ADRB3 (adrenoceptor beta 3) - Rat Genome Database

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Gene: ADRB3 (adrenoceptor beta 3) Homo sapiens
Analyze
Symbol: ADRB3
Name: adrenoceptor beta 3
RGD ID: 737467
HGNC Page HGNC:288
Description: Enables beta3-adrenergic receptor activity and protein homodimerization activity. Contributes to norepinephrine binding activity. Involved in adenylate cyclase-activating adrenergic receptor signaling pathway and positive regulation of MAPK cascade. Part of receptor complex. Implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Biomarker of congestive heart failure and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor; BETA3AR; FLJ99960
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW458_H GLUCO100_H GLUCO101_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl837,962,990 - 37,966,599 (-)EnsemblGRCh38hg38GRCh38
GRCh37837,820,508 - 37,824,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36Build 36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
T2T-CHM13v2.0838,239,389 - 38,242,998 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (EXP,ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
albuterol  (EXP)
aldehydo-D-glucose  (ISO)
alprenolol  (EXP)
Amibegron  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP,ISO)
atenolol  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
CL316243  (ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
Cuprizon  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
ethanol  (ISO)
fenoterol  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formoterol fumarate  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
glucose  (ISO)
griseofulvin  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
ICI 118551  (EXP,ISO)
isoprenaline  (EXP,ISO)
kojic acid  (EXP)
L-methionine  (ISO)
Licarin A  (ISO)
mangiferin  (ISO)
methimazole  (ISO)
metoprolol  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
octopamine  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
pindolol  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propranolol  (EXP,ISO)
pyruvic acid  (ISO)
rac-lactic acid  (ISO)
Salmeterol xinafoate  (EXP)
sodium arsenite  (ISO)
solabegron  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
tamoxifen  (ISO)
terbutaline  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
valproic acid  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,TAS)
receptor complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity. Babol K, etal., J Exp Clin Cancer Res. 2004 Dec;23(4):669-74.
2. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. beta1, beta2, and beta3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
5. Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Bracale R, etal., Eur J Clin Nutr. 2007 Oct;61(10):1213-9. Epub 2007 Feb 14.
6. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Clement K, etal., N Engl J Med 1995 Aug 10;333(6):352-4.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
9. Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese. Higashi K, etal., Biochem Biophys Res Commun. 1997 Mar 27;232(3):728-30.
10. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Hoffstedt J, etal., Diabetes. 1999 Jan;48(1):203-5.
11. Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Hojlund K, etal., Diabetes Obes Metab. 2006 May;8(3):322-30.
12. Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men. Kawamura T, etal., Metabolism. 1999 Nov;48(11):1367-70.
13. Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. Khan I, etal., Pharmacology. 2002 Feb;64(2):98-105.
14. Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
15. A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family. Lehman DM, etal., Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):331-6.
16. [Dynamic changes of alpha-AR, beta1-AR and beta2-AR expression during hepatic fibrogenesis]. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
17. The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study. Mahmoudian M J Mol Graph. 1994 Mar;12(1):22-8, 34.
18. Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS. Manneras L, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1124-31. Epub 2009 Jan 21.
19. Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Moniotte S, etal., Circulation. 2001 Mar 27;103(12):1649-55.
20. Sepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium. Moniotte S, etal., Eur J Heart Fail. 2007 Dec;9(12):1163-71. Epub 2007 Nov 19.
21. Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2). Morcillo S, etal., Clin Endocrinol (Oxf). 2008 Jan;68(1):102-7. Epub 2007 Aug 28.
22. Polymorphism of the beta3-adrenergic receptor and lipid profile in patients with rheumatoid arthritis and systemic lupus erythematosus treated with chloroquine. Munoz-Valle JF, etal., Rheumatol Int. 2003 May;23(3):99-103. Epub 2003 Mar 12.
23. Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis. Nozaki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):106S-110S.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients. Pulkkinen A, etal., Metabolism. 1999 Jul;48(7):853-6.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. Ringel J, etal., Am J Hypertens. 2000 Sep;13(9):1027-31.
30. Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. Ristori C, etal., Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):155-70. Print 2011 Jan.
31. Beta 3-adrenoreceptor gene polymorphism: a newly identified risk factor for proliferative retinopathy in NIDDM patients. Sakane N, etal., Diabetes. 1997 Oct;46(10):1633-6.
32. Trp64Arg mutation of beta3-adrenoceptor gene is associated with diabetic nephropathy in Type II diabetes mellitus. Sakane N, etal., Diabetologia. 1998 Dec;41(12):1533-4.
33. No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile. Santos JL, etal., Nutrition. 2002 Mar;18(3):255-8.
34. Diet-induced obese mice are leptin insufficient after weight reduction. Shi H, etal., Obesity (Silver Spring). 2009 Sep;17(9):1702-9. Epub 2009 Apr 16.
35. The beta3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery disease. Stangl K, etal., Metabolism. 2001 Feb;50(2):184-8.
36. Testosterone modulation of cardiac beta-adrenergic signals in a rat model of heart failure. Sun J, etal., Gen Comp Endocrinol. 2011 Jul 1;172(3):518-25. Epub 2011 Apr 28.
37. Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. Surwit RS, etal., Endocrinology. 2000 Oct;141(10):3630-7.
38. The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats. Vasina V, etal., Neurogastroenterol Motil. 2008 Sep;20(9):1030-41. Epub 2008 May 15.
39. Beta3-adrenergic receptor polymorphism and the antiretroviral therapy-related lipodystrophy syndrome. Vonkeman HE, etal., AIDS. 2000 Jul 7;14(10):1463-4.
40. Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population. Wang B, etal., J Rheumatol. 2011 Apr;38(4):738-40. Epub 2011 Feb 1.
41. Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort. Wang L, etal., J Card Fail. 2010 Jan;16(1):36-44. Epub 2009 Sep 25.
42. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. Wang Y, etal., Diabet Med. 2010 Apr;27(4):376-83.
43. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. Wankhade UD, etal., PLoS One. 2010 Aug 23;5(8):e12324.
44. Effects of UCP2 -866 G/A and ADRB3 Trp64Arg on rosiglitazone response in Chinese patients with Type 2 diabetes. Yang M, etal., Br J Clin Pharmacol. 2009 Jul;68(1):14-22.
Additional References at PubMed
PMID:1336117   PMID:1718744   PMID:2570461   PMID:7493988   PMID:7565630   PMID:7609625   PMID:7898940   PMID:8288218   PMID:8380813   PMID:8389293   PMID:8389717   PMID:8641219  
PMID:8721782   PMID:10391210   PMID:10786926   PMID:10805511   PMID:10999801   PMID:11013230   PMID:11093283   PMID:11095426   PMID:11147800   PMID:11206402   PMID:11213599   PMID:11244458  
PMID:11287026   PMID:11288809   PMID:11315829   PMID:11380082   PMID:11434877   PMID:11439286   PMID:11466580   PMID:11522702   PMID:11532330   PMID:11573151   PMID:11576322   PMID:11592045  
PMID:11699048   PMID:11706779   PMID:11716317   PMID:11743056   PMID:11743057   PMID:11769635   PMID:11798745   PMID:11808891   PMID:11854867   PMID:11872697   PMID:11875710   PMID:11949887  
PMID:11984699   PMID:12008746   PMID:12036966   PMID:12037740   PMID:12062855   PMID:12082592   PMID:12133431   PMID:12164325   PMID:12169859   PMID:12241539   PMID:12370850   PMID:12387862  
PMID:12406043   PMID:12410955   PMID:12411100   PMID:12442007   PMID:12453902   PMID:12477932   PMID:12544508   PMID:12561621   PMID:12568179   PMID:12629568   PMID:12647276   PMID:12670949  
PMID:12690078   PMID:12709137   PMID:12732844   PMID:12739018   PMID:12824951   PMID:12917707   PMID:12962933   PMID:14506613   PMID:14510956   PMID:14671190   PMID:14690019   PMID:14708035  
PMID:14713387   PMID:14715679   PMID:14739355   PMID:14742851   PMID:14747257   PMID:15042014   PMID:15061987   PMID:15079793   PMID:15123695   PMID:15166301   PMID:15179018   PMID:15192823  
PMID:15193960   PMID:15302798   PMID:15334374   PMID:15334382   PMID:15340101   PMID:15355441   PMID:15464701   PMID:15472194   PMID:15479221   PMID:15489334   PMID:15489932   PMID:15536594  
PMID:15543217   PMID:15563584   PMID:15585565   PMID:15613846   PMID:15641247   PMID:15670186   PMID:15751274   PMID:15824464   PMID:15833937   PMID:15915764   PMID:15917856   PMID:15932670  
PMID:15939803   PMID:15942638   PMID:15956122   PMID:15959859   PMID:16009000   PMID:16027735   PMID:16054001   PMID:16276029   PMID:16286518   PMID:16301818   PMID:16320158   PMID:16344560  
PMID:16369102   PMID:16408483   PMID:16449022   PMID:16493638   PMID:16648810   PMID:16715838   PMID:16779985   PMID:16820065   PMID:17046546   PMID:17087055   PMID:17124363   PMID:17190106  
PMID:17225053   PMID:17264845   PMID:17270896   PMID:17299381   PMID:17342473   PMID:17345787   PMID:17345789   PMID:17378367   PMID:17439327   PMID:17445027   PMID:17476189   PMID:17512307  
PMID:17591269   PMID:17616777   PMID:17624182   PMID:17626108   PMID:17631141   PMID:17640319   PMID:17785925   PMID:17786291   PMID:17852419   PMID:17910280   PMID:17940985   PMID:17989355  
PMID:17998022   PMID:18054709   PMID:18088254   PMID:18239290   PMID:18240029   PMID:18249022   PMID:18249219   PMID:18273796   PMID:18311486   PMID:18331634   PMID:18335327   PMID:18393130  
PMID:18422027   PMID:18426866   PMID:18441513   PMID:18482921   PMID:18484422   PMID:18510051   PMID:18513389   PMID:18574485   PMID:18611262   PMID:18617734   PMID:18625943   PMID:18636124  
PMID:18704193   PMID:18724972   PMID:18753860   PMID:18820136   PMID:18852493   PMID:18936436   PMID:18940396   PMID:18996102   PMID:18996293   PMID:19026982   PMID:19056576   PMID:19080138  
PMID:19099777   PMID:19131662   PMID:19193342   PMID:19263529   PMID:19271249   PMID:19295193   PMID:19367093   PMID:19420105   PMID:19479237   PMID:19491387   PMID:19553224   PMID:19565482  
PMID:19576569   PMID:19578796   PMID:19587357   PMID:19779464   PMID:19842096   PMID:19913121   PMID:20008926   PMID:20044737   PMID:20069060   PMID:20078877   PMID:20144152   PMID:20384434  
PMID:20401689   PMID:20410100   PMID:20449541   PMID:20459474   PMID:20467565   PMID:20468064   PMID:20503258   PMID:20602615   PMID:20628086   PMID:20662153   PMID:20686326   PMID:20705341  
PMID:20730725   PMID:20735409   PMID:20803423   PMID:20831043   PMID:20953633   PMID:21033077   PMID:21034552   PMID:21085551   PMID:21358132   PMID:21529759   PMID:21873635   PMID:21878665  
PMID:21940308   PMID:21959333   PMID:21982743   PMID:21992420   PMID:22306453   PMID:22430195   PMID:22550477   PMID:22609474   PMID:22692629   PMID:22728712   PMID:22743651   PMID:22774401  
PMID:22774474   PMID:22972489   PMID:23032405   PMID:23113754   PMID:23235150   PMID:23282015   PMID:23292548   PMID:23360304   PMID:23388888   PMID:23454374   PMID:23640967   PMID:23729572  
PMID:23736006   PMID:23907236   PMID:23968135   PMID:24038238   PMID:24138564   PMID:24190960   PMID:24201118   PMID:24378642   PMID:24460850   PMID:24556804   PMID:24579945   PMID:24658877  
PMID:24670327   PMID:24741957   PMID:24786241   PMID:24885710   PMID:24890187   PMID:24905907   PMID:24972470   PMID:25059067   PMID:25081806   PMID:25636111   PMID:25800470   PMID:25827163  
PMID:25855572   PMID:25867395   PMID:25928572   PMID:26410617   PMID:26410938   PMID:26602921   PMID:26617941   PMID:26888112   PMID:28177749   PMID:28185314   PMID:28404887   PMID:28421794  
PMID:28446460   PMID:28521197   PMID:28723418   PMID:28756611   PMID:28760490   PMID:28783993   PMID:28802864   PMID:28941386   PMID:29361938   PMID:29381017   PMID:29464546   PMID:29587766  
PMID:29606859   PMID:29866117   PMID:30541923   PMID:30580338   PMID:30721144   PMID:31009102   PMID:31030945   PMID:31353327   PMID:31477835   PMID:31609506   PMID:31651836   PMID:31670283  
PMID:31802204   PMID:31929840   PMID:31977906   PMID:32008426   PMID:32430022   PMID:32514619   PMID:33398425   PMID:34072007   PMID:34100382   PMID:34260097   PMID:34347822   PMID:34420811  
PMID:34512548   PMID:34967048   PMID:35145073   PMID:35156780   PMID:35947209   PMID:36831252   PMID:36863427   PMID:36884028   PMID:36989522   PMID:37628593   PMID:37938600   PMID:39294633  


Genomics

Comparative Map Data
ADRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl837,962,990 - 37,966,599 (-)EnsemblGRCh38hg38GRCh38
GRCh37837,820,508 - 37,824,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36Build 36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
T2T-CHM13v2.0838,239,389 - 38,242,998 (-)NCBIT2T-CHM13v2.0
Adrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,715,804 - 27,720,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,715,804 - 27,740,644 (-)EnsemblGRCm39 Ensembl
GRCm38827,225,776 - 27,230,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,225,776 - 27,250,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37828,336,248 - 28,340,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,691,712 - 28,695,524 (-)NCBIMGSCv36mm8
Celera828,716,093 - 28,719,905 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.94NCBI
Adrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81671,544,603 - 71,547,410 (+)NCBIGRCr8
mRatBN7.21664,839,820 - 64,844,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,841,788 - 64,844,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,125,571 - 70,128,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,531,913 - 73,534,677 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,777,172 - 68,779,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
Adrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546313,663,064 - 13,665,553 (-)NCBIChiLan1.0ChiLan1.0
ADRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,524,236 - 56,529,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,241,318 - 32,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,263,730 - 37,267,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,440,099 - 34,444,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,441,311 - 34,443,949 (-)Ensemblpanpan1.1panPan2
ADRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,445,601 - 27,446,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,445,601 - 27,447,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,962,835 - 27,964,030 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,344,866 - 29,346,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,344,866 - 29,346,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,566,781 - 27,567,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,144,259 - 28,145,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,183,588 - 28,184,783 (+)NCBIUU_Cfam_GSD_1.0
Adrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494350,047,746 - 50,068,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,411,446 - 1,413,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,410,589 - 1,413,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,475,144 - 48,479,562 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,468,803 - 48,478,370 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,481,787 - 55,489,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1835,993,553 - 35,998,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl835,994,775 - 35,997,060 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660526,000,510 - 6,004,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,653,499 - 5,656,138 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADRB3
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
NM_000025.3(ADRB3):c.190T>C (p.Trp64Arg) single nucleotide variant Obesity [RCV000033197]|not provided [RCV001707510] Chr8:37966280 [GRCh38]
Chr8:37823798 [GRCh37]
Chr8:8p11.23		 risk factor|benign
GRCh38/hg38 8p12-q11.21(chr8:29719897-48521849)x3 copy number gain See cases [RCV000050995] Chr8:29719897..48521849 [GRCh38]
Chr8:29577413..49434409 [GRCh37]
Chr8:29633332..49596962 [NCBI36]
Chr8:8p12-q11.21		 pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p12-11.21(chr8:34312250-43158901)x1 copy number loss See cases [RCV000050745] Chr8:34312250..43158901 [GRCh38]
Chr8:34169768..43014044 [GRCh37]
Chr8:34289310..43133201 [NCBI36]
Chr8:8p12-11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p11.23-11.21(chr8:37899430-42371734)x3 copy number gain See cases [RCV000053648] Chr8:37899430..42371734 [GRCh38]
Chr8:37756948..42229252 [GRCh37]
Chr8:37876106..42348409 [NCBI36]
Chr8:8p11.23-11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p12-11.21(chr8:29362097-40231708)x1 copy number loss See cases [RCV000136878] Chr8:29362097..40231708 [GRCh38]
Chr8:29219614..40089227 [GRCh37]
Chr8:29275533..40208384 [NCBI36]
Chr8:8p12-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p12-q12.1(chr8:36580103-59618998)x3 copy number gain See cases [RCV000139582] Chr8:36580103..59618998 [GRCh38]
Chr8:36437621..60531557 [GRCh37]
Chr8:36556779..60694111 [NCBI36]
Chr8:8p12-q12.1		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p11.23-11.22(chr8:37555526-38600788)x3 copy number gain See cases [RCV000240444] Chr8:37555526..38600788 [GRCh37]
Chr8:8p11.23-11.22		 uncertain significance
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1		 uncertain significance
GRCh37/hg19 8p11.23-11.22(chr8:37566388-38802788)x1 copy number loss See cases [RCV000447568] Chr8:37566388..38802788 [GRCh37]
Chr8:8p11.23-11.22		 likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_000025.3(ADRB3):c.785C>G (p.Pro262Arg) single nucleotide variant not specified [RCV004330031] Chr8:37965685 [GRCh38]
Chr8:37823203 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p11.23(chr8:37618754-38194831)x3 copy number gain not provided [RCV000658484] Chr8:37618754..38194831 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh37/hg19 8p12-11.21(chr8:31352498-41481295)x3 copy number gain not provided [RCV000683035] Chr8:31352498..41481295 [GRCh37]
Chr8:8p12-11.21		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p12-11.23(chr8:36486830-37992515)x1 copy number loss See cases [RCV000790586] Chr8:36486830..37992515 [GRCh37]
Chr8:8p12-11.23		 uncertain significance
NM_000025.3(ADRB3):c.1057C>T (p.Arg353Cys) single nucleotide variant not provided [RCV000879128] Chr8:37965413 [GRCh38]
Chr8:37822931 [GRCh37]
Chr8:8p11.23		 benign
NM_000025.3(ADRB3):c.978G>T (p.Pro326=) single nucleotide variant not provided [RCV000925721] Chr8:37965492 [GRCh38]
Chr8:37823010 [GRCh37]
Chr8:8p11.23		 likely benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3		 pathogenic
GRCh37/hg19 8p12-11.1(chr8:36094421-43822214)x3 copy number gain not provided [RCV000848822] Chr8:36094421..43822214 [GRCh37]
Chr8:8p12-11.1		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_000025.3(ADRB3):c.697C>A (p.Arg233Ser) single nucleotide variant not specified [RCV004294481] Chr8:37965773 [GRCh38]
Chr8:37823291 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh38/hg38 8p11.23-11.22(chr8:37814644-38528889)x1 copy number loss Hypogonadotropic hypogonadism 2 with or without anosmia [RCV003327618] Chr8:37814644..38528889 [GRCh38]
Chr8:8p11.23-11.22		 pathogenic
NM_000025.3(ADRB3):c.54C>G (p.Pro18=) single nucleotide variant not provided [RCV000888073] Chr8:37966416 [GRCh38]
Chr8:37823934 [GRCh37]
Chr8:8p11.23		 benign
NM_000025.3(ADRB3):c.*250G>C single nucleotide variant not provided [RCV001677119] Chr8:37963968 [GRCh38]
Chr8:37821486 [GRCh37]
Chr8:8p11.23		 benign
NM_000025.3(ADRB3):c.1205+307dup duplication not provided [RCV001707080] Chr8:37964944..37964945 [GRCh38]
Chr8:37822462..37822463 [GRCh37]
Chr8:8p11.23		 benign
NM_000025.3(ADRB3):c.1205+14G>T single nucleotide variant not provided [RCV001616655] Chr8:37965251 [GRCh38]
Chr8:37822769 [GRCh37]
Chr8:8p11.23		 benign
NM_000025.3(ADRB3):c.1206-96A>G single nucleotide variant not provided [RCV001649206] Chr8:37964335 [GRCh38]
Chr8:37821853 [GRCh37]
Chr8:8p11.23		 benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_000025.3(ADRB3):c.1013A>G (p.Asn338Ser) single nucleotide variant Obesity [RCV002493830]|not provided [RCV001357839]|not specified [RCV004034488] Chr8:37965457 [GRCh38]
Chr8:37822975 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.452A>G (p.Lys151Arg) single nucleotide variant Obesity [RCV002486488]|not provided [RCV001357447]|not specified [RCV004034483] Chr8:37966018 [GRCh38]
Chr8:37823536 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
NC_000008.10:g.(?_37595441)_(38314964_?)dup duplication not provided [RCV002238517] Chr8:37595441..38314964 [GRCh37]
Chr8:8p11.23-11.22		 uncertain significance
GRCh37/hg19 8p11.23-11.22(chr8:37566388-38802788) copy number loss not specified [RCV002053757] Chr8:37566388..38802788 [GRCh37]
Chr8:8p11.23-11.22		 likely pathogenic
NC_000008.10:g.(?_37595441)_(38961219_?)del deletion Hypogonadotropic hypogonadism 2 with or without anosmia [RCV001970153]|not provided [RCV001950890] Chr8:37595441..38961219 [GRCh37]
Chr8:8p11.23-11.22		 pathogenic|no classifications from unflagged records
NC_000008.10:g.(?_37595441)_(38961219_?)dup duplication Hereditary spastic paraplegia 54 [RCV003116547]|Hypogonadotropic hypogonadism 2 with or without anosmia [RCV003116548]|Spastic paraplegia [RCV003109616] Chr8:37595441..38961219 [GRCh37]
Chr8:8p11.23-11.22		 uncertain significance
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1 copy number loss not provided [RCV002472596] Chr8:26808969..38346383 [GRCh37]
Chr8:8p21.2-11.22		 pathogenic
NM_000025.3(ADRB3):c.16C>T (p.His6Tyr) single nucleotide variant not specified [RCV004087416] Chr8:37966454 [GRCh38]
Chr8:37823972 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.692C>T (p.Ala231Val) single nucleotide variant not specified [RCV004195172] Chr8:37965778 [GRCh38]
Chr8:37823296 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.202C>T (p.Leu68Phe) single nucleotide variant not specified [RCV004110133] Chr8:37966268 [GRCh38]
Chr8:37823786 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.125C>A (p.Ala42Asp) single nucleotide variant not specified [RCV004182709] Chr8:37966345 [GRCh38]
Chr8:37823863 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.767G>T (p.Arg256Leu) single nucleotide variant not specified [RCV004087203] Chr8:37965703 [GRCh38]
Chr8:37823221 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.742G>C (p.Glu248Gln) single nucleotide variant not specified [RCV004117871] Chr8:37965728 [GRCh38]
Chr8:37823246 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.578C>G (p.Pro193Arg) single nucleotide variant not specified [RCV004217520] Chr8:37965892 [GRCh38]
Chr8:37823410 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.49C>T (p.Leu17Phe) single nucleotide variant not specified [RCV004090543] Chr8:37966421 [GRCh38]
Chr8:37823939 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.1120G>T (p.Ala374Ser) single nucleotide variant not specified [RCV004072796] Chr8:37965350 [GRCh38]
Chr8:37822868 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.529T>C (p.Trp177Arg) single nucleotide variant not specified [RCV004329909] Chr8:37965941 [GRCh38]
Chr8:37823459 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.374T>C (p.Ile125Thr) single nucleotide variant not specified [RCV004275199] Chr8:37966096 [GRCh38]
Chr8:37823614 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh37/hg19 8p11.23-q11.21(chr8:36763176-50929707)x3 copy number gain See cases [RCV003329560] Chr8:36763176..50929707 [GRCh37]
Chr8:8p11.23-q11.21		 pathogenic
NM_000025.3(ADRB3):c.302G>T (p.Gly101Val) single nucleotide variant not specified [RCV004350563] Chr8:37966168 [GRCh38]
Chr8:37823686 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.784C>T (p.Pro262Ser) single nucleotide variant not specified [RCV004358790] Chr8:37965686 [GRCh38]
Chr8:37823204 [GRCh37]
Chr8:8p11.23		 uncertain significance
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21		 pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1		 pathogenic
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1		 pathogenic
NM_000025.3(ADRB3):c.169C>G (p.Leu57Val) single nucleotide variant not specified [RCV004385417] Chr8:37966301 [GRCh38]
Chr8:37823819 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.1027C>G (p.Pro343Ala) single nucleotide variant not specified [RCV004385407] Chr8:37965443 [GRCh38]
Chr8:37822961 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.395C>A (p.Ala132Asp) single nucleotide variant not specified [RCV004385437] Chr8:37966075 [GRCh38]
Chr8:37823593 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.985C>T (p.Leu329Phe) single nucleotide variant not specified [RCV004385484] Chr8:37965485 [GRCh38]
Chr8:37823003 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.1120G>A (p.Ala374Thr) single nucleotide variant not specified [RCV004385411] Chr8:37965350 [GRCh38]
Chr8:37822868 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.460G>T (p.Ala154Ser) single nucleotide variant not specified [RCV004385448] Chr8:37966010 [GRCh38]
Chr8:37823528 [GRCh37]
Chr8:8p11.23		 uncertain significance
NM_000025.3(ADRB3):c.785C>A (p.Pro262Gln) single nucleotide variant not specified [RCV004620049] Chr8:37965685 [GRCh38]
Chr8:37823203 [GRCh37]
Chr8:8p11.23		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:881
Count of miRNA genes:603
Interacting mature miRNAs:664
Transcripts:ENST00000345060, ENST00000520341
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558703SCL6_HSerum cholesterol level QTL 1 (human)1.2Lipid levelHDL cholesterol81246863538468635Human

Markers in Region
WI-9207  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,820,549 - 37,820,664UniSTSGRCh37
Build 36837,939,706 - 37,939,821RGDNCBI36
Celera836,772,258 - 36,772,373RGD
Cytogenetic Map8p12UniSTS
HuRef836,354,949 - 36,355,064UniSTS
GeneMap99-GB4 RH Map8156.44UniSTS
Whitehead-RH Map8201.3UniSTS
PMC164531P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,823,755 - 37,823,832UniSTSGRCh37
Build 36837,942,912 - 37,942,989RGDNCBI36
Celera836,775,464 - 36,775,541RGD
HuRef836,358,155 - 36,358,232UniSTS
PMC310777P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,823,661 - 37,823,908UniSTSGRCh37
Build 36837,942,818 - 37,943,065RGDNCBI36
Celera836,775,370 - 36,775,617RGD
Cytogenetic Map8p12UniSTS
HuRef836,358,061 - 36,358,308UniSTS
ADRB3_418  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,820,520 - 37,821,365UniSTSGRCh37
Build 36837,939,677 - 37,940,522RGDNCBI36
Celera836,772,229 - 36,773,074RGD
HuRef836,354,920 - 36,355,765UniSTS
D8S2331  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,820,582 - 37,820,865UniSTSGRCh37
Build 36837,939,739 - 37,940,022RGDNCBI36
Celera836,772,291 - 36,772,574RGD
Cytogenetic Map8p12UniSTS
HuRef836,354,982 - 36,355,265UniSTS
ADRB3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,823,464 - 37,823,827UniSTSGRCh37
Celera836,775,173 - 36,775,536UniSTS
HuRef836,357,864 - 36,358,227UniSTS
MARC_68773-68774:1209743884:2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37837,823,070 - 37,823,642UniSTSGRCh37
Celera836,774,779 - 36,775,351UniSTS
HuRef836,357,470 - 36,358,042UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1044 2264 1258 1224 3271 834 1303 3 171 624 98 1507 3598 3887 24 2393 559 1379 950 76

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY487247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ024407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA904248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ104441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ170286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ170287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S53291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000345060   ⟹   ENSP00000343782
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl837,962,990 - 37,966,599 (-)Ensembl
Ensembl Acc Id: ENST00000520341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl837,964,974 - 37,966,597 (-)Ensembl
RefSeq Acc Id: NM_000025   ⟹   NP_000016
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38837,962,990 - 37,966,599 (-)NCBI
GRCh37837,820,513 - 37,824,184 (-)ENTREZGENE
Build 36837,939,673 - 37,943,341 (-)NCBI Archive
HuRef836,354,913 - 36,358,584 (-)ENTREZGENE
CHM1_1838,021,981 - 38,025,652 (-)NCBI
T2T-CHM13v2.0838,239,389 - 38,242,998 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000016   ⟸   NM_000025
- UniProtKB: P13945 (UniProtKB/Swiss-Prot),   Q4JFT4 (UniProtKB/Swiss-Prot),   B8X6N0 (UniProtKB/TrEMBL),   B8X6N1 (UniProtKB/TrEMBL),   A8KAG8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000343782   ⟸   ENST00000345060
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13945-F1-model_v2 AlphaFold P13945 1-408 view protein structure

Promoters
RGD ID:7213107
Promoter ID:EPDNEW_H12299
Type:initiation region
Name:ADRB3_1
Description:adrenoceptor beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38837,966,927 - 37,966,987EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:288 AgrOrtholog
COSMIC ADRB3 COSMIC
Ensembl Genes ENSG00000188778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000345060 ENTREZGENE
  ENST00000345060.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000188778 GTEx
HGNC ID HGNC:288 ENTREZGENE
Human Proteome Map ADRB3 Human Proteome Map
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 155 ENTREZGENE
OMIM 109691 OMIM
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-3 ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24598 PharmGKB
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB3AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8KAG8 ENTREZGENE, UniProtKB/TrEMBL
  ADRB3_HUMAN UniProtKB/Swiss-Prot
  B8X6N0 ENTREZGENE, UniProtKB/TrEMBL
  B8X6N1 ENTREZGENE, UniProtKB/TrEMBL
  P13945 ENTREZGENE
  Q4JFT4 ENTREZGENE
UniProt Secondary Q4JFT4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 ADRB3  adrenoceptor beta 3  ADRB3  adrenergic, beta-3-, receptor  Symbol and/or name change 5135510 APPROVED