Gsto1 (glutathione S-transferase omega 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gsto1 (glutathione S-transferase omega 1) Rattus norvegicus
Analyze
Symbol: Gsto1
Name: glutathione S-transferase omega 1
RGD ID: 70952
Description: Enables glutathione dehydrogenase (ascorbate) activity. Involved in L-ascorbic acid biosynthetic process. Located in several cellular components, including basement membrane; cell body; and nuclear membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human GSTO1 (glutathione S-transferase omega 1); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase omega 1-1; glutathione S-transferase omega-1; glutathione-dependent dehydroascorbate reductase; GSTO 1-1; GSTO-1; MGC94845; MMA(V) reductase; monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; SPG-R
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,662,377 - 256,672,515 (+)NCBIGRCr8
mRatBN7.21246,721,089 - 246,731,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,721,221 - 246,731,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1254,848,516 - 254,858,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,541,609 - 261,551,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,191,672 - 254,201,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,607,437 - 267,617,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,418 - 267,617,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,040,049 - 275,050,033 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41253,228,547 - 253,238,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11253,493,307 - 253,503,274 (+)NCBI
Celera1242,486,178 - 242,496,113 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
hemin  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
Mesaconitine  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
basement membrane  (IDA)
cell body  (IDA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA)
nuclear membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Toward protein biomarkers for allergy: CD4+ T cell proteomics in allergic and nonallergic subjects sampled in and out of pollen season. Bluggel M, etal., J Proteome Res. 2011 Apr 1;10(4):1558-70. Epub 2011 Mar 16.
2. Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease. Capurso C, etal., Rejuvenation Res. 2010 Dec;13(6):645-52. Epub 2010 Sep 6.
3. Subcellular localization of a glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Fornai F, etal., Neuroscience. 2001;104(1):15-31.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
7. Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase. Ishikawa T, etal., J Biol Chem 1998 Oct 30;273(44):28708-12.
8. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li YJ, etal., Hum Mol Genet 2003 Dec 15;12(24):3259-67. Epub 2003 Oct 21.
9. Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver. Maellaro E, etal., Biochem J 1994 Jul 15;301 ( Pt 2):471-6.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk A, etal., Neurobiol Aging. 2005 Aug-Sep;26(8):1161-5. Epub 2004 Dec 18.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
18. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Wahner AD, etal., Neurosci Lett. 2007 Feb 21;413(3):274-8. Epub 2006 Dec 27.
Additional References at PubMed
PMID:11035031   PMID:11511179   PMID:12477932   PMID:12928150   PMID:19056867   PMID:20458337   PMID:23376485   PMID:23533145   PMID:31505169   PMID:32057363  


Genomics

Comparative Map Data
Gsto1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,662,377 - 256,672,515 (+)NCBIGRCr8
mRatBN7.21246,721,089 - 246,731,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,721,221 - 246,731,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1254,848,516 - 254,858,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,541,609 - 261,551,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,191,672 - 254,201,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,607,437 - 267,617,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,418 - 267,617,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,040,049 - 275,050,033 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41253,228,547 - 253,238,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11253,493,307 - 253,503,274 (+)NCBI
Celera1242,486,178 - 242,496,113 (+)NCBICelera
Cytogenetic Map1q54NCBI
GSTO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810104,254,173 - 104,267,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10104,235,356 - 104,267,459 (+)EnsemblGRCh38hg38GRCh38
GRCh3710106,013,931 - 106,027,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,004,668 - 106,017,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410106,004,667 - 106,017,199NCBI
Celera1099,754,787 - 99,768,056 (+)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef1099,645,735 - 99,659,002 (+)NCBIHuRef
CHM1_110106,297,838 - 106,311,108 (+)NCBICHM1_1
T2T-CHM13v2.010105,142,310 - 105,155,591 (+)NCBIT2T-CHM13v2.0
Gsto1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,843,412 - 47,853,229 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1947,843,409 - 47,853,229 (+)EnsemblGRCm39 Ensembl
GRCm381947,854,973 - 47,864,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,854,970 - 47,864,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv371947,929,479 - 47,939,280 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361947,908,300 - 47,918,101 (+)NCBIMGSCv36mm8
Celera1948,615,471 - 48,625,281 (+)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1940.41NCBI
GSTO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28116,140,609 - 116,153,570 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110116,145,764 - 116,158,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010100,853,682 - 100,866,892 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110104,312,403 - 104,325,733 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,313,024 - 104,325,733 (+)Ensemblpanpan1.1panPan2
GSTO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,569,421 - 16,579,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,569,066 - 16,619,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2816,741,837 - 16,751,645 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02817,047,667 - 17,057,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2817,047,318 - 17,057,465 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12816,595,211 - 16,605,015 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,623,890 - 16,633,711 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,762,582 - 16,772,417 (+)NCBIUU_Cfam_GSD_1.0
Gsto1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,328,927 - 30,339,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366001,930,695 - 1,943,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366001,932,152 - 1,943,342 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,206,188 - 115,216,613 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114115,206,434 - 115,216,624 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,175,630 - 125,185,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSTO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,305,094 - 97,317,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604858,424,657 - 58,438,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsto1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248313,342,584 - 3,352,467 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248313,342,539 - 3,351,766 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gsto1
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000016851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016851   ⟹   ENSRNOP00000016851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,721,298 - 246,731,468 (+)Ensembl
Rnor_6.0 Ensembl1267,607,437 - 267,617,387 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076367   ⟹   ENSRNOP00000067943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1267,607,418 - 267,617,367 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,721,221 - 246,722,689 (+)Ensembl
Rnor_6.0 Ensembl1267,607,483 - 267,608,950 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097867   ⟹   ENSRNOP00000095479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,721,255 - 246,731,468 (+)Ensembl
RefSeq Acc Id: NM_001007602   ⟹   NP_001007603
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,662,531 - 256,672,515 (+)NCBI
mRatBN7.21246,721,243 - 246,731,228 (+)NCBI
Rnor_6.01267,607,437 - 267,617,387 (+)NCBI
Rnor_5.01275,040,049 - 275,050,033 (+)NCBI
RGSC_v3.41253,228,547 - 253,238,531 (+)RGD
Celera1242,486,178 - 242,496,113 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108850   ⟹   XP_038964778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,662,377 - 256,672,515 (+)NCBI
mRatBN7.21246,721,089 - 246,731,221 (+)NCBI
RefSeq Acc Id: NP_001007603   ⟸   NM_001007602
- UniProtKB: Q9Z339 (UniProtKB/Swiss-Prot),   Q6AXR6 (UniProtKB/TrEMBL),   A6JHR8 (UniProtKB/TrEMBL),   B6DYQ5 (UniProtKB/TrEMBL),   F7F9Z0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016851   ⟸   ENSRNOT00000016851
Ensembl Acc Id: ENSRNOP00000067943   ⟸   ENSRNOT00000076367
RefSeq Acc Id: XP_038964778   ⟸   XM_039108850
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095479   ⟸   ENSRNOT00000097867
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z339-F1-model_v2 AlphaFold Q9Z339 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690981
Promoter ID:EPDNEW_R1506
Type:initiation region
Name:Gsto1_1
Description:glutathione S-transferase omega 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01267,607,462 - 267,607,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70952 AgrOrtholog
BioCyc Gene G2FUF-55463 BioCyc
Ensembl Genes ENSRNOG00000028746 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016851.6 UniProtKB/TrEMBL
  ENSRNOT00000077011.2 UniProtKB/TrEMBL
  ENSRNOT00000097867.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109248 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_omega UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_Omega/HSP26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Omega/Tau-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114846 UniProtKB/TrEMBL
MGC_CLONE MGC:94845 IMAGE-MGC_LOAD
NCBI Gene 114846 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE OMEGA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43968 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C_3 UniProtKB/TrEMBL
  GST_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_3 UniProtKB/TrEMBL
PhenoGen Gsto1 PhenoGen
PRINTS GSTRNSFRASEO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028746 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZS8_RAT UniProtKB/TrEMBL
  A0A8I6B2N7_RAT UniProtKB/TrEMBL
  A6JHR8 ENTREZGENE, UniProtKB/TrEMBL
  A6JHR9_RAT UniProtKB/TrEMBL
  B6DYQ5 ENTREZGENE, UniProtKB/TrEMBL
  F7F9Z0 ENTREZGENE, UniProtKB/TrEMBL
  GSTO1_RAT UniProtKB/Swiss-Prot
  Q6AXR6 ENTREZGENE
  Q9Z339 ENTREZGENE
UniProt Secondary Q6AXR6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Gsto1  glutathione S-transferase omega 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 1.5 fold in SHR compared with WKY rats 1357414
gene_protein 213 amino acids with a molecular weight of 24,929 70644