Ins1 (insulin 1) - Rat Genome Database

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Gene: Ins1 (insulin 1) Rattus norvegicus
Analyze
Symbol: Ins1
Name: insulin 1
RGD ID: 2915
Description: Exhibits insulin receptor binding activity. Involved in response to cAMP; response to cytokine; and response to peptide hormone. Localizes to extracellular space. Colocalizes with cytoplasm. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin); PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; autophagy pathway; INTERACTS WITH benzo[a]pyrene (ortholog); crocidolite asbestos (ortholog); triclosan (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Insulin; insulin-1
RGD Orthologs
Human
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21251,244,973 - 251,245,540 (+)NCBI
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
Celera1246,946,414 - 246,946,981 (+)NCBICelera
RH 3.4 Map11654.9RGD
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (IEA)
extracellular space  (IDA)

Molecular Function

References

References - curated
1. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
2. Chin-Chance CV, etal., J Investig Med. 2006 Apr;54(3):132-42.
3. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60.
4. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
5. Egido EM, etal., Eur J Endocrinol 2002 Feb;146(2):241-4.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70.
9. Guest PC, etal., J Endocrinol. 2002 Dec;175(3):637-47.
10. Hah JS, etal., Biochemistry 2002 Dec 3;41(48):14364-71.
11. Ivarsson R, etal., Traffic. 2005 Nov;6(11):1027-35.
12. Jehle PM, etal., Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:31-6.
13. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
14. Julien S, etal., Diabetes 2004 Jun;53(6):1526-34.
15. Kaneto H, etal., J Biol Chem 2002 Apr 12;277(15):12998-3006.
16. Kemp DM and Habener JF, Biochem Pharmacol. 2002 Aug 15;64(4):689-97.
17. Krause U, etal., Eur J Biochem 2002 Aug;269(15):3742-50.
18. Kuwahata M, etal., Biochim Biophys Acta. 2007 Jan;1772(1):60-5. Epub 2006 Oct 4.
19. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6.
21. Lomedico PT, etal., Ann N Y Acad Sci 1980;343:425-32.
22. MGD data from the GO Consortium
23. Morimoto S, etal., Endocrinology 2001 Apr;142(4):1442-7.
24. Naslund E, etal., Regul Pept 2002 Jun 15;106(1-3):89-95.
25. NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602.
27. OMIM Disease Annotation Pipeline
28. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):184-91.
29. Pipeline to import KEGG annotations from KEGG into RGD
30. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
31. RGD automated data pipeline
32. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. RGD automated import pipeline for gene-chemical interactions
34. Ribaux P, etal., Endocrinology 2002 Oct;143(10):3766-72.
35. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
36. Zhang B, etal., Zhonghua Shao Shang Za Zhi 2002 Aug;18(4):220-2.
Additional References at PubMed
PMID:325648   PMID:358198   PMID:498283   PMID:498284   PMID:4311938   PMID:4554104   PMID:4640931   PMID:11824480   PMID:11884412   PMID:12038757   PMID:12120208   PMID:12771145  
PMID:12914929   PMID:12928442   PMID:14707149   PMID:14976144   PMID:15068957   PMID:15093702   PMID:15161751   PMID:15466647   PMID:15466888   PMID:15564337   PMID:15632182   PMID:15637161  
PMID:15687408   PMID:15833775   PMID:15899886   PMID:15983214   PMID:15983215   PMID:16553787   PMID:16597920   PMID:16717097   PMID:16909201   PMID:16933034   PMID:17023527   PMID:17068290  
PMID:17127041   PMID:17170237   PMID:17273787   PMID:17292859   PMID:17327422   PMID:17454971   PMID:17550999   PMID:17715136   PMID:17906111   PMID:17982240   PMID:17993259   PMID:18039179  
PMID:18063688   PMID:18165568   PMID:18450959   PMID:19008912   PMID:19194835   PMID:19375131   PMID:19375767   PMID:19549853   PMID:19671839   PMID:19728324   PMID:20225168   PMID:20571033  
PMID:20668029   PMID:20857410   PMID:20886068   PMID:21149828   PMID:21332026   PMID:21402379   PMID:21454690   PMID:21773965   PMID:21792084   PMID:21911493   PMID:22002008   PMID:22065581  
PMID:22119580   PMID:22319612   PMID:22715380   PMID:22750144   PMID:22996137   PMID:23016131   PMID:23016132   PMID:23703573   PMID:24084692   PMID:24425760   PMID:24425765   PMID:24440707  
PMID:24569992   PMID:24894193   PMID:25011481   PMID:25159330   PMID:25232145   PMID:25961284   PMID:26449460   PMID:26632509   PMID:26775660   PMID:26882284   PMID:26986474   PMID:27336168  
PMID:27495870   PMID:28084108   PMID:28188284   PMID:28237718   PMID:28359774   PMID:28410130   PMID:28689409   PMID:29952285   PMID:30112574   PMID:30879761   PMID:31257494   PMID:32325912  
PMID:32631952  


Genomics

Candidate Gene Status
Ins1 is a candidate Gene for QTL Scl67
Ins1 is a candidate Gene for QTL Stl31
Ins1 is a candidate Gene for QTL Iddm21
Comparative Map Data
Ins1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21251,244,973 - 251,245,540 (+)NCBI
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
Celera1246,946,414 - 246,946,981 (+)NCBICelera
RH 3.4 Map11654.9RGD
Cytogenetic Map1q55NCBI
INS-IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,132,538 - 2,161,209 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl112,129,112 - 2,158,391 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,129,117 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,150,347 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,926 - 2,139,015 (-)NCBINCBI36hg18NCBI36
Celera112,186,841 - 2,218,946 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,940,864 - 1,972,702 (-)NCBIHuRef
CHM1_1112,148,968 - 2,181,387 (-)NCBICHM1_1
LOC120889510
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,733,854 - 1,743,304 (-)NCBI

Position Markers
D1Ztm5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,258,770 - 251,259,068 (+)MAPPER
Rnor_6.01272,813,582 - 272,813,879NCBIRnor6.0
Rnor_5.01280,227,413 - 280,227,710UniSTSRnor5.0
RGSC_v3.41258,014,919 - 258,015,216UniSTSRGSC3.4
Celera1246,960,238 - 246,960,535UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,246,901 - 251,247,066 (+)MAPPER
Rnor_6.01272,801,713 - 272,801,877NCBIRnor6.0
Rnor_5.01280,215,544 - 280,215,708UniSTSRnor5.0
RGSC_v3.41258,003,050 - 258,003,214UniSTSRGSC3.4
Celera1246,948,343 - 246,948,533UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,260,995 - 251,261,233 (+)MAPPER
Rnor_6.01272,815,807 - 272,816,044NCBIRnor6.0
Rnor_5.01280,229,638 - 280,229,875UniSTSRnor5.0
RGSC_v3.41258,017,144 - 258,017,381UniSTSRGSC3.4
Celera1246,962,465 - 246,962,707UniSTS
Cytogenetic Map1q54-q55UniSTS
D1Ztm3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,246,810 - 251,247,089 (+)MAPPER
Rnor_6.01272,801,622 - 272,801,900NCBIRnor6.0
Rnor_5.01280,215,453 - 280,215,731UniSTSRnor5.0
RGSC_v3.41258,002,959 - 258,003,237UniSTSRGSC3.4
Celera1246,948,252 - 246,948,556UniSTS
Cytogenetic Map1q54-q55UniSTS
AA986540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,377 - 251,245,516 (+)MAPPER
Rnor_6.01272,800,189 - 272,800,327NCBIRnor6.0
Rnor_5.01280,214,020 - 280,214,158UniSTSRnor5.0
RGSC_v3.41258,001,526 - 258,001,664UniSTSRGSC3.4
Celera1246,946,819 - 246,946,957UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC123023P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,426 - 197,844,133 (+)MAPPER
mRatBN7.21251,245,183 - 251,245,392 (+)MAPPER
Rnor_6.01272,799,995 - 272,800,203NCBIRnor6.0
Rnor_6.01215,857,117 - 215,857,823NCBIRnor6.0
Rnor_5.01280,213,826 - 280,214,034UniSTSRnor5.0
Rnor_5.01222,751,936 - 222,752,642UniSTSRnor5.0
RGSC_v3.41202,935,638 - 202,936,344UniSTSRGSC3.4
RGSC_v3.41258,001,332 - 258,001,540UniSTSRGSC3.4
Celera1246,946,625 - 246,946,833UniSTS
Celera1195,461,459 - 195,462,165UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21231P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,360 - 197,844,160 (+)MAPPER
mRatBN7.21251,245,156 - 251,245,457 (+)MAPPER
Rnor_6.01272,799,968 - 272,800,268NCBIRnor6.0
Rnor_6.01215,857,051 - 215,857,850NCBIRnor6.0
Rnor_5.01280,213,799 - 280,214,099UniSTSRnor5.0
Rnor_5.01222,751,870 - 222,752,669UniSTSRnor5.0
RGSC_v3.41202,935,572 - 202,936,371UniSTSRGSC3.4
RGSC_v3.41258,001,305 - 258,001,605UniSTSRGSC3.4
Celera1246,946,598 - 246,946,898UniSTS
Celera1195,461,393 - 195,462,192UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21334P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,378 - 197,844,106 (+)MAPPER
mRatBN7.21251,245,210 - 251,245,439 (+)MAPPER
Rnor_6.01272,800,022 - 272,800,250NCBIRnor6.0
Rnor_6.01215,857,069 - 215,857,796NCBIRnor6.0
Rnor_5.01280,213,853 - 280,214,081UniSTSRnor5.0
Rnor_5.01222,751,888 - 222,752,615UniSTSRnor5.0
RGSC_v3.41202,935,590 - 202,936,317UniSTSRGSC3.4
RGSC_v3.41258,001,359 - 258,001,587UniSTSRGSC3.4
Celera1246,946,652 - 246,946,880UniSTS
Celera1195,461,411 - 195,462,138UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,160 - 251,245,460 (+)MAPPER
Rnor_6.01272,799,972 - 272,800,271NCBIRnor6.0
Rnor_5.01280,213,803 - 280,214,102UniSTSRnor5.0
RGSC_v3.41258,001,309 - 258,001,608UniSTSRGSC3.4
Celera1246,946,602 - 246,946,901UniSTS
Cytogenetic Map1q54-q55UniSTS
RH94799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,380 - 197,844,179 (+)MAPPER
mRatBN7.21251,245,137 - 251,245,437 (+)MAPPER
Rnor_6.01272,799,949 - 272,800,248NCBIRnor6.0
Rnor_6.01215,857,071 - 215,857,869NCBIRnor6.0
Rnor_5.01280,213,780 - 280,214,079UniSTSRnor5.0
Rnor_5.01222,751,890 - 222,752,688UniSTSRnor5.0
RGSC_v3.41202,935,592 - 202,936,390UniSTSRGSC3.4
RGSC_v3.41258,001,286 - 258,001,585UniSTSRGSC3.4
Celera1246,946,579 - 246,946,878UniSTS
Celera1195,461,413 - 195,462,211UniSTS
RH 3.4 Map11654.9UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
PMC123023P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,148 - 251,245,480 (+)MAPPER
mRatBN7.21197,843,337 - 197,844,168 (+)MAPPER
Rnor_6.01215,857,028 - 215,857,858NCBIRnor6.0
Rnor_6.01272,799,960 - 272,800,291NCBIRnor6.0
Rnor_5.01280,213,791 - 280,214,122UniSTSRnor5.0
Rnor_5.01222,751,847 - 222,752,677UniSTSRnor5.0
RGSC_v3.41202,935,549 - 202,936,379UniSTSRGSC3.4
RGSC_v3.41258,001,297 - 258,001,628UniSTSRGSC3.4
Celera1246,946,590 - 246,946,921UniSTS
Celera1195,461,370 - 195,462,200UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC24644P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,343 - 197,844,030 (+)MAPPER
mRatBN7.21251,245,286 - 251,245,474 (+)MAPPER
Rnor_6.01272,800,098 - 272,800,285NCBIRnor6.0
Rnor_6.01215,857,034 - 215,857,720NCBIRnor6.0
Rnor_5.01280,213,929 - 280,214,116UniSTSRnor5.0
Rnor_5.01222,751,853 - 222,752,539UniSTSRnor5.0
RGSC_v3.41202,935,555 - 202,936,241UniSTSRGSC3.4
RGSC_v3.41258,001,435 - 258,001,622UniSTSRGSC3.4
Celera1246,946,728 - 246,946,915UniSTS
Celera1195,461,376 - 195,462,062UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:267003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,055 (+)MAPPER
mRatBN7.21251,245,261 - 251,245,479 (+)MAPPER
Rnor_6.01272,800,073 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,745NCBIRnor6.0
Rnor_5.01280,213,904 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,564UniSTSRnor5.0
RGSC_v3.41202,935,550 - 202,936,266UniSTSRGSC3.4
RGSC_v3.41258,001,410 - 258,001,627UniSTSRGSC3.4
Celera1246,946,703 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,087UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,159 - 251,245,461 (+)MAPPER
Rnor_6.01272,799,971 - 272,800,272NCBIRnor6.0
Rnor_5.01280,213,802 - 280,214,103UniSTSRnor5.0
RGSC_v3.41258,001,308 - 258,001,609UniSTSRGSC3.4
Celera1246,946,601 - 246,946,902UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,149 (+)MAPPER
mRatBN7.21251,245,167 - 251,245,479 (+)MAPPER
Rnor_6.01272,799,979 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,839NCBIRnor6.0
Rnor_5.01280,213,810 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,658UniSTSRnor5.0
RGSC_v3.41258,001,316 - 258,001,627UniSTSRGSC3.4
RGSC_v3.41202,935,550 - 202,936,360UniSTSRGSC3.4
Celera1246,946,609 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,181UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,333 - 251,245,517 (+)MAPPER
Rnor_6.01272,800,145 - 272,800,328NCBIRnor6.0
Rnor_5.01280,213,976 - 280,214,159UniSTSRnor5.0
RGSC_v3.41258,001,482 - 258,001,665UniSTSRGSC3.4
Celera1246,946,775 - 246,946,958UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1233663100273792054Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1252948438281795785Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1252955158280632620Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1258709726281795785Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1266793821279986079Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000016052
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium 1 1 4 1
Low 3 3 3 3 2 2
Below cutoff 8 5 4 5 2 2 5 4 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016052   ⟹   ENSRNOP00000016052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)Ensembl
RefSeq Acc Id: NM_019129   ⟹   NP_062002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21251,244,973 - 251,245,540 (+)NCBI
Rnor_6.01272,799,784 - 272,800,351 (+)NCBI
Rnor_5.01280,213,615 - 280,214,182 (+)NCBI
RGSC_v3.41258,001,134 - 258,001,688 (+)RGD
Celera1246,946,414 - 246,946,981 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062002 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41439 (Get FASTA)   NCBI Sequence Viewer  
  AAA41442 (Get FASTA)   NCBI Sequence Viewer  
  CAA24559 (Get FASTA)   NCBI Sequence Viewer  
  EDL94407 (Get FASTA)   NCBI Sequence Viewer  
  P01322 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062002   ⟸   NM_019129
- Peptide Label: preproprotein
- UniProtKB: P01322 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016052   ⟸   ENSRNOT00000016052

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850044
Promoter ID:EP11131
Type:single initiation site
Name:RN_INS1
Description:Insulin I, INS1 or INS-1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 45; Mammalian insulin
Tissues & Cell Lines:pancreas islet cells
Experiment Methods:Length measurement of an RNA product; RNA Pol II in vitro system;; low-precision data; Nuclease protection; transfected or transformed cells; Primer extension; transfected or transformed cells; Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41258,001,119 - 258,001,179EPD
RGD ID:13690985
Promoter ID:EPDNEW_R1510
Type:single initiation site
Name:Ins1_1
Description:insulin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01272,799,784 - 272,799,844EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2915 AgrOrtholog
Ensembl Genes ENSRNOG00000012052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016052 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016052 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:24505 UniProtKB/Swiss-Prot
NCBI Gene 24505 ENTREZGENE
PANTHER PTHR11454 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Ins1 PhenoGen
PRINTS INSULIN UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt INS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ins1  insulin 1    Insulin  Name updated 625702 APPROVED
2002-06-10 Ins1  Insulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function recruits GLUT4 to the plasma membrane 727471
gene_function polypeptide hormone and ligand for insulin receptor 625703
gene_process causes rapid and sustained phosphorylation of protein kinase B, induces glucokinase transcription and hypophosphorylates Erk 1 and 2 625703
gene_process involved in carbohydrate metabolism 625703
gene_regulation testosterone administration increases mRNA level and release 625703