RGD Reference Report - NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. - Rat Genome Database

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NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences.

Authors: Ying, W 
Citation: Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
RGD ID: 5129954
Pubmed: PMID:18020963   (View Abstract at PubMed)
DOI: DOI:10.1089/ars.2007.1672   (Journal Full-text)

Accumulating evidence has suggested that NAD (including NAD+ and NADH) and NADP (including NADP+ and NADPH) could belong to the fundamental common mediators of various biological processes, including energy metabolism, mitochondrial functions, calcium homeostasis, antioxidation/generation of oxidative stress, gene expression, immunological functions, aging, and cell death: First, it is established that NAD mediates energy metabolism and mitochondrial functions; second, NADPH is a key component in cellular antioxidation systems; and NADH-dependent reactive oxygen species (ROS) generation from mitochondria and NADPH oxidase-dependent ROS generation are two critical mechanisms of ROS generation; third, cyclic ADP-ribose and several other molecules that are generated from NAD and NADP could mediate calcium homeostasis; fourth, NAD and NADP modulate multiple key factors in cell death, such as mitochondrial permeability transition, energy state, poly(ADP-ribose) polymerase-1, and apoptosis-inducing factor; and fifth, NAD and NADP profoundly affect aging-influencing factors such as oxidative stress and mitochondrial activities, and NAD-dependent sirtuins also mediate the aging process. Moreover, many recent studies have suggested novel paradigms of NAD and NADP metabolism. Future investigation into the metabolism and biological functions of NAD and NADP may expose fundamental properties of life, and suggest new strategies for treating diseases and slowing the aging process.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GOT1Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
GOT2Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
GPD1Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
GPD2Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
Got1Ratnicotinamide adenine dinucleotide metabolic pathway   ISOGOT1 (Homo sapiens) RGD 
Got1Mousenicotinamide adenine dinucleotide metabolic pathway   ISOGOT1 (Homo sapiens) RGD 
Got2Ratnicotinamide adenine dinucleotide metabolic pathway   ISOGOT2 (Homo sapiens) RGD 
Got2Mousenicotinamide adenine dinucleotide metabolic pathway   ISOGOT2 (Homo sapiens) RGD 
Gpd1Ratnicotinamide adenine dinucleotide metabolic pathway   ISOGPD1 (Homo sapiens) RGD 
Gpd1Mousenicotinamide adenine dinucleotide metabolic pathway   ISOGPD1 (Homo sapiens) RGD 
Gpd2Ratnicotinamide adenine dinucleotide metabolic pathway   ISOGPD2 (Homo sapiens) RGD 
Gpd2Mousenicotinamide adenine dinucleotide metabolic pathway   ISOGPD2 (Homo sapiens) RGD 
MDH1Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
MDH2Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
Mdh1Ratnicotinamide adenine dinucleotide metabolic pathway   ISOMDH1 (Homo sapiens) RGD 
Mdh1Mousenicotinamide adenine dinucleotide metabolic pathway   ISOMDH1 (Homo sapiens) RGD 
Mdh2Mousenicotinamide adenine dinucleotide metabolic pathway   ISOMDH2 (Homo sapiens) RGD 
Mdh2Ratnicotinamide adenine dinucleotide metabolic pathway   ISOMDH2 (Homo sapiens) RGD 
SLC1A3Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
SLC25A12Humannicotinamide adenine dinucleotide metabolic pathway   TAS  RGD 
Slc1a3Ratnicotinamide adenine dinucleotide metabolic pathway   ISOSLC1A3 (Homo sapiens) RGD 
Slc1a3Mousenicotinamide adenine dinucleotide metabolic pathway   ISOSLC1A3 (Homo sapiens) RGD 
Slc25a12Ratnicotinamide adenine dinucleotide metabolic pathway   ISOSLC25A12 (Homo sapiens) RGD 
Slc25a12Mousenicotinamide adenine dinucleotide metabolic pathway   ISOSLC25A12 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Got1  (glutamic-oxaloacetic transaminase 1)
Got2  (glutamic-oxaloacetic transaminase 2)
Gpd1  (glycerol-3-phosphate dehydrogenase 1)
Gpd2  (glycerol-3-phosphate dehydrogenase 2)
Mdh1  (malate dehydrogenase 1)
Mdh2  (malate dehydrogenase 2)
Slc1a3  (solute carrier family 1 member 3)
Slc25a12  (solute carrier family 25 member 12)

Genes (Mus musculus)
Got1  (glutamic-oxaloacetic transaminase 1, soluble)
Got2  (glutamatic-oxaloacetic transaminase 2, mitochondrial)
Gpd1  (glycerol-3-phosphate dehydrogenase 1 (soluble))
Gpd2  (glycerol phosphate dehydrogenase 2, mitochondrial)
Mdh1  (malate dehydrogenase 1, NAD (soluble))
Mdh2  (malate dehydrogenase 2, NAD (mitochondrial))
Slc1a3  (solute carrier family 1 (glial high affinity glutamate transporter), member 3)
Slc25a12  (solute carrier family 25 (mitochondrial carrier, Aralar), member 12)

Genes (Homo sapiens)
GOT1  (glutamic-oxaloacetic transaminase 1)
GOT2  (glutamic-oxaloacetic transaminase 2)
GPD1  (glycerol-3-phosphate dehydrogenase 1)
GPD2  (glycerol-3-phosphate dehydrogenase 2)
MDH1  (malate dehydrogenase 1)
MDH2  (malate dehydrogenase 2)
SLC1A3  (solute carrier family 1 member 3)
SLC25A12  (solute carrier family 25 member 12)


Additional Information