Pnlip (pancreatic lipase) - Rat Genome Database

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Gene: Pnlip (pancreatic lipase) Rattus norvegicus
Symbol: Pnlip
Name: pancreatic lipase
RGD ID: 3360
Description: Enables triglyceride lipase activity. Involved in several processes, including post-embryonic development; response to lipid; and response to peptide hormone. Located in extracellular space. Used to study obesity. Orthologous to human PNLIP (pancreatic lipase); PARTICIPATES IN glycerolipid metabolic pathway; retinol metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride.
Type: protein-coding
Previously known as: LOC108349706; pancreatic triacylglycerol lipase; pancreatic triglyceride lipase; PANLI; PL; uncharacterized LOC108349706
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Bw54
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21257,774,012 - 257,811,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,798,581 - 257,811,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,009,226 - 266,022,367 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01272,715,238 - 272,728,379 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01265,351,509 - 265,364,696 (+)NCBIRnor_WKY
Rnor_6.01279,798,187 - 279,811,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,136,617 - 287,172,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,107,812 - 265,120,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,318,856 - 265,332,014 (+)NCBI
Celera1253,456,158 - 253,469,343 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats. Birk RZ, etal., Pediatr Res. 2004 Aug;56(2):256-62. Epub 2004 Jun 4.
2. Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat. Elinson N, etal., Br J Nutr. 2006 Oct;96(4):691-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
6. A structural domain (the lid) found in pancreatic lipases is absent in the guinea pig (phospho)lipase. Hjorth A, etal., Biochemistry 1993 May 11;32(18):4702-7.
7. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. Jennens ML and Lowe ME, J Lipid Res. 1995 Nov;36(11):2374-82.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Kullman J, etal., Am J Physiol. 1996 May;270(5 Pt 1):G746-51.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat. Muramatsu Y, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):1270-6.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development. Payne RM, etal., Am J Physiol 1994 May;266(5 Pt 1):G914-21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Identification and cloning of GP-3 from rat pancreatic acinar zymogen granules as a glycosylated membrane-associated lipase. Wishart MJ, etal., J Biol Chem 1993 May 15;268(14):10303-11.
Additional References at PubMed
PMID:9631512   PMID:12915407   PMID:19760487   PMID:21382969   PMID:21469501   PMID:24262094   PMID:25862608  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21257,774,012 - 257,811,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,798,581 - 257,811,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,009,226 - 266,022,367 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01272,715,238 - 272,728,379 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01265,351,509 - 265,364,696 (+)NCBIRnor_WKY
Rnor_6.01279,798,187 - 279,811,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,136,617 - 287,172,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,107,812 - 265,120,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,318,856 - 265,332,014 (+)NCBI
Celera1253,456,158 - 253,469,343 (+)NCBICelera
Cytogenetic Map1q55NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3810116,545,931 - 116,567,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10116,545,931 - 116,567,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3710118,305,443 - 118,327,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,295,418 - 118,317,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,295,448 - 118,317,356NCBI
Celera10112,034,704 - 112,056,644 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10111,932,653 - 111,954,591 (+)NCBIHuRef
CHM1_110118,588,590 - 118,610,538 (+)NCBICHM1_1
T2T-CHM13v2.010117,439,962 - 117,461,884 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391958,658,797 - 58,670,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,640,930 - 58,670,220 (+)EnsemblGRCm39 Ensembl
GRCm381958,670,365 - 58,681,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,652,498 - 58,681,788 (+)EnsemblGRCm38mm10GRCm38
MGSCv371958,744,855 - 58,756,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361958,723,615 - 58,735,038 (+)NCBIMGSCv36mm8
Celera1960,867,340 - 60,878,784 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.46NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.110116,568,110 - 116,589,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,568,273 - 116,589,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010113,067,443 - 113,158,473 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12827,139,028 - 27,156,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,675,917 - 27,749,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14126,772,911 - 126,790,001 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,017,775 - 138,032,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.19109,330,050 - 109,375,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604870,600,324 - 70,623,276 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Pnlip
203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:52
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,807,548 - 257,808,665 (+)MAPPERmRatBN7.2
Rnor_6.01279,807,267 - 279,808,383NCBIRnor6.0
Rnor_5.01287,168,807 - 287,169,923UniSTSRnor5.0
RGSC_v3.41265,116,864 - 265,117,980UniSTSRGSC3.4
Celera1253,465,238 - 253,466,354UniSTS
RH 3.4 Map11690.9UniSTS
Cytogenetic Map1q55UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 8 6 3 6 14
Low 2 11 1 7 1 6 7 38 6 25 7 6
Below cutoff 2 12 5 1 2 1 2 2 16 9 10 1 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024065   ⟹   ENSRNOP00000024065
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,798,581 - 257,811,654 (+)Ensembl
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103590   ⟹   ENSRNOP00000095754
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,799,020 - 257,811,654 (+)Ensembl
RefSeq Acc Id: NM_013161   ⟹   NP_037293
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,798,469 - 257,811,654 (+)NCBI
Rnor_6.01279,798,187 - 279,811,372 (+)NCBI
Rnor_5.01287,136,617 - 287,172,914 (+)NCBI
RGSC_v3.41265,107,812 - 265,120,969 (+)RGD
Celera1253,456,158 - 253,469,343 (+)RGD
RefSeq Acc Id: XM_039102162   ⟹   XP_038958090
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21257,774,012 - 257,811,656 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037293   ⟸   NM_013161
- Peptide Label: precursor
- UniProtKB: G3V8A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024065   ⟸   ENSRNOT00000024065
RefSeq Acc Id: XP_038958090   ⟸   XM_039102162
- Peptide Label: isoform X1
- UniProtKB: G3V8A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095754   ⟸   ENSRNOT00000103590
Protein Domains
Lipase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27657-F1-model_v2 AlphaFold P27657 1-465 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3360 AgrOrtholog
BioCyc Gene G2FUF-55270 BioCyc
Ensembl Genes ENSRNOG00000017725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024065 ENTREZGENE
  ENSRNOP00000024065.4 UniProtKB/TrEMBL
  ENSRNOP00000095754.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024065 ENTREZGENE
  ENSRNOT00000024065.6 UniProtKB/TrEMBL
  ENSRNOT00000103590.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_panc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25702 UniProtKB/Swiss-Prot
PANTHER PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnlip PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pnlip  pancreatic lipase  LOC108349706  uncharacterized LOC108349706  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108349706  uncharacterized LOC108349706      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pnlip  Pancreatic lipase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression is low in the fetal pancreas but rises rapidly during the suckling-weanling transition 728275
gene_function digests lipids 728275