Rbp4 (retinol binding protein 4) - Rat Genome Database

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Gene: Rbp4 (retinol binding protein 4) Rattus norvegicus
Symbol: Rbp4
Name: retinol binding protein 4
RGD ID: 3546
Description: Enables retinol binding activity. Involved in response to ethanol and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4); PARTICIPATES IN retinoic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: plasma retinol-binding protein; PRBP; RBP; RBPA; retinol binding protein 4, plasma; retinol-binding protein 4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21235,893,917 - 235,901,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,315,318 - 244,322,517 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01251,211,097 - 251,218,299 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01244,049,331 - 244,056,533 (-)NCBIRnor_WKY
Rnor_6.01256,806,476 - 256,813,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,286,998 - 264,294,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,443,795 - 242,450,997 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,637,193 - 242,644,147 (-)NCBI
Celera1232,987,269 - 232,994,470 (-)NCBICelera
RH 3.4 Map11581.5RGD
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP)
beta-carotene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A5  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
folic acid  (ISO)
fonofos  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glycogen  (ISO)
GW 4064  (ISO)
hydrazine  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
metformin  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-N-nitrosourea  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl ethyl ether  (EXP)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes. Akbay E, etal., J Endocrinol Invest. 2010 Nov;33(10):725-9. doi: 10.1007/BF03346678. Epub 2010 Apr 30.
2. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Berry DC and Noy N, Biochim Biophys Acta. 2012 Jan;1821(1):168-76. Epub 2011 Jul 12.
3. Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy. Bobbert P, etal., Eur J Heart Fail. 2009 Dec;11(12):1163-8. doi: 10.1093/eurjhf/hfp153.
4. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes. Cabré A, etal., J Intern Med. 2007 Oct;262(4):496-503. doi: 10.1111/j.1365-2796.2007.01849.x.
5. Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement. Chavarria N, etal., Circ J. 2012;76(9):2148-52. doi: 10.1253/circj.cj-12-0350. Epub 2012 Jun 12.
6. Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia. Chayanupatkul M, etal., Hepatol Int. 2011 Dec;5(4):906-12. doi: 10.1007/s12072-011-9262-2. Epub 2011 Mar 6.
7. Associations of metabolic factors, especially serum retinol-binding protein 4 (RBP4), with blood pressure in Japanese--the Tanno and Sobetsu study. Chiba M, etal., Endocr J. 2010;57(9):811-7. doi: 10.1507/endocrj.k10e-054. Epub 2010 Aug 24.
8. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Craig RL, etal., Mol Genet Metab. 2007 Mar;90(3):338-44. Epub 2006 Dec 14.
9. Retinol-binding protein 4 levels and susceptibility to ischaemic events in men. Cubedo J, etal., Eur J Clin Invest. 2014;44(3):266-75. doi: 10.1111/eci.12229. Epub 2014 Jan 11.
10. [Serum levels of retinol-binding protein-4 and its association with metabolic syndrome in first-degree relatives of type 2 diabetes mellitus]. Gao S, etal., Zhonghua Yi Xue Za Zhi. 2009 Aug 11;89(30):2129-33.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis? Gerdes S, etal., Exp Dermatol. 2012 Jan;21(1):43-7. doi: 10.1111/j.1600-0625.2011.01402.x.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Structural modifications of serum transthyretin in rats during protein-energy malnutrition. Henze A, etal., Rapid Commun Mass Spectrom. 2008 Oct;22(20):3270-4.
15. Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. Ingelsson E, etal., Atherosclerosis. 2009 Sep;206(1):239-44. doi: 10.1016/j.atherosclerosis.2009.02.029. Epub 2009 Mar 11.
16. The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability. Kadoglou NP, etal., Atherosclerosis. 2014 Aug;235(2):606-12. doi: 10.1016/j.atherosclerosis.2014.05.957. Epub 2014 Jun 8.
17. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Kang L, etal., Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11.
18. Novel role for retinol-binding protein 4 in the regulation of blood pressure. Kraus BJ, etal., FASEB J. 2015 Aug;29(8):3133-40. doi: 10.1096/fj.14-266064. Epub 2015 Apr 24.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease. Lambadiari V, etal., Cardiovasc Diabetol. 2014 Aug 21;13:121. doi: 10.1186/s12933-014-0121-z.
21. Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein. Laurent BC, etal., J Biol Chem 1985 Sep 25;260(21):11476-80.
22. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Lee DC, etal., Metabolism. 2007 Mar;56(3):327-31. doi: 10.1016/j.metabol.2006.10.011.
23. Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia. Li F, etal., Am J Med Sci. 2014 Dec;348(6):474-9. doi: 10.1097/MAJ.0000000000000347.
24. Retinol-binding protein 4 is closely correlated to blood pressure level and E/A in untreated essential hypertension patients. Li X, etal., Ann Palliat Med. 2019 Nov;8(5):645-650. doi: 10.21037/apm.2019.11.07.
25. Circulating retinol binding protein 4 is associated with coronary lesion severity of patients with coronary artery disease. Liu Y, etal., Atherosclerosis. 2015 Jan;238(1):45-51. doi: 10.1016/j.atherosclerosis.2014.11.016. Epub 2014 Nov 20.
26. Serum markers of pre-eclampsia identified on proteomics. Lu Q, etal., J Obstet Gynaecol Res. 2016 Sep;42(9):1111-8. doi: 10.1111/jog.13037. Epub 2016 Jun 8.
27. Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women. Mallat Z, etal., J Clin Endocrinol Metab. 2009 Jan;94(1):255-60. doi: 10.1210/jc.2008-0253. Epub 2008 Oct 14.
28. Retinol-binding protein 4 and insulin resistance in preeclampsia. Masuyama H, etal., Endocr J. 2011;58(1):47-53. doi: 10.1507/endocrj.k10e-288. Epub 2010 Dec 14.
29. Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models. Mercader J, etal., Horm Metab Res. 2008 Jul;40(7):467-72. Epub 2008 Mar 27.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Studies on the transport and cellular distribution of vitamin A in normal and vitamin A-deficient rats with special reference to the vitamin A-binding plasma protein. Peterson PA, etal., J Biol Chem. 1973 Jun 10;248(11):4009-22.
35. Microalbuminuria is a major determinant of elevated plasma retinol-binding protein 4 in type 2 diabetic patients. Raila J, etal., Kidney Int. 2007 Aug;72(4):505-11. doi: 10.1038/sj.ki.5002372. Epub 2007 Jun 13.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Comprehensive gene review and curation RGD comprehensive gene curation
40. Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Salgado-Somoza A, etal., Clin Endocrinol (Oxf). 2012 Jan;76(1):51-8. doi: 10.1111/j.1365-2265.2011.04140.x.
41. Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction. Sasaki M, etal., Metabolism. 2010 Apr;59(4):527-32. doi: 10.1016/j.metabol.2009.08.015. Epub 2009 Oct 20.
42. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Seeliger MW, etal., Invest Ophthalmol Vis Sci. 1999 Jan;40(1):3-11.
43. Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women. Seol HJ, etal., J Perinat Med. 2011 May;39(3):287-9. doi: 10.1515/jpm.2011.016. Epub 2011 Feb 7.
44. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
45. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Shangguan X, etal., Clin Chim Acta. 2009 Sep;407(1-2):58-61. doi: 10.1016/j.cca.2009.06.031. Epub 2009 Jun 29.
46. The correlation of retinol-binding protein-4 and lipoprotein combine index with the prevalence and diagnosis of acute coronary syndrome. Si Y, etal., Heart Vessels. 2020 Nov;35(11):1494-1501. doi: 10.1007/s00380-020-01627-8. Epub 2020 May 24.
47. Retinol-binding protein-4 in women with untreated essential hypertension. Solini A, etal., Am J Hypertens. 2009 Sep;22(9):1001-6. doi: 10.1038/ajh.2009.116. Epub 2009 Jun 25.
48. Serum retinol-binding protein 4 is associated with the presence and severity of coronary artery disease in patients with subclinical hypothyroidism. Sun HX, etal., Aging (Albany NY). 2019 Jul 6;11(13):4510-4520. doi: 10.18632/aging.102065.
49. Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults. Sun L, etal., J Nutr. 2014 May;144(5):722-8. doi: 10.3945/jn.113.189860. Epub 2014 Mar 19.
50. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Sun Q, etal., Circulation. 2013 May 14;127(19):1938-47. doi: 10.1161/CIRCULATIONAHA.113.002073. Epub 2013 Apr 12.
51. Amino acid sequence homologies between rabbit, rat, and human serum retinol-binding proteins. Sundelin J, etal., J Biol Chem 1985 May 25;260(10):6472-80.
52. Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis. Toyama T, etal., J Eur Acad Dermatol Venereol. 2013 Mar;27(3):337-44. doi: 10.1111/j.1468-3083.2011.04413.x. Epub 2011 Dec 26.
53. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.
54. Retinol-binding protein 4 regulates the biological functions and molecular mechanisms of JEG-3 cells. Wang F, etal.
55. Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage. Wang J, etal., Atherosclerosis. 2015 Jun;240(2):335-44. doi: 10.1016/j.atherosclerosis.2015.03.036. Epub 2015 Mar 28.
56. Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Xu M, etal., Diabetologia. 2009 Aug;52(8):1511-9. Epub 2009 Jun 9.
57. Interactions of transthyretin (TTR) and retinol-binding protein (RBP) in the uptake of retinol by primary rat hepatocytes. Yamamoto Y, etal., Exp Cell Res. 1997 Aug 1;234(2):373-8.
58. Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese. Zhang JX, etal., J Hum Hypertens. 2017 Oct;31(10):611-615. doi: 10.1038/jhh.2017.44. Epub 2017 Jun 22.
59. Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Zhang W, etal., Chin Med J (Engl). 2008 Nov 5;121(21):2124-8.
60. Evaluation of serum retinol-binding protein-4 levels as a biomarker of poor short-term prognosis in ischemic stroke. Zhu YY, etal., Biosci Rep. 2018 Sep 12;38(5):BSR20180786. doi: 10.1042/BSR20180786. Print 2018 Oct 31.
Additional References at PubMed
PMID:571335   PMID:1299958   PMID:5132677   PMID:9757135   PMID:10232633   PMID:10469643   PMID:10944490   PMID:11562477   PMID:12237133   PMID:12477932   PMID:12484775   PMID:12663486  
PMID:15314099   PMID:15994349   PMID:16034410   PMID:16586441   PMID:17003346   PMID:18093970   PMID:18466349   PMID:19056867   PMID:21365528   PMID:21487070   PMID:22015466   PMID:23105095  
PMID:23376485   PMID:23533145   PMID:24604418   PMID:24888764   PMID:26923513   PMID:33503180   PMID:34177800  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21235,893,917 - 235,901,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,315,318 - 244,322,517 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01251,211,097 - 251,218,299 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01244,049,331 - 244,056,533 (-)NCBIRnor_WKY
Rnor_6.01256,806,476 - 256,813,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,286,998 - 264,294,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,443,795 - 242,450,997 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,637,193 - 242,644,147 (-)NCBI
Celera1232,987,269 - 232,994,470 (-)NCBICelera
RH 3.4 Map11581.5RGD
Cytogenetic Map1q53NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381093,591,694 - 93,601,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1093,591,687 - 93,601,744 (-)EnsemblGRCh38hg38GRCh38
GRCh371095,351,451 - 95,361,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,341,583 - 95,350,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 341095,341,583 - 95,350,983NCBI
Celera1089,092,718 - 89,102,118 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,979,353 - 88,988,753 (-)NCBIHuRef
CHM1_11095,634,147 - 95,643,547 (-)NCBICHM1_1
T2T-CHM13v2.01094,471,646 - 94,481,695 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391938,105,068 - 38,113,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,105,077 - 38,113,729 (-)EnsemblGRCm39 Ensembl
GRCm381938,116,620 - 38,125,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,116,629 - 38,125,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371938,191,110 - 38,199,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,181,773 - 38,190,392 (-)NCBIMGSCv36mm8
Celera1938,908,311 - 38,919,212 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan110105,635,040 - 105,644,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01090,337,879 - 90,347,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,848,166 - 93,857,679 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,848,166 - 93,857,887 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1287,822,936 - 7,830,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,822,944 - 7,830,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721339,768,612 - 39,777,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,402,691 - 1,410,208 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366011,401,215 - 1,410,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14105,037,464 - 105,044,765 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,037,360 - 105,044,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,769,053 - 114,775,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1986,831,042 - 86,840,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,830,957 - 86,840,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604847,606,135 - 47,615,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247374,791,628 - 4,800,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,795,054 - 4,800,830 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Rbp4
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:105
Interacting mature miRNAs:114
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,893,954 - 235,894,089 (+)MAPPERmRatBN7.2
Rnor_6.01256,806,514 - 256,806,648NCBIRnor6.0
Rnor_5.01264,287,036 - 264,287,170UniSTSRnor5.0
RGSC_v3.41242,443,833 - 242,443,967UniSTSRGSC3.4
Celera1232,987,307 - 232,987,441UniSTS
RH 3.4 Map11581.5UniSTS
Cytogenetic Map1q53UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 37 37 37
Medium 2 1 19 4 7 4 4 4 36 14 24 11 4
Low 1 32 1 11 4 7 38 21 17 4
Below cutoff 9 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021055   ⟹   ENSRNOP00000021055
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,893,920 - 235,901,135 (-)Ensembl
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098047   ⟹   ENSRNOP00000088132
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)Ensembl
RefSeq Acc Id: NM_013162   ⟹   NP_037294
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,893,917 - 235,901,119 (-)NCBI
Rnor_6.01256,806,476 - 256,813,678 (-)NCBI
Rnor_5.01264,286,998 - 264,294,396 (-)NCBI
RGSC_v3.41242,443,795 - 242,450,997 (-)RGD
Celera1232,987,269 - 232,994,470 (-)RGD
RefSeq Acc Id: XM_039102172   ⟹   XP_038958100
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,893,917 - 235,901,315 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037294   ⟸   NM_013162
- Peptide Label: precursor
- UniProtKB: P04916 (UniProtKB/Swiss-Prot),   B2RZC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021055   ⟸   ENSRNOT00000021055
RefSeq Acc Id: XP_038958100   ⟸   XM_039102172
- Peptide Label: isoform X1
- UniProtKB: P04916 (UniProtKB/Swiss-Prot),   B2RZC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088132   ⟸   ENSRNOT00000098047
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04916-F1-model_v2 AlphaFold P04916 1-201 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690883
Promoter ID:EPDNEW_R1407
Type:multiple initiation site
Description:retinol binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01256,813,697 - 256,813,757EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3546 AgrOrtholog
BioCyc Gene G2FUF-55792 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
  PWY-6861 [the visual cycle I (vertebrates)] BioCyc
  PWY-6872 [retinoate biosynthesis I] BioCyc
  PWY-6875 [retinoate biosynthesis II] BioCyc
Ensembl Genes ENSRNOG00000015518 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021055 ENTREZGENE
  ENSRNOP00000021055.4 UniProtKB/Swiss-Prot
  ENSRNOP00000088132.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021055 ENTREZGENE
  ENSRNOT00000021055.8 UniProtKB/Swiss-Prot
  ENSRNOT00000098047.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinol-bd/Purpurin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11873 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rbp4 PhenoGen
PIRSF Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBP_purpurin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P04916 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Rbp4  retinol binding protein 4  Rbp4  retinol binding protein 4, plasma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rbp4  retinol binding protein 4, plasma    retinol binding protein 4  Name updated 1299863 APPROVED
2002-06-10 Rbp4  Retinol binding protein 4      Symbol and Name status set to approved 70586 APPROVED