Ins1 (insulin I) - Rat Genome Database

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Gene: Ins1 (insulin I) Mus musculus
Analyze
Symbol: Ins1
Name: insulin I
RGD ID: 10811
MGI Page MGI
Description: Predicted to enable several functions, including identical protein binding activity; signaling receptor activator activity; and signaling receptor binding activity. Involved in insulin receptor signaling pathway. Acts upstream of with a positive effect on receptor internalization. Located in cytosol. Is active in extracellular space. Is expressed in several structures, including gut; liver; trunk; and yolk sac. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Ins-1; Ins2-rs1; insulin-1
RGD Orthologs
Human
Rat
Squirrel
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391952,252,735 - 52,253,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1952,252,735 - 52,253,914 (+)EnsemblGRCm39 Ensembl
GRCm381952,264,297 - 52,265,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1952,264,297 - 52,265,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv371952,338,813 - 52,339,966 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361952,317,762 - 52,318,343 (+)NCBIMGSCv36mm8
Celera1954,451,492 - 54,452,645 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1946.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Ins1MouseAcute Liver Failure  ISOIns1 (Rattus norvegicus)2298712mRNA:increased expression:pancreatic isletRGD 
Ins1MouseAlzheimer's disease  ISOIns1 (Rattus norvegicus)2298713mRNA:decreased expression:hippocampusRGD 
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Ins1MouseBeckwith-Wiedemann syndrome  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Beckwith-Wiedemann syndromeClinVarPMID:21910219 more ...
Ins1Mousecolorectal cancer  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Colorectal cancerClinVar 
Ins1Mousedelta beta-thalassemia  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Thalassemia and gamma-delta-betaClinVarPMID:2798417
Ins1Mousedevelopmental and epileptic encephalopathy  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Ins1Mousediabetes mellitus  ISOINS-IGF2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11921414 more ...
Ins1Mouseearly infantile epileptic encephalopathy  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
Ins1Mousegenetic disease  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11921414 more ...
Ins1MouseHyperproinsulinemia  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: HyperproinsulinemiaClinVarPMID:11921414 more ...
Ins1MouseHypoinsulinemia  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: HypoinsulinemiaClinVarPMID:12610512 more ...
Ins1Mouseimmunodeficiency 39  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 39ClinVarPMID:28492532
Ins1Mousematurity-onset diabetes of the young  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Maturity onset diabetes mellitus in youngClinVarPMID:11921414 more ...
Ins1Mousematurity-onset diabetes of the young  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Maturity onset diabetes mellitus in youngClinVarPMID:11921414 more ...
Ins1Mousematurity-onset diabetes of the young type 1  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:17047922 more ...
Ins1Mousematurity-onset diabetes of the young type 10  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Maturity-onset diabetes of the young type 10ClinVarPMID:11921414 more ...
Ins1Mouseneonatal diabetes mellitus  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal diabetes mellitusClinVarPMID:11921414 more ...
Ins1Mouseneuronal ceroid lipofuscinosis  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:28492532
Ins1Mousepermanent neonatal diabetes mellitus  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Permanent neonatal diabetes mellitusClinVarPMID:11921414 more ...
Ins1MousePermanent Neonatal Diabetes Mellitus 4  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Diabetes mellitus and permanent neonatal 4ClinVarPMID:11921414 more ...
Ins1MouseSegawa Syndrome, Autosomal Recessive  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive DOPA responsive dystoniaClinVarPMID:11921414 more ...
Ins1MouseSilver-Russell Syndrome 1  ISOINS-IGF2 (Homo sapiens)8554872ClinVar Annotator: match by term: Silver-Russell syndrome 1ClinVar 
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Original Reference(s)
Ins1MouseAbnormal Reflexes  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:3525850
Ins1MouseAnimal Mammary Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21558470
Ins1MouseBradycardia  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:3525850
Ins1Mousedepressive disorder  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:34352274
Ins1MouseDiabetic Cardiomyopathies  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:6225876
Ins1MouseExperimental Diabetes Mellitus  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:2975197 and PMID:3044883
Ins1Mousehepatocellular carcinoma  ISOINS-IGF2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560
Ins1Mousehyperglycemia  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:26887929 more ...
Ins1Mousehypoglycemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:222008 more ...
Ins1MouseInsulin Resistance  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19586609
Ins1MouseKetosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:29420703
Ins1MouseNecrosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:9826672
Ins1Mousetype 2 diabetes mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19586609
Ins1MouseVentricular Dysfunction, Left  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:29682576
Ins1MouseWeight Loss  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:29682576 and PMID:34352274
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Original Reference(s)
Ins1Mouse(+)-catechin multiple interactionsEXP 6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 proteinCTDPMID:25663641
Ins1Mouse(+)-catechin increases secretionISOIns1 (Rattus norvegicus)6480464Catechin results in increased secretion of INS1 proteinCTDPMID:30445784
Ins1Mouse(+)-catechin multiple interactionsISOIns1 (Rattus norvegicus)6480464Catechin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]CTDPMID:23365609
Ins1Mouse(+)-epicatechin-3-O-gallate multiple interactionsEXP 6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 proteinCTDPMID:25663641
Ins1Mouse(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of INS1 protein more ...CTDPMID:18591783 and PMID:25663641
Ins1Mouse(aminooxy)acetic acid multiple interactionsEXP 6480464[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein] and [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]CTDPMID:10199125 and PMID:10464266
Ins1Mouse(R)-adrenaline multiple interactionsEXP 6480464INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]CTDPMID:10777495
Ins1Mouse(R)-adrenaline multiple interactionsISOIns1 (Rattus norvegicus)6480464cilostamide inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids more ...CTDPMID:15172182
Ins1Mouse(R)-carnitine decreases uptakeEXP 6480464INS1 protein results in decreased uptake of CarnitineCTDPMID:28298333
Ins1Mouse(R)-carnitine multiple interactionsISOIns1 (Rattus norvegicus)6480464Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]CTDPMID:30256492
Ins1Mouse(R)-lipoic acid multiple interactionsISOIns1 (Rattus norvegicus)6480464acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] more ...CTDPMID:21461750 and PMID:29760339
Ins1Mouse(R)-noradrenaline multiple interactionsISOIns1 (Rattus norvegicus)6480464INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP]CTDPMID:4306506
Ins1Mouse(R)-pantothenic acid multiple interactionsISOINS-IGF2 (Homo sapiens)6480464[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA more ...CTDPMID:34323617
Ins1Mouse(R,R,R)-alpha-tocopherol multiple interactionsISOIns1 (Rattus norvegicus)6480464[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 proteinCTDPMID:12949374
Ins1Mouse(S)-colchicine multiple interactionsISOIns1 (Rattus norvegicus)6480464Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]CTDPMID:19070612
Ins1Mouse(S)-nicotine multiple interactionsEXP 6480464[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA more ...CTDPMID:33091441
Ins1Mouse(S)-nicotine multiple interactionsISOIns1 (Rattus norvegicus)6480464Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein]CTDPMID:31857090
Ins1Mouse(S)-nicotine increases expressionISOIns1 (Rattus norvegicus)6480464Nicotine results in increased expression of INS1 proteinCTDPMID:29155039 and PMID:31857090
Ins1Mouse1,4-dithiothreitol decreases activityISOIns1 (Rattus norvegicus)6480464Dithiothreitol results in decreased activity of INS1 proteinCTDPMID:2262933
Ins1Mouse1,4-dithiothreitol multiple interactionsISOIns1 (Rattus norvegicus)6480464Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein] and Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]CTDPMID:2262933

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Biological Process
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Original Reference(s)
Ins1Mouseactivation of protein kinase B activity involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mouseacute-phase response involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousealpha-beta T cell activation involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousecellular response to glucose stimulus  ISOIns1 (Rattus norvegicus)9068941 RGDPMID:18562674 and REF_RGD_ID:152177517
Ins1Mousecellular response to glucose stimulus involved_inIEAUniProtKB:P01322 and ensembl:ENSRNOP000000160522290270 EnsemblGO_REF:0000107
Ins1Mousecellular response to oxygen-containing compound  ISOIns1 (Rattus norvegicus)9068941isradipineRGDPMID:18562674 and REF_RGD_ID:152177517
Ins1MouseD-glucose transmembrane transport acts_upstream_of_or_withinTAS 2290270 PMID:12297296MGIPMID:12297296
Ins1Mousefatty acid homeostasis involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1MouseG protein-coupled receptor signaling pathway involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mouseglucose homeostasis involved_inIBAPANTHER:PTN000155764 more ...2290270 GO_CentralGO_REF:0000033
Ins1Mouseglucose homeostasis involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mouseglucose metabolic process involved_inIEAUniProtKB-KW:KW-03132290270 UniProtGO_REF:0000043
Ins1Mouseinsulin receptor signaling pathway involved_inISOUniProtKB:P013082290270 PMID:29512653GO_CentralGO_REF:0000119 and PMID:29512653
Ins1Mouseinsulin receptor signaling pathway involved_inIMPMGI:21818772290270 PMID:20056832MGIPMID:20056832
Ins1Mousenegative regulation of acute inflammatory response involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousenegative regulation of fatty acid metabolic process involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousenegative regulation of feeding behavior involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousenegative regulation of gene expression acts_upstream_ofISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousenegative regulation of glycogen catabolic process involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mousenegative regulation of lipid catabolic process involved_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
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Cellular Component
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Ins1Mousecollagen-containing extracellular matrix located_inHDA 2290270 PMID:28071719BHF-UCLPMID:28071719
Ins1Mousecytosol located_inTAS 2290270 ReactomeReactome:R-MMU-186535
Ins1Mousecytosol located_inIDA 2290270 PMID:21828338MGIPMID:21828338
Ins1Mouseendoplasmic reticulum lumen located_inTAS 2290270 ReactomeReactome:R-MMU-9770101
Ins1Mouseextracellular region located_inTAS 2290270 ReactomeReactome:R-MMU-216883
Ins1Mouseextracellular space  ISOIns1 (Rattus norvegicus)9068941MMO:0000075RGDPMID:20873977 and REF_RGD_ID:152985538
Ins1Mouseextracellular space located_inISOUniProtKB:P013082290270 GO_CentralGO_REF:0000119
Ins1Mouseextracellular space is_active_inIDA 2290270 PMID:27055260 and PMID:9452465MGIPMID:27055260 and PMID:9452465
Ins1Mouseextracellular space located_inISOIns1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ins1Mouseextracellular space is_active_inIBAPANTHER:PTN002606702 more ...2290270 GO_CentralGO_REF:0000033
Ins1Mouseextracellular space  ISOIns1 (Rattus norvegicus)9068941 RGDPMID:12475375 and REF_RGD_ID:2298715
Ins1Mousesecretory granule lumen located_inTAS 2290270 ReactomeReactome:R-MMU-216806 more ...
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Molecular Function
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RGD Manual Annotations


  
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Original Reference(s)
Ins1Mouseinsulin signaling pathway   ISOINS (Homo sapiens)1625124 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Ins1Mousealdosterone signaling pathway   IEA 6907045 KEGGmmu:04960
Ins1Mouseautophagy pathway   IEA 6907045 KEGGmmu:04140
Ins1Mouseinsulin signaling pathway   IEA 6907045 KEGGmmu:04910
Ins1Mousematurity-onset diabetes of the young pathway  IEA 6907045 KEGGmmu:04950
Ins1MousemTOR signaling pathway   IEA 6907045 KEGGmmu:04150
Ins1Mouseprostate cancer pathway   IEA 6907045 KEGGmmu:05215
Ins1Mousetype 1 diabetes mellitus pathway  IEA 6907045 KEGGmmu:04940
Ins1Mousetype 2 diabetes mellitus pathway   IEA 6907045 KEGGmmu:04930
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Original Reference(s)
Ins1Mouseabnormal circulating insulin level  IAGP 5509061 MGIPMID:19680229
Ins1Mouseabnormal glucose homeostasis  IAGP 5509061 MGIPMID:9144203
Ins1Mouseabnormal glucose homeostasis  IAGP 5509061 MGIPMID:11272179
Ins1Mouseabnormal immune system physiology  IAGP 5509061 MGIPMID:19680229
Ins1Mouseabnormal interferon-gamma secretion  IAGP 5509061 MGIPMID:19680229
Ins1Mouseabnormal pancreatic beta cell physiology  IAGP 5509061 MGIPMID:19680229
Ins1Mouseabnormal T cell physiology  IAGP 5509061 MGIPMID:19680229
Ins1Mouseacidosis  IAGP 5509061 MGIPMID:9144203
Ins1Mouseautoimmune response  IAGP 5509061 MGIPMID:15889095
Ins1Mousedecreased anti-insulin autoantibody level  IAGP 5509061 MGIPMID:15889095
Ins1Mousedecreased birth weight  IAGP 5509061 MGIPMID:11897712
Ins1Mousedecreased body size  IAGP 5509061 MGIPMID:9144203
Ins1Mousedecreased fetal weight  IAGP 5509061 MGIPMID:11897712
Ins1Mousedecreased insulin secretion  IAGP 5509061 MGIPMID:29864031
Ins1Mousedecreased pancreatic beta cell number  IAGP 5509061 MGIPMID:19680229
Ins1Mousedecreased pancreatic islet cell apoptosis  IAGP 5509061 MGIPMID:11897712
Ins1Mousedecreased pancreatic islet cell apoptosis  IAGP 5509061 MGIPMID:25830089
Ins1Mousedecreased susceptibility to autoimmune diabetes  IAGP 5509061 MGIPMID:12925730
Ins1Mousedecreased susceptibility to autoimmune diabetes  IAGP 5509061 MGIPMID:15889095
Ins1Mouseembryonic growth retardation  IAGP 5509061 MGIPMID:9144203
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Reference Title
Reference Citation
1. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. Chen Y, etal., FEBS Lett 1994 Jun 27;347(2-3):279-83.
2. Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60.
3. Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
4. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70.
5. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
6. Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure. Kuwahata M, etal., Biochim Biophys Acta. 2007 Jan;1772(1):60-5. Epub 2006 Oct 4.
7. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. A variant insulin promoter in non-insulin-dependent diabetes mellitus. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Soares MB, etal., Mol Cell Biol 1985 Aug;5(8):2090-103.
18. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
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PMID:1346376   PMID:1358795   PMID:1371010   PMID:1460423   PMID:1701096   PMID:1811941   PMID:2397023   PMID:2608062   PMID:3104603   PMID:5063718   PMID:6690234   PMID:7493641  
PMID:7600975   PMID:7663515   PMID:7698766   PMID:7729600   PMID:7768185   PMID:7822777   PMID:7867492   PMID:7901001   PMID:7935793   PMID:7959751   PMID:8012378   PMID:8012396  
PMID:8043949   PMID:8075499   PMID:8148038   PMID:8421685   PMID:8499657   PMID:8625795   PMID:8625829   PMID:8631275   PMID:8681804   PMID:8787762   PMID:8812459   PMID:8861960  
PMID:8863190   PMID:8960823   PMID:8963443   PMID:9021159   PMID:9107690   PMID:9121556   PMID:9144203   PMID:9224716   PMID:9291463   PMID:9368764   PMID:9417918   PMID:9441664  
PMID:9452465   PMID:9465295   PMID:9584121   PMID:9774514   PMID:9799617   PMID:9851981   PMID:9914469   PMID:9922458   PMID:10049364   PMID:10078553   PMID:10079507   PMID:10102687  
PMID:10349636   PMID:10471495   PMID:10471502   PMID:10473596   PMID:10506199   PMID:10602987   PMID:10677506   PMID:10725233   PMID:10725249   PMID:10769089   PMID:10825208   PMID:10842072  
PMID:10851133   PMID:10866045   PMID:10868931   PMID:10903178   PMID:11042159   PMID:11044404   PMID:11062007   PMID:11076772   PMID:11076861   PMID:11159375   PMID:11217851   PMID:11272179  
PMID:11371557   PMID:11414755   PMID:11430820   PMID:11448939   PMID:11577200   PMID:11606464   PMID:11685688   PMID:11748146   PMID:11784060   PMID:11897712   PMID:11912494   PMID:12049785  
PMID:12101187   PMID:12189445   PMID:12297296   PMID:12397372   PMID:12399441   PMID:12412008   PMID:12466851   PMID:12477932   PMID:12559489   PMID:12604355   PMID:12666204   PMID:12681500  
PMID:12702762   PMID:12711597   PMID:12815626   PMID:12843653   PMID:12914928   PMID:12917290   PMID:12917627   PMID:12921743   PMID:12925730   PMID:12949354   PMID:14517990   PMID:14561778  
1 to 10 of 72 rows



Ins1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391952,252,735 - 52,253,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1952,252,735 - 52,253,914 (+)EnsemblGRCm39 Ensembl
GRCm381952,264,297 - 52,265,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1952,264,297 - 52,265,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv371952,338,813 - 52,339,966 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361952,317,762 - 52,318,343 (+)NCBIMGSCv36mm8
Celera1954,451,492 - 54,452,645 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1946.76NCBI
INS-IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,132,538 - 2,161,209 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,150,347 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,926 - 2,139,015 (-)NCBINCBI36Build 36hg18NCBI36
Celera112,186,841 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,864 - 1,972,702 (-)NCBIHuRef
CHM1_1112,148,968 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,248,857 (-)NCBIT2T-CHM13v2.0
Ins1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81261,186,119 - 261,186,686 (+)NCBIGRCr8
mRatBN7.21251,244,973 - 251,245,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1251,244,973 - 251,245,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1259,368,906 - 259,369,473 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01266,074,993 - 266,075,560 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01258,728,428 - 258,728,995 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01272,799,784 - 272,800,351 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1272,799,784 - 272,800,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01280,213,615 - 280,214,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41258,001,134 - 258,001,688 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11258,267,212 - 258,267,545 (+)NCBI
Celera1246,946,414 - 246,946,981 (+)NCBICelera
RH 3.4 Map11654.9RGD
Cytogenetic Map1q55NCBI
LOC120889510
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,733,854 - 1,743,304 (-)NCBIHiC_Itri_2

.

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Variants in Ins1
37 total Variants

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:127
Interacting mature miRNAs:135
Transcripts:ENSMUST00000039652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141412Acsns1_mAngiostrongylus costaricensis nematode susceptibility 1 (mouse)Not determined4789788055026545Mouse

1 to 10 of 25 rows
RH94798  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,372 - 52,264,629UniSTSGRCm38
MGSCv371952,338,862 - 52,339,119UniSTSGRCm37
Celera1954,451,541 - 54,451,798UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
RH94799  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,613 - 52,264,906UniSTSGRCm38
GRCm387142,678,757 - 142,679,544UniSTSGRCm38
MGSCv377149,864,662 - 149,865,449UniSTSGRCm37
MGSCv371952,339,103 - 52,339,396UniSTSGRCm37
Celera1954,451,782 - 54,452,075UniSTS
Celera7142,435,086 - 142,435,873UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
cM Map1949.0UniSTS
X04725  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,265,052 - 52,265,154UniSTSGRCm38
MGSCv371952,339,542 - 52,339,644UniSTSGRCm37
Celera1954,452,221 - 54,452,323UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Whitehead_YAC19 UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,471 - 52,264,845UniSTSGRCm38
GRCm38115,207,570 - 5,208,085UniSTSGRCm38
MGSCv37115,107,573 - 5,108,088UniSTSGRCm37
MGSCv371952,338,961 - 52,339,335UniSTSGRCm37
Celera1954,451,640 - 54,452,014UniSTS
Celera115,707,168 - 5,707,683UniSTS
Cytogenetic Map19D2UniSTS
Cytogenetic Map11A1UniSTS
cM Map1949.0UniSTS
cM Map1949.0UniSTS
cM Map769.1UniSTS
PMC152933P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,471 - 52,264,853UniSTSGRCm38
MGSCv371952,338,961 - 52,339,343UniSTSGRCm37
Celera1954,451,640 - 54,452,022UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
PMC21231P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,632 - 52,264,926UniSTSGRCm38
MGSCv371952,339,122 - 52,339,416UniSTSGRCm37
Celera1954,451,801 - 54,452,095UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
PMC312732P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,685 - 52,264,903UniSTSGRCm38
GRCm387142,678,760 - 142,679,472UniSTSGRCm38
MGSCv377149,864,665 - 149,865,377UniSTSGRCm37
MGSCv371952,339,175 - 52,339,393UniSTSGRCm37
Celera1954,451,854 - 54,452,072UniSTS
Celera7142,435,089 - 142,435,801UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,455 - 52,264,943UniSTSGRCm38
MGSCv371952,338,945 - 52,339,433UniSTSGRCm37
Celera1954,451,624 - 54,452,112UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,807 - 52,264,988UniSTSGRCm38
MGSCv371952,339,297 - 52,339,478UniSTSGRCm37
Celera1954,451,976 - 54,452,157UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,809 - 52,264,987UniSTSGRCm38
GRCm387142,678,676 - 142,678,860UniSTSGRCm38
MGSCv371952,339,299 - 52,339,477UniSTSGRCm37
MGSCv377149,864,581 - 149,864,765UniSTSGRCm37
Celera1954,451,978 - 54,452,156UniSTS
Celera7142,435,005 - 142,435,189UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map769.1UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387142,678,733 - 142,679,522UniSTSGRCm38
MGSCv377149,864,638 - 149,865,427UniSTSGRCm37
Celera7142,435,062 - 142,435,851UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,643 - 52,264,948UniSTSGRCm38
GRCm387142,678,715 - 142,679,514UniSTSGRCm38
MGSCv371952,339,133 - 52,339,438UniSTSGRCm37
MGSCv377149,864,620 - 149,865,419UniSTSGRCm37
Celera1954,451,812 - 54,452,117UniSTS
Celera7142,435,044 - 142,435,843UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
Cytogenetic Map7F5UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
Cytogenetic Map7F5UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,448 - 52,264,913UniSTSGRCm38
MGSCv371952,338,938 - 52,339,403UniSTSGRCm37
Celera1954,451,617 - 54,452,082UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
cM Map1949.0UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,762 - 52,264,943UniSTSGRCm38
GRCm387142,678,720 - 142,679,395UniSTSGRCm38
MGSCv371952,339,252 - 52,339,433UniSTSGRCm37
MGSCv377149,864,625 - 149,865,300UniSTSGRCm37
Celera1954,451,931 - 54,452,112UniSTS
Celera7142,435,049 - 142,435,724UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,737 - 52,264,948UniSTSGRCm38
GRCm387142,678,715 - 142,679,420UniSTSGRCm38
MGSCv371952,339,227 - 52,339,438UniSTSGRCm37
MGSCv377149,864,620 - 149,865,325UniSTSGRCm37
Celera1954,451,906 - 54,452,117UniSTS
Celera7142,435,044 - 142,435,749UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map19D2UniSTS






1 to 16 of 16 rows
RefSeq Transcripts NM_008386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP771435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP773571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ126282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ479923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSMUST00000039652   ⟹   ENSMUSP00000049095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1952,252,735 - 52,253,914 (+)Ensembl
GRCm38.p6 Ensembl1952,264,297 - 52,265,476 (+)Ensembl
RefSeq Acc Id: NM_008386   ⟹   NP_032412
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391952,252,735 - 52,253,453 (+)NCBI
GRCm381952,264,297 - 52,265,015 (+)NCBI
MGSCv371952,338,813 - 52,339,966 (+)RGD
Celera1954,451,492 - 54,452,645 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032412   ⟸   NM_008386
- Peptide Label: preproprotein
- UniProtKB: Q545I7 (UniProtKB/Swiss-Prot),   Q9D907 (UniProtKB/Swiss-Prot),   P01325 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000049095   ⟸   ENSMUST00000039652

Name Modeler Protein Id AA Range Protein Structure
AF-P01325-F1-model_v2 AlphaFold P01325 1-108 view protein structure

RGD ID:13679760
Promoter ID:EPDNEW_M24029
Type:multiple initiation site
Name:Ins1_1
Description:Mus musculus insulin I , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381952,264,449 - 52,264,509EPDNEW
RGD ID:6850038
Promoter ID:EP17068
Type:single initiation site
Name:MM_INS1
Description:Insulin I, INS1 or INS-1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 45; Mammalian insulin
Experiment Methods:Nuclease protection; experiments performed with closely related; gene; Nuclease protection; transfected or transformed cells; experiments; performed with closely related gene; Primer extension; experiments performed with closely related; gene; Primer extension; transfected or transformed cells; experiments; performed with closely related gene
Regulation:pancreas islet b' (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) glucose
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371952,338,937 - 52,338,997EPD
MGSCv361952,338,937 - 52,338,997EPD


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000035804 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039652 ENTREZGENE
  ENSMUST00000039652.6 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report mmu:16333 UniProtKB/Swiss-Prot
MGD MGI:96572 ENTREZGENE
NCBI Gene 16333 ENTREZGENE
PANTHER INSULIN UniProtKB/Swiss-Prot
  PTHR11454 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Ins1 PhenoGen
PRINTS INSULIN UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt INS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q545I7 ENTREZGENE
  Q9D907 ENTREZGENE
UniProt Secondary Q545I7 UniProtKB/Swiss-Prot
  Q9D907 UniProtKB/Swiss-Prot
1 to 26 of 26 rows