GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tcf7l2 | decreases expression | ISO | Tcf7l2 (Mus musculus) | 6480464 | CTD | Fluorouracil results in decreased expression of TCF7L2 mRNA; Fluorouracil results in decreased expression of TCF7L2 protein | PMID:25178657 | Tcf7l2 | multiple interactions | ISO | TCF7L2 (Homo sapiens) | 6480464 | CTD | TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] | PMID:18678097 | Tcf7l2 | multiple interactions | ISO | Tcf7l2 (Mus musculus) | 6480464 | CTD | [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]; [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]; Fluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC1 protein]; Fluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC2 protein]; TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]; TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA] | PMID:25178657 | |
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