Adrb3 (adrenergic receptor, beta 3) - Rat Genome Database

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Gene: Adrb3 (adrenergic receptor, beta 3) Mus musculus
Analyze
Symbol: Adrb3
Name: adrenergic receptor, beta 3
RGD ID: 10110
MGI Page MGI
Description: Enables beta-3 adrenergic receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrb; Adrb-3; beta 3-AR; beta-3 adrenergic receptor; Beta-3 adrenoceptor; beta-3 adrenoreceptor; Beta-3 AR; beta3-adrenergic receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,715,804 - 27,720,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,715,804 - 27,740,644 (-)EnsemblGRCm39 Ensembl
GRCm38827,225,776 - 27,230,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,225,776 - 27,250,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37828,336,248 - 28,340,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,691,712 - 28,695,524 (-)NCBIMGSCv36mm8
Celera828,716,093 - 28,719,905 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
alprenolol  (ISO)
Amibegron  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP,ISO)
atenolol  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (EXP)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
CL316243  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (EXP)
Cuprizon  (ISO)
D-glucose  (EXP)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
dobutamine  (ISO)
ethanol  (EXP)
fenoterol  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formoterol fumarate  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
glucose  (EXP)
griseofulvin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ICI 118551  (ISO)
isoprenaline  (EXP,ISO)
kojic acid  (ISO)
L-methionine  (EXP)
Licarin A  (EXP)
mangiferin  (EXP)
methimazole  (ISO)
metoprolol  (ISO)
N-nitrosodiethylamine  (ISO)
octopamine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenytoin  (ISO)
pindolol  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propranolol  (EXP,ISO)
pyruvic acid  (EXP)
rac-lactic acid  (EXP)
Salmeterol xinafoate  (ISO)
sodium arsenite  (EXP)
solabegron  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
tamoxifen  (EXP)
terbutaline  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
titanium dioxide  (EXP)
valproic acid  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IDA)
plasma membrane  (IBA,IEA)
receptor complex  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity. Babol K, etal., J Exp Clin Cancer Res. 2004 Dec;23(4):669-74.
2. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. beta1, beta2, and beta3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
5. Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Bracale R, etal., Eur J Clin Nutr. 2007 Oct;61(10):1213-9. Epub 2007 Feb 14.
6. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
7. Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese. Higashi K, etal., Biochem Biophys Res Commun. 1997 Mar 27;232(3):728-30.
8. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Hoffstedt J, etal., Diabetes. 1999 Jan;48(1):203-5.
9. Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men. Kawamura T, etal., Metabolism. 1999 Nov;48(11):1367-70.
10. Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. Khan I, etal., Pharmacology. 2002 Feb;64(2):98-105.
11. Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
12. A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family. Lehman DM, etal., Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):331-6.
13. [Dynamic changes of alpha-AR, beta1-AR and beta2-AR expression during hepatic fibrogenesis]. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
14. The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study. Mahmoudian M J Mol Graph. 1994 Mar;12(1):22-8, 34.
15. Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS. Manneras L, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1124-31. Epub 2009 Jan 21.
16. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Moniotte S, etal., Circulation. 2001 Mar 27;103(12):1649-55.
20. Sepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium. Moniotte S, etal., Eur J Heart Fail. 2007 Dec;9(12):1163-71. Epub 2007 Nov 19.
21. Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2). Morcillo S, etal., Clin Endocrinol (Oxf). 2008 Jan;68(1):102-7. Epub 2007 Aug 28.
22. Polymorphism of the beta3-adrenergic receptor and lipid profile in patients with rheumatoid arthritis and systemic lupus erythematosus treated with chloroquine. Munoz-Valle JF, etal., Rheumatol Int. 2003 May;23(3):99-103. Epub 2003 Mar 12.
23. Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis. Nozaki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):106S-110S.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients. Pulkkinen A, etal., Metabolism. 1999 Jul;48(7):853-6.
27. Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition. Revelli JP, etal., J Clin Invest. 1997 Sep 1;100(5):1098-106.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. Ringel J, etal., Am J Hypertens. 2000 Sep;13(9):1027-31.
32. Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. Ristori C, etal., Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):155-70. Print 2011 Jan.
33. Beta 3-adrenoreceptor gene polymorphism: a newly identified risk factor for proliferative retinopathy in NIDDM patients. Sakane N, etal., Diabetes. 1997 Oct;46(10):1633-6.
34. Trp64Arg mutation of beta3-adrenoceptor gene is associated with diabetic nephropathy in Type II diabetes mellitus. Sakane N, etal., Diabetologia. 1998 Dec;41(12):1533-4.
35. No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile. Santos JL, etal., Nutrition. 2002 Mar;18(3):255-8.
36. Diet-induced obese mice are leptin insufficient after weight reduction. Shi H, etal., Obesity (Silver Spring). 2009 Sep;17(9):1702-9. Epub 2009 Apr 16.
37. The beta3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery disease. Stangl K, etal., Metabolism. 2001 Feb;50(2):184-8.
38. Testosterone modulation of cardiac beta-adrenergic signals in a rat model of heart failure. Sun J, etal., Gen Comp Endocrinol. 2011 Jul 1;172(3):518-25. Epub 2011 Apr 28.
39. Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. Surwit RS, etal., Endocrinology. 2000 Oct;141(10):3630-7.
40. The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats. Vasina V, etal., Neurogastroenterol Motil. 2008 Sep;20(9):1030-41. Epub 2008 May 15.
41. Beta3-adrenergic receptor polymorphism and the antiretroviral therapy-related lipodystrophy syndrome. Vonkeman HE, etal., AIDS. 2000 Jul 7;14(10):1463-4.
42. Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population. Wang B, etal., J Rheumatol. 2011 Apr;38(4):738-40. Epub 2011 Feb 1.
43. Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort. Wang L, etal., J Card Fail. 2010 Jan;16(1):36-44. Epub 2009 Sep 25.
44. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. Wang Y, etal., Diabet Med. 2010 Apr;27(4):376-83.
45. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. Wankhade UD, etal., PLoS One. 2010 Aug 23;5(8):e12324.
46. Effects of UCP2 -866 G/A and ADRB3 Trp64Arg on rosiglitazone response in Chinese patients with Type 2 diabetes. Yang M, etal., Br J Clin Pharmacol. 2009 Jul;68(1):14-22.
Additional References at PubMed
PMID:1290451   PMID:1336117   PMID:1718744   PMID:7493988   PMID:7733225   PMID:7733267   PMID:7738011   PMID:8202547   PMID:8389293   PMID:8666142   PMID:8680474   PMID:8969197  
PMID:9002984   PMID:9133593   PMID:9200670   PMID:9305858   PMID:9305915   PMID:9606417   PMID:9726236   PMID:9826121   PMID:10198177   PMID:10349636   PMID:10358009   PMID:10441518  
PMID:10455305   PMID:10714358   PMID:10800773   PMID:10842103   PMID:10948198   PMID:10974023   PMID:11013230   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11713213   PMID:11716511  
PMID:11737201   PMID:11997176   PMID:12370125   PMID:12387862   PMID:12466851   PMID:12477932   PMID:12581209   PMID:12943691   PMID:14551227   PMID:14610273   PMID:14651995   PMID:14966518  
PMID:15474034   PMID:15665039   PMID:15791602   PMID:15939797   PMID:16141072   PMID:16141073   PMID:16160864   PMID:16180138   PMID:16602821   PMID:16631628   PMID:16767221   PMID:16876797  
PMID:17251187   PMID:17446185   PMID:17885689   PMID:18031735   PMID:18245567   PMID:18256599   PMID:18304529   PMID:18691638   PMID:18694395   PMID:18799693   PMID:18801900   PMID:19107190  
PMID:19420258   PMID:19477016   PMID:19596833   PMID:19619525   PMID:19744528   PMID:19766235   PMID:20138019   PMID:20354155   PMID:20363288   PMID:20381543   PMID:20406048   PMID:20435159  
PMID:21135361   PMID:21138422   PMID:21209093   PMID:21282332   PMID:21282381   PMID:21366703   PMID:21527738   PMID:21677750   PMID:21772246   PMID:21873635   PMID:21878665   PMID:21976502  
PMID:22222438   PMID:22227600   PMID:22282499   PMID:22326222   PMID:22482730   PMID:22535965   PMID:22863835   PMID:23133676   PMID:23219791   PMID:23235150   PMID:23283573   PMID:23473322  
PMID:23846904   PMID:23892270   PMID:23907538   PMID:23911886   PMID:24011077   PMID:24599317   PMID:24911015   PMID:24951958   PMID:24952646   PMID:25043017   PMID:25139049   PMID:25362208  
PMID:25725113   PMID:26063704   PMID:26132918   PMID:26566631   PMID:26673120   PMID:26910302   PMID:27206969   PMID:27444755   PMID:27453471   PMID:27492130   PMID:27672060   PMID:27846311  
PMID:28138551   PMID:28223294   PMID:28322782   PMID:28483278   PMID:28513874   PMID:28570265   PMID:28622359   PMID:28724789   PMID:28752049   PMID:28877454   PMID:28918935   PMID:29019320  
PMID:29106524   PMID:29123236   PMID:29514069   PMID:29589323   PMID:29688375   PMID:29715048   PMID:29728617   PMID:29736022   PMID:29914852   PMID:29937373   PMID:30174297   PMID:30352954  
PMID:30353008   PMID:30361261   PMID:30541923   PMID:30892909   PMID:31260855   PMID:31303548   PMID:32093135   PMID:32514619   PMID:32610084   PMID:32755608   PMID:32892421   PMID:33183171  
PMID:33807329   PMID:33878523   PMID:34437647   PMID:34483955   PMID:34551310   PMID:34563949   PMID:34847077   PMID:35087060   PMID:35145073   PMID:35455951   PMID:35636458   PMID:35652349  
PMID:35714603   PMID:35733999   PMID:35737830   PMID:36243005   PMID:36669474   PMID:36884028   PMID:37380764   PMID:37445699   PMID:37550517   PMID:38355793   PMID:38455846   PMID:39017739  


Genomics

Comparative Map Data
Adrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,715,804 - 27,720,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,715,804 - 27,740,644 (-)EnsemblGRCm39 Ensembl
GRCm38827,225,776 - 27,230,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,225,776 - 27,250,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37828,336,248 - 28,340,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,691,712 - 28,695,524 (-)NCBIMGSCv36mm8
Celera828,716,093 - 28,719,905 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.94NCBI
ADRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl837,962,990 - 37,966,599 (-)EnsemblGRCh38hg38GRCh38
GRCh37837,820,508 - 37,824,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36Build 36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
T2T-CHM13v2.0838,239,389 - 38,242,998 (-)NCBIT2T-CHM13v2.0
Adrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81671,544,603 - 71,547,410 (+)NCBIGRCr8
mRatBN7.21664,839,820 - 64,844,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,841,788 - 64,844,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,125,571 - 70,128,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,531,913 - 73,534,677 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,777,172 - 68,779,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
Adrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546313,663,064 - 13,665,553 (-)NCBIChiLan1.0ChiLan1.0
ADRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,524,236 - 56,529,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,241,318 - 32,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,263,730 - 37,267,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,440,099 - 34,444,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,441,311 - 34,443,949 (-)Ensemblpanpan1.1panPan2
ADRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,445,601 - 27,446,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,445,601 - 27,447,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,962,835 - 27,964,030 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,344,866 - 29,346,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,344,866 - 29,346,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,566,781 - 27,567,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,144,259 - 28,145,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,183,588 - 28,184,783 (+)NCBIUU_Cfam_GSD_1.0
Adrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494350,047,746 - 50,068,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,411,446 - 1,413,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,410,589 - 1,413,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,475,144 - 48,479,562 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,468,803 - 48,478,370 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,481,787 - 55,489,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1835,993,553 - 35,998,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl835,994,775 - 35,997,060 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660526,000,510 - 6,004,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,653,499 - 5,656,138 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adrb3
487 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:702
Count of miRNA genes:370
Interacting mature miRNAs:417
Transcripts:ENSMUST00000081438, ENSMUST00000117565, ENSMUST00000121838
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse

Markers in Region
Adrb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,227,905 - 27,228,267UniSTSGRCm38
MGSCv37828,338,377 - 28,338,739UniSTSGRCm37
Celera828,718,222 - 28,718,584UniSTS
Cytogenetic Map8A2-A4UniSTS
cM Map810.0UniSTS
Adrb3_-_d8Rck5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,228,675 - 27,228,860UniSTSGRCm38
MGSCv37828,339,147 - 28,339,332UniSTSGRCm37
Celera828,718,992 - 28,719,177UniSTS
Cytogenetic Map8A2-A4UniSTS
Whitehead_YAC17 UniSTS
X72862  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,225,867 - 27,226,013UniSTSGRCm38
MGSCv37828,336,339 - 28,336,485UniSTSGRCm37
Celera828,716,184 - 28,716,330UniSTS
Cytogenetic Map8A2-A4UniSTS
Whitehead/MRC_RH8313.61UniSTS
PMC164531P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,228,196 - 27,228,273UniSTSGRCm38
MGSCv37828,338,668 - 28,338,745UniSTSGRCm37
Celera828,718,513 - 28,718,590UniSTS
Cytogenetic Map8A2-A4UniSTS
UniSTS:489183  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,226,812 - 27,228,444UniSTSGRCm38
MGSCv37828,337,284 - 28,338,916UniSTSGRCm37
Celera828,717,129 - 28,718,761UniSTS
Cytogenetic Map8A2-A4UniSTS
UniSTS:494118  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,226,808 - 27,228,494UniSTSGRCm38
MGSCv37828,337,280 - 28,338,966UniSTSGRCm37
Celera828,717,125 - 28,718,811UniSTS
Cytogenetic Map8A2-A4UniSTS
Adrb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38827,226,825 - 27,227,290UniSTSGRCm38
MGSCv37828,337,297 - 28,337,762UniSTSGRCm37
Celera828,717,142 - 28,717,607UniSTS
Cytogenetic Map8A2-A4UniSTS
cM Map810.0UniSTS
Adrb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A2-A4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000081438   ⟹   ENSMUSP00000080162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl827,715,804 - 27,719,616 (-)Ensembl
GRCm38.p6 Ensembl827,225,776 - 27,229,588 (-)Ensembl
Ensembl Acc Id: ENSMUST00000117565   ⟹   ENSMUSP00000113732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl827,716,827 - 27,718,522 (-)Ensembl
GRCm38.p6 Ensembl827,226,799 - 27,228,494 (-)Ensembl
Ensembl Acc Id: ENSMUST00000121838   ⟹   ENSMUSP00000113006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl827,716,029 - 27,718,611 (-)Ensembl
GRCm38.p6 Ensembl827,226,001 - 27,228,583 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl827,719,264 - 27,720,852 (-)Ensembl
GRCm38.p6 Ensembl827,229,236 - 27,230,824 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl827,718,487 - 27,740,644 (-)Ensembl
GRCm38.p6 Ensembl827,228,459 - 27,250,616 (-)Ensembl
RefSeq Acc Id: NM_013462   ⟹   NP_038490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,715,804 - 27,719,616 (-)NCBI
GRCm38827,225,776 - 27,229,588 (-)NCBI
MGSCv37828,336,248 - 28,340,060 (-)RGD
Celera828,716,093 - 28,719,905 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030243246   ⟹   XP_030099106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,716,015 - 27,719,715 (-)NCBI
GRCm38827,225,987 - 27,230,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243247   ⟹   XP_030099107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,716,015 - 27,719,715 (-)NCBI
GRCm38827,225,987 - 27,230,092 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003947220
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,716,015 - 27,719,715 (-)NCBI
GRCm38827,225,987 - 27,230,845 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934750
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,716,015 - 27,720,833 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934751
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39827,716,015 - 27,720,833 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038490   ⟸   NM_013462
- UniProtKB: A2RS74 (UniProtKB/Swiss-Prot),   Q9QZ98 (UniProtKB/Swiss-Prot),   P25962 (UniProtKB/Swiss-Prot),   Q3UP63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099106   ⟸   XM_030243246
- Peptide Label: isoform X1
- UniProtKB: P25962 (UniProtKB/Swiss-Prot),   A2RS74 (UniProtKB/Swiss-Prot),   Q9QZ98 (UniProtKB/Swiss-Prot),   Q3UP63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030099107   ⟸   XM_030243247
- Peptide Label: isoform X1
- UniProtKB: P25962 (UniProtKB/Swiss-Prot),   A2RS74 (UniProtKB/Swiss-Prot),   Q9QZ98 (UniProtKB/Swiss-Prot),   Q3UP63 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000080162   ⟸   ENSMUST00000081438
Ensembl Acc Id: ENSMUSP00000113732   ⟸   ENSMUST00000117565
Ensembl Acc Id: ENSMUSP00000113006   ⟸   ENSMUST00000121838
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25962-F1-model_v2 AlphaFold P25962 1-400 view protein structure

Promoters
RGD ID:6842706
Promoter ID:MM_KWN:54057
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Lung
Transcripts:ENSMUST00000110553,   NM_013462,   UC009LIF.1,   UC009LIG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36828,338,024 - 28,338,524 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87939 AgrOrtholog
Ensembl Genes ENSMUSG00000031489 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081438 ENTREZGENE
  ENSMUST00000081438.10 UniProtKB/Swiss-Prot
  ENSMUST00000117565.2 UniProtKB/Swiss-Prot
  ENSMUST00000121838 ENTREZGENE
  ENSMUST00000121838.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87939 ENTREZGENE
NCBI Gene 11556 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-3 ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adrb3 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB3AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RS74 ENTREZGENE
  ADRB3_MOUSE UniProtKB/Swiss-Prot
  H9U0Q5_MOUSE UniProtKB/TrEMBL
  P25962 ENTREZGENE
  Q3UP63 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZ98 ENTREZGENE
UniProt Secondary A2RS74 UniProtKB/Swiss-Prot
  Q9QZ98 UniProtKB/Swiss-Prot