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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2721
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Got1increases secretionEXP 6480464CTDStreptozocin results in increased secretion of GOT1 proteinPMID:30657622
Got1multiple interactionsEXP 6480464CTD[Resveratrol co-treated with Streptozocin] results in decreased expression of GOT1 mRNA; Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GOT1 protein]PMID:25905778 PMID:30657622
Got1multiple interactionsISOGot1 (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of GOT1 protein; [Streptozocin co-treated with Dietary Fats] results in increased secretion of GOT1 protein; aucubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of GOT1 protein]; bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GOT1 protein]PMID:35961541 PMID:37482253
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