Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2915
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Ins1
Name:	insulin 1

Acc ID:	CHEBI:73918
Term:	3-O-methyl-D-glucose
Definition:	A D-aldohexose that is D-glucose in which the hydrogen of the hydroxy group at position 3 has been substituted by a methyl group. It is a non-metabolisable glucose analogue that is not phosphorylated by hexokinase and is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.
Chemical ID:	MESH:D019325

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ins1	increases transport	EXP		6480464	CTD	INS1 protein results in increased transport of 3-O-Methylglucose	PMID:2185640
Ins1	increases uptake	EXP		6480464	CTD	INS1 protein results in increased uptake of 3-O-Methylglucose	PMID:2204694 PMID:8404595
Ins1	multiple interactions	EXP		6480464	CTD	Manganese deficiency inhibits the reaction [INS1 protein results in increased uptake of 3-O-Methylglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of 3-O-Methylglucose]; pervanadate promotes the reaction [INS1 protein results in increased uptake of 3-O-Methylglucose]; Quercetin inhibits the reaction [pervanadate promotes the reaction [INS1 protein results in increased uptake of 3-O-Methylglucose]]	PMID:2185640 PMID:2204694 PMID:8404595

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