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Gene: Tcf7l2 (transcription factor 7 like 2) Rattus norvegicus
Symbol: Tcf7l2
Name: transcription factor 7 like 2
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and armadillo repeat domain binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleus; and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; pancreatic cancer pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17beta-estradiol; bisphenol A; cobalt dichloride.
Type: protein-coding
Also known as: LOC679869; similar to transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box
Homo sapiens (human) : TCF7L2 (transcription factor 7 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf7l2 (transcription factor 7 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF7L2 (transcription factor 7 like 2)
Canis lupus familiaris (dog) : TCF7L2 (transcription factor 7 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf7l2 (transcription factor 7 like 2)
Sus scrofa (pig) : TCF7L2 (transcription factor 7 like 2)
Chlorocebus sabaeus (African green monkey) : TCF7L2 (transcription factor 7 like 2)
Heterocephalus glaber (naked mole-rat) : Tcf7l2 (transcription factor 7 like 2)
more info ...
Allele / Splice: Tcf7l2em1Mcwi  
Genetic Models: SS-Tcf7l2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tcf7l2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1583621
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.