Gene: Slk (STE20-like kinase) Rattus norvegicus
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Symbol: Slk
Name: STE20-like kinase
Description: ENCODES a protein that exhibits protein kinase activity; identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to tumor necrosis factor; positive regulation of apoptotic process; positive regulation of histone phosphorylation; ASSOCIATED WITH Reperfusion Injury; substance-related disorder (ortholog); FOUND IN cytoplasm; cell leading edge (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 2,4-dinitrotoluene
AGR Description: Exhibits protein kinase activity; involved in several processes, including cellular response to tumor necrosis factor, positive regulation of apoptotic process, and positive regulation of histone phosphorylation; localizes to the cytoplasm; orthologous to human SLK (STE20 like kinase).
Merged Description: Exhibits protein kinase activity; involved in several processes, including cellular response to tumor necrosis factor, positive regulation of apoptotic process, and positive regulation of histone phosphorylation; localizes to the cytoplasm; orthologous to human SLK (STE20 like kinase); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: serine/threonine kinase 2; STE20-like kinase (yeast); STE20-like serine/threonine-protein kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Stk2
Orthologs:
Homo sapiens (human) : SLK (STE20 like kinase)  HGNC  Alliance
Mus musculus (house mouse) : Slk (STE20-like kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slk (STE20 like kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SLK (STE20 like kinase)
Canis lupus familiaris (dog) : SLK (STE20 like kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slk (STE20 like kinase)
Sus scrofa (pig) : SLK (STE20 like kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01267,359,761 - 267,415,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01274,792,996 - 274,848,925 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,954,514 - 253,007,330 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11253,219,115 - 253,271,839 (+)NCBI
Celera1242,240,482 - 242,293,210 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3780
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.