Cox15 (cytochrome c oxidase assembly homolog COX15) - Rat Genome Database

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Gene: Cox15 (cytochrome c oxidase assembly homolog COX15) Rattus norvegicus
Analyze
Symbol: Cox15
Name: cytochrome c oxidase assembly homolog COX15
RGD ID: 1312043
Description: Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; INTERACTS WITH 2,6-dinitrotoluene; aconitine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX15 cytochrome c oxidase assembly homolog; COX15 homolog; COX15 homolog, cytochrome c oxidase assembly protein; COX15 homolog, cytochrome c oxidase assembly protein (yeast); cytochrome c oxidase assembly homolog 15; cytochrome c oxidase assembly homolog 15 (yeast); cytochrome c oxidase assembly protein COX15 homolog; LOC100911779; LOC309391; MGC124864
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,554,811 - 252,571,471 (-)NCBIGRCr8
mRatBN7.21242,605,588 - 242,622,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,605,588 - 242,622,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,754,535 - 250,770,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,451,478 - 257,467,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,104,684 - 250,121,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,494,850 - 263,511,510 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,494,852 - 263,511,505 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,939,907 - 270,956,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,077,102 - 247,093,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,191,602 - 247,208,363 (+)NCBI
Celera1238,424,532 - 238,441,036 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy. Antonicka H, etal., Am J Hum Genet. 2003 Jan;72(1):101-14. Epub 2002 Dec 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Isoforms of mammalian cytochrome c oxidase: correlation with human cytochrome c oxidase deficiency. Kennaway NG, etal., Pediatr Res. 1990 Nov;28(5):529-35.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome. Oquendo CE, etal., J Med Genet. 2004 Jul;41(7):540-4.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9878253   PMID:12477932   PMID:12865426   PMID:15060005   PMID:18614015  


Genomics

Comparative Map Data
Cox15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,554,811 - 252,571,471 (-)NCBIGRCr8
mRatBN7.21242,605,588 - 242,622,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,605,588 - 242,622,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,754,535 - 250,770,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,451,478 - 257,467,987 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,104,684 - 250,121,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,494,850 - 263,511,510 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,494,852 - 263,511,505 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,939,907 - 270,956,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,077,102 - 247,093,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,191,602 - 247,208,363 (+)NCBI
Celera1238,424,532 - 238,441,036 (-)NCBICelera
Cytogenetic Map1q54NCBI
COX15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,694,293 - 99,732,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,710,868 - 99,732,127 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,454,050 - 101,491,884 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,461,591 - 101,481,890 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,461,595 - 101,481,890NCBI
Celera1095,205,889 - 95,229,808 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,095,974 - 95,119,811 (-)NCBIHuRef
CHM1_110101,750,991 - 101,774,908 (-)NCBICHM1_1
T2T-CHM13v2.010100,577,297 - 100,615,117 (-)NCBIT2T-CHM13v2.0
Cox15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,721,693 - 43,741,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,721,693 - 43,741,439 (-)EnsemblGRCm39 Ensembl
GRCm381943,733,254 - 43,753,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,733,254 - 43,753,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv371943,807,744 - 43,827,490 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,788,436 - 43,806,292 (-)NCBIMGSCv36mm8
Celera1944,521,185 - 44,540,963 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
LOC102017801
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,600,605 - 5,617,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,600,605 - 5,617,556 (-)NCBIChiLan1.0ChiLan1.0
LOC100993532
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28111,620,808 - 111,641,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110111,627,555 - 111,646,375 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,328,841 - 96,349,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,803,670 - 99,841,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,820,763 - 99,841,554 (-)Ensemblpanpan1.1panPan2
COX15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,609,690 - 12,625,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,610,401 - 12,624,087 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,790,871 - 12,808,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,075,249 - 13,093,330 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,076,157 - 13,091,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,622,120 - 12,640,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,653,043 - 12,671,103 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,794,631 - 12,812,729 (-)NCBIUU_Cfam_GSD_1.0
LOC101959085
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,346,091 - 34,362,230 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636385,018 - 401,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636385,198 - 401,090 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,875,619 - 110,894,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,875,614 - 110,895,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,327,186 - 120,341,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COX15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,739,137 - 92,797,190 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,779,573 - 92,796,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,774,517 - 53,798,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715399
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,435,074 - 11,453,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,435,006 - 11,452,934 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox15
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:815
Count of miRNA genes:321
Interacting mature miRNAs:411
Transcripts:ENSRNOT00000023215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
RH127403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,605,687 - 242,605,869 (+)MAPPERmRatBN7.2
Rnor_6.01263,494,950 - 263,495,131NCBIRnor6.0
Rnor_6.01263,005,446 - 263,005,627NCBIRnor6.0
Rnor_5.01270,450,622 - 270,450,803UniSTSRnor5.0
Rnor_5.01270,940,007 - 270,940,188UniSTSRnor5.0
RGSC_v3.41247,093,476 - 247,093,657UniSTSRGSC3.4
Celera1238,424,632 - 238,424,813UniSTS
Cytogenetic Map1q54UniSTS
RH128398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,605,836 - 242,606,020 (+)MAPPERmRatBN7.2
Rnor_6.01263,495,099 - 263,495,282NCBIRnor6.0
Rnor_6.01263,005,595 - 263,005,778NCBIRnor6.0
Rnor_5.01270,940,156 - 270,940,339UniSTSRnor5.0
Rnor_5.01270,450,771 - 270,450,954UniSTSRnor5.0
RGSC_v3.41247,093,325 - 247,093,508UniSTSRGSC3.4
Celera1238,424,781 - 238,424,964UniSTS
RH 3.4 Map11618.5UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 2 2 2 32 20 22
Low 3 21 55 39 19 39 8 11 42 15 19 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023215   ⟹   ENSRNOP00000023215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,605,588 - 242,622,261 (-)Ensembl
Rnor_6.0 Ensembl1263,494,852 - 263,511,505 (-)Ensembl
RefSeq Acc Id: NM_001033699   ⟹   NP_001028871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,554,811 - 252,571,471 (-)NCBI
mRatBN7.21242,605,588 - 242,622,249 (-)NCBI
Rnor_6.01263,494,850 - 263,511,510 (-)NCBI
Rnor_5.01270,939,907 - 270,956,562 (-)NCBI
RGSC_v3.41247,077,102 - 247,093,757 (+)RGD
Celera1238,424,532 - 238,441,036 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028871 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01930 (Get FASTA)   NCBI Sequence Viewer  
  EDL94260 (Get FASTA)   NCBI Sequence Viewer  
  EDL94261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023215
  ENSRNOP00000023215.3
RefSeq Acc Id: NP_001028871   ⟸   NM_001033699
- UniProtKB: D4A414 (UniProtKB/TrEMBL),   A6JHD6 (UniProtKB/TrEMBL),   I6L9I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023215   ⟸   ENSRNOT00000023215

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A414-F1-model_v2 AlphaFold D4A414 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690928
Promoter ID:EPDNEW_R1452
Type:initiation region
Name:Cox15_1
Description:COX15 cytochrome c oxidase assembly homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,511,511 - 263,511,571EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312043 AgrOrtholog
BioCyc Gene G2FUF-55621 BioCyc
Ensembl Genes ENSRNOG00000017230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023215 ENTREZGENE
  ENSRNOT00000023215.6 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7939237 IMAGE-MGC_LOAD
InterPro Cyt_oxidase_assembly UniProtKB/TrEMBL
  HemeA_Synthase_type2 UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
KEGG Report rno:309391 UniProtKB/TrEMBL
MGC_CLONE MGC:124864 IMAGE-MGC_LOAD
NCBI Gene 309391 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG UniProtKB/TrEMBL
  PTHR23289 UniProtKB/TrEMBL
Pfam COX15-CtaA UniProtKB/TrEMBL
PhenoGen Cox15 PhenoGen
RatGTEx ENSRNOG00000017230 RatGTEx
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6JHD6 ENTREZGENE, UniProtKB/TrEMBL
  A6JHD7_RAT UniProtKB/TrEMBL
  D4A414 ENTREZGENE, UniProtKB/TrEMBL
  I6L9I0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cox15  cytochrome c oxidase assembly homolog COX15  LOC100911779  cytochrome c oxidase assembly protein COX15 homolog  Data merged from RGD:6491000 737654 PROVISIONAL
2018-07-20 Cox15  cytochrome c oxidase assembly homolog COX15  Cox15  COX15 cytochrome c oxidase assembly homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-17 Cox15  COX15 cytochrome c oxidase assembly homolog  Cox15  cytochrome c oxidase assembly homolog 15 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-24 Cox15  cytochrome c oxidase assembly homolog 15 (yeast)  Cox15  COX15 homolog, cytochrome c oxidase assembly protein (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911779  cytochrome c oxidase assembly protein COX15 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Cox15  COX15 homolog, cytochrome c oxidase assembly protein (yeast)  Cox15_predicted  COX15 homolog, cytochrome c oxidase assembly protein (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cox15_predicted  COX15 homolog, cytochrome c oxidase assembly protein (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED