Tcf7l2 (transcription factor 7 like 2) - Rat Genome Database

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Gene: Tcf7l2 (transcription factor 7 like 2) Rattus norvegicus
Analyze
Symbol: Tcf7l2
Name: transcription factor 7 like 2
RGD ID: 1583621
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and armadillo repeat domain binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to localize to several cellular components, including chromatin; nucleus; and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; pancreatic cancer pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17beta-estradiol; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC108348158; LOC679869; similar to transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; uncharacterized LOC108348158
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tcf7l2em1Mcwi  
Genetic Models: SS-Tcf7l2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,785,956 - 254,978,967 (+)NCBI
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
AH23848  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
geraniol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
lithium chloride  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
N,N-dimethylaniline  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
blood vessel development  (ISO)
bone mineralization  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  (ISO)
cellular glucose homeostasis  (ISO)
cellular response to starvation  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic genitalia morphogenesis  (ISO)
embryonic hindgut morphogenesis  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycogen metabolic process  (ISO)
in utero embryonic development  (ISO)
insulin metabolic process  (ISO)
maintenance of DNA repeat elements  (ISO)
multicellular organism growth  (ISO)
myoblast fate commitment  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
neural tube development  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte development  (ISO)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of heparan sulfate proteoglycan biosynthetic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
post-embryonic development  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of gluconeogenesis  (ISO)
regulation of hormone metabolic process  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of myelination  (ISO)
regulation of oligodendrocyte differentiation  (ISO)
regulation of skeletal muscle tissue development  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (ISO)
response to glucose  (ISO)
secretory granule localization  (ISO)
skin development  (ISO)
somatic stem cell population maintenance  (ISO)

Cellular Component

References

References - curated
1. Blackman SM, etal., Diabetologia. 2009 Sep;52(9):1858-65. Epub 2009 Jul 8.
2. Chen CS, etal., Int J Med Sci. 2015 Feb 5;12(3):243-7. doi: 10.7150/ijms.10953. eCollection 2015.
3. Drake I, etal., Prostate. 2014 Sep;74(12):1161-70. doi: 10.1002/pros.22832. Epub 2014 Jun 24.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
6. Lauenborg J, etal., J Clin Endocrinol Metab. 2009 Jan;94(1):145-50. Epub 2008 Nov 4.
7. Ling C, etal., PLoS One. 2015 Jan 24;10(1):e0116753. doi: 10.1371/journal.pone.0116753. eCollection 2015.
8. Liu PH, etal., J Clin Endocrinol Metab. 2009 Jun 9.
9. Luo Y, etal., Diabetes Res Clin Pract. 2009 Aug;85(2):139-46. Epub 2009 May 30.
10. OMIM Disease Annotation Pipeline
11. Pipeline to import KEGG annotations from KEGG into RGD
12. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. RGD automated import pipeline for gene-chemical interactions
14. RGD comprehensive gene curation
15. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
16. Shu L, etal., Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.
17. Wu LS, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3360-6. Epub 2009 Jun 8.
18. Zhou Y, etal., Hum Mol Genet. 2012 Jan 1;21(1):196-207. doi: 10.1093/hmg/ddr454. Epub 2011 Sep 30.
Additional References at PubMed
PMID:9065401   PMID:9065402   PMID:9488439   PMID:9697701   PMID:9727977   PMID:9784592   PMID:9792805   PMID:10027409   PMID:10937998   PMID:12408825   PMID:12408868   PMID:12799378  
PMID:12861022   PMID:12874278   PMID:14661054   PMID:15057272   PMID:15525634   PMID:15578569   PMID:15778706   PMID:15853773   PMID:16007074   PMID:16532032   PMID:16714285   PMID:17072303  
PMID:17122440   PMID:17699607   PMID:17727834   PMID:17919533   PMID:18216022   PMID:18755497   PMID:19168596   PMID:19213727   PMID:19251639   PMID:19443654   PMID:19503085   PMID:19718027  
PMID:19741146   PMID:19920216   PMID:20044351   PMID:20093419   PMID:20128911   PMID:21177349   PMID:21335239   PMID:21901280   PMID:23028378   PMID:23260145   PMID:23824574   PMID:27996060  
PMID:29733821   PMID:31619789   PMID:31805307  


Genomics

Comparative Map Data
Tcf7l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,785,956 - 254,978,967 (+)NCBI
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
TCF7L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10112,950,247 - 113,167,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,950,247 - 113,167,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,710,006 - 114,927,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,700,201 - 114,916,063 (+)NCBINCBI36hg18NCBI36
Build 3410114,700,200 - 114,916,058NCBI
Celera10108,437,726 - 108,655,178 (+)NCBI
Cytogenetic Map10q25.2-q25.3NCBI
HuRef10108,337,509 - 108,554,907 (+)NCBIHuRef
CHM1_110114,992,047 - 115,209,474 (+)NCBICHM1_1
Tcf7l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,730,226 - 55,922,091 (+)NCBIGRCm39mm39
GRCm39 Ensembl1955,730,252 - 55,922,086 (+)Ensembl
GRCm381955,741,797 - 55,933,659 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,741,820 - 55,933,654 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,816,300 - 56,008,145 (+)NCBIGRCm37mm9NCBIm37
MGSCv361955,795,518 - 55,986,492 (+)NCBImm8
Celera1957,933,629 - 58,125,906 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.59NCBI
Tcf7l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543118,020,409 - 18,209,134 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543118,020,309 - 18,207,926 (+)NCBIChiLan1.0ChiLan1.0
TCF7L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110112,991,588 - 113,193,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,978,167 - 113,192,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010109,541,524 - 109,759,499 (+)NCBIMhudiblu_PPA_v0panPan3
TCF7L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,966,079 - 24,162,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,966,073 - 24,163,737 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2824,117,480 - 24,314,328 (+)NCBI
ROS_Cfam_1.02824,497,513 - 24,694,859 (+)NCBI
UMICH_Zoey_3.12824,055,048 - 24,251,831 (+)NCBI
UNSW_CanFamBas_1.02824,062,829 - 24,259,963 (+)NCBI
UU_Cfam_GSD_1.02824,261,768 - 24,459,019 (+)NCBI
Tcf7l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,900,727 - 22,087,420 (-)NCBI
SpeTri2.0NW_0049364863,473,877 - 3,660,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14123,343,694 - 123,546,417 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114123,343,695 - 123,547,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214134,586,288 - 134,790,019 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,828,834 - 106,047,810 (+)NCBI
Vero_WHO_p1.0NW_02366604867,043,029 - 67,262,341 (+)NCBI
Tcf7l2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473733,341,574 - 33,526,814 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1252955158280632620Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1252948438281795785Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1266793821279986079Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1258709726281795785Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat


Genetic Models
This gene Tcf7l2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:193
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000019681, ENSRNOT00000045642
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 40 17 17 10 17 107 40 54 10
Low 1 42 93 65 27 65 16 22 41 30 27 12 16
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ227431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019681   ⟹   ENSRNOP00000019681
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045642   ⟹   ENSRNOP00000050120
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)Ensembl
RefSeq Acc Id: NM_001191052   ⟹   NP_001177981
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,091 - 254,978,967 (+)NCBI
Rnor_6.01276,686,911 - 276,730,517 (+)NCBI
Rnor_5.01283,387,566 - 283,412,364 (-)NCBI
Rnor_5.01284,077,353 - 284,118,928 (+)NCBI
Celera1250,490,882 - 250,683,257 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090214   ⟹   XP_038946142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090215   ⟹   XP_038946143
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090216   ⟹   XP_038946144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090218   ⟹   XP_038946146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090221   ⟹   XP_038946149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090222   ⟹   XP_038946150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090224   ⟹   XP_038946152
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090225   ⟹   XP_038946153
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090226   ⟹   XP_038946154
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090227   ⟹   XP_038946155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090232   ⟹   XP_038946160
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090241   ⟹   XP_038946169
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090252   ⟹   XP_038946180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090263   ⟹   XP_038946191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090268   ⟹   XP_038946196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090271   ⟹   XP_038946199
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090276   ⟹   XP_038946204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090279   ⟹   XP_038946207
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090283   ⟹   XP_038946211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090286   ⟹   XP_038946214
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090292   ⟹   XP_038946220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090297   ⟹   XP_038946225
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090300   ⟹   XP_038946228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090305   ⟹   XP_038946233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090306   ⟹   XP_038946234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090315   ⟹   XP_038946243
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,972,077 (+)NCBI
RefSeq Acc Id: XM_039090317   ⟹   XP_038946245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,932 (+)NCBI
RefSeq Acc Id: XM_039090320   ⟹   XP_038946248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,973,118 (+)NCBI
RefSeq Acc Id: XM_039090324   ⟹   XP_038946252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090331   ⟹   XP_038946259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090335   ⟹   XP_038946263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090339   ⟹   XP_038946267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,932 (+)NCBI
RefSeq Acc Id: XM_039090344   ⟹   XP_038946272
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090346   ⟹   XP_038946274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090352   ⟹   XP_038946280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090360   ⟹   XP_038946288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090365   ⟹   XP_038946293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,944,392 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090370   ⟹   XP_038946298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090375   ⟹   XP_038946303
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090377   ⟹   XP_038946305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090379   ⟹   XP_038946307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090384   ⟹   XP_038946312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090388   ⟹   XP_038946316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090393   ⟹   XP_038946321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090397   ⟹   XP_038946325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090403   ⟹   XP_038946331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090409   ⟹   XP_038946337
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090415   ⟹   XP_038946343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,785,956 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090417   ⟹   XP_038946345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XR_005492199
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,786,519 - 254,977,141 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177981 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946142 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946143 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946144 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946146 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946149 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946150 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946152 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946153 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946154 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946155 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946169 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946180 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946191 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946199 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946204 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946211 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946214 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946220 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946243 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946245 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946248 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946252 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946259 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946263 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946267 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946272 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946274 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946280 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946288 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946293 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946298 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946303 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946305 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946307 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946312 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946316 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946321 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946325 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946331 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946337 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946343 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946345 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001177981   ⟸   NM_001191052
- Sequence:
RefSeq Acc Id: ENSRNOP00000050120   ⟸   ENSRNOT00000045642
RefSeq Acc Id: ENSRNOP00000019681   ⟸   ENSRNOT00000019681
RefSeq Acc Id: XP_038946343   ⟸   XM_039090415
- Peptide Label: isoform X46
RefSeq Acc Id: XP_038946155   ⟸   XM_039090227
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038946142   ⟸   XM_039090214
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946152   ⟸   XM_039090224
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038946150   ⟸   XM_039090222
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946263   ⟸   XM_039090335
- Peptide Label: isoform X29
RefSeq Acc Id: XP_038946146   ⟸   XM_039090218
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946144   ⟸   XM_039090216
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946149   ⟸   XM_039090221
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946143   ⟸   XM_039090215
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946160   ⟸   XM_039090232
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038946196   ⟸   XM_039090268
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038946305   ⟸   XM_039090377
- Peptide Label: isoform X38
RefSeq Acc Id: XP_038946180   ⟸   XM_039090252
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038946204   ⟸   XM_039090276
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038946199   ⟸   XM_039090271
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038946307   ⟸   XM_039090379
- Peptide Label: isoform X39
RefSeq Acc Id: XP_038946169   ⟸   XM_039090241
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038946274   ⟸   XM_039090346
- Peptide Label: isoform X32
RefSeq Acc Id: XP_038946191   ⟸   XM_039090263
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038946316   ⟸   XM_039090388
- Peptide Label: isoform X41
RefSeq Acc Id: XP_038946153   ⟸   XM_039090225
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946154   ⟸   XM_039090226
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038946272   ⟸   XM_039090344
- Peptide Label: isoform X31
RefSeq Acc Id: XP_038946207   ⟸   XM_039090279
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038946220   ⟸   XM_039090292
- Peptide Label: isoform X21
RefSeq Acc Id: XP_038946337   ⟸   XM_039090409
- Peptide Label: isoform X45
RefSeq Acc Id: XP_038946211   ⟸   XM_039090283
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038946228   ⟸   XM_039090300
- Peptide Label: isoform X23
RefSeq Acc Id: XP_038946225   ⟸   XM_039090297
- Peptide Label: isoform X22
RefSeq Acc Id: XP_038946214   ⟸   XM_039090286
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038946233   ⟸   XM_039090305
- Peptide Label: isoform X24
RefSeq Acc Id: XP_038946345   ⟸   XM_039090417
- Peptide Label: isoform X47
RefSeq Acc Id: XP_038946252   ⟸   XM_039090324
- Peptide Label: isoform X27
RefSeq Acc Id: XP_038946280   ⟸   XM_039090352
- Peptide Label: isoform X33
RefSeq Acc Id: XP_038946288   ⟸   XM_039090360
- Peptide Label: isoform X34
RefSeq Acc Id: XP_038946312   ⟸   XM_039090384
- Peptide Label: isoform X40
RefSeq Acc Id: XP_038946321   ⟸   XM_039090393
- Peptide Label: isoform X42
RefSeq Acc Id: XP_038946325   ⟸   XM_039090397
- Peptide Label: isoform X43
RefSeq Acc Id: XP_038946245   ⟸   XM_039090317
- Peptide Label: isoform X26
RefSeq Acc Id: XP_038946267   ⟸   XM_039090339
- Peptide Label: isoform X30
RefSeq Acc Id: XP_038946234   ⟸   XM_039090306
- Peptide Label: isoform X25
RefSeq Acc Id: XP_038946259   ⟸   XM_039090331
- Peptide Label: isoform X28
RefSeq Acc Id: XP_038946298   ⟸   XM_039090370
- Peptide Label: isoform X36
RefSeq Acc Id: XP_038946303   ⟸   XM_039090375
- Peptide Label: isoform X37
RefSeq Acc Id: XP_038946331   ⟸   XM_039090403
- Peptide Label: isoform X44
RefSeq Acc Id: XP_038946248   ⟸   XM_039090320
- Peptide Label: isoform X26
RefSeq Acc Id: XP_038946243   ⟸   XM_039090315
- Peptide Label: isoform X25
RefSeq Acc Id: XP_038946293   ⟸   XM_039090365
- Peptide Label: isoform X35
Protein Domains
CTNNB1_binding   HMG box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583621 AgrOrtholog
Ensembl Genes ENSRNOG00000013993 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049232 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019681 UniProtKB/TrEMBL
  ENSRNOP00000050120 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019681 UniProtKB/TrEMBL
  ENSRNOT00000045642 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
NCBI Gene 679869 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PhenoGen Tcf7l2 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt D3Z9D1_RAT UniProtKB/TrEMBL
  D4A8X6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tcf7l2  transcription factor 7 like 2  LOC108348158  uncharacterized LOC108348158  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108348158  uncharacterized LOC108348158      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-08-12 Tcf7l2  transcription factor 7-like 2 (T-cell specific, HMG-box)  LOC679869  similar to transcription factor 7-like 2, T-cell specific, HMG-box  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679869  similar to transcription factor 7-like 2, T-cell specific, HMG-box      Symbol and Name status set to provisional 70820 PROVISIONAL