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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2915
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins1
Name: insulin 1
Acc ID: CHEBI:18320
Term: 1,4-dithiothreitol
Definition: The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.
Chemical ID: MESH:D004229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins1decreases activityEXP 6480464CTDDithiothreitol results in decreased activity of INS1 proteinPMID:2262933
Ins1multiple interactionsEXP 6480464CTDDithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]PMID:2262933
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