RGD Reference Report - Retinol-binding protein-4 in women with untreated essential hypertension. - Rat Genome Database

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Retinol-binding protein-4 in women with untreated essential hypertension.

Authors: Solini, Anna  Santini, Eleonora  Madec, Stephanie  Rossi, Chiara  Muscelli, Elza 
Citation: Solini A, etal., Am J Hypertens. 2009 Sep;22(9):1001-6. doi: 10.1038/ajh.2009.116. Epub 2009 Jun 25.
RGD ID: 329845861
Pubmed: PMID:19556974   (View Abstract at PubMed)
DOI: DOI:10.1038/ajh.2009.116   (Journal Full-text)


BACKGROUND: Retinol-binding protein-4 (RBP4) is a novel adipokine able to modulate the action of insulin in several tissues. A variable degree of insulin resistance characterizes the vast majority of hypertensive (HYP) patients. The aim of this study was to evaluate the relationship between RBP4 and essential hypertension, exploring potential links between RBP4 and other adipokines with some proxies of early vascular damage in female naive HYP patients.
METHODS: Serum RBP4, leptin, adiponectin, and resistin levels were determined in 35 HYP and 35 normotensive lean women with normal glucose tolerance paired by age and body mass index (BMI) served as controls (CTL); carotid intima-media thickness (IMT) was also measured.
RESULTS: A striking difference was observed in RBP4 levels between HYP and CTL with significantly higher levels in the former than in the latter. No relationship was observed between glomerular filtration rate (GFR) and RBP4. Adiponectin levels were slightly but significantly lower in HYP than in CTL, whereas no differences were observed in resistin and leptin concentrations between the two groups of women. In the whole study group, a strong linear relationship was observed between IMT value and both RBP4 (rho = 0.321, P = 0.0076) and resistin (rho = 0.340, P = 0.0048); these two adipocytokines, together with cholesterol, were the only variables independently related to IMT (r(2) = 0.24; P = 0.004) by a stepwise analysis.
CONCLUSIONS: RBP4 levels are increased in naive HYP women and correlated with the degree of IMT suggesting a participation of this adipocytokine in the modulation of the atherosclerotic process exerted by the adipose tissue as endocrine organ.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
essential hypertension disease_progressionIEP 329845861protein:increased expression:blood serum (human)RGD 
essential hypertension disease_progressionISORBP4 (Homo sapiens)329845861; 329845861protein:increased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rbp4  (retinol binding protein 4)

Genes (Mus musculus)
Rbp4  (retinol binding protein 4, plasma)

Genes (Homo sapiens)
RBP4  (retinol binding protein 4)


Additional Information