RGD Reference Report - Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy. - Rat Genome Database

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Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy.

Authors: Vaisbuch, Edi  Romero, Roberto  Mazaki-Tovi, Shali  Kusanovic, Juan Pedro  Chaiworapongsa, Tinnakorn  Dong, Zhong  Kim, Sun Kwon  Ogge, Giovanna  Gervasi, Maria Teresa  Hassan, Sonia S 
Citation: Vaisbuch E, etal., J Perinat Med. 2010 Jul;38(4):359-66. doi: 10.1515/jpm.2010.066.
RGD ID: 329853301
Pubmed: PMID:20163326   (View Abstract at PubMed)
PMCID: PMC3034079   (View Article at PubMed Central)
DOI: DOI:10.1515/jpm.2010.066   (Journal Full-text)


OBJECTIVE: Adipokines have been implicated in metabolic regulation and the immune response thus providing a molecular mechanism for the interaction between these two systems. Retinol binding protein 4 (RBP4) is a novel adipokine that plays a role in the pathophysiology of obesity-induced insulin resistance, as well as in the modulation of inflammation. The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in pregnant women with acute pyelonephritis.
STUDY DESIGN: This cross-sectional study included pregnant women in the following groups: 1) normal pregnancy (n=80); 2) pyelonephritis (n=39). Maternal plasma RBP4 concentrations were determined by enzyme-linked immunoassays. Non-parametric statistics were used for analyses.
RESULTS: 1) The median maternal plasma RBP4 concentration was lower in patients with acute pyelonephritis than in those with a normal pregnancy (3709.6 ng/mL, interquartile range (IQR) 2917.7-5484.2 vs. 9167.6 ng/mL, IQR 7496.1- 10,384.1, P<0.001; 2) the median maternal plasma RBP4 concentration did not differ significantly between patients with acute pyelonephritis who had a positive blood culture and those with a negative culture (3285.3 ng/mL, IQR 2274.1-4741.1 vs. 3922.6 ng/mL, IQR 3126.8-5547.1, respectively, P=0.2); and 3) lower maternal plasma RBP4 concentrations were independently associated with pyelonephritis after adjustment for confounding factors.
CONCLUSIONS: In contrast to what has been reported in preeclampsia, acute pyelonephritis during pregnancy is associated with lower maternal plasma RBP4 concentrations than in normal pregnancy. This finding suggests that the acute maternal inflammatory process associated with pyelonephritis is fundamentally different from that of the chronic systemic inflammatory process suggested in preeclampsia, in which RBP4 concentrations were found to be elevated.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RBP4Humanacute pyelonephritis  IEP protein:decreased expression:blood plasma (human)RGD 
Rbp4Ratacute pyelonephritis  ISORBP4 (Homo sapiens)protein:decreased expression:blood plasma (human)RGD 
Rbp4Mouseacute pyelonephritis  ISORBP4 (Homo sapiens)protein:decreased expression:blood plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rbp4  (retinol binding protein 4)

Genes (Mus musculus)
Rbp4  (retinol binding protein 4, plasma)

Genes (Homo sapiens)
RBP4  (retinol binding protein 4)


Additional Information