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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2721
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Got1decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of GOT1 mRNAPMID:15953391 PMID:17108234
Got1increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of GOT1 mRNAPMID:12075121 PMID:16174780 PMID:17351261
Got1affects expressionISOGot1 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of GOT1 mRNAPMID:17555576
Got1increases expressionISOGot1 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of GOT1 mRNAPMID:16174780 PMID:17942748
Got1increases secretionISOGot1 (Mus musculus)6480464CTDEthinyl Estradiol results in increased secretion of GOT1 proteinPMID:36329302
Got1multiple interactionsISOGot1 (Mus musculus)6480464CTD[Ethinyl Estradiol co-treated with IL17A protein] results in increased secretion of GOT1 protein; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOT1 mRNA; CXCL10 promotes the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein]PMID:17942748 PMID:36329302
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