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Gene: Got1 (glutamic-oxaloacetic transaminase 1) Rattus norvegicus
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
Description: Exhibits L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Localizes to axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1); PARTICIPATES IN gluconeogenesis pathway; AGAT deficiency pathway; alkaptonuria pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AAT1; ASAT; aspartate aminotransferase 1; aspartate aminotransferase, cytoplasmic; Aspat; cAspAT; cCAT; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Gaspat; glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; Glutamic-oxaloacetic transaminase 1 soluble (aspartate aminotransferase cytosolic) see also D1Mgh12; glutamic-oxaloacetic transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12; transaminase A
Homo sapiens (human) : GOT1 (glutamic-oxaloacetic transaminase 1)  HGNC  Alliance
Mus musculus (house mouse) : Got1 (glutamic-oxaloacetic transaminase 1, soluble)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Got1 (glutamic-oxaloacetic transaminase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GOT1 (glutamic-oxaloacetic transaminase 1)
Canis lupus familiaris (dog) : GOT1 (glutamic-oxaloacetic transaminase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Got1 (glutamic-oxaloacetic transaminase 1)
Sus scrofa (pig) : GOT1 (glutamic-oxaloacetic transaminase 1)
Chlorocebus sabaeus (African green monkey) : GOT1 (glutamic-oxaloacetic transaminase 1)
Heterocephalus glaber (naked mole-rat) : Got1 (glutamic-oxaloacetic transaminase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01263,246,248 - 263,269,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,691,424 - 270,714,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,324,285 - 247,347,553 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1238,178,819 - 238,202,121 (-)NCBICelera
Cytogenetic Map1q54NCBI
RH 3.4 Map1 RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Got1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2721
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.