus glaber (naked mole-rat) : Adrb3 (adrenoceptor beta 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl837,962,990 - 37,966,599 (-)Ensembl
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37837,820,513 - 37,824,184 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADRB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737467
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.