Tcf7l2 (transcription factor 7 like 2) - Rat Genome Database

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Gene: Tcf7l2 (transcription factor 7 like 2) Rattus norvegicus
Analyze
Symbol: Tcf7l2
Name: transcription factor 7 like 2
RGD ID: 1583621
Description: Enables promoter-specific chromatin binding activity. Involved in negative regulation of apoptotic process; negative regulation of gluconeogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and chromatin. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; pancreatic cancer pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC108348158; LOC679869; similar to transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; uncharacterized LOC108348158
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tcf7l2em1Mcwi  
Genetic Models: SS-Tcf7l2em1Mcwi SS-Tcf7l2em1Mcwi-/+ SS-Tcf7l2em1Mcwi-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,791,335 - 264,984,225 (+)NCBIGRCr8
mRatBN7.21254,785,956 - 254,978,967 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,786,091 - 254,978,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1262,991,450 - 263,184,389 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,697,531 - 269,890,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01262,346,051 - 262,538,954 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lithium chloride  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
Morroniside  (EXP)
N,N-dimethylaniline  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (ISO)
BMP signaling pathway  (ISO)
bone mineralization  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cellular response to starvation  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic genitalia morphogenesis  (ISO)
embryonic hindgut morphogenesis  (ISO)
epithelial cell proliferation  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycogen metabolic process  (ISO)
in utero embryonic development  (ISO)
insulin metabolic process  (ISO)
intracellular glucose homeostasis  (ISO)
maintenance of DNA repeat elements  (ISO)
multicellular organism growth  (ISO)
myoblast fate commitment  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gluconeogenesis  (IMP)
negative regulation of organ growth  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
neural tube development  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte development  (ISO)
organ growth  (ISO)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of heparan sulfate proteoglycan biosynthetic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
post-embryonic development  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of hormone metabolic process  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of myelination  (ISO)
regulation of oligodendrocyte differentiation  (ISO)
regulation of skeletal muscle tissue development  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to glucose  (ISO)
secretory granule localization  (ISO)
skin development  (ISO)
somatic stem cell population maintenance  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis. Blackman SM, etal., Diabetologia. 2009 Sep;52(9):1858-65. Epub 2009 Jul 8.
2. Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in localized prostate cancer. Chen CS, etal., Int J Med Sci. 2015 Feb 5;12(3):243-7. doi: 10.7150/ijms.10953. eCollection 2015.
3. TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer. Drake I, etal., Prostate. 2014 Sep;74(12):1161-70. doi: 10.1002/pros.22832. Epub 2014 Jun 24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
6. Common type 2 diabetes risk gene variants associate with gestational diabetes. Lauenborg J, etal., J Clin Endocrinol Metab. 2009 Jan;94(1):145-50. Epub 2008 Nov 4.
7. A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. Ling C, etal., PLoS One. 2015 Jan 24;10(1):e0116753. doi: 10.1371/journal.pone.0116753. eCollection 2015.
8. Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults. Liu PH, etal., J Clin Endocrinol Metab. 2009 Jun 9.
9. Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population. Luo Y, etal., Diabetes Res Clin Pract. 2009 Aug;85(2):139-46. Epub 2009 May 30.
10. Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism. Norton L, etal., Diabetologia. 2011 Dec;54(12):3132-42. doi: 10.1007/s00125-011-2289-z. Epub 2011 Sep 7.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
17. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Shu L, etal., Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.
18. Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population. Wei W, etal., Genet Mol Res. 2013 Dec 4;12(4):6268-74. doi: 10.4238/2013.December.4.14.
19. Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes. Wu LS, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3360-6. Epub 2009 Jun 8.
20. Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway. Zhou Y, etal., Hum Mol Genet. 2012 Jan 1;21(1):196-207. doi: 10.1093/hmg/ddr454. Epub 2011 Sep 30.
Additional References at PubMed
PMID:9065401   PMID:9065402   PMID:9488439   PMID:9697701   PMID:9727977   PMID:9784592   PMID:9792805   PMID:10027409   PMID:10937998   PMID:12408825   PMID:12408868   PMID:12799378  
PMID:12861022   PMID:12874278   PMID:14661054   PMID:15057272   PMID:15525634   PMID:15578569   PMID:15778706   PMID:15853773   PMID:16007074   PMID:16532032   PMID:16714285   PMID:17072303  
PMID:17122440   PMID:17699607   PMID:17727834   PMID:17919533   PMID:18216022   PMID:18755497   PMID:19168596   PMID:19213727   PMID:19251639   PMID:19443654   PMID:19503085   PMID:19718027  
PMID:19741146   PMID:19920216   PMID:20044351   PMID:20093419   PMID:20128911   PMID:21177349   PMID:21335239   PMID:23028378   PMID:23260145   PMID:23824574   PMID:27996060   PMID:29733821  
PMID:31619789   PMID:31805307   PMID:36060928  


Genomics

Comparative Map Data
Tcf7l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,791,335 - 264,984,225 (+)NCBIGRCr8
mRatBN7.21254,785,956 - 254,978,967 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,786,091 - 254,978,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1262,991,450 - 263,184,389 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,697,531 - 269,890,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01262,346,051 - 262,538,954 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
TCF7L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,950,247 - 113,167,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10112,950,247 - 113,167,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3710114,710,006 - 114,927,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,700,201 - 114,916,063 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410114,700,200 - 114,916,058NCBI
Celera10108,437,726 - 108,655,178 (+)NCBICelera
Cytogenetic Map10q25.2-q25.3NCBI
HuRef10108,337,509 - 108,554,907 (+)NCBIHuRef
CHM1_110114,992,047 - 115,209,474 (+)NCBICHM1_1
T2T-CHM13v2.010113,841,538 - 114,058,955 (+)NCBIT2T-CHM13v2.0
Tcf7l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,730,227 - 55,922,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1955,730,252 - 55,922,086 (+)EnsemblGRCm39 Ensembl
GRCm381955,741,797 - 55,933,659 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,741,820 - 55,933,654 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,816,300 - 56,008,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361955,795,518 - 55,986,492 (+)NCBIMGSCv36mm8
Celera1957,933,629 - 58,125,906 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.59NCBI
Tcf7l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543118,020,409 - 18,209,134 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543118,020,309 - 18,207,926 (+)NCBIChiLan1.0ChiLan1.0
TCF7L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28124,826,392 - 125,043,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110124,831,339 - 125,049,334 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010109,541,524 - 109,759,499 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110112,991,588 - 113,193,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,978,167 - 113,192,281 (+)Ensemblpanpan1.1panPan2
TCF7L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,966,079 - 24,162,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,966,073 - 24,163,737 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2824,117,480 - 24,314,328 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02824,497,513 - 24,694,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2824,497,021 - 24,735,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12824,055,048 - 24,251,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02824,062,829 - 24,259,963 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02824,261,768 - 24,459,019 (+)NCBIUU_Cfam_GSD_1.0
Tcf7l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,900,727 - 22,087,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364863,473,843 - 3,660,576 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364863,473,877 - 3,660,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14123,343,412 - 123,546,417 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114123,343,695 - 123,547,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214134,586,288 - 134,790,019 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,828,834 - 106,047,810 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604867,043,029 - 67,262,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473733,341,029 - 33,526,928 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473733,341,574 - 33,526,814 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcf7l2
478 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:193
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000019681, ENSRNOT00000045642
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat


Genetic Models
This gene Tcf7l2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 40 17 17 10 17 107 40 54 10
Low 1 42 93 65 27 65 16 22 41 30 27 12 16
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ227431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000019681   ⟹   ENSRNOP00000019681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,941,443 - 254,978,925 (+)Ensembl
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045642   ⟹   ENSRNOP00000050120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,786,558 - 254,977,218 (+)Ensembl
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096775   ⟹   ENSRNOP00000095963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,786,091 - 254,978,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097397   ⟹   ENSRNOP00000092403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,786,091 - 254,978,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100362   ⟹   ENSRNOP00000087697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,786,091 - 254,978,967 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101679   ⟹   ENSRNOP00000086842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,786,500 - 254,978,952 (+)Ensembl
RefSeq Acc Id: NM_001415805   ⟹   NP_001402734
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,335 - 264,984,225 (+)NCBI
mRatBN7.21254,786,048 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090214   ⟹   XP_038946142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090215   ⟹   XP_038946143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090216   ⟹   XP_038946144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090218   ⟹   XP_038946146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090221   ⟹   XP_038946149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090226   ⟹   XP_038946154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090232   ⟹   XP_038946160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090241   ⟹   XP_038946169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090263   ⟹   XP_038946191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090268   ⟹   XP_038946196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090271   ⟹   XP_038946199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090276   ⟹   XP_038946204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090279   ⟹   XP_038946207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090283   ⟹   XP_038946211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090286   ⟹   XP_038946214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090292   ⟹   XP_038946220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090297   ⟹   XP_038946225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090300   ⟹   XP_038946228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090305   ⟹   XP_038946233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090306   ⟹   XP_038946234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,129 (+)NCBI
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090317   ⟹   XP_038946245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,177 (+)NCBI
mRatBN7.21254,786,519 - 254,976,932 (+)NCBI
RefSeq Acc Id: XM_039090344   ⟹   XP_038946272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090352   ⟹   XP_038946280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090360   ⟹   XP_038946288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090370   ⟹   XP_038946298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,129 (+)NCBI
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090375   ⟹   XP_038946303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,129 (+)NCBI
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090377   ⟹   XP_038946305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090379   ⟹   XP_038946307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090384   ⟹   XP_038946312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090388   ⟹   XP_038946316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090393   ⟹   XP_038946321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090397   ⟹   XP_038946325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,977,170 (+)NCBI
RefSeq Acc Id: XM_039090403   ⟹   XP_038946331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,129 (+)NCBI
mRatBN7.21254,786,519 - 254,976,931 (+)NCBI
RefSeq Acc Id: XM_039090409   ⟹   XP_038946337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090415   ⟹   XP_038946343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,785,956 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_039090417   ⟹   XP_038946345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
mRatBN7.21254,786,519 - 254,978,967 (+)NCBI
RefSeq Acc Id: XM_063273365   ⟹   XP_063129435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273382   ⟹   XP_063129452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273389   ⟹   XP_063129459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273402   ⟹   XP_063129472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273415   ⟹   XP_063129485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273417   ⟹   XP_063129487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273435   ⟹   XP_063129505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273448   ⟹   XP_063129518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,978,377 (+)NCBI
RefSeq Acc Id: XM_063273456   ⟹   XP_063129526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,177 (+)NCBI
RefSeq Acc Id: XM_063273458   ⟹   XP_063129528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XM_063273461   ⟹   XP_063129531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,129 (+)NCBI
RefSeq Acc Id: XM_063273464   ⟹   XP_063129534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,984,225 (+)NCBI
RefSeq Acc Id: XR_005492199
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,791,850 - 264,982,164 (+)NCBI
mRatBN7.21254,786,519 - 254,977,141 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001402734 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946142 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946143 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946144 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946146 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946149 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946154 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946169 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946191 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946199 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946204 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946211 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946214 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946220 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946245 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946272 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946280 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946288 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946298 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946303 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946305 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946307 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946312 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946316 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946321 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946325 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946331 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946337 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946343 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946345 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129435 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129452 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129459 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129472 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129485 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129487 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129505 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129518 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129526 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129528 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129531 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019681.7
  ENSRNOP00000050120
  ENSRNOP00000050120.5
  ENSRNOP00000086842
  ENSRNOP00000086842.1
  ENSRNOP00000087697.1
  ENSRNOP00000092403
  ENSRNOP00000092403.1
  ENSRNOP00000095963
  ENSRNOP00000095963.1
RefSeq Acc Id: ENSRNOP00000050120   ⟸   ENSRNOT00000045642
RefSeq Acc Id: ENSRNOP00000019681   ⟸   ENSRNOT00000019681
RefSeq Acc Id: XP_038946343   ⟸   XM_039090415
- Peptide Label: isoform X46
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946142   ⟸   XM_039090214
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946146   ⟸   XM_039090218
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946144   ⟸   XM_039090216
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946149   ⟸   XM_039090221
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946143   ⟸   XM_039090215
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946160   ⟸   XM_039090232
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946196   ⟸   XM_039090268
- Peptide Label: isoform X13
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946305   ⟸   XM_039090377
- Peptide Label: isoform X38
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946204   ⟸   XM_039090276
- Peptide Label: isoform X16
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946199   ⟸   XM_039090271
- Peptide Label: isoform X15
- UniProtKB: A0A8I6AGH1 (UniProtKB/TrEMBL),   A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946307   ⟸   XM_039090379
- Peptide Label: isoform X39
- UniProtKB: A0A8I6A761 (UniProtKB/TrEMBL),   A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946169   ⟸   XM_039090241
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946191   ⟸   XM_039090263
- Peptide Label: isoform X12
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946316   ⟸   XM_039090388
- Peptide Label: isoform X41
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946154   ⟸   XM_039090226
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946272   ⟸   XM_039090344
- Peptide Label: isoform X32
RefSeq Acc Id: XP_038946207   ⟸   XM_039090279
- Peptide Label: isoform X17
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946220   ⟸   XM_039090292
- Peptide Label: isoform X22
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946337   ⟸   XM_039090409
- Peptide Label: isoform X45
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946211   ⟸   XM_039090283
- Peptide Label: isoform X20
- UniProtKB: D3Z9D1 (UniProtKB/TrEMBL),   A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946228   ⟸   XM_039090300
- Peptide Label: isoform X25
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946225   ⟸   XM_039090297
- Peptide Label: isoform X24
- UniProtKB: A0A8I6ARM6 (UniProtKB/TrEMBL),   A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946214   ⟸   XM_039090286
- Peptide Label: isoform X21
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946233   ⟸   XM_039090305
- Peptide Label: isoform X26
- UniProtKB: A0A8I6A9A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946345   ⟸   XM_039090417
- Peptide Label: isoform X47
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946280   ⟸   XM_039090352
- Peptide Label: isoform X34
RefSeq Acc Id: XP_038946288   ⟸   XM_039090360
- Peptide Label: isoform X35
RefSeq Acc Id: XP_038946312   ⟸   XM_039090384
- Peptide Label: isoform X40
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946321   ⟸   XM_039090393
- Peptide Label: isoform X42
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946325   ⟸   XM_039090397
- Peptide Label: isoform X43
- UniProtKB: A6JI05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946245   ⟸   XM_039090317
- Peptide Label: isoform X28
RefSeq Acc Id: XP_038946234   ⟸   XM_039090306
- Peptide Label: isoform X27
RefSeq Acc Id: XP_038946298   ⟸   XM_039090370
- Peptide Label: isoform X36
RefSeq Acc Id: XP_038946303   ⟸   XM_039090375
- Peptide Label: isoform X37
RefSeq Acc Id: XP_038946331   ⟸   XM_039090403
- Peptide Label: isoform X44
RefSeq Acc Id: ENSRNOP00000095963   ⟸   ENSRNOT00000096775
RefSeq Acc Id: ENSRNOP00000086842   ⟸   ENSRNOT00000101679
RefSeq Acc Id: ENSRNOP00000092403   ⟸   ENSRNOT00000097397
RefSeq Acc Id: ENSRNOP00000087697   ⟸   ENSRNOT00000100362
RefSeq Acc Id: NP_001402734   ⟸   NM_001415805
RefSeq Acc Id: XP_063129435   ⟸   XM_063273365
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063129452   ⟸   XM_063273382
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063129534   ⟸   XM_063273464
- Peptide Label: isoform X33
RefSeq Acc Id: XP_063129472   ⟸   XM_063273402
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063129485   ⟸   XM_063273415
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063129459   ⟸   XM_063273389
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063129528   ⟸   XM_063273458
- Peptide Label: isoform X30
RefSeq Acc Id: XP_063129505   ⟸   XM_063273435
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063129487   ⟸   XM_063273417
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063129526   ⟸   XM_063273456
- Peptide Label: isoform X29
RefSeq Acc Id: XP_063129531   ⟸   XM_063273461
- Peptide Label: isoform X31
RefSeq Acc Id: XP_063129518   ⟸   XM_063273448
- Peptide Label: isoform X27
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9D1-F1-model_v2 AlphaFold D3Z9D1 1-155 view protein structure
AF-D4A8X6-F1-model_v2 AlphaFold D4A8X6 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583621 AgrOrtholog
BioCyc Gene G2FUF-55340 BioCyc
Ensembl Genes ENSRNOG00000013993 Ensembl
  ENSRNOG00000049232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019681.7 UniProtKB/TrEMBL
  ENSRNOT00000045642.5 UniProtKB/TrEMBL
  ENSRNOT00000096775.1 UniProtKB/TrEMBL
  ENSRNOT00000097397.1 UniProtKB/TrEMBL
  ENSRNOT00000100362.1 UniProtKB/TrEMBL
  ENSRNOT00000101679.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
NCBI Gene 679869 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR 7-LIKE 2 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PhenoGen Tcf7l2 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013993 RatGTEx
  ENSRNOG00000049232 RatGTEx
SMART c-clamp UniProtKB/TrEMBL
  HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A8I6A761 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9A2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARM6 ENTREZGENE, UniProtKB/TrEMBL
  A6JI04_RAT UniProtKB/TrEMBL
  A6JI05 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9D1 ENTREZGENE, UniProtKB/TrEMBL
  D4A8X6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tcf7l2  transcription factor 7 like 2  LOC108348158  uncharacterized LOC108348158  Data merged from RGD:11426686 737654 PROVISIONAL
2016-08-02 LOC108348158  uncharacterized LOC108348158      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-08-12 Tcf7l2  transcription factor 7-like 2 (T-cell specific, HMG-box)  LOC679869  similar to transcription factor 7-like 2, T-cell specific, HMG-box  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679869  similar to transcription factor 7-like 2, T-cell specific, HMG-box      Symbol and Name status set to provisional 70820 PROVISIONAL