TCF7L2 (transcription factor 7 like 2) - Rat Genome Database
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Gene: TCF7L2 (transcription factor 7 like 2) Homo sapiens
Analyze
Symbol: TCF7L2
Name: transcription factor 7 like 2
RGD ID: 1317786
HGNC Page HGNC
Description: Exhibits several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of protein transport; regulation of cellular macromolecule biosynthetic process; and regulation of signal transduction. Localizes to chromatin; nucleus; and protein-DNA complex. Implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HMG box transcription factor 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-4; TCF4; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10112,950,247 - 113,167,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,950,247 - 113,167,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,710,006 - 114,927,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,700,201 - 114,916,063 (+)NCBINCBI36hg18NCBI36
Build 3410114,700,200 - 114,916,058NCBI
Celera10108,437,726 - 108,655,178 (+)NCBI
Cytogenetic Map10q25.2-q25.3NCBI
HuRef10108,337,509 - 108,554,907 (+)NCBIHuRef
CHM1_110114,992,047 - 115,209,474 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP,ISO)
acrolein  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
AH23848  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
capecitabine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP)
diarsenic trioxide  (EXP)
diclofenac  (EXP)
dicrotophos  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
geraniol  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
lithium chloride  (ISO)
menadione  (EXP)
methapyrilene  (ISO)
N,N-dimethylaniline  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
testosterone  (ISO)
tetraphene  (ISO)
toluene  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
beta-catenin-TCF complex assembly  (TAS)
blood vessel development  (IMP)
bone mineralization  (ISO)
canonical Wnt signaling pathway  (IBA,IC,ISO)
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  (IMP)
cell cycle arrest  (IMP)
cellular glucose homeostasis  (ISO)
cellular response to starvation  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic genitalia morphogenesis  (ISO)
embryonic hindgut morphogenesis  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (IDA)
glucose homeostasis  (IDA,ISO)
glucose metabolic process  (ISO)
glycogen metabolic process  (ISO)
in utero embryonic development  (ISO)
insulin metabolic process  (ISO)
maintenance of DNA repeat elements  (IMP)
multicellular organism growth  (ISO)
myoblast fate commitment  (IDA,ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription, DNA-templated  (IDA,IMP)
negative regulation of type B pancreatic cell apoptotic process  (ISO,ISS)
neural tube development  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte development  (ISO)
pancreas development  (TAS)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of epithelial cell proliferation  (IMP,ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of heparan sulfate proteoglycan biosynthetic process  (IMP)
positive regulation of insulin secretion  (IMP,ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of protein binding  (IDA)
positive regulation of protein export from nucleus  (IMP)
positive regulation of protein kinase B signaling  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
post-embryonic development  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of hormone metabolic process  (IDA)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of myelination  (ISO)
regulation of oligodendrocyte differentiation  (ISO)
regulation of skeletal muscle tissue development  (ISO)
regulation of smooth muscle cell proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
regulation of transcription initiation from RNA polymerase II promoter  (TAS)
regulation of transcription, DNA-templated  (ISO)
response to glucose  (ISO,ISS)
secretory granule localization  (ISO)
skin development  (ISO)
somatic stem cell population maintenance  (ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway, calcium modulating pathway  (TAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1741298   PMID:8125298   PMID:8889548   PMID:9065401   PMID:9065402   PMID:9727977   PMID:9916915   PMID:10080941   PMID:10694436   PMID:10828605   PMID:10919662   PMID:10937998  
PMID:11266540   PMID:11500377   PMID:11504726   PMID:11528255   PMID:11711551   PMID:11713475   PMID:11713476   PMID:11739494   PMID:11931652   PMID:11940574   PMID:11980438   PMID:12086873  
PMID:12368361   PMID:12378619   PMID:12408825   PMID:12408868   PMID:12417018   PMID:12446687   PMID:12477932   PMID:12556497   PMID:12711682   PMID:12727872   PMID:12799378   PMID:12861022  
PMID:14661054   PMID:15040893   PMID:15294866   PMID:15331612   PMID:15377999   PMID:15489334   PMID:15514942   PMID:15525529   PMID:15525634   PMID:15578569   PMID:15591320   PMID:15670774  
PMID:15684397   PMID:15806138   PMID:15853773   PMID:15905022   PMID:16007074   PMID:16204248   PMID:16230076   PMID:16291872   PMID:16311123   PMID:16344560   PMID:16385451   PMID:16415884  
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PMID:18498634   PMID:18516622   PMID:18519685   PMID:18541996   PMID:18546086   PMID:18555673   PMID:18591388   PMID:18597214   PMID:18598350   PMID:18599616   PMID:18611970   PMID:18621708  
PMID:18650481   PMID:18655717   PMID:18689695   PMID:18694974   PMID:18702948   PMID:18706099   PMID:18712344   PMID:18719881   PMID:18755497   PMID:18762805   PMID:18772112   PMID:18799618  
PMID:18806947   PMID:18823720   PMID:18839133   PMID:18853134   PMID:18931037   PMID:18958766   PMID:18972257   PMID:18992165   PMID:18992263   PMID:18996470   PMID:19002430   PMID:19012045  
PMID:19020323   PMID:19020324   PMID:19033397   PMID:19050058   PMID:19053027   PMID:19055834   PMID:19056611   PMID:19057525   PMID:19074834   PMID:19082521   PMID:19105201   PMID:19124064  
PMID:19131553   PMID:19139842   PMID:19141695   PMID:19141698   PMID:19149908   PMID:19156536   PMID:19168596   PMID:19169495   PMID:19172244   PMID:19183934   PMID:19202075   PMID:19211816  
PMID:19221600   PMID:19225753   PMID:19228405   PMID:19247372   PMID:19247628   PMID:19252133   PMID:19258404   PMID:19258437   PMID:19267370   PMID:19269971   PMID:19274049   PMID:19279076  
PMID:19286335   PMID:19288077   PMID:19304756   PMID:19322201   PMID:19324937   PMID:19351735   PMID:19368707   PMID:19380854   PMID:19401414   PMID:19443654   PMID:19473183   PMID:19497595  
PMID:19502414   PMID:19533015   PMID:19563778   PMID:19573884   PMID:19592620   PMID:19602480   PMID:19602701   PMID:19615048   PMID:19636253   PMID:19643578   PMID:19679347   PMID:19713311  
PMID:19718565   PMID:19720844   PMID:19732438   PMID:19734900   PMID:19741467   PMID:19760027   PMID:19778269   PMID:19789636   PMID:19794065   PMID:19806338   PMID:19808892   PMID:19816403  
PMID:19825152   PMID:19833889   PMID:19864407   PMID:19876004   PMID:19885641   PMID:19895682   PMID:19913121   PMID:19924244   PMID:19924301   PMID:19933996   PMID:19934000   PMID:19948975  
PMID:20027603   PMID:20028944   PMID:20032493   PMID:20033802   PMID:20041287   PMID:20043145   PMID:20054294   PMID:20075150   PMID:20081857   PMID:20081858   PMID:20092643   PMID:20095040  
PMID:20097709   PMID:20107109   PMID:20118932   PMID:20122174   PMID:20126258   PMID:20128911   PMID:20141612   PMID:20142250   PMID:20161779   PMID:20185807   PMID:20203524   PMID:20215779  
PMID:20219685   PMID:20299486   PMID:20361036   PMID:20372961   PMID:20379614   PMID:20384434   PMID:20424228   PMID:20437825   PMID:20459822   PMID:20478041   PMID:20485196   PMID:20490451  
PMID:20503258   PMID:20508220   PMID:20532534   PMID:20540670   PMID:20546291   PMID:20550665   PMID:20571754   PMID:20578204   PMID:20581827   PMID:20597906   PMID:20602615   PMID:20616309  
PMID:20628086   PMID:20640398   PMID:20648057   PMID:20654575   PMID:20682688   PMID:20694148   PMID:20696899   PMID:20705583   PMID:20712903   PMID:20739273   PMID:20798759   PMID:20802253  
PMID:20816152   PMID:20849430   PMID:20873210   PMID:20878273   PMID:20879858   PMID:20889853   PMID:20923526   PMID:20929593   PMID:20957343   PMID:20967696   PMID:20980453   PMID:21109996  
PMID:21115178   PMID:21150882   PMID:21159844   PMID:21256126   PMID:21282610   PMID:21285352   PMID:21292023   PMID:21301999   PMID:21347282   PMID:21357677   PMID:21383188   PMID:21384500  
PMID:21388956   PMID:21414605   PMID:21423583   PMID:21436631   PMID:21441570   PMID:21454679   PMID:21510814   PMID:21543200   PMID:21595284   PMID:21599871   PMID:21636708   PMID:21641671  
PMID:21670201   PMID:21673050   PMID:21678030   PMID:21707949   PMID:21720709   PMID:21764279   PMID:21772333   PMID:21814547   PMID:21855162   PMID:21856776   PMID:21857094   PMID:21873549  
PMID:21873635   PMID:21892161   PMID:21913056   PMID:21921652   PMID:21956205   PMID:21983179   PMID:21988832   PMID:22014570   PMID:22016394   PMID:22022540   PMID:22056988   PMID:22101970  
PMID:22109281   PMID:22109522   PMID:22136959   PMID:22155184   PMID:22156527   PMID:22157225   PMID:22231735   PMID:22232078   PMID:22245614   PMID:22247771   PMID:22258766   PMID:22275441  
PMID:22296403   PMID:22301903   PMID:22304967   PMID:22318732   PMID:22355027   PMID:22402060   PMID:22441719   PMID:22443257   PMID:22480428   PMID:22487833   PMID:22524208   PMID:22552033  
PMID:22558147   PMID:22581228   PMID:22583123   PMID:22591707   PMID:22674979   PMID:22693455   PMID:22699938   PMID:22712642   PMID:22766303   PMID:22768190   PMID:22782288   PMID:22805760  
PMID:22843023   PMID:22862926   PMID:22885420   PMID:22911383   PMID:22916254   PMID:22923468   PMID:22942101   PMID:22945304   PMID:22951069   PMID:22967502   PMID:23010200   PMID:23011354  
PMID:23014255   PMID:23029137   PMID:23030478   PMID:23034957   PMID:23041303   PMID:23050589   PMID:23085767   PMID:23086040   PMID:23107111   PMID:23142382   PMID:23144361   PMID:23152614  
PMID:23188737   PMID:23193183   PMID:23209189   PMID:23224985   PMID:23295285   PMID:23295773   PMID:23300278   PMID:23306204   PMID:23311683   PMID:23349771   PMID:23395167   PMID:23395904  
PMID:23434931   PMID:23437103   PMID:23504200   PMID:23527206   PMID:23535729   PMID:23536853   PMID:23544013   PMID:23558246   PMID:23577093   PMID:23579632   PMID:23603903   PMID:23613959  
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PMID:27301468   PMID:27310578   PMID:27323175   PMID:27430592   PMID:27465520   PMID:27480250   PMID:27504909   PMID:27605886   PMID:27639123   PMID:27684187   PMID:27706609   PMID:27738320  
PMID:27755946   PMID:27792933   PMID:27793664   PMID:27801786   PMID:27902311   PMID:27929407   PMID:27958632   PMID:27998387   PMID:28002648   PMID:28039460   PMID:28101933   PMID:28117551  
PMID:28183453   PMID:28192407   PMID:28220878   PMID:28253288   PMID:28254843   PMID:28263491   PMID:28277135   PMID:28299838   PMID:28320874   PMID:28404897   PMID:28420445   PMID:28430825  
PMID:28450117   PMID:28514442   PMID:28536608   PMID:28579156   PMID:28611053   PMID:28611215   PMID:28689657   PMID:28699988   PMID:28783164   PMID:28794006   PMID:28795454   PMID:28829046  
PMID:28916740   PMID:28921929   PMID:29025879   PMID:29171469   PMID:29174029   PMID:29180619   PMID:29182660   PMID:29301589   PMID:29317436   PMID:29325021   PMID:29326107   PMID:29331016  
PMID:29395067   PMID:29432739   PMID:29476053   PMID:29514658   PMID:29540185   PMID:29631902   PMID:29959006   PMID:29971604   PMID:29975781   PMID:30006590   PMID:30026326   PMID:30027476  
PMID:30177026   PMID:30194258   PMID:30266127   PMID:30275285   PMID:30290587   PMID:30467975   PMID:30557604   PMID:30585266   PMID:30614312   PMID:30614797   PMID:30656477   PMID:30682148  
PMID:30702596   PMID:30721637   PMID:30776466   PMID:30804502   PMID:30814579   PMID:30833792   PMID:30914432   PMID:30918250   PMID:31012334   PMID:31049566   PMID:31070566   PMID:31089877  
PMID:31125083   PMID:31211453   PMID:31288068   PMID:31288725   PMID:31300015   PMID:31340839   PMID:31392276   PMID:31409726   PMID:31436384   PMID:31470081   PMID:31492908   PMID:31504696  
PMID:31517619   PMID:31536510   PMID:31676834   PMID:31691451   PMID:31775533   PMID:31843716   PMID:32127821   PMID:32133972   PMID:32203164   PMID:32265994   PMID:32296183   PMID:32788640  


Genomics

Comparative Map Data
TCF7L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10112,950,247 - 113,167,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,950,247 - 113,167,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,710,006 - 114,927,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,700,201 - 114,916,063 (+)NCBINCBI36hg18NCBI36
Build 3410114,700,200 - 114,916,058NCBI
Celera10108,437,726 - 108,655,178 (+)NCBI
Cytogenetic Map10q25.2-q25.3NCBI
HuRef10108,337,509 - 108,554,907 (+)NCBIHuRef
CHM1_110114,992,047 - 115,209,474 (+)NCBICHM1_1
Tcf7l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,730,226 - 55,922,091 (+)NCBIGRCm39mm39
GRCm39 Ensembl1955,730,252 - 55,922,086 (+)Ensembl
GRCm381955,741,797 - 55,933,659 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,741,820 - 55,933,654 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,816,300 - 56,008,145 (+)NCBIGRCm37mm9NCBIm37
MGSCv361955,795,518 - 55,986,492 (+)NCBImm8
Celera1957,933,629 - 58,125,906 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.59NCBI
Tcf7l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,785,956 - 254,978,967 (+)NCBI
Rnor_6.0 Ensembl1276,011,416 - 276,012,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,659,542 - 276,730,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
Tcf7l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543118,020,409 - 18,209,134 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543118,020,309 - 18,207,926 (+)NCBIChiLan1.0ChiLan1.0
TCF7L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110112,991,588 - 113,193,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,978,167 - 113,192,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010109,541,524 - 109,759,499 (+)NCBIMhudiblu_PPA_v0panPan3
TCF7L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2823,966,073 - 24,163,737 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12823,966,079 - 24,162,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tcf7l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364863,473,877 - 3,660,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14123,343,694 - 123,546,417 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114123,343,695 - 123,547,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214134,586,288 - 134,790,019 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,828,834 - 106,047,810 (+)NCBI
Tcf7l2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473733,341,574 - 33,526,814 (-)NCBI

Position Markers
D10S168  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,745,515 - 114,745,679UniSTSGRCh37
Celera10108,473,297 - 108,473,461UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map10q25.2UniSTS
HuRef10108,372,773 - 108,372,935UniSTS
Marshfield Genetic Map10130.9RGD
Marshfield Genetic Map10130.9UniSTS
deCODE Assembly Map10130.05UniSTS
Whitehead-YAC Contig Map10 UniSTS
WI-20234  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,925,776 - 114,926,044UniSTSGRCh37
Build 3610114,915,766 - 114,916,034RGDNCBI36
Celera10108,653,516 - 108,653,784RGD
Cytogenetic Map10q25.3UniSTS
GeneMap99-GB4 RH Map10515.11UniSTS
Whitehead-RH Map10621.5UniSTS
SHGC-6704  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,838,979 - 114,839,174UniSTSGRCh37
Build 3610114,828,969 - 114,829,164RGDNCBI36
Celera10108,566,763 - 108,566,958RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,466,576 - 108,466,771UniSTS
G43540  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,927,289 - 114,927,418UniSTSGRCh37
Build 3610114,917,279 - 114,917,408RGDNCBI36
Celera10108,655,030 - 108,655,159RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,554,759 - 108,554,888UniSTS
RH102533  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,748,868 - 114,749,052UniSTSGRCh37
Build 3610114,738,858 - 114,739,042RGDNCBI36
Celera10108,476,650 - 108,476,834RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,376,123 - 108,376,307UniSTS
GeneMap99-GB4 RH Map10517.09UniSTS
SHGC-112532  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,887,646 - 114,887,926UniSTSGRCh37
Build 3610114,877,636 - 114,877,916RGDNCBI36
Celera10108,615,386 - 108,615,666RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,515,117 - 108,515,397UniSTS
TNG Radiation Hybrid Map1055903.0UniSTS
SHGC-144967  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,795,176 - 114,795,497UniSTSGRCh37
Build 3610114,785,166 - 114,785,487RGDNCBI36
Celera10108,522,950 - 108,523,271RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,422,431 - 108,422,752UniSTS
TNG Radiation Hybrid Map1055849.0UniSTS
STS-T81462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,924,139 - 114,924,273UniSTSGRCh37
Build 3610114,914,129 - 114,914,263RGDNCBI36
Celera10108,651,879 - 108,652,013RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,551,609 - 108,551,743UniSTS
GeneMap99-GB4 RH Map10517.2UniSTS
SHGC-33545  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,924,179 - 114,924,328UniSTSGRCh37
Build 3610114,914,169 - 114,914,318RGDNCBI36
Celera10108,651,919 - 108,652,068RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,551,649 - 108,551,798UniSTS
TNG Radiation Hybrid Map1055884.0UniSTS
Stanford-G3 RH Map105229.0UniSTS
GeneMap99-GB4 RH Map10517.42UniSTS
Whitehead-RH Map10620.3UniSTS
NCBI RH Map101234.5UniSTS
GeneMap99-G3 RH Map105465.0UniSTS
RH48450  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,868,979 - 114,869,119UniSTSGRCh37
Build 3610114,858,969 - 114,859,109RGDNCBI36
Celera10108,596,758 - 108,596,898RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,496,540 - 108,496,680UniSTS
GeneMap99-GB4 RH Map10545.6UniSTS
NCBI RH Map101208.8UniSTS
SHGC-58284  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,859,590 - 114,859,747UniSTSGRCh37
Build 3610114,849,580 - 114,849,737RGDNCBI36
Celera10108,587,361 - 108,587,518RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,487,144 - 108,487,301UniSTS
TNG Radiation Hybrid Map1055894.0UniSTS
RH66532  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,732,757 - 114,732,922UniSTSGRCh37
Build 3610114,722,747 - 114,722,912RGDNCBI36
Celera10108,460,539 - 108,460,704RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,360,013 - 108,360,178UniSTS
GeneMap99-GB4 RH Map10517.39UniSTS
STS-T97004  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,739,863 - 114,740,018UniSTSGRCh37
GRCh3710114,739,844 - 114,740,035UniSTSGRCh37
Build 3610114,729,853 - 114,730,008RGDNCBI36
Celera10108,467,626 - 108,467,817UniSTS
Celera10108,467,645 - 108,467,800RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,367,121 - 108,367,276UniSTS
HuRef10108,367,102 - 108,367,293UniSTS
GeneMap99-GB4 RH Map10517.52UniSTS
RH11324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,927,151 - 114,927,300UniSTSGRCh37
Build 3610114,917,141 - 114,917,290RGDNCBI36
Celera10108,654,892 - 108,655,041RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,554,621 - 108,554,770UniSTS
GeneMap99-GB4 RH Map10515.64UniSTS
D10S1597  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,741,796 - 114,742,046UniSTSGRCh37
Build 3610114,731,786 - 114,732,036RGDNCBI36
Celera10108,469,578 - 108,469,828RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,369,054 - 108,369,304UniSTS
Whitehead-YAC Contig Map10 UniSTS
G20756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,925,921 - 114,926,039UniSTSGRCh37
Build 3610114,915,911 - 114,916,029RGDNCBI36
Celera10108,653,661 - 108,653,779RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,553,390 - 108,553,508UniSTS
A006F09  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,925,921 - 114,926,039UniSTSGRCh37
Build 3610114,915,911 - 114,916,029RGDNCBI36
Celera10108,653,661 - 108,653,779RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,553,390 - 108,553,508UniSTS
GeneMap99-GB4 RH Map10517.39UniSTS
D10S2296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,717,839 - 114,718,080UniSTSGRCh37
Build 3610114,707,829 - 114,708,070RGDNCBI36
Celera10108,445,621 - 108,445,862RGD
Cytogenetic Map10q25.3UniSTS
HuRef10108,345,366 - 108,345,607UniSTS
Whitehead-YAC Contig Map10 UniSTS
STS-T97004  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q25.3UniSTS
GeneMap99-GB4 RH Map10514.18UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9520
Count of miRNA genes:1102
Interacting mature miRNAs:1345
Transcripts:ENST00000277945, ENST00000346198, ENST00000349937, ENST00000352065, ENST00000355717, ENST00000355995, ENST00000369386, ENST00000369389, ENST00000369395, ENST00000369397, ENST00000466338, ENST00000470254, ENST00000471569, ENST00000476887, ENST00000480888, ENST00000494353, ENST00000534894, ENST00000536810, ENST00000538897, ENST00000542695, ENST00000543371, ENST00000545257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2110 1387 1116 366 445 240 3403 794 987 205 1134 1493 137 1191 1962 3
Low 329 1574 610 258 1119 225 954 1403 2743 214 324 119 38 1 13 826 2 2
Below cutoff 29 356 3 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001198531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001349870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001349871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001367943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB034691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB440195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF522996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ270778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL158212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL445486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL451084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM701919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ900611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU619467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA394991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA473655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA590466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ010174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM352851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF772717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF772718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z99386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000277945   ⟹   ENSP00000277945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,146,072 - 113,165,632 (+)Ensembl
RefSeq Acc Id: ENST00000346198   ⟹   ENSP00000345640
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,916 - 113,141,316 (+)Ensembl
RefSeq Acc Id: ENST00000349937   ⟹   ENSP00000298692
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,125,536 - 113,146,096 (+)Ensembl
RefSeq Acc Id: ENST00000352065   ⟹   ENSP00000344823
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,660 - 113,165,612 (+)Ensembl
RefSeq Acc Id: ENST00000355717   ⟹   ENSP00000347949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,586 - 113,165,972 (+)Ensembl
RefSeq Acc Id: ENST00000355995   ⟹   ENSP00000348274
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000369386   ⟹   ENSP00000358393
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,151,083 - 113,166,324 (+)Ensembl
RefSeq Acc Id: ENST00000369389   ⟹   ENSP00000358396
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,126,690 - 113,151,774 (+)Ensembl
RefSeq Acc Id: ENST00000369395   ⟹   ENSP00000358402
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,660 - 113,165,612 (+)Ensembl
RefSeq Acc Id: ENST00000369397   ⟹   ENSP00000358404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,452 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000466338   ⟹   ENSP00000490260
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,151,771 - 113,166,309 (+)Ensembl
RefSeq Acc Id: ENST00000470254   ⟹   ENSP00000435694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,151,831 - 113,165,940 (+)Ensembl
RefSeq Acc Id: ENST00000471569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,157,773 - 113,165,587 (+)Ensembl
RefSeq Acc Id: ENST00000480888   ⟹   ENSP00000490004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,152,414 - 113,165,961 (+)Ensembl
RefSeq Acc Id: ENST00000494353
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,161,231 - 113,165,681 (+)Ensembl
RefSeq Acc Id: ENST00000534894   ⟹   ENSP00000443626
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000536810   ⟹   ENSP00000446238
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000538897   ⟹   ENSP00000446172
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000542695   ⟹   ENSP00000443883
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000543371   ⟹   ENSP00000444972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,250 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000545257   ⟹   ENSP00000440547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,664 - 113,166,160 (+)Ensembl
RefSeq Acc Id: ENST00000627217   ⟹   ENSP00000486891
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,247 - 113,167,678 (+)Ensembl
RefSeq Acc Id: ENST00000629706   ⟹   ENSP00000487507
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,950,757 - 113,165,972 (+)Ensembl
RefSeq Acc Id: ENST00000636236
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,129,646 - 113,151,087 (+)Ensembl
RefSeq Acc Id: ENST00000636309
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,132,022 - 113,151,758 (+)Ensembl
RefSeq Acc Id: ENST00000636447
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,129,206 - 113,151,057 (+)Ensembl
RefSeq Acc Id: ENST00000636585
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,132,896 - 113,146,094 (+)Ensembl
RefSeq Acc Id: ENST00000637321
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,126,022 - 113,151,023 (+)Ensembl
RefSeq Acc Id: ENST00000637416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,126,957 - 113,151,766 (+)Ensembl
RefSeq Acc Id: ENST00000637574   ⟹   ENSP00000490478
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10113,129,357 - 113,146,088 (+)Ensembl
RefSeq Acc Id: NM_001146274   ⟹   NP_001139746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001146283   ⟹   NP_001139755
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001146284   ⟹   NP_001139756
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001146285   ⟹   NP_001139757
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001146286   ⟹   NP_001139758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198525   ⟹   NP_001185454
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198526   ⟹   NP_001185455
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198527   ⟹   NP_001185456
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198528   ⟹   NP_001185457
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198529   ⟹   NP_001185458
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198530   ⟹   NP_001185459
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001198531   ⟹   NP_001185460
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001349870   ⟹   NP_001336799
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810113,129,271 - 113,167,678 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001349871   ⟹   NP_001336800
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810113,126,633 - 113,167,678 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001363501   ⟹   NP_001350430
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
RefSeq Acc Id: NM_001367943   ⟹   NP_001354872
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
RefSeq Acc Id: NM_030756   ⟹   NP_110383
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 113,167,678 (+)NCBI
GRCh3710114,709,978 - 114,927,437 (+)NCBI
Build 3610114,700,201 - 114,916,063 (+)NCBI Archive
HuRef10108,337,509 - 108,554,907 (+)ENTREZGENE
CHM1_110114,992,047 - 115,209,474 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001139746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139755 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139756 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139757 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139758 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185454 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185455 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185456 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185457 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185458 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185459 (Get FASTA)   NCBI Sequence Viewer  
  NP_001185460 (Get FASTA)   NCBI Sequence Viewer  
  NP_001336799 (Get FASTA)   NCBI Sequence Viewer  
  NP_001336800 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350430 (Get FASTA)   NCBI Sequence Viewer  
  NP_001354872 (Get FASTA)   NCBI Sequence Viewer  
  NP_110383 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH32656 (Get FASTA)   NCBI Sequence Viewer  
  AAQ08860 (Get FASTA)   NCBI Sequence Viewer  
  ACI28522 (Get FASTA)   NCBI Sequence Viewer  
  ACI28523 (Get FASTA)   NCBI Sequence Viewer  
  ACI28524 (Get FASTA)   NCBI Sequence Viewer  
  ACI28525 (Get FASTA)   NCBI Sequence Viewer  
  ACI28526 (Get FASTA)   NCBI Sequence Viewer  
  ACI28527 (Get FASTA)   NCBI Sequence Viewer  
  ACI28528 (Get FASTA)   NCBI Sequence Viewer  
  ACI28529 (Get FASTA)   NCBI Sequence Viewer  
  ACI28530 (Get FASTA)   NCBI Sequence Viewer  
  ACI28531 (Get FASTA)   NCBI Sequence Viewer  
  ACI28532 (Get FASTA)   NCBI Sequence Viewer  
  ADK35174 (Get FASTA)   NCBI Sequence Viewer  
  ADK35175 (Get FASTA)   NCBI Sequence Viewer  
  ADK35176 (Get FASTA)   NCBI Sequence Viewer  
  ADK35177 (Get FASTA)   NCBI Sequence Viewer  
  ADK35178 (Get FASTA)   NCBI Sequence Viewer  
  ADK35179 (Get FASTA)   NCBI Sequence Viewer  
  ADK35180 (Get FASTA)   NCBI Sequence Viewer  
  ADK35181 (Get FASTA)   NCBI Sequence Viewer  
  ADK35182 (Get FASTA)   NCBI Sequence Viewer  
  ADK35183 (Get FASTA)   NCBI Sequence Viewer  
  ADK35184 (Get FASTA)   NCBI Sequence Viewer  
  ADK35185 (Get FASTA)   NCBI Sequence Viewer  
  ADK35186 (Get FASTA)   NCBI Sequence Viewer  
  ADK35187 (Get FASTA)   NCBI Sequence Viewer  
  AXC43357 (Get FASTA)   NCBI Sequence Viewer  
  AXC43358 (Get FASTA)   NCBI Sequence Viewer  
  BAA86225 (Get FASTA)   NCBI Sequence Viewer  
  BAG51988 (Get FASTA)   NCBI Sequence Viewer  
  BAG59004 (Get FASTA)   NCBI Sequence Viewer  
  BAG61310 (Get FASTA)   NCBI Sequence Viewer  
  BAG62997 (Get FASTA)   NCBI Sequence Viewer  
  BAG64677 (Get FASTA)   NCBI Sequence Viewer  
  BAG70080 (Get FASTA)   NCBI Sequence Viewer  
  BAH14482 (Get FASTA)   NCBI Sequence Viewer  
  BAH24004 (Get FASTA)   NCBI Sequence Viewer  
  CAA72166 (Get FASTA)   NCBI Sequence Viewer  
  CAB97212 (Get FASTA)   NCBI Sequence Viewer  
  CAB97213 (Get FASTA)   NCBI Sequence Viewer  
  CAB97214 (Get FASTA)   NCBI Sequence Viewer  
  CAB97215 (Get FASTA)   NCBI Sequence Viewer  
  CAB97216 (Get FASTA)   NCBI Sequence Viewer  
  CAB97217 (Get FASTA)   NCBI Sequence Viewer  
  CAB97218 (Get FASTA)   NCBI Sequence Viewer  
  CAB97219 (Get FASTA)   NCBI Sequence Viewer  
  CAG38811 (Get FASTA)   NCBI Sequence Viewer  
  EAW49506 (Get FASTA)   NCBI Sequence Viewer  
  EAW49507 (Get FASTA)   NCBI Sequence Viewer  
  EAW49508 (Get FASTA)   NCBI Sequence Viewer  
  EAW49509 (Get FASTA)   NCBI Sequence Viewer  
  EAW49510 (Get FASTA)   NCBI Sequence Viewer  
  EAW49511 (Get FASTA)   NCBI Sequence Viewer  
  EAW49512 (Get FASTA)   NCBI Sequence Viewer  
  EAW49513 (Get FASTA)   NCBI Sequence Viewer  
  EAW49514 (Get FASTA)   NCBI Sequence Viewer  
  EAW49515 (Get FASTA)   NCBI Sequence Viewer  
  EAW49516 (Get FASTA)   NCBI Sequence Viewer  
  EAW49517 (Get FASTA)   NCBI Sequence Viewer  
  Q9NQB0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001139746   ⟸   NM_001146274
- Peptide Label: isoform 1
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001185460   ⟸   NM_001198531
- Peptide Label: isoform 13
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139755   ⟸   NM_001146283
- Peptide Label: isoform 3
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001185454   ⟸   NM_001198525
- Peptide Label: isoform 7
- UniProtKB: C6ZRJ7 (UniProtKB/TrEMBL),   C6ZRK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001185457   ⟸   NM_001198528
- Peptide Label: isoform 10
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_110383   ⟸   NM_030756
- Peptide Label: isoform 2
- UniProtKB: Q6FHW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001185458   ⟸   NM_001198529
- Peptide Label: isoform 11
- UniProtKB: C6ZRK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139757   ⟸   NM_001146285
- Peptide Label: isoform 5
- UniProtKB: C6ZRK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001185455   ⟸   NM_001198526
- Peptide Label: isoform 8
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139758   ⟸   NM_001146286
- Peptide Label: isoform 6
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001185456   ⟸   NM_001198527
- Peptide Label: isoform 9
- UniProtKB: Q5VVR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139756   ⟸   NM_001146284
- Peptide Label: isoform 4
- UniProtKB: Q9NQB0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001185459   ⟸   NM_001198530
- Peptide Label: isoform 12
- UniProtKB: A0A0A0MTL7 (UniProtKB/TrEMBL),   C6ZRK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001336800   ⟸   NM_001349871
- Peptide Label: isoform 15
- Sequence:
RefSeq Acc Id: NP_001336799   ⟸   NM_001349870
- Peptide Label: isoform 14
- Sequence:
RefSeq Acc Id: NP_001354872   ⟸   NM_001367943
- Peptide Label: isoform 17
RefSeq Acc Id: NP_001350430   ⟸   NM_001363501
- Peptide Label: isoform 16
RefSeq Acc Id: ENSP00000443883   ⟸   ENST00000542695
RefSeq Acc Id: ENSP00000345640   ⟸   ENST00000346198
RefSeq Acc Id: ENSP00000444972   ⟸   ENST00000543371
RefSeq Acc Id: ENSP00000490478   ⟸   ENST00000637574
RefSeq Acc Id: ENSP00000440547   ⟸   ENST00000545257
RefSeq Acc Id: ENSP00000490260   ⟸   ENST00000466338
RefSeq Acc Id: ENSP00000298692   ⟸   ENST00000349937
RefSeq Acc Id: ENSP00000490004   ⟸   ENST00000480888
RefSeq Acc Id: ENSP00000486891   ⟸   ENST00000627217
RefSeq Acc Id: ENSP00000443626   ⟸   ENST00000534894
RefSeq Acc Id: ENSP00000446238   ⟸   ENST00000536810
RefSeq Acc Id: ENSP00000487507   ⟸   ENST00000629706
RefSeq Acc Id: ENSP00000344823   ⟸   ENST00000352065
RefSeq Acc Id: ENSP00000435694   ⟸   ENST00000470254
RefSeq Acc Id: ENSP00000446172   ⟸   ENST00000538897
RefSeq Acc Id: ENSP00000348274   ⟸   ENST00000355995
RefSeq Acc Id: ENSP00000347949   ⟸   ENST00000355717
RefSeq Acc Id: ENSP00000358404   ⟸   ENST00000369397
RefSeq Acc Id: ENSP00000358402   ⟸   ENST00000369395
RefSeq Acc Id: ENSP00000358396   ⟸   ENST00000369389
RefSeq Acc Id: ENSP00000358393   ⟸   ENST00000369386
RefSeq Acc Id: ENSP00000277945   ⟸   ENST00000277945
Protein Domains
CTNNB1_binding   HMG box

Promoters
RGD ID:7218699
Promoter ID:EPDNEW_H15095
Type:initiation region
Name:TCF7L2_1
Description:transcription factor 7 like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15096  EPDNEW_H15097  EPDNEW_H15098  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,247 - 112,950,307EPDNEW
RGD ID:7218701
Promoter ID:EPDNEW_H15096
Type:initiation region
Name:TCF7L2_4
Description:transcription factor 7 like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15095  EPDNEW_H15097  EPDNEW_H15098  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,361 - 112,950,421EPDNEW
RGD ID:7218703
Promoter ID:EPDNEW_H15097
Type:initiation region
Name:TCF7L2_2
Description:transcription factor 7 like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15095  EPDNEW_H15096  EPDNEW_H15098  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,493 - 112,950,553EPDNEW
RGD ID:7218705
Promoter ID:EPDNEW_H15098
Type:initiation region
Name:TCF7L2_3
Description:transcription factor 7 like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15095  EPDNEW_H15096  EPDNEW_H15097  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,950,671 - 112,950,731EPDNEW
RGD ID:6788304
Promoter ID:HG_KWN:11204
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   NB4
Transcripts:ENST00000277945,   ENST00000340914,   ENST00000346198,   ENST00000349937,   ENST00000352065,   ENST00000355717,   ENST00000355995,   ENST00000369395,   NM_001146274,   NM_001146283,   NM_001146284,   NM_001146285,   NM_001146286,   OTTHUMT00000050412,   OTTHUMT00000050413
Position:
Human AssemblyChrPosition (strand)Source
Build 3610114,699,916 - 114,700,662 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001146274.2(TCF7L2):c.450+33966C>T single nucleotide variant Diabetes mellitus type 2, susceptibility to [RCV000007838]|sulfonamides, urea derivatives response - Efficacy [RCV000211424] Chr10:112998590 [GRCh38]
Chr10:114758349 [GRCh37]
Chr10:10q25.2		 risk factor|drug response
NM_001146274.2(TCF7L2):c.552+9017G>T single nucleotide variant Diabetes mellitus type 2, susceptibility to [RCV000007839] Chr10:113049143 [GRCh38]
Chr10:114808902 [GRCh37]
Chr10:10q25.2		 risk factor
NM_001146274.2(TCF7L2):c.552+7162G>C single nucleotide variant Diabetes mellitus type 2, susceptibility to [RCV000007840] Chr10:113047288 [GRCh38]
Chr10:114807047 [GRCh37]
Chr10:10q25.2		 risk factor
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3		 pathogenic
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.11(chr10:107191100-118761489)x1 copy number loss See cases [RCV000052570] Chr10:107191100..118761489 [GRCh38]
Chr10:108950858..120521001 [GRCh37]
Chr10:108940848..120510991 [NCBI36]
Chr10:10q25.1-26.11		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:112074094-115537174)x1 copy number loss See cases [RCV000135960] Chr10:112074094..115537174 [GRCh38]
Chr10:113833852..117032437 [GRCh37]
Chr10:113823842..117286674 [NCBI36]
Chr10:10q25.2-25.3		 pathogenic
GRCh38/hg38 10q25.2-26.12(chr10:112701186-120970617)x3 copy number gain See cases [RCV000137511] Chr10:112701186..120970617 [GRCh38]
Chr10:114460945..122730130 [GRCh37]
Chr10:114450935..122720120 [NCBI36]
Chr10:10q25.2-26.12		 likely pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:110804735-114884010)x1 copy number loss See cases [RCV000139783] Chr10:110804735..114884010 [GRCh38]
Chr10:112564493..116643769 [GRCh37]
Chr10:112554483..116633759 [NCBI36]
Chr10:10q25.2-25.3		 likely pathogenic
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3		 pathogenic
NM_001146274.2(TCF7L2):c.552+46764_552+47838del deletion Normal pregnancy [RCV000161613] Chr10:113086890..113087964 [GRCh38]
Chr10:114846649..114847723 [GRCh37]
Chr10:10q25.2		 not provided
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590)x1 copy number loss See cases [RCV000448581] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_001146274.2(TCF7L2):c.1509T>A (p.Pro503=) single nucleotide variant not provided [RCV000929425] Chr10:113165672 [GRCh38]
Chr10:114925431 [GRCh37]
Chr10:10q25.3		 likely benign
NM_001146274.2(TCF7L2):c.1485C>G (p.Pro495=) single nucleotide variant not provided [RCV000892397] Chr10:113165648 [GRCh38]
Chr10:114925407 [GRCh37]
Chr10:10q25.3		 benign
NM_001146274.2(TCF7L2):c.219A>G (p.Glu73=) single nucleotide variant not provided [RCV000925190] Chr10:112951236 [GRCh38]
Chr10:114710995 [GRCh37]
Chr10:10q25.2		 likely benign
NM_001146274.2(TCF7L2):c.1483C>G (p.Pro495Ala) single nucleotide variant not provided [RCV000970465] Chr10:113165646 [GRCh38]
Chr10:114925405 [GRCh37]
Chr10:10q25.3		 benign
NM_001146274.2(TCF7L2):c.1484C>G (p.Pro495Arg) single nucleotide variant not provided [RCV000971569] Chr10:113165647 [GRCh38]
Chr10:114925406 [GRCh37]
Chr10:10q25.3		 likely benign
NM_001146274.2(TCF7L2):c.348C>T (p.Leu116=) single nucleotide variant not provided [RCV000949766] Chr10:112951574 [GRCh38]
Chr10:114711333 [GRCh37]
Chr10:10q25.2		 benign
NM_001146274.2(TCF7L2):c.84G>A (p.Glu28=) single nucleotide variant not provided [RCV000879760] Chr10:112950840 [GRCh38]
Chr10:114710599 [GRCh37]
Chr10:10q25.2		 likely benign
NM_001146274.2(TCF7L2):c.1693C>A (p.Pro565Thr) single nucleotide variant not provided [RCV000917687] Chr10:113165856 [GRCh38]
Chr10:114925615 [GRCh37]
Chr10:10q25.3		 likely benign
GRCh37/hg19 10q25.1-26.3(chr10:110022170-135439095) copy number gain not provided [RCV000767665] Chr10:110022170..135439095 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
NM_001146274.2(TCF7L2):c.702G>A (p.Pro234=) single nucleotide variant not provided [RCV000893310] Chr10:113143939 [GRCh38]
Chr10:114903698 [GRCh37]
Chr10:10q25.3		 likely benign
GRCh37/hg19 10q25.2-25.3(chr10:114666574-114942837)x1 copy number loss not provided [RCV000848563] Chr10:114666574..114942837 [GRCh37]
Chr10:10q25.2-25.3		 uncertain significance
GRCh37/hg19 10q25.2-26.3(chr10:114544537-135427143)x3 copy number gain not provided [RCV000847820] Chr10:114544537..135427143 [GRCh37]
Chr10:10q25.2-26.3		 pathogenic
NM_001146274.2(TCF7L2):c.1753T>C (p.Ser585Pro) single nucleotide variant not provided [RCV000962071] Chr10:113165916 [GRCh38]
Chr10:114925675 [GRCh37]
Chr10:10q25.3		 benign
NM_001146274.2(TCF7L2):c.45C>T (p.Asn15=) single nucleotide variant not provided [RCV000962054] Chr10:112950801 [GRCh38]
Chr10:114710560 [GRCh37]
Chr10:10q25.2		 benign
NM_001146274.2(TCF7L2):c.1484C>A (p.Pro495His) single nucleotide variant not provided [RCV000950752] Chr10:113165647 [GRCh38]
Chr10:114925406 [GRCh37]
Chr10:10q25.3		 benign
NM_001146274.2(TCF7L2):c.1686T>G (p.Ala562=) single nucleotide variant not provided [RCV000890808] Chr10:113165849 [GRCh38]
Chr10:114925608 [GRCh37]
Chr10:10q25.3		 benign
NM_001146274.2(TCF7L2):c.381+10T>C single nucleotide variant not provided [RCV000911494] Chr10:112951617 [GRCh38]
Chr10:114711376 [GRCh37]
Chr10:10q25.2		 likely benign
NM_001146274.2(TCF7L2):c.397G>A (p.Gly133Ser) single nucleotide variant Intellectual disability [RCV001255105] Chr10:112964571 [GRCh38]
Chr10:114724330 [GRCh37]
Chr10:10q25.2		 uncertain significance
NM_001146274.2(TCF7L2):c.875+1G>C single nucleotide variant Neurodevelopmental abnormality [RCV001264698] Chr10:113146098 [GRCh38]
Chr10:114905857 [GRCh37]
Chr10:10q25.3		 uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11641 AgrOrtholog
COSMIC TCF7L2 COSMIC
Ensembl Genes ENSG00000148737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000277945 UniProtKB/TrEMBL
  ENSP00000298692 UniProtKB/TrEMBL
  ENSP00000344823 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000345640 UniProtKB/TrEMBL
  ENSP00000347949 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000348274 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358393 UniProtKB/TrEMBL
  ENSP00000358396 UniProtKB/TrEMBL
  ENSP00000358402 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000358404 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000435694 UniProtKB/TrEMBL
  ENSP00000440547 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000443626 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000443883 UniProtKB/TrEMBL
  ENSP00000444972 UniProtKB/TrEMBL
  ENSP00000446172 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446238 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000486891 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000487507 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000490004 UniProtKB/TrEMBL
  ENSP00000490260 UniProtKB/TrEMBL
  ENSP00000490478 UniProtKB/TrEMBL
Ensembl Transcript ENST00000277945 UniProtKB/TrEMBL
  ENST00000346198 UniProtKB/TrEMBL
  ENST00000349937 UniProtKB/TrEMBL
  ENST00000352065 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000355717 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000355995 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369386 UniProtKB/TrEMBL
  ENST00000369389 UniProtKB/TrEMBL
  ENST00000369395 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000369397 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000466338 UniProtKB/TrEMBL
  ENST00000470254 UniProtKB/TrEMBL
  ENST00000480888 UniProtKB/TrEMBL
  ENST00000534894 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000536810 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000538897 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000542695 UniProtKB/TrEMBL
  ENST00000543371 UniProtKB/TrEMBL
  ENST00000545257 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000627217 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000629706 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000637574 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000148737 GTEx
HGNC ID HGNC:11641 ENTREZGENE
Human Proteome Map TCF7L2 Human Proteome Map
InterPro Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCF/LEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6934 UniProtKB/Swiss-Prot
NCBI Gene 6934 ENTREZGENE
OMIM 125853 OMIM
  602228 OMIM
PANTHER PTHR10373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36394 PharmGKB
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MTL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9SGH8_HUMAN UniProtKB/TrEMBL
  A0A1B0GU84_HUMAN UniProtKB/TrEMBL
  A0A1B0GUV5_HUMAN UniProtKB/TrEMBL
  A0A1B0GVE1_HUMAN UniProtKB/TrEMBL
  A0A2Z5HTM8_HUMAN UniProtKB/TrEMBL
  A0A2Z5HTN9_HUMAN UniProtKB/TrEMBL
  B5BU30_HUMAN UniProtKB/TrEMBL
  C6ZRJ6_HUMAN UniProtKB/TrEMBL
  C6ZRJ7 ENTREZGENE, UniProtKB/TrEMBL
  C6ZRK1 ENTREZGENE, UniProtKB/TrEMBL
  C6ZRK2 ENTREZGENE, UniProtKB/TrEMBL
  C6ZRK5 ENTREZGENE, UniProtKB/TrEMBL
  E2GH13_HUMAN UniProtKB/TrEMBL
  E2GH15_HUMAN UniProtKB/TrEMBL
  E2GH16_HUMAN UniProtKB/TrEMBL
  E2GH18_HUMAN UniProtKB/TrEMBL
  E2GH23_HUMAN UniProtKB/TrEMBL
  E2GH26_HUMAN UniProtKB/TrEMBL
  H0YEE5_HUMAN UniProtKB/TrEMBL
  Q5JRY3_HUMAN UniProtKB/TrEMBL
  Q5JRY4_HUMAN UniProtKB/TrEMBL
  Q5JRY5_HUMAN UniProtKB/TrEMBL
  Q5VVR5_HUMAN UniProtKB/TrEMBL
  Q5VVR7 ENTREZGENE, UniProtKB/TrEMBL
  Q5VVR8_HUMAN UniProtKB/TrEMBL
  Q6FHW4 ENTREZGENE, UniProtKB/TrEMBL
  Q9NQB0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B4DRJ8 UniProtKB/Swiss-Prot
  B9X074 UniProtKB/Swiss-Prot
  C6ZRJ8 UniProtKB/Swiss-Prot
  C6ZRJ9 UniProtKB/TrEMBL
  C6ZRK0 UniProtKB/Swiss-Prot
  E2GH14 UniProtKB/Swiss-Prot
  E2GH19 UniProtKB/Swiss-Prot
  E2GH20 UniProtKB/Swiss-Prot
  E2GH24 UniProtKB/Swiss-Prot
  E2GH25 UniProtKB/Swiss-Prot
  E9PFH9 UniProtKB/Swiss-Prot
  F8W742 UniProtKB/Swiss-Prot
  F8W7T5 UniProtKB/Swiss-Prot
  O00185 UniProtKB/Swiss-Prot
  Q9NQB1 UniProtKB/Swiss-Prot
  Q9NQB2 UniProtKB/Swiss-Prot
  Q9NQB3 UniProtKB/Swiss-Prot
  Q9NQB4 UniProtKB/Swiss-Prot
  Q9NQB5 UniProtKB/Swiss-Prot
  Q9NQB6 UniProtKB/Swiss-Prot
  Q9NQB7 UniProtKB/Swiss-Prot
  Q9ULC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 TCF7L2  transcription factor 7 like 2  TCF7L2  transcription factor 7-like 2 (T-cell specific, HMG-box)  Symbol and/or name change 5135510 APPROVED