Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:736743 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of SLIT1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of SLIT1 mRNA | CTD | PMID:16079270 | 17beta-estradiol | decreases expression | ISO | RGD:733848 | 6480464 | Estradiol results in decreased expression of SLIT1 mRNA | CTD | PMID:21185374 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SLIT1 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SLIT1 mRNA | CTD | PMID:32741896 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | RGD:733848 | 6480464 | 2 more ... | CTD | PMID:31326446 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLIT1 mRNA | CTD | PMID:32109520 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | RGD:733848 | 6480464 | tetrabromobisphenol A results in increased expression of SLIT1 mRNA | CTD | PMID:31326446 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:736743 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of SLIT1 mRNA | CTD | PMID:20188158 | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1, 2-dithiol-3-thione results in increased expression of SLIT1 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:736743 | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of SLIT1 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:736743 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of SLIT1 mRNA | CTD | PMID:30951980 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SLIT1 mRNA | CTD | PMID:24780913, PMID:25825206 | acrylamide | decreases expression | ISO | RGD:733848 | 6480464 | Acrylamide results in decreased expression of SLIT1 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | RGD:733848 | 6480464 | Aflatoxin B1 results in increased methylation of SLIT1 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | RGD:733848 | 6480464 | Aflatoxin B1 results in decreased methylation of SLIT1 3' UTR | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:733848 | 6480464 | aflatoxin B2 results in increased methylation of SLIT1 3' UTR, aflatoxin B2 results in increased methylation of SLIT1 intron | CTD | PMID:30157460 | alendronic acid | affects expression | EXP | | 6480464 | Alendronate affects the expression of SLIT1 mRNA | CTD | PMID:16079270 | all-trans-retinoic acid | increases expression | ISO | RGD:733848 | 6480464 | Tretinoin results in increased expression of SLIT1 mRNA | CTD | PMID:17045167 | all-trans-retinoic acid | decreases expression | ISO | RGD:733848 | 6480464 | Tretinoin results in decreased expression of SLIT1 mRNA | CTD | PMID:23724009 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLIT1 mRNA | CTD | PMID:16483693 | amphotericin B | decreases expression | ISO | RGD:733848 | 6480464 | Amphotericin B results in decreased expression of SLIT1 mRNA | CTD | PMID:20849824 | arsenite(3-) | increases expression | ISO | RGD:736743 | 6480464 | arsenite results in increased expression of SLIT1 mRNA | CTD | PMID:33053406 | belinostat | increases expression | ISO | RGD:733848 | 6480464 | belinostat results in increased expression of SLIT1 mRNA | CTD | PMID:26272509 | belinostat | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | increases methylation | ISO | RGD:733848 | 6480464 | Benzo(a)pyrene results in increased methylation of SLIT1 5' UTR, Benzo(a)pyrene results in increased methylation of SLIT1 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:733848 | 6480464 | Benzo(a)pyrene affects the methylation of SLIT1 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | bisphenol A | increases expression | ISO | RGD:736743 | 6480464 | bisphenol A results in increased expression of SLIT1 mRNA | CTD | PMID:23798566 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SLIT1 mRNA | CTD | PMID:25181051, PMID:30816183 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of SLIT1 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLIT1 mRNA | CTD | PMID:25607892 | bisphenol F | increases expression | ISO | RGD:736743 | 6480464 | bisphenol F results in increased expression of SLIT1 mRNA | CTD | PMID:30951980 | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of SLIT1 mRNA | CTD | PMID:32479839 | Butylparaben | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of SLIT1 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLIT1 mRNA | CTD | PMID:25607892 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of SLIT1 mRNA | CTD | PMID:16278290 | chlorpyrifos | affects expression | EXP | | 6480464 | Chlorpyrifos affects the expression of SLIT1 mRNA | CTD | PMID:26775027 | chlorpyrifos | decreases expression | ISO | RGD:736743 | 6480464 | Chlorpyrifos results in decreased expression of SLIT1 mRNA | CTD | PMID:29156651 | cisplatin | decreases expression | ISO | RGD:733848 | 6480464 | Cisplatin results in decreased expression of SLIT1 mRNA | CTD | PMID:20849824 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of SLIT1 mRNA | CTD | PMID:26577399 | cyclophosphamide | decreases expression | ISO | RGD:733848 | 6480464 | Cyclophosphamide results in decreased expression of SLIT1 mRNA | CTD | PMID:20849824 | DDE | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | decabromodiphenyl ether | increases expression | ISO | RGD:733848 | 6480464 | decabromobiphenyl ether results in increased expression of SLIT1 mRNA | CTD | PMID:31326446 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | dorsomorphin | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | RGD:733848 | 6480464 | entinostat results in increased expression of SLIT1 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | enzacamene | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of SLIT1 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SLIT1 mRNA | CTD | PMID:25607892 | epoxiconazole | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | ethanol | increases expression | ISO | RGD:736743 | 6480464 | Ethanol results in increased expression of SLIT1 mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | ISO | RGD:736743 | 6480464 | Ethanol affects the expression of and affects the splicing of SLIT1 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of SLIT1 mRNA | CTD | PMID:30307764 | gentamycin | decreases expression | ISO | RGD:733848 | 6480464 | Gentamicins results in decreased expression of SLIT1 mRNA | CTD | PMID:20849824 | lead(0) | affects expression | ISO | RGD:733848 | 6480464 | Lead affects the expression of SLIT1 mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:733848 | 6480464 | Lead affects the expression of SLIT1 mRNA | CTD | PMID:28903495 | linuron | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:736743 | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of SLIT1 mRNA | CTD | PMID:22401849 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SLIT1 gene | CTD | PMID:33148267 | panobinostat | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | RGD:733848 | 6480464 | panobinostat results in increased expression of SLIT1 mRNA | CTD | PMID:26272509 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SLIT1 gene | CTD | PMID:33148267 | pioglitazone | multiple interactions | ISO | RGD:736743 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of SLIT1 mRNA | CTD | PMID:27935865 | prochloraz | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | procymidone | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | progesterone | decreases expression | ISO | RGD:733848 | 6480464 | Progesterone results in decreased expression of SLIT1 mRNA | CTD | PMID:18037150 | raloxifene | affects expression | EXP | | 6480464 | Raloxifene Hydrochloride affects the expression of SLIT1 mRNA | CTD | PMID:16079270 | SB 431542 | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | affects methylation | ISO | RGD:733848 | 6480464 | sodium arsenite affects the methylation of SLIT1 gene | CTD | PMID:28589171 | T-2 toxin | decreases expression | EXP | | 6480464 | T-2 Toxin results in decreased expression of SLIT1 mRNA | CTD | PMID:26141394 | tebuconazole | decreases expression | ISO | RGD:733848 | 6480464 | tebuconazole results in decreased expression of SLIT1 mRNA | CTD | PMID:30458266 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SLIT1 mRNA | CTD | PMID:32741896 | Tetrachlorobisphenol A | increases expression | ISO | RGD:733848 | 6480464 | tetrachlorodian results in increased expression of SLIT1 mRNA | CTD | PMID:31326446 | trichostatin A | increases expression | ISO | RGD:733848 | 6480464 | trichostatin A results in increased expression of SLIT1 mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | triptonide | increases expression | ISO | RGD:736743 | 6480464 | triptonide results in increased expression of SLIT1 mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | RGD:733848 | 6480464 | Valproic Acid results in increased methylation of SLIT1 gene | CTD | PMID:29154799 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of SLIT1 mRNA | CTD | PMID:29427782 | valproic acid | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | RGD:733848 | 6480464 | Valproic Acid results in increased expression of SLIT1 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | RGD:733848 | 6480464 | Valproic Acid affects the expression of SLIT1 mRNA | CTD | PMID:25979313 | vinclozolin | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA | CTD | PMID:25607892 | vorinostat | increases expression | ISO | RGD:733848 | 6480464 | vorinostat results in increased expression of SLIT1 mRNA | CTD | PMID:26272509 | vorinostat | multiple interactions | ISO | RGD:733848 | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT1 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Brose K, etal., Cell 1999 Mar 19;96(6):795-806. |
| 2. | Chen B, etal., J Immunol. 2004 Nov 15;173(10):5914-7. |
| 3. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 4. | Itoh A, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):175-86. |
| 5. | Liang Y, etal., J Biol Chem 1999 Jun 18;274(25):17885-92. |
| 6. | Marillat V, etal., J Comp Neurol. 2002 Jan 7;442(2):130-55. |
| 7. | MGD data from the GO Consortium |
| 8. | Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34. |
| 9. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. | Plump AS, etal., Neuron 2002 Jan 17;33(2):219-32. |
| 11. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 12. | RGD automated import pipeline for gene-chemical interactions |
| 13. | Tanno T, etal., J Biochem (Tokyo) 2004 Nov;136(5):575-81. |
| 14. | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 15. | Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44. |
Additional References at PubMed
| PMID:8889548 | PMID:10433822 | PMID:10864956 | PMID:11748139 | PMID:11804571 | PMID:12051827 | PMID:12097499 | PMID:12954717 | PMID:14960623 | PMID:15091338 | PMID:15207848 | PMID:16162649 |
| PMID:16828733 | PMID:16840550 | PMID:16885222 | PMID:18755265 | PMID:20172023 |
Genomics
