Hif1an (hypoxia inducible factor 1 subunit alpha inhibitor) - Rat Genome Database

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Gene: Hif1an (hypoxia inducible factor 1 subunit alpha inhibitor) Rattus norvegicus
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Symbol: Hif1an
Name: hypoxia inducible factor 1 subunit alpha inhibitor
RGD ID: 1308281
Description: Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; positive regulation of myoblast differentiation; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypoxia-inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; LOC309434
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,368,400 - 253,385,495 (+)NCBIGRCr8
mRatBN7.21243,419,175 - 243,440,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,419,194 - 243,434,327 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,564,114 - 251,578,965 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,265,303 - 258,276,602 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,914,313 - 250,928,924 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,309,214 - 264,319,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,309,214 - 264,319,267 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,752,379 - 271,762,022 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,607,945 - 249,618,000 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,868,052 - 249,878,559 (+)NCBI
Celera1239,233,319 - 239,243,566 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1anRatrenal coloboma syndrome  ISOHIF1AN (Homo sapiens)8554872ClinVar Annotator: match by term: Renal coloboma syndromeClinVarPMID:11461952 more ...

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1anRat(-)-epigallocatechin 3-gallate multiple interactionsISOHIF1AN (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIF1AN mRNACTDPMID:22079256
Hif1anRat(1->4)-beta-D-glucan multiple interactionsISOHif1an (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HIF1AN mRNACTDPMID:36331819
Hif1anRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of HIF1AN mRNACTDPMID:29097150
Hif1anRat2,2',5,5'-tetrachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23829299
Hif1anRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHif1an (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of HIF1AN mRNACTDPMID:28213091
Hif1anRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HIF1AN mRNACTDPMID:33387578
Hif1anRat2-hydroxypropanoic acid decreases expressionISOHIF1AN (Homo sapiens)6480464Lactic Acid results in decreased expression of HIF1AN mRNACTDPMID:30851411
Hif1anRat5-chloro-7-iodoquinolin-8-ol multiple interactionsISOHIF1AN (Homo sapiens)6480464Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]CTDPMID:16973622
Hif1anRat5-chloro-7-iodoquinolin-8-ol decreases activityISOHIF1AN (Homo sapiens)6480464Clioquinol results in decreased activity of HIF1AN proteinCTDPMID:16973622
Hif1anRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of HIF1AN mRNACTDPMID:31881176
Hif1anRataflatoxin B1 decreases methylationISOHIF1AN (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of HIF1AN intronCTDPMID:30157460
Hif1anRatamphotericin B multiple interactionsISOHIF1AN (Homo sapiens)6480464Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]CTDPMID:16189267
Hif1anRataristolochic acid A increases expressionISOHIF1AN (Homo sapiens)6480464aristolochic acid I results in increased expression of HIF1AN mRNACTDPMID:33212167
Hif1anRatatrazine decreases expressionISOHIF1AN (Homo sapiens)6480464Atrazine results in decreased expression of HIF1AN mRNACTDPMID:22378314
Hif1anRatbenzo[a]pyrene decreases methylationISOHif1an (Mus musculus)6480464Benzo(a)pyrene results in decreased methylation of HIF1AN intronCTDPMID:27901495
Hif1anRatbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Testosterone] results in decreased expression of HIF1AN mRNACTDPMID:26496021
Hif1anRatbisphenol A decreases methylationISOHIF1AN (Homo sapiens)6480464bisphenol A results in decreased methylation of HIF1AN geneCTDPMID:31601247
Hif1anRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of HIF1AN mRNACTDPMID:29097150
Hif1anRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of HIF1AN mRNACTDPMID:25181051 and PMID:34947998
Hif1anRatbisphenol AF increases expressionEXP 6480464bisphenol AF results in increased expression of HIF1AN mRNACTDPMID:27567155

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Biological Process
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1anRatcytoplasm located_inISOHIF1AN (Homo sapiens)1624291 PMID:14734545RGDPMID:14734545
Hif1anRatcytoplasm located_inIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatcytoplasm is_active_inIBAPANTHER:PTN000967060 and UniProtKB:Q9NWT61600115GO_REF:0000033GO_CentralGO_REF:0000033
Hif1anRatcytosol located_inIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatcytosol located_inISOHIF1AN (Homo sapiens)1624291 RGDGO_REF:0000052
Hif1anRatnucleoplasm located_inIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatnucleoplasm located_inISOHIF1AN (Homo sapiens)1624291 RGDGO_REF:0000052
Hif1anRatnucleus located_inISOHIF1AN (Homo sapiens)1624291 PMID:18299578RGDPMID:18299578
Hif1anRatnucleus located_inIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatnucleus is_active_inIBAPANTHER:PTN000967060 and UniProtKB:Q9NWT61600115GO_REF:0000033GO_CentralGO_REF:0000033
Hif1anRatperinuclear region of cytoplasm located_inISOHIF1AN (Homo sapiens)1624291 PMID:19726677RGDPMID:19726677
Hif1anRatperinuclear region of cytoplasm located_inIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 12 of 12 rows

Molecular Function
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1anRat[protein]-asparagine 3-dioxygenase activity enablesISOHIF1AN (Homo sapiens)1624291 PMID:12080085 more ...RGDPMID:12080085 more ...
Hif1anRat[protein]-asparagine 3-dioxygenase activity enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRat[protein]-asparagine 3-dioxygenase activity enablesIBAPANTHER:PTN000967060 and UniProtKB:Q9NWT61600115GO_REF:0000033GO_CentralGO_REF:0000033
Hif1anRatankyrin repeat binding enablesISOHIF1AN (Homo sapiens)1624291UniProtKB:P16157 more ...RGDPMID:17003112 more ...
Hif1anRatankyrin repeat binding enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatcarboxylic acid binding enablesISOHIF1AN (Homo sapiens)1624291 PMID:17135241RGDPMID:17135241
Hif1anRatcarboxylic acid binding enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatferrous iron binding enablesISOHIF1AN (Homo sapiens)1624291 PMID:12446723RGDPMID:12446723
Hif1anRatferrous iron binding enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatNF-kappaB binding enablesISOHIF1AN (Homo sapiens)1624291UniProtKB:P19838 and PMID:17003112RGDPMID:17003112
Hif1anRatNF-kappaB binding enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatNotch binding enablesISOHIF1AN (Homo sapiens)1624291UniProtKB:O35516 more ...RGDPMID:17573339 and PMID:18299578
Hif1anRatNotch binding enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatpeptidyl-aspartic acid 3-dioxygenase activity enablesISOHIF1AN (Homo sapiens)1624291 PMID:21177872RGDPMID:21177872
Hif1anRatpeptidyl-aspartic acid 3-dioxygenase activity enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatpeptidyl-histidine dioxygenase activity enablesISOHIF1AN (Homo sapiens)1624291 PMID:21251231RGDPMID:21251231
Hif1anRatpeptidyl-histidine dioxygenase activity enablesIEAUniProtKB:Q9NWT6 and ensembl:ENSP000002991631600115GO_REF:0000107EnsemblGO_REF:0000107
Hif1anRatpeptidyl-histidine dioxygenase activity enablesIBAPANTHER:PTN000967060 and UniProtKB:Q9NWT61600115GO_REF:0000033GO_CentralGO_REF:0000033
Hif1anRatprotein binding enablesISOHIF1AN (Homo sapiens)1624291UniProtKB:O15379 more ...RGDPMID:11641274 more ...
Hif1anRatprotein binding enablesISOHif1an (Mus musculus)1624291UniProtKB:Q9CZK6 and PMID:25671767RGDPMID:25671767
1 to 20 of 27 rows

RGD Manual Annotations


  

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hif1anRathypoxia inducible factor pathway   ISOHIF1AN (Homo sapiens)6484113 PIDPID:200036

#
Reference Title
Reference Citation
1. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Bruick RK Genes Dev 2003 Nov 1;17(21):2614-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Keith B, etal., Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
PMID:11641274   PMID:12042299   PMID:12080085   PMID:12215170   PMID:12446723   PMID:12477932   PMID:14701857   PMID:14734545   PMID:15239670   PMID:17003112   PMID:17135241   PMID:17573339  
PMID:17636018   PMID:18299578   PMID:19245366   PMID:19726677   PMID:20720525   PMID:21177872   PMID:21251231   PMID:24867948   PMID:25728779   PMID:26025394  



Hif1an
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,368,400 - 253,385,495 (+)NCBIGRCr8
mRatBN7.21243,419,175 - 243,440,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,419,194 - 243,434,327 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,564,114 - 251,578,965 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,265,303 - 258,276,602 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,914,313 - 250,928,924 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,309,214 - 264,319,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,309,214 - 264,319,267 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,752,379 - 271,762,022 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,607,945 - 249,618,000 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,868,052 - 249,878,559 (+)NCBI
Celera1239,233,319 - 239,243,566 (+)NCBICelera
Cytogenetic Map1q54NCBI
HIF1AN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,535,943 - 100,559,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,529,072 - 100,559,998 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,295,700 - 102,319,755 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,285,631 - 102,303,671 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410102,285,685 - 102,299,745NCBI
Celera1096,033,472 - 96,051,511 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,924,437 - 95,942,312 (+)NCBIHuRef
CHM1_110102,580,289 - 102,598,327 (+)NCBICHM1_1
T2T-CHM13v2.010101,419,020 - 101,443,061 (+)NCBIT2T-CHM13v2.0
Hif1an
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,551,293 - 44,564,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,551,289 - 44,564,713 (+)EnsemblGRCm39 Ensembl
GRCm381944,562,854 - 44,576,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,562,850 - 44,576,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371944,637,344 - 44,650,764 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,616,165 - 44,629,585 (+)NCBIMGSCv36mm8
Celera1945,330,539 - 45,343,961 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1937.98NCBI
Hif1an
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,592,106 - 9,602,019 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554859,592,106 - 9,602,019 (-)NCBIChiLan1.0ChiLan1.0
HIF1AN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,419,630 - 112,437,585 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,424,952 - 112,442,905 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01097,135,751 - 97,148,378 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,616,208 - 100,634,201 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,616,208 - 100,628,470 (+)Ensemblpanpan1.1panPan2
HIF1AN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,253,646 - 13,277,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,258,765 - 13,267,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,424,601 - 13,448,956 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,722,856 - 13,747,207 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,727,221 - 13,747,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,269,337 - 13,293,495 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,310,952 - 13,335,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,441,952 - 13,472,609 (+)NCBIUU_Cfam_GSD_1.0
Hif1an
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,499,365 - 33,518,892 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366005,106,166 - 5,116,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF1AN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,636,376 - 111,650,318 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,636,317 - 111,654,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,295,774 - 121,311,992 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF1AN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,557,143 - 93,569,301 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,557,055 - 93,569,035 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,605,396 - 54,623,074 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hif1an
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831206,414 - 216,592 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624831206,856 - 226,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hif1an
50 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000019070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 62 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat

1 to 10 of 62 rows
Hif1an  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,419,727 - 243,419,862 (+)MAPPERmRatBN7.2
Rnor_6.01264,309,738 - 264,309,872NCBIRnor6.0
Rnor_5.01271,752,903 - 271,753,037UniSTSRnor5.0
Celera1239,233,843 - 239,233,977UniSTS
Cytogenetic Map1q54UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019070   ⟹   ENSRNOP00000019070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,419,194 - 243,427,254 (+)Ensembl
Rnor_6.0 Ensembl1264,309,214 - 264,319,267 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114444   ⟹   ENSRNOP00000078637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,419,210 - 243,434,327 (+)Ensembl
RefSeq Acc Id: NM_001113749   ⟹   NP_001107221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,368,424 - 253,380,665 (+)NCBI
mRatBN7.21243,419,204 - 243,431,445 (+)NCBI
Rnor_6.01264,309,214 - 264,319,269 (+)NCBI
Rnor_5.01271,752,379 - 271,762,022 (+)NCBI
RGSC_v3.41249,607,945 - 249,618,000 (+)RGD
Celera1239,233,319 - 239,243,566 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080364   ⟹   XP_038936292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,368,400 - 253,385,495 (+)NCBI
mRatBN7.21243,419,175 - 243,440,464 (+)NCBI
Protein RefSeqs NP_001107221 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936292 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58811 (Get FASTA)   NCBI Sequence Viewer  
  EDL94289 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019070.6
  ENSRNOP00000078637
  ENSRNOP00000078637.1
RefSeq Acc Id: NP_001107221   ⟸   NM_001113749
- UniProtKB: B0BNG5 (UniProtKB/TrEMBL),   A0A8I6G3J3 (UniProtKB/TrEMBL),   F7F9I0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019070   ⟸   ENSRNOT00000019070
RefSeq Acc Id: XP_038936292   ⟸   XM_039080364
- Peptide Label: isoform X1
- UniProtKB: F7F9I0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078637   ⟸   ENSRNOT00000114444
JmjC

Name Modeler Protein Id AA Range Protein Structure
AF-B0BNG5-F1-model_v2 AlphaFold B0BNG5 1-349 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690941
Promoter ID:EPDNEW_R1466
Type:multiple initiation site
Name:Hif1an_1
Description:hypoxia-inducible factor 1, alpha subunit inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01264,309,207 - 264,309,267EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-55584 BioCyc
Ensembl Genes ENSRNOG00000014234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019070.6 UniProtKB/TrEMBL
  ENSRNOT00000114444 ENTREZGENE
  ENSRNOT00000114444.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1010 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7368955 IMAGE-MGC_LOAD
InterPro Cupin_8 UniProtKB/TrEMBL
  FIH-1_domII UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  TF_JmjC_AAH UniProtKB/TrEMBL
KEGG Report rno:309434 UniProtKB/TrEMBL
MGC_CLONE MGC:188245 IMAGE-MGC_LOAD
NCBI Gene 309434 ENTREZGENE
PANTHER HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED UniProtKB/TrEMBL
  HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR UniProtKB/TrEMBL
Pfam Cupin_8 UniProtKB/TrEMBL
PhenoGen Hif1an PhenoGen
PROSITE JMJC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014234 RatGTEx
SMART JmjC UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt A0A8I6G3J3 ENTREZGENE, UniProtKB/TrEMBL
  B0BNG5 ENTREZGENE, UniProtKB/TrEMBL
  F7F9I0 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Hif1an  hypoxia inducible factor 1 subunit alpha inhibitor  Hif1an  hypoxia-inducible factor 1, alpha subunit inhibitor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hif1an  hypoxia-inducible factor 1, alpha subunit inhibitor   Hif1an_predicted  hypoxia-inducible factor 1, alpha subunit inhibitor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hif1an_predicted  hypoxia-inducible factor 1, alpha subunit inhibitor (predicted)      Symbol and Name status set to approved 70820 APPROVED