Iddm9 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm9 (Insulin dependent diabetes mellitus QTL 9) Rattus norvegicus

Symbol: Iddm9
Name: Insulin dependent diabetes mellitus QTL 9
RGD ID: 631669
Previously known as: Iddm5r
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: plasma glucose level   (CMO:0000042)    
LOD Score: 2.8
P Value: 0.039
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81233,349,180 - 270,518,180RGD_MAPPER_PIPELINE
mRatBN7.21233,190,394 - 258,625,266RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01252,955,158 - 280,632,620RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01270,716,905 - 287,992,330RGDRnor5.0
RGSC_v3.41247,322,146 - 266,002,939RGDRGSC3.4
RGSC_v3.11247,436,621 - 266,213,984RGD
Cross Type: backcross
Strains Crossed: BB/OK SHR/Mol 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Rattype 1 diabetes mellitus  IAGP 6903877 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Ratincreased circulating glucose level  IAGP 6903877 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Ratplasma glucose level  IDA 6903877 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Ratcontrol condition  IDA 6903877 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Ratblood glucose test strip read by electrochemical glucometer  IDA 6903877 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9RatBB/OK  IEA 6903877 RGD 
Iddm9RatSHR/Mol  IEA 6903877 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm9Ratblood glucose amount  IDA 6903877 RGD 


#
Reference Title
Reference Citation
1. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
2. Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat. Kloting I, etal., Int J Mol Med. 1998 Nov;2(5):597-601.
3. TYPE 1 DIABETES IN THE BB RAT: A POLYGENIC DISEASE. Wallis RH, etal., Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23

Related QTL Description Reference
Iddm25 maps to same region RGD:2303106



1 to 20 of 379 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
41008230LOC120100195U6 spliceosomal RNA1233392193233392295Rat
41034025LOC120100447small nucleolar RNA SNORA171233401988233402113Rat
41089904LOC120100148U6 spliceosomal RNA1233558763233558869Rat
41320941LOC120100024uncharacterized LOC1201000241233596287233599642Rat
41299898LOC120100436small nucleolar RNA SNORA171233608349233608479Rat
71034Htr75-hydroxytryptamine receptor 71233636442233761063Rat
11385874LOC108353431glyceraldehyde-3-phosphate dehydrogenase pseudogene1233710372233711552Rat
1595116Rpp30ribonuclease P/MRP subunit p301233786048233808958Rat
61989Ankrd1ankyrin repeat domain 11233815851233834891Rat
1583513Pcgf5polycomb group ring finger 51234063854234180022Rat
9179158LOC103691349uncharacterized LOC1036913491234225875234229702Rat
1305536Hectd2HECT domain E3 ubiquitin protein ligase 21234274967234345598Rat
41029999LOC120100025uncharacterized LOC1201000251234369639234371254Rat
1309132Ppp1r3cprotein phosphatase 1, regulatory subunit 3C1234460958234465961Rat
7595572LOC102553702uncharacterized LOC1025537021234506902234511615Rat
41343048U3l9small nucleolar RNA U3 like 91234564075234564231Rat
1305026Tnks2tankyrase 21234567888234621079Rat
41265797LOC120100026uncharacterized LOC1201000261234639342234643034Rat
1560326Fgfbp3fibroblast growth factor binding protein 31234644023234646028Rat
1564130Btaf1B-TFIID TATA-box binding protein associated factor 11234653219234743903Rat

1 to 20 of 379 rows
1 to 20 of 618 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10097D1Smu21291253050519253050648Ratregion
10105D1Smu11691255785337255785506Ratregion
10432D1Mgh243011245542075245542378Ratregion
10445D1Wox251821238755477238755659Ratregion
10446D1Mgh291061238755490238755596Ratregion
10805D1Mgh131381245907761245907899Ratregion
33830D1Mit321491244113147244113296Ratregion
33844D1Mit141041258625162258625266Ratregion
34194D1Mgh141231256448513256448636Ratregion
34232D1Mgh151601254773191254773351Ratregion
34517D1Mgh321091241799011241799120Ratregion
33569D1Mit311791245480298245480477Ratregion
36083D1Rat1191731236036277236036450Ratregion
36169D1Rat891711257976324257976495Ratregion
37506D1Rat1512401244863660244863900Ratregion
35266D1Rat791251240698709240698822Ratregion
36828D1Rat851321251790438251790570Ratregion
36874D1Rat821261243747836243747962Ratregion
37030D14Rat31711242824821242824860Ratregion
37030D14Rat31711242824825242824866Ratregion
1 to 20 of 618 rows

Flank 1: (D1Mgh12)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01270,716,905 - 270,717,037NCBI
RGSC_v3.41247,322,146 - 247,322,277RGD
RGSC_v3.11247,436,621 - 247,436,752RGD
Celera1238,204,080 - 238,204,181UniSTS
RH 3.4 Map11616.91UniSTS
RH 3.4 Map11616.91RGD
RH 2.0 Map11221.1RGD
SHRSP x BN Map1133.51RGD
Cytogenetic Map1q54UniSTS
Peak: (D1Mgh13)
Rat AssemblyChrPosition (strand)Source
GRCr81255,849,111 - 255,849,249 (+)Marker Load Pipeline
mRatBN7.21245,907,761 - 245,907,899 (+)MAPPER
Rnor_6.01266,793,821 - 266,793,958NCBI
Rnor_5.01274,224,224 - 274,224,361UniSTS
RGSC_v3.41252,340,389 - 252,340,527RGD
RGSC_v3.41252,340,390 - 252,340,527UniSTS
RGSC_v3.11252,604,962 - 252,605,100RGD
Celera1241,679,423 - 241,679,560UniSTS
RH 3.4 Map11641.5RGD
RH 3.4 Map11641.5UniSTS
RH 2.0 Map11237.1RGD
Cytogenetic Map1q54UniSTS
Flank 2: (D1Mit14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21258,625,162 - 258,625,266 (+)MAPPER
Rnor_6.01280,632,517 - 280,632,620NCBI
Rnor_5.01287,992,227 - 287,992,330UniSTS
RGSC_v3.41266,002,835 - 266,002,939RGD
RGSC_v3.41266,002,836 - 266,002,939UniSTS
RGSC_v3.11266,213,881 - 266,213,984RGD
Celera1254,274,522 - 254,274,625UniSTS
RH 3.4 Map11706.6UniSTS
RH 3.4 Map11706.6RGD
RH 2.0 Map11324.4999RGD
FHH x ACI Map1132.1799RGD
Cytogenetic Map1q55UniSTS


1 to 10 of 83 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464234238494Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat

1 to 10 of 83 rows


Database
Acc Id
Source(s)
NCBI Gene Iddm9

Note Type Note Reference
qtl_cross_type backcross  
qtl_disease this QTL region confers protection from diabetes development 61077
qtl_general shows suggestive linkage to blood glucose in non-diabetic animals 619674
qtl_general homologous to the 11p15 region in human 61077